Hillman Acetates Research Articles

Stereoselective and regioselective synthesis of $N$-substituted methyl 2-((azolyl)methyl)-3-arylacrylates from Baylis--Hillman acetates

$N$-Substituted methyl 2-((azolyl)methyl)-3-arylacrylates were synthesized stereo- and regioselectively with one-pot reaction between Baylis--Hillman acetates and a suitable acylazole in the presence of K$_{2}$CO$_{3}$ as a base catalyst. The targeted $N$-substituted azole acrylates were efficiently obtained in good yields (39%-89%).

Synthesis of Unsaturated Seven-Membered Ring Lactams through Palladium-Catalyzed Amination and Intramolecular Cyclocarbonylation Reactions of Amines and Baylis−Hillman Acetates

A versatile synthesis of unsaturated seven-membered ring lactams has been developed. The sequence involves hydroamination of Baylis-Hillman acetate with amines, followed by intramolecular cyclocarbonylation reactions of the resulting allylamines. This process can tolerate a wide array of functional groups, and affords lactams in excellent yields.

The Baylis−Hillman Acetates as a Valuable Source for One-Pot Multistep Synthesis: A Facile Synthesis of Functionalized Tri-/Tetracyclic Frameworks Containing Azocine Moiety

The Baylis-Hillman acetates have been conveniently transformed into tri-/tetracyclic heterocyclic frameworks containing an important azocine moiety via one-pot multistep protocol involving alkylation, reduction, and cyclization sequence.