e13626 Background: The dynamic and easily accessible nature of social media platforms, particularly YouTube (YT), has revolutionized the way breast cancer (BC) patients seek and process information. This study aims to evaluate the quality of YT videos addressing post-mastectomy reconstruction (PMR) that target Arabic-speaking women (ASW), a heavily digitally connected segment of society that may experience challenges in accessing mainstream medical information in Arabic Language (AL). Methods: YT was searched incognito, using the terms: "post mastectomy reconstruction" in (AL) in July 2023. Upload date, video length, number of views, poster identity and other relevant information were compiled. Video understandability and actionability were assessed by physician-reviewers (PR) with the Patient Education Materials Assessment Tool for audiovisual materials (PEMAT A/V), while the DISCERN tool appraised quality. Sponsorship presence, patient vs health care professional narratives, and intended audience were documented. Thematic analysis of most discussed topics was performed. Additionally, cluster analysis was employed to categorize the videos based on their quality. Results: Of 109 videos (mean length: 7 mins.), 67% had sponsorship (of which 45% corporate); 92% were information-based (vs experience-based); 82% targeted general population over BC patients; 93.6% were in AL, and 5.5% had translation. Mean PEMAT scores were 61.3% (understandability) and 20% (actionability). Mean DISCERN score was 2.6/5. Only 21% of videos featured women. Predominant themes were awareness (82.6%), appearance, and body image (68.8%). Less prevalent: sexuality and fertility (4.6%). The likelihood that the PR would recommend the video to a patient was low at 43.1%. Cluster analysis showed that high-quality videos had a higher understandability (74%), actionability (40.5%) and greater likelihood of being recommended by a PR (90.5%). Conclusions: YT content on PMR for ASW is easily understandable but lacks actionability and has moderate overall quality. Videos are highly sponsored and questionably representative of patients’ and women’s perspective. Therefore, Improving YT content, especially in AL, is crucial for supporting BC patients exploring PMR. The identified themes and insights into gender representation provide valuable guidance for content creators aiming to improve digital resources for this digitally connected demographic.