Higher Response Amplitudes Research Articles

Virtual stimulation of the interictal EEG network localizes the EZ as a measure of cortical excitability.

Introduction: For patients with drug-resistant epilepsy, successful localization and surgical treatment of the epileptogenic zone (EZ) can bring seizure freedom. However, surgical success rates vary widely because there are currently no clinically validated biomarkers of the EZ. Highly epileptogenic regions often display increased levels of cortical excitability, which can be probed using single-pulse electrical stimulation (SPES), where brief pulses of electrical current are delivered to brain tissue. It has been shown that high-amplitude responses to SPES can localize EZ regions, indicating a decreased threshold of excitability. However, performing extensive SPES in the epilepsy monitoring unit (EMU) is time-consuming. Thus, we built patient-specific in silico dynamical network models from interictal intracranial EEG (iEEG) to test whether virtual stimulation could reveal information about the underlying network to identify highly excitable brain regions similar to physical stimulation of the brain. Methods: We performed virtual stimulation in 69 patients that were evaluated at five centers and assessed for clinical outcome 1year post surgery. We further investigated differences in observed SPES iEEG responses of 14 patients stratified by surgical outcome. Results: Clinically-labeled EZ cortical regions exhibited higher excitability from virtual stimulation than non-EZ regions with most significant differences in successful patients and little difference in failure patients. These trends were also observed in responses to extensive SPES performed in the EMU. Finally, when excitability was used to predict whether a channel is in the EZ or not, the classifier achieved an accuracy of 91%. Discussion: This study demonstrates how excitability determined via virtual stimulation can capture valuable information about the EZ from interictal intracranial EEG.

Different Soil-Structure Interaction Modelling Strategies for Seismic Analysis of a Masonry Church

ABSTRACT Masonry structures can be damaged different external reasons such as war, flood, earthquake etc. For protecting and transfer to the next generations, these structures can be examined detailed. Finite element analysis has generally been used for the seismic evaluation of masonry structures. The fixed base assumption has been used in traditional finite element analysis of masonry structures. Interacting with the surrounding soil and structure was generally ignored. The seismic behavior of masonry structures is significantly influenced by the soil-structure interaction (SSI). There are various soil structure interaction modelling strategies in the recent studies. In this paper, the dimensions, mechanical properties and material model of the soil are considered constant. One of them had no soil-structure interaction. The others, roller support case, fixed support case, absorbing boundary case, free field columns and Winkler supports. Variations in the seismic response of a historical masonry church were investigated using 4 different SSI models and a fixed base (SSI ignored) model. Nonlinear time history analyses were employed for the finite element analysis. The soil borehole provided the material characteristics of the surrounding soil. According to the analysis results, higher response amplitudes were obtained when SSI was considered.

Sleep- and sleep deprivation-related changes of vertex auditory evoked potentials during the estrus cycle in female rats

The estrus cycle in female rodents has been shown to affect a variety of physiological functions. However, little is known about its presumably thorough effect on auditory processing during the sleep–wake cycle and sleep deprivation. Vertex auditory evoked potentials (vAEPs) were evoked by single click tone stimulation and recorded during different stages of the estrus cycle and sleep deprivation performed in metestrus and proestrus in female rats. vAEPs showed a strong sleep-dependency, with the largest amplitudes present during slow wave sleep while the smallest ones during wakefulness. Higher amplitudes and longer latencies were seen in the light phase during all vigilance stages. The largest amplitudes were found during proestrus (light phase) while the shortest latencies were seen during estrus (dark phase) compared to the 2nd day diestrus baseline. High-amplitude responses without latency changes were also seen during metestrus with increased homeostatic sleep drive. More intense and faster processing of auditory information during proestrus and estrus suggesting a more effective perception of relevant environmental cues presumably in preparation for sexual receptivity. A 4-h sleep deprivation resulted in more pronounced sleep recovery in metestrus compared to proestrus without difference in delta power replacement suggesting a better tolerance of sleep deprivation in proestrus. Sleep deprivation decreased neuronal excitability and responsiveness in a similar manner both during metestrus and proestrus, suggesting that the negative consequences of sleep deprivation on auditory processing may have a limited correlation with the estrus cycle stage.

Sound radiation of a vibrating circular plate set in a hemispherical enclosure

This study rigorously addresses the Neumann–Robin problem of sound radiation from a vibrating flexible disk embedded into a hemispherical enclosure. The enclosure is acoustically soft on its inside surface and hard on its outside surface. The method of superimposed solutions, expressed in terms of Dini series and spherical harmonics, has been applied for this purpose. The presented solution is applicable to any vibration velocity profile on the radiator, with an elastically supported thin plate excited asymmetrically used as an example. The results presented here can be valuable for modeling vibroacoustic responses of various speakers, sensors, and microphones with edges either clamped to the enclosure or nearly free. Achieving this involves modifying the values of the boundary stiffness for resisting transverse displacement and the rotation of the plate’s edge. Additionally, when applying these results to model the responses of alarm or signaling transducers, high-amplitude responses are expected for selected resonant frequencies. In such cases, the boundary stiffness values can be set to ensure multiple strong and wide resonant maxima in the frequency characteristics. In addition, the results presented in this study include solving the dynamic equation of motion for the plate or rigid piston with external excitation. This equation is coupled with the wave equation inside and outside the hemispherical enclosure, allowing the inclusion of the enclosure’s effect on the plate-enclosure system’s responses. This approach can be useful for modeling and improving the acoustic responses of spherical speakers. In such cases, the boundary stiffness values should be relatively small to emulate a soft suspension of the plate. The impedance of the enclosure’s internal surface can be arbitrarily selected, ranging from acoustically hard to acoustically soft. In this study, the impedance of mineral wool has been applied. Numerical analysis is presented for frequencies below 4kHz, with errors smaller than 0.2%. The results have been validated using the finite element method.

Numerical study into the impact of fixed upstream cylinder diameter ratios on vibration of leeward tandem cylinders

Multiple-cylinder fluid flows present challenges due to the strong interference between wakes, shear layers, and Kármán vortex streets, resulting in high-amplitude vibration responses. Despite these challenges, recent research has explored the potential for extracting hydrokinetic energy from such phenomena. In the present study, high-fidelity simulations are performed for flow-induced vibrations (FIV) of large spacing tandem cylinders, located leeward of a fixed cylinder with a small spacing ratio. The objective is to investigate the effect of diameter ratios of the upstream fixed cylinder on the energy conversion of its leeward tandem cylinders. Vibration responses of the midstream and downstream cylinders are identified by analyzing their amplitudes, frequencies and force coefficients, as well as vorticity contours. Results show that the presence of a large fixed upstream cylinder generates large vortices capable of synchronizing the vibrations of leeward cylinders, resulting in regular, larger amplitudes, and higher power harnessing efficiency compared to a fixed upstream cylinder with smaller diameters. Overall, this study contributes to a better understanding of fluid–structure interactions and their potential for energy conversion in multiple-cylinder systems.

Rapid Magnetic Susceptibility Characterization of Coastal Morphosedimentary Units at Two Insular Strandplains in Estonia

Coastal archives of changing hydrometeorological conditions include mineralogical anomalies, such as heavy-mineral concentrations (HMCs) of variable thickness and intensity, which contain varying ferrimagnetic (e.g., magnetite) fractions. As an effective alternative to laborious mineralogical and granulometric analysis, we present the first set of bulk-volume low-field magnetic susceptibility (MS) databases from beach and dune lithosomes in the Western Estonian archipelago: Harilaid cuspate foreland (westernmost Saaremaa Island) and Tahkuna strandplain (northernmost Hiiumaa Island). Readings were conducted both in situ from trench walls and on core subsamples. At the Tahkuna site, late Holocene beach ridges reveal substantially lower values: quartz-dominated dune sequences grade from 5–20 μSI downward to diamagnetically dominated (−1–7 μSI) beach facies. Values are higher (20–140 μSI) in historically reactivated parabolic dunes that are encroaching southward over the strandplain. At the Harilaid site, four beach dune ridges (height: 2–3 m) that span the past 250–300 years show a general increase in mean MS from 320–850 μSI with decreasing age, with peaks of 1000–2000 μSI below the dune crests (depth: ~0.3–0.6 m) likely related to contemporary wind acceleration during ridge aggradation. The highest mineralogical anomalies range from 2000–5500 μSI in the historic dune sections and exceed 8000 μSI along the actively eroding upper-berm segments, typical of HMCs generated by moderate storms. MS anomalies are likely correlated with high-amplitude electromagnetic signal responses in georadar records and provide useful information for optical luminescence sampling strategies. Our study demonstrates that magnetic susceptibility trends provide a useful means of rapidly assessing relative temporal changes in overall wave/wind climates, help identify and correlate discrete anomalies related to extreme events, serve as local beach/dune boundary indicators, and represent potentially quantifiable paleo-energy indices.

Optimizing energy dissipation in gas foil bearings to eliminate bifurcations of limit cycles in unbalanced rotor systems

High-speed rotor systems mounted on gas foil bearings present bifurcations which change the quality of stability, and may compromise the operability of rotating systems, or increase noise level when amplitude of specific harmonics drastically increases. The paper identifies the dissipating work in the gas film to be the source of self-excited motions driving the rotor whirling close to bearing’s surface. The energy flow among the components of a rotor gas foil bearing system with unbalance is evaluated for various design sets of bump foil properties, rotor stiffness and unbalance magnitude. The paper presents a methodology to retain the dissipating work at positive values during the periodic limit cycle motions caused by unbalance. An optimization technique is embedded in the pseudo-arc length continuation of limit cycles, those evaluated (when exist) utilizing an orthogonal collocation method. The optimization scheme considers the bump foil stiffness and damping as the variables for which bifurcations do not appear in a certain speed range. It is found that secondary Hopf (Neimark–Sacker) bifurcations, which trigger large limit cycle motions, do not exist in the unbalanced rotors when bump foil properties follow the optimization pattern. Period-doubling (flip) bifurcations are possible to occur, without driving the rotor in high response amplitude. Different design sets of rotor stiffness and unbalance magnitude are investigated for the efficiency of the method to eliminate bifurcations. The quality of the optimization pattern allows optimization in real time, and gas foil bearing properties shift values during operation, eliminating bifurcations and allowing operation at higher speed margins. Compliant bump foil is found to enhance the stability of the system.

Adaptation of stimulation duration to enhance auditory response in fNIRS block design

Functional near-infrared spectroscopy (fNIRS) is an increasingly popular method in hearing research. However, few studies have considered efficient stimulation parameters for the auditory experimental design of fNIRS. The objectives of our study are (1) to identify the most effective paradigm for the stimulation blocks with increasing duration (8s, 10s, 15s, 20s) in terms of response amplitude, i.e., the most-efficient stimulation duration; (2) to assess the linearity/nonlinearity of the hemodynamic responses with respect to increasing block durations; and (3) to generalize results to more ecological environmental stimuli. We found that cortical activity is augmented following the increments in stimulation durations and reaches a plateau after about 15s of stimulation. The linearity analysis showed that this augmentation due to stimulation duration is not linear in the auditory cortex, non-linearity being more pronounced for shorter durations (15s and 20s). The 15s block duration that we propose as the most suitable precludes signal saturation and is associated with a high response amplitude and a relatively short total experimental duration. Moreover, the distribution of stimuli among the 15s blocks, which is the most effective for white noise stimulation, also provides a comparably strong response for environmental sounds. The sum of these findings suggests that 15s stimulation duration used in the appropriate experimental setup allows researchers to acquire optimal fNIRS signal quality.

Experimental parametric study on hydroelastic behaviour of a 15000-TEU container ship based on segmented ship model

ABSTRACT Large-scale ships with high elasticity and low natural frequency, behave high dynamic response amplitude under impulsive wave loads (whipping) and short period waves (springing), which could result in serious ultimate loads and fatigue damage. The segmented model test is a more powerful approach for the ship hydroelastic analysis compared with ship seakeeping test. However, the effect of some test parameters on the hydroelastic responses is still not a clear statement. Therefore, the number of segments, propulsion mode and backbone form are chosen for the parametric study on ship hydroelastic behaviour. A three-dimensional (3-D) nonlinear time-domain hydroelastic method is developed, in which the nonlinearity of instantaneous wetted surface and slamming force are considered. Through the analysis of natural frequencies and vertical bending moments (VBM), the impact on hydroelastic behaviour is discussed. Results show that self-propelling models with variable cross-section backbones are more suitable and reliable in studying nonlinear hydroelastic behaviour.

COMPUTATIONAL ANALYSIS ON HEAVE AND PITCH MOTIONS PERFORMANCE OF A HYDROFOIL SHIP

Hydrofoil ship usually experiences high resistance and excessive heave and pitch that may lead to downgrade her seakeeping performance. Therefore, a reliable investigation on prediction of a seakeeping performance of a hydrofoil ship in head-seas is obviously required. To achieve this objective, an analysis of Computational Fluid Dynamic (CFD) approach on hydrofoil ship motion is then proposed. Several parameters such as angle of stern foil and Froude Number have been accordingly taken into account in the simulation, where the fore foil angle is constantly 5 . In general, the results revealed that the increase of the stern foil angle was proportional to the heave motion of the hydrofoil ship. As compared to the magnitude of the stern foil angle of 5 and 10 , the heave motion of the hydrofoil ship has sufficiently decreased at the stern foil angle of 7.5, which leads to have a better seakeeping performance. Furthermore, the subsequent increase of Froude number pointing towards reduction of heave motion, which was inversely proportional to the magnitude of her pitch motion. Inherently, these have led to degrade of the hydrofoil ship seakeeping performances presented in the form of high Response Amplitude Operators (RAO). In general, this CFD simulation is very beneficial to ensure an operational effectiveness of hydrofoil design in high sea states with respect to the aforementioned design parameter.

Constructing of Bacillus subtilis-Based Lux-Biosensors with the Use of Stress-Inducible Promoters.

Here, we present a new lux-biosensor based on Bacillus subtilis for detecting of DNA-tropic and oxidative stress-causing agents. Hybrid plasmids pNK-DinC, pNK-AlkA, and pNK-MrgA have been constructed, in which the Photorhabdus luminescens reporter genes luxABCDE are transcribed from the stress-inducible promoters of B. subtilis: the SOS promoter PdinC, the methylation-specific response promoter PalkA, and the oxidative stress promoter PmrgA. The luminescence of B. subtilis-based biosensors specifically increases in response to the appearance in the environment of such common toxicants as mitomycin C, methyl methanesulfonate, and H2O2. Comparison with Escherichia coli-based lux-biosensors, where the promoters PdinI, PalkA, and Pdps were used, showed generally similar characteristics. However, for B. subtilis PdinC, a higher response amplitude was observed, and for B. subtilis PalkA, on the contrary, both the amplitude and the range of detectable toxicant concentrations were decreased. B. subtilis PdinC and B. subtilis PmrgA showed increased sensitivity to the genotoxic effects of the 2,2′-bis(bicyclo [2.2.1] heptane) compound, which is a promising propellant, compared to E. coli-based lux-biosensors. The obtained biosensors are applicable for detection of toxicants introduced into soil. Such bacillary biosensors can be used to study the differences in the mechanisms of toxicity against Gram-positive and Gram-negative bacteria.

SEAKEEPING PERFORMANCE OF A HYDROFOIL IN WAVES USING CFD APPROACH

Hydrofoil usually experiences high resistance and excessive vertical motions (heave and pitch) that may affect the passenger’s comfort due to the harsh environmental condition. Therefore, it is necessary to investigate seakeeping performance of a hydrofoil ship in waves due to the presence of a complex hydrodynamic phenomenon. To achieve this objective, an analysis of Computational Fluid Dynamic (CFD) approach on a hydrofoil ship motion is proposed. Several parameters such as Froude Number and foil angle of attack have been taken into account. The results revealed that the subsequent increase of Froude Number was inversely proportional to the heave and pitch motions. Inherently, these have led to an upgrade of hydrofoil seakeeping performances presented in the form of high Response Amplitude Operators (RAO). Furthermore, the increasing angle of the foil bow was proportional to the heave motion while for the foil stern, 7.5o showed lower heave motion, then followed by 5o and 10o respectively. For the pitch motion, the increase of foil bow was lower at 5o then followed by 10o and 7.5o. The increase of the foil stern was proportional to the pitch motion experiences by a hydrofoil. In general, this CFD simulation is very beneficial to ensure operational effectiveness of hydrofoil design in high sea states with respect to the aforementioned design parameter.

Optimizing the methodology for saphenous nerve somatosensory evoked potentials for monitoring upper lumbar roots and femoral nerve during lumbar spine surgery: technical note.

The demand for intraoperative monitoring (IOM) of lumbar spine surgeries has escalated to accommodate more challenging surgical approaches to prevent perioperative neurologic deficits. Identifying impending injury of individual lumbar roots can be done by assessing free-running EMG and by monitoring the integrity of sensory and motor fibers within the roots by eliciting somatosensory (SEP), and motor evoked potentials. However, the common nerves for eliciting lower limb SEP do not monitor the entire lumbar plexus, excluding fibers from L1 to L4 roots. We aimed to technically optimize the methodology for saphenous nerve SEP (Sap-SEP) proposed for monitoring upper lumbar roots in the operating room. In the first group, the saphenous nerve was consecutively stimulated in two different locations: proximal in the thigh and distal close to the tibia. In the second group, three different recording derivations (10-20 International system) to distal saphenous stimulation were tested. Distal stimulation yielded a higher Sap-SEP amplitude (mean ± SD) than proximal: 1.36 ± 0.9µV versus 0.62 ± 0.6µV, (p < 0.0001). Distal stimulation evoked either higher (73%) or similar (12%) Sap-SEP amplitude compared to proximal in most of the nerves. The recording derivation CPz-cCP showed the highest amplitude in 65% of the nerves, followed by CPz-Fz (24%). Distal stimulation for Sap-SEP has advantages over proximal stimulation, including simplicity, lack of movement and higher amplitude responses. The use of two derivations (CPz-cCP, CPz-Fz) optimizes Sap-SEP recording.

Distinct patterns of activity in individual cortical neurons and local networks in primary somatosensory cortex of mice evoked by square-wave mechanical limb stimulation.

Artificial forms of mechanical limb stimulation are used within multiple fields of study to determine the level of cortical excitability and to map the trajectory of neuronal recovery from cortical damage or disease. Square-wave mechanical or electrical stimuli are often used in these studies, but a characterization of sensory-evoked response properties to square-waves with distinct fundamental frequencies but overlapping harmonics has not been performed. To distinguish between somatic stimuli, the primary somatosensory cortex must be able to represent distinct stimuli with unique patterns of activity, even if they have overlapping features. Thus, mechanical square-wave stimulation was used in conjunction with regional and cellular imaging to examine regional and cellular response properties evoked by different frequencies of stimulation. Flavoprotein autofluorescence imaging was used to map the somatosensory cortex of anaesthetized C57BL/6 mice, and in vivo two-photon Ca2+ imaging was used to define patterns of neuronal activation during mechanical square-wave stimulation of the contralateral forelimb or hindlimb at various frequencies (3, 10, 100, 200, and 300 Hz). The data revealed that neurons within the limb associated somatosensory cortex responding to various frequencies of square-wave stimuli exhibit stimulus-specific patterns of activity. Subsets of neurons were found to have sensory-evoked activity that is either primarily responsive to single stimulus frequencies or broadly responsive to multiple frequencies of limb stimulation. High frequency stimuli were shown to elicit more population activity, with a greater percentage of the population responding and greater percentage of cells with high amplitude responses. Stimulus-evoked cell-cell correlations within these neuronal networks varied as a function of frequency of stimulation, such that each stimulus elicited a distinct pattern that was more consistent across multiple trials of the same stimulus compared to trials at different frequencies of stimulation. The variation in cortical response to different square-wave stimuli can thus be represented by the population pattern of supra-threshold Ca2+ transients, the magnitude and temporal properties of the evoked activity, and the structure of the stimulus-evoked correlation between neurons.

Parametric vibrational resonance in a gyroscope driven by dual-frequency forces

We examine and analyze vibrational resonance (VR) in a dual-frequency-driven gyroscope subject to a parametric excitation and an additive periodic forces. The method of direct separation of the fast and slow motions is used to derive the response amplitude analytically from the equation for slow oscillations of the system, in terms of the parameters of the high-frequency signal and the parametric excitation. Numerical simulations are carried out to validate the theoretical results. It is further shown that, when the parametric excitation and additive periodic force consist of low and high frequencies, respectively, a much higher response amplitude can occur. It is about three times larger than the response obtained when the forcing actions are reversed and is attributable to the optimization of low-frequency parametric excitation by the high-frequency additive signal.

Dexmedetomidine - Commonly Used in Functional Imaging Studies - Increases Susceptibility to Seizures in Rats But Not in Wild Type Mice.

Functional MRI (fMRI) utilizes changes in metabolic and hemodynamic signals to indirectly infer the underlying local changes in neuronal activity. To investigate the mechanisms of fMRI responses, spontaneous fluctuations, and functional connectivity in the resting-state, it is important to pursue fMRI in animal models. Animal studies commonly use dexmedetomidine sedation. It has been demonstrated that potent sensory stimuli administered under dexmedetomidine are prone to inducing seizures in Sprague-Dawley (SD) rats. Here we combined optical imaging of intrinsic signals and cerebral blood flow with neurophysiological recordings to measure responses in rat area S1FL to electrical forepaw stimulation administered at 8 Hz. We show that the increased susceptibility to seizures starts no later than 1 h and ends no sooner than 3 h after initiating a continuous administration of dexmedetomidine. By administering different combinations of anesthetic and sedative agents, we demonstrate that dexmedetomidine is the sole agent necessary for the increased susceptibility to seizures. The increased susceptibility to seizures prevails under a combination of 0.3–0.5% isoflurane and dexmedetomidine anesthesia. The blood-oxygenation and cerebral blood flow responses to seizures induced by forepaw stimulation have a higher amplitude and a larger spatial extent relative to physiological responses to the same stimuli. The epileptic activity and the associated blood oxygenation and cerebral blood flow responses stretched beyond the stimulation period. We observed seizures in response to forepaw stimulation with 1–2 mA pulses administered at 8 Hz. In contrast, responses to stimuli administered at 4 Hz were seizure-free. We demonstrate that such seizures are generated not only in SD rats but also in Long-Evans rats, but not in C57BL6 mice stimulated with similar potent stimuli under dexmedetomidine sedation. We conclude that high-amplitude hemodynamic functional imaging responses evoked by peripheral stimulation in rats sedated with dexmedetomidine are possibly due to the induction of epileptic activity. Therefore, caution should be practiced in experiments that combine the administration of potent stimuli with dexmedetomidine sedation. We propose stimulation paradigms that elicit seizure-free, well detectable neurophysiological and hemodynamic responses in rats. We further conclude that the increased susceptibility to seizures under dexmedetomidine sedation is species dependent.

Vortex-induced vibration of elastically connected multiple circular cylinders in a side-by-side arrangement in steady flow

Vortex-induced vibration (VIV) of multiple circular cylinders elastically connected together in a side-by-side arrangement subject to steady flow is investigated numerically at a low Reynolds number of 150 and a mass ratio of 2. Simulations are conducted for two-, five- and ten-cylinder systems over a wide range of reduced velocities. The aim of the study is to identify the high-amplitude response range of the reduced velocity for the multiple degree of freedom vibration system and identify the difference between the responses of the single- and multiple-degree-of-freedom vibrations. Unlike the single cylinder case, distinct lock-in between the response frequency and any of the structural natural frequencies in a wide range of reduced velocity is not observed in the multiple-cylinder cases. Instead, the response frequency increases continuously with increasing reduced velocity. High response amplitudes are found when the response frequency is between the first and the highest modal frequencies. In a multiple-cylinder system, the single-mode response, where the vibration is dominated by one mode, can be only found in low reduced velocity range. In the single-mode branch, the dominance of a single mode shape in the response can be clearly identified except at the boundary reduced velocity between two modes. The maximum response amplitude occurs in the multiple-mode response and interaction between the vortices in the wake of the cylinders is strong when the response amplitudes are high.

Cortical Tonotopic Map Changes in Humans Are Larger in Hearing Loss Than in Additional Tinnitus.

Neural plasticity due to hearing loss results in tonotopic map changes. Several studies have suggested a relation between hearing loss-induced tonotopic reorganization and tinnitus. This large fMRI study on humans was intended to clarify the relations between hearing loss, tinnitus, and tonotopic reorganization. To determine the differential effect of hearing loss and tinnitus, both male and female participants with bilateral high-frequency hearing loss, with and without tinnitus, and a control group were included. In a total of 90 participants, bilateral cortical responses to sound stimulation were measured with loudness-matched pure-tone stimuli (0.25-8 kHz). In the bilateral auditory cortices, the high-frequency sound-evoked activation level was higher in both hearing-impaired participant groups, compared with the control group. This was most prominent in the hearing loss group without tinnitus. Similarly, the tonotopic maps for the hearing loss without tinnitus group were significantly different from the controls, whereas the maps of those with tinnitus were not. These results show that higher response amplitudes and map reorganization are a characteristic of hearing loss, not of tinnitus. Both tonotopic maps and response amplitudes of tinnitus participants appear intermediate to the controls and hearing loss without tinnitus group. This observation suggests a connection between tinnitus and an incomplete form of central compensation to hearing loss, rather than excessive adaptation. One implication of this may be that treatments for tinnitus shift their focus toward enhancing the cortical plasticity, instead of reversing it.SIGNIFICANCE STATEMENT Tinnitus, a common and potentially devastating condition, is the presence of a "phantom" sound that often accompanies hearing loss. Hearing loss is known to induce plastic changes in cortical and subcortical areas. Although plasticity is a valuable trait that allows the human brain to rewire and recover from injury and sensory deprivation, it can lead to tinnitus as an unwanted side effect. In this large fMRI study, we provide evidence that tinnitus is related to a more conservative form of reorganization than in hearing loss without tinnitus. This result contrasts with the previous notion that tinnitus is related to excessive reorganization. As a consequence, treatments for tinnitus may need to enhance the cortical plasticity, rather than reverse it.

3D Numerical Modeling of Induced-Polarization Grounded Electrical-Source Airborne Transient Electromagnetic Response Based on the Fictitious Wave Field Methods

The grounded electrical-source airborne transient electromagnetic (GREATEM) system is widely used in mineral exploration. Meanwhile, the induced polarization (IP) effect, which indicates the polarizability of the earth, is often found. In this paper, the Maxwell equations in the frequency domain are transformed into fictitious wave domain, where Maxwell equations are solved by the time domain finite difference method. Then, an integral transformation method is used to convert the calculation results back to the time domain. A three-dimensional (3D) numerical simulation in a polarizable medium is presented. The accuracy of this method is proven by comparing it with the analytical solution and the existing method, and the calculation efficiency is increased five-fold. The simulation results show that the GREATEM system has a higher response amplitude in the conductive region, while IP effects cannot be identified in the conductive area. The GREATEM system has a higher response amplitude in the low-resistance region, but IP effects cannot be identified in the low-resistance area, and the detection of IP effects is more suitable for the high-resistance area. Therefore, it is necessary to improve the detection ability of the GREATEM system in the low-resistance area.

Electromyographic Responses Across Different Pulse-Widths of Sacral Neuromodulation in Sheep

In rodents, we reported that short pulse-width (PW) neuromodulation might provide more efficient therapy delivery than traditional 0.21 msec PW. Using fully implanted, commercialized systems in the sheep, the goal of this study was to characterize the relationship of electromyographic (EMG) responses of the external anal sphincter (EAS) to different PWs of sacral neuromodulation (SNM). In seven sheep, InterStim® quadripolar tined leads were implanted adjacent to the S3 nerve root bilaterally to deliver SNM and two pairs of intramuscular leads were placed on either side of the EAS for EMG sensing. The EMG responses to SNM with different PWs were examined using variable intensities in both anesthetized and conscious conditions. The EMG responses from ipsilateral EAS (IEAS ) and contralateral EAS (CEAS ) were compared. The area under the curve of EMG responses from IEAS were significantly stronger than that from CEAS. The late component EMGs were more sensitive to nerve stimulation with a higher response amplitude in awake sheep. The response threshold-PW relationship from the IEAS as ascertained visually and with EMG in anesthetized and awake sheep were fitted with a monoexponential nonlinear regression; the resulting chronaxies were of 0.05 msec (n = 6), and 0.04 msec (n = 6), and 0.04 msec (n = 8), respectively. In both anesthetized and awake conditions, a similar motor response may be evoked in the EAS at PWs much shorter (0.04-0.05 msec) than the 0.21 msec typically used with SNM. Potential battery savings manifested by shorter PW would provide more efficient therapy delivery and increased longevity of the stimulator.