Background: Computer Vision Syndrome (CVS) is prevalent among students due to extensive digital screen use, leading to various ocular and musculoskeletal symptoms.Objective: To assess the prevalence and associated risk factors of CVS among undergraduate students in Pakistan.Methods: A cross-sectional analytical study was conducted among 422 undergraduate students at the University of Lahore from March to April 2020. Participants were selected using non-probability convenient sampling. Data were collected through a structured, web-based questionnaire covering demographics, computer usage patterns, and CVS symptoms. Statistical analysis was performed using SPSS version 25, employing chi-square tests and logistic regression to identify significant associations, with p-values <0.05 considered significant. Ethical approval was obtained, and the study adhered to the Declaration of Helsinki.Results: CVS prevalence was 70.4% among participants, with higher rates in females (45.6%) compared to males (36%) (p=0.03). Prolonged computer use (>3 hours/day) was significantly associated with CVS (p=0.04). Regular breaks every 30 minutes reduced CVS prevalence significantly (p=0.01).Conclusion: CVS is highly prevalent among undergraduate students, especially among females and those with prolonged computer use. Interventions focusing on ergonomic practices and regular breaks are recommended.