High Level Of Interaction Research Articles

On the role of visual feedback and physiotherapist-patient interaction in robot-assisted gait training: an eye-tracking and HD-EEG study

BackgroundTreadmill based Robotic-Assisted Gait Training (t-RAGT) provides for automated locomotor training to help the patient achieve a physiological gait pattern, reducing the physical effort required by therapist. By introducing the robot as a third agent to the traditional one-to-one physiotherapist-patient (Pht-Pt) relationship, the therapist might not be fully aware of the patient’s motor performance. This gap has been bridged by the integration in rehabilitation robots of a visual FeedBack (FB) that informs about patient’s performance. Despite the recognized importance of FB in t-RAGT, the optimal role of the therapist in the complex patient-robot interaction is still unclear. This study aimed to describe whether the type of FB combined with different modalities of Pht’s interaction toward Pt would affect the patients’ visual attention and emotional engagement during t-RAGT.MethodsTen individuals with incomplete Spinal Cord Injury (C or D ASIA Impairment Scale level) were assessed using eye-tracking (ET) and high-density EEG during seven t-RAGT sessions with Lokomat where (i) three types of visual FB (chart, emoticon and game) and (ii) three levels of Pht-Pt interaction (low, medium and high) were randomly combined. ET metrics (fixations and saccades) were extracted for each of the three defined areas of interest (AoI) (monitor, Pht and surrounding) and compared among the different experimental conditions (FB, Pht-Pt interaction level). The EEG spectral activations in theta and alpha bands were reconstructed for each FB type applying Welch periodogram to data localised in the whole grey matter volume using sLORETA.ResultsWe found an effect of FB type factor on all the ET metrics computed in the three AoIs while the factor Pht-Pt interaction level also combined with FB type showed an effect only on the ET metrics calculated in Pht and surrounding AoIs. Neural activation in brain regions crucial for social cognition resulted for high Pht-Pt interaction level, while activation of the insula was found during low interaction, independently on the FB used.ConclusionsThe type of FB and the way in which Pht supports the patients both have a strong impact on patients’ engagement and should be considered in the design of a t-RAGT-based rehabilitation session.

Intensitas Bermain Game Online dan Empati pada Remaja

Playing online games is a common activity among adolescents in Indonesia as a form of entertainment, and it often becomes an influence on the development of empathy, especially in teenagers. This research aims to determine whether there is a difference in empathy among adolescents based on the intensity of online gaming. The game genre studied is MOBA (Multiplayer Online Battle Arena), which is played by 10 people, with each team consisting of 5 players. One match is estimated to last between 10-30 minutes or longer, and the objective is to destroy the opposing team's base. This game requires a high level of teamwork and social interaction among team members. The study uses the Basic Empathy Scale (BES) as a tool to measure empathy, which assesses two components of empathy: affective and cognitive. To measure the intensity of online gaming, the researchers collected data on the average amount of time spent playing online games per week. There were 108 respondents in this study, aged 15-18 years, who played MOBA games and resided in Jabodetabek. Using the ANOVA analysis method, the results showed a significant difference in empathy based on the intensity of online gaming, with a significance value of 0.027 (p-value <0.05). Significant differences in empathy were found between adolescents with moderate and high levels of online gaming intensity (p-value 0.02 <0.05). However, there was no significant difference between the low and moderate groups (p-value 0.547 >0.05), nor between the high and low groups (p-value 0.054 >0.05). Adolescents with high gaming intensity tend to have higher levels of empathy. In the context of MOBA games, which are typically played with friends and require intensive social interaction, it can be concluded that games with high social interaction (in this study, the MOBA genre) are associated with higher empathy. These findings align with other studies that have found that social interaction in games can enhance empathy.

Marine Bacteria: A Source of Novel Bioactive Natural Products.

Marine natural products have great pharmacological potential due to their unique and diverse chemical structures. The marine bacterial biodiversity and the unique marine environment lead to a high level of complexity and ecological interaction among marine species. This results in the production of metabolic pathways and adaptation mechanisms that are different from those of terrestrial organisms, which has drawn significant attention from researchers in the field of natural medicine. This review provides an analysis of the distribution and frequency of keywords in the literature on marine bacterial natural products as well as an overview of the new natural products isolated from the secondary metabolites of marine bacteria in recent years. Finally, it discusses the current research hotspots in this field and speculates on future directions and limitations.

Gene expression-based modeling of overall survival in Black or African American patients with lung adenocarcinoma.

Lung cancer is a leading cause of cancer-related deaths worldwide. Black/African American (B/AA) populations, in particular, exhibit the highest incidence and mortality rates of lung adenocarcinoma (LUAD) in the United States. This study aims to explore gene expression patterns linked to LUAD in B/AA and case-matched white patients, with the goal of developing predictive models for prognosis. Leveraging RNA sequencing data from The Cancer Genome Atlas (TCGA) database, genes and pathways associated with overall survival (OS) were identified. The OS-associated genes in B/AA patients were distinct from those in white patients, showing predominant enrichment in immune-related pathways. Furthermore, mRNA co-expression network analysis revealed that OS-associated genes in B/AA patients had higher levels of interaction with various pathways, including those related to immunity, cell-ECM interaction, and specific intracellular signaling pathways. Notably, a potential B/AA-specific biomarker, C9orf64, demonstrated significant correlations with genes involved in immune response. Unsupervised machine learning algorithms stratified B/AA patients into groups with distinct survival outcomes, while supervised algorithms demonstrated a higher accuracy in predicting survival for B/AA LUAD patients compared to white patients. In total, this study explored OS-associated genes and pathways specific for B/AA LUAD patients. Further validation and clinical application of these findings are warranted to address disparities and improve outcomes in diverse patient populations.

Exploring the Importance of Race and Gender Concordance Between Patients and Physical Therapists in Digital Rehabilitation for Musculoskeletal Conditions: Observational, Longitudinal Study.

Race/ethnicity and gender concordance between patients and providers is a potential strategy to improve health care interventions. In digital health, where human interactions occur both synchronously and asynchronously, the effect of concordance between patients and providers is unknown. This study aimed to evaluate the impact of race/ethnicity or gender concordance between patients and physical therapists (PTs) in engagement and the clinical outcomes following a digital care program (DCP) in patients with musculoskeletal (MSK) conditions. This secondary analysis of 2 prospective longitudinal studies (originally focused on assessing the acceptance, engagement, and clinical outcomes after a remote DCP) examined the impact of both race/ethnicity concordance and gender concordance between patients and PTs on outcomes for a digital intervention for MSK conditions. Outcomes included engagement (measured by the completion rate and communication, assessed by text interactions), satisfaction, and clinical outcomes (response rate, ie, percentage of patients achieving at least a minimal clinically important change in pain, measured by the Numerical Pain Rating Scale [NPRS]; anxiety, measured by the Generalized Anxiety Disorder 7-item scale [GAD-7]; depression, measured by the Patient Health Questionnaire 9-item [PHQ-9]; and daily activity impairment, measured by the Work Productivity and Activity Impairment [WPAI] questionnaire). Of 71,201 patients, 63.9% (n=45,507) were matched with their PT in terms of race/ethnicity, while 61.2% (n=43,560) were matched for gender. Concordant dyads showed a higher completion rate among White (adjusted odds ratio [aOR] 1.11, 95% CI 1.05-1.19, P<.001) and Hispanic (aOR 1.27, 95% CI 1.08-1.54, P=.009) groups, as well as women (aOR 1.10, 95% CI 1.06-1.18, P<.001), when compared to discordant dyads. High and similar levels of interaction between patients and PTs were observed across race/ethnicity and gender dyads, except for Asian concordant dyads (adjusted β coefficient 5.32, 95% CI 3.28-7.36, P<.001). Concordance did not affect satisfaction, with high values (>8.52, 95% CI 8.27-8.77) reported across all dyads. Response rates for pain, anxiety, and daily activity impairment were unaffected by race/ethnicity concordance. An exception was observed for depression, with White patients reporting a higher response rate when matched with PTs from other races/ethnicities (aOR 1.20, 95% CI 1.02-1.39, P=.02). In terms of gender, men had a slightly higher pain response rate in discordant dyads (aOR 1.08, 95% CI 1.01-1.15, P=.03) and a higher depression response rate in concordant dyads (aOR 1.23, 95% CI 1.05-1.47, P=.01). Race/ethnicity and gender concordance between patients and PTs does not translate into higher satisfaction or improvement for most clinical outcomes, aside from a positive effect on treatment completion. These results highlight the importance of other PT characteristics, in addition to race/ethnicity or gender concordance, suggesting the potential benefit of experience, languages spoken, and cultural safety training as ways to optimize care. ClinicalTrials.gov NCT04092946, NCT05417685; https://clinicaltrials.gov/study/NCT05417685, https://clinicaltrials.gov/study/NCT04092946.

The potential use of immersive virtual environments for collecting and archiving heritage gameplay activities in digital libraries

Purpose This paper aims to discuss and propose the potential use of immersive virtual environments (IVEs) for archiving and collecting heritage gameplay activities in digital libraries, which is expected to triangulate further discussions on the said knowledge scopes. Design/methodology/approach The key question of this paper is, how we can preserve and revitalize fading heritage game activities in digital libraries? To answer this, the paper is going to understand the applications of IVEs in heritage studies; the use of telepresence experiences in IVEs for activity-based collection; the creation of virtual and telepresence experiences in digital libraries; and a proposed use of IVEs for archiving heritage gameplay activities. Findings The applications of IVEs and/or other virtual technologies have certainly been gaining positive feedback about their ability to provide vivid images of artefacts and art pieces; perform a high level of interactivity between the exhibits and visitors; enhance visitors’ sense of immersion that evoke their memories of heritage issues; facilitate visitors’ learning process in libraries; increase enjoyment in digital libraries. As mentioned in the previous section, the activity-based historical collection, for instance, the heritage gameplay activities, can be preserved and archived vividly using IVEs. Research limitations/implications This paper is explorative, there is no empirical result for generalization. Originality/value This paper aims to provide librarians with valuable insight to apply IVEs for archiving and collecting heritage gameplay activities. Setting up a new type of digital library is affected greatly by the openness of librarians, visitors’ expectations and a whole lot of things that are happening around the technological world and digital culture. This paper addresses the applications of IVEs in heritage studies, the importance of creating virtual and telepresence experiences for library visits as well as proposing the use of IVEs for archiving heritage gameplay activities.

Bridging diversity management and intellectual capital: insights and impacts in healthcare organizations

PurposeThe study examines the relationship between diversity management (DM) and intellectual capital (IC) in healthcare organizations. It aims to understand how embracing diversity across various domains – including cultural, gender and physical ability – enhances strategic value and competitive edge among healthcare institutions. This study is among the first papers to link DM and IC in the healthcare setting.Design/methodology/approachThe two-phased methodological framework began with a bibliometric analysis of previous literature to distil significant variables commonly associated with DM in healthcare. Subsequently, based on the identified variables, the policy and planning documents of 17 Italian healthcare organizations were mapped to assess how well European Commission policies promoting the integration of DM into IC have been adopted, identifying any key oversights.FindingsA significant link exists between effective DM and enhanced IC, particularly in fostering an inclusive organizational culture that values diverse employee backgrounds. This enhancement is evident in the increased recognition of varied cultural perspectives, improved gender diversity in leadership positions and the implementation of comprehensive anti-discrimination policies. Despite these benefits being recognized theoretically, the extent of practical application in healthcare settings varies. Some organizations show robust integration of these principles, while others exhibit significant gaps, especially in the Italian sample analysed.Originality/valueThis research underscores DM’s critical role in strengthening IC, particularly within the healthcare sector, which demands a high level of interpersonal interaction and cultural competence. The study’s insights encourage healthcare organizations to adopt more strategic approaches to DM, ultimately contributing to a more equitable healthcare system.

The The Influence Of Media On Teenagers In Choosing Panjang Beach For Tourism In The Digital Era

Abstract: Social media has become essential for tourism promotion in this digital era. This research analyses the influence of social media platforms on tourism promotion in Bengkulu, using James S. Coleman's rational choice theory. This research uses a closed questionnaire given to 90 students who use social media to find a tourism destination. The analysis technique used is multiple linear regression analysis and percentage descriptive statistics. The results showed that the review of social media posts significantly influenced teenagers' interest in visiting a destination. 52.22% of respondents prefer Instagram as their travel reference, supported by reviews of tourist destinations in promotional posts. Tourism destinations that are active and creative in utilizing social media and have good reviews tend to have a higher level of interaction with potential tourists. The results of this study guide tourist destinations and tourism marketers to maximize the potential of social media in their promotion.

Digital disinformation strategies of European climate change obstructionist think tanks

This study explores how European think tanks with obstructive positions on climate policy use the social network X to advance their agendas. The aim is to understand their digital communication strategies, the issues they address, the use of hyperlinks, and the impact on interaction and online polarization. A mixed-methods analysis was conducted on tweets from twelve organizations known for opposing climate policies. Out of an initial 96,607 tweets, 803 relevant messages were selected to evaluate thematic content and interaction reach. The analysis identified five dominant thematic areas in the tweets: economic impacts of climate policy, ideological perspectives, questioning of official science, proposed technological solutions, and other messages. The higher levels of interaction were generated by messages with a political or ideological focus and those proposing technological solutions. In addition, most hyperlinks directed users to the think tanks' own websites rather than to external sources. European anti-climate change think tanks use social network X to promote their agendas through ideological and technical messages that generate high engagement.

Urban Planning and Landscape Projects on Urban Riverbanks in Europe: Comparative Study of the Ebro River, Zaragoza, and the Isar River, Munich

The tension between rivers and cities reaches its highest expression in urban river basins. Given the high level of interaction between natural and cultural factors in many riverfronts, an integral project design is essential. The large number of urban river basin enhancement cases that have been conducted has resulted in a large amount of urban scientific literature. The multifaceted nature of these systems renders their analysis and contextualization a challenging endeavor. The objective of this research is to propose a novel evaluation tool based on a reformulation of Lynch’s theory of urban form performance, which has been updated from a landscape urbanism perspective. The conceptual framework provides a comprehensive method for translating diverse design strategies into comparable and meaningful categories. The results illustrate the impact of urban riverbank requalification initiatives on the formal quality dimensions of the city–river socio-ecological system. The assessment tool was applied to two cases: the Ebro River in Zaragoza (Spain) and the Isar River in Munich (Germany). Despite differences between the cases, comparative analysis revealed similar levels of urban landscape quality parameters and common elements that can provide new insights when considering the solutions applied and the degree of improvement in quality and river–city cohesion achieved with these projects.

Dropout in elite sport: What stressors and resilience factors are perceived in youth sport climbing?

Introduction &amp; Purpose Psychosocial stress is a major risk factor for the development of a wide range of psychiatric and somatic illnesses (Hughes et al., 2017). Social factors such as perceived autonomy and competence, relatedness and task climate appear to be related to people dropping out of a sport (Balish et al., 2014). To this point in time, the developmental aspects in youth sports are insufficiently described in the literature. Previous studies dealing with dropout have indicated critical aspects on a personal, contextual, chronological, and procedural level (Moulds et al., 2024). The perception of these aspects seems to determine the individual stress experience. Therefore, the aim of the study was to identify stressors and resources in youth sport climbing and to gain a deeper understanding of how these relate to dropout. Methods Guided by the theoretical framework of the bioecological system theory (Bronfenbrenner &amp; Morris, 2006), two active and six non-active climbers between the ages of 18 and 25 were interviewed using a semi-structured interview approach. The non-active climbers were dropouts, defined here as an athlete ending their competitive sport career before reaching their individual performance peak. In this case they were asked about the related circumstances. Active athletes started the interview from their current perspective. Each development-relevant factor (person, process, context, time; Bronfenbrenner &amp; Morris, 2006) was then reflected on in terms of resources and stressors. The inclusion criterion was the qualification for the national team. A qualitative content analysis was carried out according to Mayring and Fenzl (2022). The data was analyzed using MAXQDA 24 software. Results The interviewed climbers addressed the context of family, school, social environment, training, and personal factors. A high level of social interaction was experienced. The topics of bodyweight and nutrition were often reported with negative connotations, particularly impacted by external factors. Communication skills were a consistently mentioned factor as a resource and potential stressor. A lack of individualisation and opportunities for personal development were reported as long-term stress factors. Feelings of responsibility and self-inflicted pressure were described as additional loads. Professional attachment was reported as a personal resource when positively evaluated. Reflection skills were recognised as a helpful stress management tool. As illustrated in Figure 1, the mindset of individuals appears to be shaped by the internal and external interplay of available resources, aspects of motivation and beliefs that are internalised. Discussion &amp; Conclusion Several factors seem to interact modifying an individual’s experience of stress. The perception of stress at a certain point in time must be seen as a combination of the load experienced and the individual available resources. Sport-specific requirements should be considered. Dropout can be one of the consequences of overall stress in competitive sports and should be analysed systemically. The intention was to identify starting points for reducing dropout rates in sports and support health-promoting participation. These are the first results of this project, in which further athletes from climbing and other sports will be interviewed.

A way to aging well: A qualitative study to identify psychological barriers and facilitators to the use of information and communication technologies (ICT) by older adults

ABSTRACT Using information and communication technologies (ICT) can be a major challenge for older people. Some data exists in the literature on the elements that enable their use, but none has focused specifically on the elderly. ICT provide individuals with a means to interact with each other, thus, ICT represent a factor facilitating interactions. However, although such technologies are ever more present in our physical environment, some older adults still do not use ICT, suggesting that other barriers could exist. The aim of this study was therefore to identify the psychological barriers that prevent older people from using ICT and to identify the facilitators. These facilitators could promote the use of ICT and thus enable older adults to age well through maintaining a high level of social interactions. Thirteen older adults participated in a semi-structured interview and Nvivo 12 software was used to analyze the content. Three themes were identified: sense of self-efficacy, perception of available resources, and individual and environmental components. Each of these themes included sub-themes which were either facilitators or barriers and those of the first two themes (sense of self-efficacy, and individual and environmental components) can fluctuate from facilitator to barrier depending on the individual. By identifying psychological facilitators and barriers to older adults’ use of ICT can help public and not-for-profit organizations to develop training designed for this public. Promoting older adults’ use of ICT could provide a means to maintain social interactions and, thus, contribute to successful aging.

Integrated machine learning screened glutamine metabolism-associated biomarker SLC1A5 to predict immunotherapy response in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) stands as one of the most prevalent malignancies. While PD-1 immune checkpoint inhibitors have demonstrated promising therapeutic efficacy in HCC, not all patients exhibit a favorable response to these treatments. Glutamine is a crucial immune cell regulatory factor, and tumor cells exhibit glutamine dependence. In this study, HCC patients were divided into two subtypes (C1 and C2) based on glutamine metabolism-related genes via consensus clustering. The C1 pattern, in contrast to C2, was associated with a lower survival probability among HCC patients. Additionally, the C1 pattern exhibited higher proportions of patients with advanced tumor stages. The activity of C1 in glutamine metabolism and transport is significantly enhanced, while its oxidative phosphorylation activity is reduced. And, C1 was mainly involved in the progression-related pathway of HCC. Furthermore, C1 exhibited high levels of immunosuppressive cells, cytokine-receptor interactions and immune checkpoint genes, suggesting C1 as an immunosuppressive subtype. After stepwise selection based on integrated four machine learning methods, SLC1A5 was finally identified as the pivotal gene that distinguishes the subtypes. The expression of SLC1A5 was significantly positively correlated with immunosuppressive status. SLC1A5 showed the most significant correlation with macrophage infiltration, and this correlation was confirmed through the RNA-seq data of CLCA project and our cohort. Low-SLC1A5-expression samples had better immunogenicity and responsiveness to immunotherapy. As expected, SubMap and survival analysis indicated that individuals with low SLC1A5 expression were more responsive to anti-PD1 therapy. Collectively, this study categorized HCC patients based on glutamine metabolism-related genes and proposed two subclasses with different clinical traits, biological behavior, and immune status. Machine learning was utilized to identify the hub gene SLC1A5 for HCC classification, which also could predict immunotherapy response.

Anthropozoonotic parasitoses of dogs and cats in the urban ecosystem of Vladivostok, Russia

To investigate the role of domestic dogs and cats in the spread of parasitoses in the Vladivostok urban ecosystem. Biological materials from 782 dogs and 189 cats were used in the research, which were examined by methods of complete parasitological autopsy, microscopy and flotation of faecal samples using saturated solutions of zinc sulfate and sodium nitrate.Fourteen parasite taxa have been identified: nematodes (Nematoda) Ancylostoma caninum, Dirofilaria immitis, Toxascaris leonina, Toxocara canis, T. mystax, Uncinaria stenocephala, Taenia sp., T. hydatigena; tapeworms (Cestoda) Diphyllobothrium latum, Dipylidium caninum, Hydatigera taeniaeformis; flukes (Trematoda) Metagonimus sp.; and parasitic alveolates (Conoidasida) Cystoisospora sp., C. felis. The paper presents the values of the prevalence of infection and statistical reliability of their differences for different groups of animals, depending on gender and age. Nematodes were the core taxa of the parasitofauna identified. Explanations for the results obtained are offered and possible sources of human infection are described. Despite the fact that parasitic‐faunal complexes in the ecosystem of a modern city are much less branched and represented by fewer species than in the wild, there remains a high risk of human infection with zoonotic parasites in urban biocenoses due to the high level of intensive population interactions. Therefore, there is a requirement of high alertness of supervisory authorities in relation to anthropozoonotic parasitoses in an urban environment.

Assessment of domestic pig–bushpig (Potamochoerus larvatus) interactions through local knowledge in rural areas of Madagascar

In many parts of the world, domestic and wild animal populations interact at the interface between natural and agricultural ecosystems. Introduced with the first inhabitants arriving from eastern Africa, the bushpig (Potamochoerus larvatus) is the largest living terrestrial mammal in Madagascar. Bushpigs are regularly reported close to human settlements where they damage crops and gardens. As domestic pigs are often raised in free-ranging conditions around the villages, bushpigs and domestic pigs can interact leading to the transmission and circulation of shared swine pathogens that impact both animal and human health. In this study, we characterized the socio-ecological context of bushpig–domestic pig interactions in two different regions of western Madagascar. We conducted participatory mapping sessions and focus group interviews with 65 hunters, 80 pig farmers and 96 crop farmers in 20 fokontany, the smallest administrative unit in Madagascar. After discussing with participants, we gathered information about the spatialization of interactions and their potential geographical drivers. We explored data by performing multiple correspondence analysis and hierarchical clustering on principal components. Based on the reported occurrence or absence of bushpig-domestic pig interactions we were able to classify areas with high or intermediate levels of interactions or no interactions at all. Interactions between the two pig species were reported in only 25% of the fokontany assessed. Even though both suid species were attracted to fruit trees, crops, and water sources, only indirect interactions in those spots were reported. Direct interactions were reported in 10% of cases and referred to interspecific sexual and/or agonistic behavior. The participatory methods used to acquire local knowledge about natural events were confirmed as valuable, low-cost exploratory methods to characterize areas with wild-domestic animal interactions. The results of this study will help plan future studies to characterize the interface between the two species from an ecological or epidemiological perspective using more sensitive and sophisticated ecological approaches.

The Role of Designing Virtual Advertisements in the External Environment

Virtual advertisements in outdoor environments depend on employing modern digital technologies and require the infrastructure of the communication network used to deliver content, communication protocols, software, and equipment used in content management and repetition of the display, and depend on different standards, each according to the marketing and promotional objective of the advertisement. The research problem was determined through the following questions: What are virtual ads? What are digital technology and the modern technologies that have introduced it in the modern era? What are the methods of advertising display for marketing and promotion? The research aimed to identify virtual advertisements, their promotional and marketing techniques and methods. The descriptive-analytical approach was followed in monitoring and analyzing the information. The research reached the most important results, which are: 1- Outdoor environment advertisements achieved an overlap between the form of the advertisement and the urban space surrounding it in the commercial center or urban buildings, and it had a functional and aesthetic role in the urban environment. 2- It achieved A high level of control and interaction between the customer and the advertisement, so that he becomes a participant and part of the advertisement. 3- The advertisements used various methods in addressing the public and potential customers. The method of drawing attention was used in samples 1, 3, 4, and 5, and the method of addressing instincts was used in samples 1, 2. ,5. The method of enticement and motivation was used in sample 2.5. It also employed the method of being realistic and presenting facts in Sample 3, while the method of arousing and stimulating consumerism was one of the most widely used methods and this appeared in Samples 1, 2, 4, and 5.

Once upon a game: boosting brand storytelling through gamification

PurposeThe purpose of this study is to explore the impact of gamifying brand storytelling on user immersion in the brand narrative, a concept referred to as “narrative transportation”. The aim is to comprehend how transportation influences users’ experience and their responses to the brand, with particular focus on brand attitude and WOM. The study also explores the role of interactivity in brand storytelling and its effects on transportation and user engagement.Design/methodology/approachFour experiments were conducted to sequentially test the proposed hypotheses. Each experiment involves ad hoc gamified brand stories for different product categories (wine, museum, glasses and frozen fruit).FindingsFindings indicate that including gamification elements in brand stories heightens narrative transportation and enhances the information obtained by users as well as their entertainment. Users thus respond more positively to the brand in terms of attitude and WOM. The study also reveals that high levels of interactivity in the game may actually decrease narrative transportation in the story, although this is offset by the perception of greater entertainment.Originality/valueThis research contributes to current understanding of brand storytelling and its impact on branding. It highlights the importance of offering users a gamified experience that can provide them with information about the brand whilst also offering them entertainment. The results also hold implications for gamification literature by emphasizing the need to ensure a balance between game and story vis-à-vis enhancing the impact of gamified storytelling on brand response.

Unravelling the molecular tapestry of pterygium: insights into genes for diagnostic and therapeutic innovations.

Pterygium, an ocular surface disorder, manifests as a wing-shaped extension from the corneoscleral limbus onto the cornea, impacting vision and causing inflammation. With a global prevalence of 12%, varying by region, the condition is linked to UV exposure, age, gender, and socioeconomic factors. This review focuses on key genes associated with pterygium, shedding light on potential therapeutic targets. Matrix metalloproteinases (MMPs), especially MMP2 and MMP9, contribute to ECM remodelling and angiogenesis in pterygium. Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis and is elevated in pterygium tissues. B-cell lymphoma-2, S100 proteins, DNA repair genes (hOGG1, XRCC1), CYP monooxygenases, p53, and p16 are implicated in pterygium development. A protein-protein interaction network analysis highlighted 28 edges between the aforementioned proteins, except for VEGF, indicating a high level of interaction. Gene ontology, microRNA and pathway analyses revealed the involvement of processes such as base excision repair, IL-17 and p53 signalling, ECM disassembly, oxidative stress, hypoxia, metallopeptidase activity and others that are essential for pterygium development. In addition, miR-29, miR-125, miR-126, miR-143, miR-200, miR-429, and miR-451a microRNAs were predicted, which were shown to have a role in pterygium development and disease severity. Identification of these molecular mechanisms provides insights for potential diagnostic and therapeutic strategies for pterygium.

An efficient method to prepare high grafting montmorillonite with silane coupling agent and its improvements for styrene butadiene rubber composites

AbstractThe quantity of silane chemically bonded to the organoclay's surface significantly influences its dispersion within the polymer matrix, as well as the interfacial interaction. This research presents a groundbreaking method for enhancing the surface properties of montmorillonite (Mt) through the use of γ‐(methacryloxy) propyl trimethoxy silane (KH570) coupled with acid treatment, leading to increased grafting efficiency. Confirmed by FT‐IR, TGA, and XRD, the process effectively bonds organo‐silanes to Mt and achieves a high grafting level of 1.59 mequiv/g. Utilizing a latex compounding method, Mt/rubber nanocomposites are synthesized with thoroughly modified clay for peak performance. Dispersion and interfacial properties are evaluated through XRD, TEM, AFM, and DMTA. The findings reveal that the well‐modified Mt is an exceptional filler, ensuring a high level of dispersion and robust interaction with the rubber matrix. This synergy translates to a marked improvement in the mechanical properties of the composite, with notable enhancements observed in both tensile strength and elongation at break of 9.7 MPa and 1141%, respectively. This innovative approach to the graft modification of clays presents a potent method, offering the potential for the industrial‐scale manufacture of high‐performance clay‐based composites.Highlights A processing method for preparing high grafting clay with a silane coupling agent. Functionalized clay presents better nano‐dispersion in the polymeric matrix. Strong covalent interfacial interaction is constructed between clay and rubber. Tensile Strength and elongation at break of the composites are obliviously improved.

Smartphone-Based Survey and Message Compliance in Adults Initially Unready to Quit Smoking: Secondary Analysis of a Randomized Controlled Trial.

Efficacy of smartphone-based interventions depends on intervention content quality and level of exposure to that content. Smartphone-based survey completion rates tend to decline over time; however, few studies have identified variables that predict this decline over longer-term interventions (eg, 26 weeks). This study aims to identify predictors of survey completion and message viewing over time within a 26-week smoking cessation trial. This study examined data from a 3-group pilot randomized controlled trial of adults who smoke (N=152) and were not ready to quit smoking within the next 30 days. For 182 days, two intervention groups received smartphone-based morning and evening messages based on current readiness to quit smoking. The control group received 2 daily messages unrelated to smoking. All participants were prompted to complete 26 weekly smartphone-based surveys that assessed smoking behavior, quit attempts, and readiness to quit. Compliance was operationalized as percentages of weekly surveys completed and daily messages viewed. Linear regression and mixed-effects models were used to identify predictors (eg, intervention group, age, and sex) of weekly survey completion and daily message viewing and decline in compliance over time. The sample (mean age 50, SD 12.5, range 19-75 years; mean years of education 13.3, SD 1.6, range 10-20 years) was 67.8% (n=103) female, 74.3% (n=113) White, 77% (n=117) urban, and 52.6% (n=80) unemployed, and 61.2% (n=93) had mental health diagnoses. On average, participants completed 18.3 (71.8%) out of 25.5 prompted weekly surveys and viewed 207.3 (60.6%) out of 345.1 presented messages (31,503/52,460 total). Age was positively associated with overall weekly survey completion (P=.003) and daily message viewing (P=.02). Mixed-effects models indicated a decline in survey completion from 77% (114/148) in the first week of the intervention to 56% (84/150) in the last week of the intervention (P<.001), which was significantly moderated by age, sex, ethnicity, municipality (ie, rural/urban), and employment status. Similarly, message viewing declined from 72.3% (1533/2120) in the first week of the intervention to 44.6% (868/1946) in the last week of the intervention (P<.001). This decline in message viewing was significantly moderated by age, sex, municipality, employment status, and education. This study demonstrated the feasibility of a 26-week smartphone-based smoking cessation intervention. Study results identified subgroups that displayed accelerated rates in the decline of survey completion and message viewing. Future research should identify ways to maintain high levels of interaction with mobile health interventions that span long intervention periods, especially among subgroups that have demonstrated declining rates of intervention engagement over time. ClinicalTrials.gov NCT03405129; https://clinicaltrials.gov/ct2/show/NCT03405129.