Abstract Background Mothers’ health is crucial as it significantly impacts the overall health of their children and families. The first year of motherhood can be especially difficult and can lead to a considerable decline in mental health and well-being. However, studies have shown that these challenges persist throughout early childhood. This study examined the association between mothers’ self-compassion, social support, and self-care behaviors and their physical and mental well-being. Methods In August 2023, a survey was conducted among 521 Israeli mothers (437 Jewish and 84 Arab mothers) of children aged three and under. Linear regression models were used to assess the factors that predict the mothers’ physical and mental health. These models explained 11% of the variance in the mothers’ physical health and 39% of the variance in their mental health. Results Respondents’ ages ranged from 19 to 48, with a mean age of 31.5 years. Reported physical health was relatively high (n = 442, M = 78.36, SD = 21 on a scale of 0-100). However, the reported mental health was lower (n = 401, M = 65.88, SD = 20.28 on a scale of 0-100). Reported Physical health was found to be higher for Jewish mothers, younger mothers, and mothers with higher income levels. Further, higher social support and higher self-compassion levels were associated with better perceived physical health (Adj R2=0.11, P < 0.001). Mental health was higher for Jewish mothers, younger mothers, and full-time employed mothers. Further, higher social support, self-compassion, and reported self-care were associated with better perceived mental health (Adj R2=0.39, P < 0.001). Conclusions Health practitioners who work with mothers of young children should take a proactive approach to helping them establish a nurturing environment, practice self-compassion, and engage in self-care activities. Key messages • Encouraging self-compassion and self-care in postpartum mothers is crucial, as it is essential to prioritize the mother’s health alongside her baby. • Low socioeconomic background and Ethnicity are risk factors for lower physical and mental health after childbirth. Reducing health disparities and targeting these vulnerable populations is crucial.