Background: Lexical properties such as orthographic neighbours have been shown to have an influence on reading and writing; however, this phenomenon is yet to be explored in the Southern Bantu languages.Objectives: We investigate the role of orthographic neighbourhood density and neighbourhood frequency in reading and spelling in Grade 3 isiXhosa home-language learners. The aim is to establish whether orthographic neighbours facilitate or hinder reading and spelling. The dual-route model of orthographic processing is used to interpret our findings.Method: Data were collected from 97 Grade 3 isiXhosa home-language learners. Lexical decision, word reading, and spelling tasks were administered. Tasks included both real and pseudowords varying in orthographic neighbourhood density and neighbourhood frequency, while controlling for word length and word frequency.Results: Findings show a significant inhibitory effect of orthographic neighbourhood frequency and word length for spelling accuracy. Longer words with higher frequency neighbours were more likely to be spelt incorrectly. No effect was recorded for the lexical decision and word reading tasks.Conclusion: Our findings suggest that spelling in isiXhosa relies partially on lexical processing strategies, which allows for the inhibitory effects of orthographic neighbours to be observed. While in reading, sublexical processing is more prominent, therefore mitigating the effect of orthographic neighbours.Contribution: Empirical evidence for the effects of orthographic neighbours, specifically in a Southern Bantu language, provides a clearer picture of the underlying cognitive-linguistic processes involved in reading and writing. This evidence may contribute to the development of targeted pedagogical practices to address spelling errors.