Higher Body Mass Index Values Research Articles

The biochemical effect correlated with pulmonary dysfunction and complications in obese patients

Objective: Obesity, an epidemic metabolic disorder, is associated with various biochemical, inflammatory, oxidative and immunological pathways. We aimed to investigate the biochemical effect correlated with pulmonary dysfunction and complications in overweight and obese patients. Material and Methods: We aimed to evaluate retrospectively the effect of biochemical parameters on pulmonary dysfunction and complications in 79 overweight and obese patients. The correlative effect of biochemical values, including CRP, and spirometric measurements, such as forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1), on pulmonary dysfunction and complications in 79 overweight and obese patients seen in the outpatient clinic were evaluated. Body mass index (BMI), FEV1 and FVC, and total biochemistry values, including creatinine, AST, ALT and CRP values were correlated among each other. Results: Low FVC levels, leukocytosis, high AST and ALT levels, and comorbidities of obesity are significantly associated with high BMI values by univariate analysis in these patients. Higher AST levels are significantly correlated with higher leucocyte counts, and both AST and ALT levels are significantly correlated with platelet counts. Conclusion: We investigated the effect of biochemical parameters on pulmonary dysfunction and complications in obese patients. Obesity can be helpful to categorize high-risk patients with low FVC levels in the context of respiratory diseases and high AST and ALT levels for other comorbidities as steatohepatitis, diabetes mellitus and coronary artery disease. This study sheds light on future research on obese patients for prognosis of these diseases, because of their biochemical profile correlation with pulmonary dysfunction and complications.

Association of serum asprosin with metabolic dysfunction-associated fatty liver disease in older adult type 2 diabetic patients: a cross-sectional study

BackgroundTo explore the association of serum asprosin levels with metabolic dysfunction-associated fatty liver disease (MAFLD) in older adults with type 2 diabetes mellitus (T2DM).MethodsThe cross-sectional study enrolled patients ≥ 65 years old diagnosed with T2DM at two community health service centers between November 2019 and July 2021. Logistic regression was applied to analyze the influencing factors of MAFLD.ResultsTotally 219 cases were included. Compared with diabetic individuals without MAFLD (n = 105), diabetics with MAFLD (n = 114) had younger ages, higher body mass index values, shorter time from T2DM diagnosis, increased waist-to-hip ratios, elevated triglycerides, reduced high-density lipoprotein cholesterol (HDL-C), elevated alanine aminotransferase (ALT), elevated γ-glutaryl transferase, elevated fasting insulin, and elevated HOMA-IR (all P < 0.05). Serum asprosin levels were elevated in diabetics with MAFLD in comparison with the non-MAFLD group (291.71 ± 73.69 vs. 255.24 ± 82.52 pg/ml, P = 0.001). Multivariable analysis revealed, after adjusted for age, time from T2DM diagnosis, HDL-C, and ALT, serum asprosin level (OR = 1.006, 95%CI: 1.001–1.010, P = 0.014) were independently associated with MAFLD in T2DM.ConclusionsHigh asprosin level are associated with MAFLD in older patients with T2DM, after adjusted for age, time from T2DM diagnosis, WHR, TG, HDL-C, ALT, GGT, FINS, and HOMA-IR.

Body composition and risk for sarcopenia in transgender women

ObjectivesBody composition and strength of cisgender (cis) individuals are well established. However, those for transgender women (trans women) undergoing gender-affirming hormone therapy remain unclear. This study aimed to detect possible body composition and strength variations related to sarcopenia. MethodsThis was a cross-sectional comparative study of 37 trans women, 34 cis men, and 34 cis women. Body composition was measured in all individuals by bioelectrical impedance analysis; prehensile strength by dynamometry was studied in trans women. ResultsIn this study, trans women had higher body mass index values than cis individuals (P < 0.01). Fat mass was 41% higher for trans women than cis men. Muscle mass (MM) was lower in trans women than cis men (–10%), and higher than cis women (24%). Bone mass was lower in trans women than cis men and higher in cis women (P < 0.01). Trans women's prehensile strengths were 25.26 kg for the right hand and 24.8 kg for the left. Appendicular skeletal muscle mass was 23.63 kg, and appendicular skeletal muscle mass index was 8.14 kg. ConclusionTrans women undergoing gender-affirming hormone therapy show a tendency to adapt body compartments to those of cis women with increased fat mass and reduced muscle mass. Prehensile strength in trans women was close to the cutoff points for sarcopenia risk. Nutrition, physical activity, strength, and body composition are important to avoid the possible risk for sarcopenia. More studies along these lines are necessary, especially in older adults.

Serum amyloid beta 42 levels correlated with metabolic syndrome and its components.

Beta-amyloid accumulation in the brain appears to be a key initiating event in Alzheimer's disease (AD), and factors associated with increased deposition of beta-amyloid are of great interest. Enhanced deposition of amyloid-β peptides is due to an imbalance between their production and elimination. Previous studies show that diminished levels of CSF amyloid beta 42 (Aβ42) is a biomarker in AD; however, the role of serum Aβ42 in AD is contradictory. BMI and obesity have been reported to be related to increased serum Aβ42 levels. Therefore, we aimed to investigate the relation between metabolic syndrome (MetS), its clinical measures (abdominal obesity, high glucose, high triglyceride, low high-density lipoprotein cholesterol level, and hypertension), and serum Aβ42 levels. A total of 1261 subjects, aged 18-89 years in Chengdu, China, were enrolled from January 2020 to January 2021 to explore the correlation of serum Aβ42 levels with body mass index (BMI), blood lipids, and blood pressure. Furthermore, as the risk of MetS is closely related to age, 1,212 participants (N = 49 with age ≥ 80 years old were excluded) were analyzed for the correlation of serum Aβ42 level and MetS clinical measures. The results showed that log-transformed serum Aβ42 level was positively correlated with BMI (R = 0.29; p < 0.001), log-transformed triglyceride (R = 0.14; p < 0.001), and diastolic blood pressure (DBP) (R = 0.12; p < 0.001) and negatively correlated with high-density lipoprotein (HDL-c) (R = -0.18; p < 0.001). After adjusting for age, sex, and other covariates, elevated serum Aβ42 level was correlated with higher values of BMI (βmodel1=2.694, βmodel2=2.703) and DBP (βmodel1=0.541, βmodel2=0.546) but a lower level of HDL-c (βmodel2 = -1.741). Furthermore, serum Aβ42 level was positively correlated with MetS and its clinical measures, including BMI and DBP, and negatively correlated with HDL-c level in the Han Chinese population. However, the level of serum Aβ42 did not show a significant correlation with high glucose or high triglyceride. These observations indicate that MetS and its components are associated with higher levels of serum Aβ42 and hence limit the potential of serum Aβ42 as a suitable diagnostic biomarker for AD. As such, we recommend serum Aβ42 serve as a direct risk biomarker for MetS rather than for AD.

Body Composition Variation among U-19 Futsal National Team Players from Bosnia and Herzegovina According to Playing Position

Elite futsal players in addition to other characteristics, must have suitable anthropometric and body composition according to their playing position. The research aimed to determine body composition of Bosnia and Herzegovina U-19 national futsal team players and also determine differences in anthropometric and body composition of players according to their playing position. The sample of respondents consisted of Bosnia and Herzegovina U-19 National Futsal Team players (n=14, average age 18.07±0.48 yrs, body height 181.40±5.72 cm, and body weight 77.66±10.60 kg). Anthropometric characteristics and body composition were evaluated by a battery of 11 variables: body height (BH), body mass (BM), triceps skinfold (TS), biceps skinfold (BiS), back skinfold (BS), abdominal skinfold (AS), upper leg skinfold (UlS), lower leg skinfold (LlS), body mass index (BMI), fat percentage (FP), and muscle mass percentages (MP). Futsal players were divided according to their positions in the team into goalkeepers, defenders, wingers and pivots. Based on ANOVA and post-hoc tests, the findings showed that there were significant differences between groups in 8 out of 11 anthropometric parameters. So, in relation to this, the main findings of the study indicate that: i) goalkeepers and pivots have significantly higher body mass and percentage of fat compared to defenders and wingers; ii) goalkeepers have a higher BMI than all other players, while pivots have higher BMI values than defenders and wingers; iii) muscle mass favors goalkeepers and pivots over wingers; iv) goalkeepers had significantly higher values in triceps and biceps skinfold measurements compared to other players, as well as in lower leg skinfold compared to defenders and wingers, and in back skinfold compared to wingers. Although this study is significant, because it examines the morphology of elite futsal players and indicates certain differences in the anthropometric characteristics of futsal players according to the positions in the team. However, we must interpret these results cautiously due to the limited sample size of participants.

Hubungan Aktivitas Fisik dan Pola Makan terhadap Status Indeks Masa Tubuh Normal

Body Mass Index (BMI) is a simple method used to assess the nutritional status of an individual. BMI is related to risk factors for obesity and its complications. Knowledge is needed regarding matters related to BMI in order to be able to control it and keep it in a normal or ideal state. This research aims to explain the relationship between physical activity and Body Mass Index (BMI) as well as good eating patterns to control BMI to remain normal. The research was conducted using the literature review method. Literature reviews were carried out on research articles, books and government documents. The results found that physical activity was related to BMI in terms of energy burning and fat reserves in the body. Insufficient physical activity will lead to a tendency towards high BMI values. Vice versa, high physical activity tends to set lower (normal) BMI values. Apart from managing physical activity, in order to get an ideal BMI, you need to regulate your diet well, namely by paying attention to the type, amount and schedule of food consumption.

Association of largest meal timing and eating frequency with body mass index and obesity

Background and AimsThe circadian pattern of eating behaviors has garnered increasing interest as a strategy for obesity prevention and weight loss. It is believed that the benefits stem from aligning food intake with the body's natural daily rhythms. However, the existing body of evidence is limited in scale and scope and there has been insufficient evaluation of temporal eating behaviors, such as the specific time of day in which the highest calorie consumption occurs, meal frequency, and distribution. This research aims to explore the association between the timing of the largest meal of the day and eating frequency with Body Mass Index (BMI) and obesity. MethodsParticipants (n=2 050, 18-65y) were part of an exploratory cross-sectional and population-based research, with data collection in a virtual environment. Linear regression analyses and restricted cubic splines evaluated differences in BMI associated with independent eating variables [timing of the largest meal, number of meals/day (as continuous and categorical: ≤3 or >3/day), and each largest meal of the day (breakfast/lunch/dinner)]. Logistic regression models were fitted to assess Odds Ratios (OR) and 95% Confidence Intervals (CI) of obesity associated with the same independent variables. ResultsOur main findings were that the timing of the largest meal and reporting dinner as the largest meal were associated with higher values of BMI (respectively, 0.07Kg/m2 and 0.85Kg/m2,) and increased odds of obesity [respectively OR(95%CI):1.04(1.01,1.08), and OR(95%CI):1.67(1.18,2.38)]. Those who realized more than 3 meals/day presented lower values of BMI (-0.14Kg/m2) and 32% lower odds of having obesity [OR(95%CI):0.68(0.52,0.89)]. Reporting lunch as the largest meal also protected against obesity [OR(95%CI):0.71(0.54,0.93)]. These associations were statistically significant and independent of sex, age, marital status, education level, diet quality, sleep duration, and weekly frequency of physical exercise. ConclusionHaving the largest meal earlier in the day, concentrating the majority of caloric intake during lunch, and consuming more than three meals a day, may present a promising intervention for preventing and treating obesity/overweight.

Clinical heterogeneity of sleep quality, emotional and behavioral characteristics, and eating habits in adolescents with obesity: A cluster analysis.

This study aims to examine the role of sleep quality, emotional and behavioral characteristics, and eating behavior in adolescents with obesity by means of cluster analysis. One hundred ninety-four adolescents (78 girls, 116 boys) aged 12-17 (mean 14.3 ± 2.7) with obesity (ICD-10 code E 66.0) entered the study. The Adolescent Sleep Wake Scale was used to evaluate sleep quality. The Achenbach Youth Self-Report for Ages 11-18 questionnaire was used to evaluate emotional and behavioral disturbances. The Dutch Eating Behavior Questionnaire was used to assess maladaptive eating. k-Means cluster analysis was used to clarify heterogeneity. Four clusters were identified: the first included anxious, depressed, socially withdrawn adolescents with thought problems and somatic complaints, non-aggressive, obedient, and having mean values on the sleep quality scale, inclined to restrict their food consumption. The second consisted of rule-breaking youngsters with poor sleep quality, reluctant to restrict their food consumption. The third comprised subjects with the highest values on the sleep quality and lowest values on emotional and behavioral problems, aimed at restricting food consumption. The fourth comprised adolescents with obvious signs of emotional disorders, poorest sleep quality, disinhibited behavior, and emotional and external eating. No statistically significant difference was found between the clusters in sex distribution. Patient allocation to the second or fourth cluster was associated with significantly higher body mass index values, as opposed to the reference third cluster. Conclusion: There is significant variation in teenagers with obesity who have divergent psychological profiles, which should be taken into account. What is Known: • Patients with obesity present with different clinical characteristics. What is New: • Adolescents with obesity may be partitioned into clusters described in terms of emotional, behavioral patterns, including sleep characteristics, and maladaptive eating habits.

BMI influence on total ankle arthroplasty outcomes: A systematic review

Total ankle arthroplasty has become an increasingly popular surgical treatment option for ankle arthritis. Patient selection for this procedure is a debated topic. Traditionally, total ankle arthroplasty is chosen for patients who perform only low-demand activities, those who are elderly, and those who are not overweight. More recently, foot and ankle surgeons have been expanding this selection criteria. The goal of the present study is to perform a systematic review on the impact of body mass index on total ankle survivorship and complications. 18 articles were included in the present systematic review. Five studies were analyzed for complications and indicated a potential increase in the odds of complications in patients with higher body mass index values, but this did not reach statistical significance (p > 0.05). There was not sufficient information to estimate a pooled effect of body mass index on total ankle arthroplasty survivorship. Due to the limited number of studies that met the review's inclusion and exclusion criteria, a statistical analysis was only performed on complication rates. In addition to a slight increase in complication risk for individuals with higher body mass index values, the results of this review also highlight the need for further studies that investigate the impact of body mass index on total ankle arthroplasty outcomes.

Obesity Paradox in Heart Failure with Mildly Reduced Ejection Fraction.

The study investigates the prognostic impact of body mass index (BMI) in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF). Limited data regarding the prognostic impact of BMI in patients with HFmrEF is available. Consecutive patients with HFmrEF (ie, left ventricular ejection fraction 41-49% and signs and/or symptoms of HF) were retrospectively included at one institution from 2016 to 2022. Risk stratification was performed according to WHO-defined BMI groups. The primary endpoint was all-cause mortality at 30 months (median follow-up). Kaplan-Meier, uni- and multivariable Cox proportional regression analyses were applied for statistics. 1832 consecutive patients with HFmrEF were included with a median BMI of 26.7 kg/m2 (IQR 24.0-30.8 kg/m2). Patients with lowest BMI (ie, 18.5-24.9 kg/m2) were associated with highest risk of all-cause mortality at 30 months compared to patients with higher BMI values (40.0% vs 29.0% vs 21.4% vs 20.9%; log rank p = 0.001; HR = 0.721; 95% CI 0.656-0.793; p = 0.001). Even after multivariable adjustment, higher BMI values were associated with improved survival at 30 months (HR = 0.963; 95% CI 0.943-0.985; p = 0.001). In contrast, the risk of HF- related rehospitalization at 30 months was not affected by BMI (log rank p = 0.064). In patients hospitalized with HFmrEF, lower BMI was associated with increased risk of all-cause mortality at 30 months, suggesting an obesity paradox in HFmrEF.

The relationship between body mass index and lower extremity biomechanics in children aged 10-12 years: a comprehensive analysis

Childhood obesity has emerged as a global health concern leading to complications, such as bones and muscles misalignment of knees, flat feet and changes in walking patterns. Although some studies have individually linked these conditions to body mass index (BMI), the relationship between these variables needs to be explored. This study aimed to investigate the associations between BMI and knee position, foot position and plantar footprint in children aged 10 to 12 years. Data were collected from 59 children by measuring their BMI, knee alignment, foot position and plantar footprint. Spearman’s correlation coefficient was used to examine the relationship between BMI and inter-malleolar distance (DIM), foot position and plantar footprint. The Mann- Whitney U test was used to compare these variables between boys and girls (p-value &lt; 0.05). Higher BMI values were associated with higher DIM in both boys and girls. Furthermore, we observed that genu valgum was positively correlated with foot pronation and a flattened plantar footprint. No significant differences were found in relation to BMI, variations in foot position or footprint types. Our research provides evidence that there is a connection, between BMI and genu valgum in children between the ages of 10 and 12. We have also found a correlation between genu valgum and foot pronation among children in this age group. These findings highlight the significance of addressing childhood obesity to prevent any health issues.

COVID-19'lu Kadınların İyileşme Sonrası Cinsel İşlevleri ve İlişkili Faktörler

This study was conducted to investigate the sexual function status and related factors in women after contracting COVID-19. The study comprised 261 women who had been infected with COVID-19. Data were collected using the Personal Information Form, the Female Sexual Function Scale, and the State-Trait Anxiety Inventory. Sub-dimension scores for desire (3.80 ± 1.16, 3.66 ± 1.17), arousal (4.25 ± 1.40, 4.11 ± 1.41), orgasm (4.36 ± 1.25, 4.29 ± 1.26), and sexual satisfaction (4.50 ± 1.49, 4.40 ± 1.49) in women, as well as the Female Sexual Function Scale total score (26.50 ± 6.79, 26.00 ± 6.93), decreased following COVID-19 infection. Moreover, the frequency of weekly intercourse decreased (2.78 ± 0.90; 2.60 ± 0.92) compared to the pre-infection levels, and the frequency of sexual dysfunction increased (FSFI &lt; 26 = 38.7%, 46.0%). In this study, advanced age, high body mass index (BMI) value, low education, income level, unemployment, smoking, lack of physical activity, anxiety, decreased coital frequency, and COVID-19 infection were identified as risk factors for sexual dysfunction. There was no significant relationship between the time elapsed after recovery from COVID-19 and sexual function. In conclusion, this research suggests that COVID-19 infection may lead to sexual dysfunction in women. Based on these research findings, health practitioners should assess the sexual health of female patients who have had COVID-19 infections, ensuring that women feel comfortable discussing their sexual health issues and referring them to appropriate treatment and counseling services when needed.

The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes-New Perspectives.

Obesity is a characteristic disease of the twenty-first century that is affecting an increasing percentage of society. Obesity expresses itself in different phenotypes: normal-weight obesity (NWO), metabolically obese normal-weight (MONW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUO). A range of pathophysiological mechanisms underlie the occurrence of obesity, including inflammation, oxidative stress, adipokine secretion, and other processes related to the pathophysiology of adipose tissue (AT). Body mass index (BMI) is the key indicator in the diagnosis of obesity; however, in the case of the NWO and MONW phenotypes, the metabolic disturbances are present despite BMI being within the normal range. On the other hand, MHO subjects with elevated BMI values do not present metabolic abnormalities. The MUO phenotype involves both a high BMI value and an abnormal metabolic profile. In this regard, attention has been focused on the variety of molecules produced by AT and their role in the development of obesity. Nesfatin-1, neuregulin 4, myonectin, irisin, and brain-derived neurotrophic factor (BDNF) all seem to have protective effects against obesity. The primary mechanism underlying the action of nesfatin-1 involves an increase in insulin sensitivity and reduced food intake. Neuregulin 4 sup-presses lipogenesis, decreases lipid accumulation, and reduces chronic low-grade inflammation. Myonectin lowers the amount of fatty acids in the bloodstream by increasing their absorption in the liver and AT. Irisin stimulates the browning of white adipose tissue (WAT) and consequently in-creases energy expenditure, additionally regulating glucose metabolism. Another molecule, BDNF, has anorexigenic effects. Decorin protects against the development of hyperglycemia, but may also contribute to proinflammatory processes. Similar effects are shown in the case of visfatin and chemerin, which may predispose to obesity. Visfatin increases adipogenesis, causes cholesterol accumulation in macrophages, and contributes to the development of glucose intolerance. Chemerin induces angiogenesis, which promotes the expansion of AT. This review aims to discuss the role of adipokines and myokines in the pathogenesis of the different obesity phenotypes.

Abstract 15587: Iimpact of Body Mass Index on Bleeding Events Patients Undergoing Percutaneous Coronary Intervention With or Without High Bleeding Risk

Introduction: High body mass index (BMI) values are associated with a lower risk of ischemic complications after percutaneous coronary intervention (PCI). Hypothesis : Higher BMI values may correlate with fewer bleeding after PCI in patients meeting or not the High Bleeding Risk (HBR) criteria of the Academic Research Consortium (ARC). Methods: All patients undergoing PCI between 2012 and 2019 at the Mount Sinai Hospital were included and stratified in 5 BMI categories according to World Health Organization definition. Patients where considered at HBR if they fulfilled ≥1 major or ≥2 minor ARC-HBR criteria. The primary outcome was major bleeding, the secondary outcome was post-discharge major bleeding at 1 year after PCI. Risks for these outcomes were obtained using a multivariable Cox regression model adjusted for the ARC-HBR criteria. Results: Among 16,229 patients, 20.2% had a BMI ≥18.5-25 (normal), 40.7% had a BMI ≥25-30, 24.4% had a BMI ≥30-35, 9.2% had a BMI ≥35-40, and 4.8% had a BMI ≥40 kg/m 2 . The proportion of patients meeting the ARC-HBR criteria progressively decreased from 48% in the normal BMI group to 41% in the highest BMI group. As compared to the normal BMI group (6.0%), the 1-year risk of major bleeding was significantly lower (p&lt;0.05) in the groups with BMI ≥25-30 (4.1%, adj. HR 0.73, 95% CI 0.60-0.88), with BMI ≥30-35 (3.5%, Adj. HR 0.62, 95% CI 0.49-0.77), with BMI ≥35-40 (4.2%; Adj. HR 0.72, 95% CI 0.54-0.9), while it was similar in the group of BMI ≥40 (4.9%, Adj. HR 0.83, 95% CI 0.58-1.18) ( A ). These differences were driven by lower rates of in-hospital bleeding in patients with BMI ≥25-40 kg/m 2 . Among HBR patients, 1-year rates of major bleeding were consistently above 4% in each BMI category, but relatively lower for BMI ≥25-40 kg/m 2 ( B ). Conclusions: BMI values between 25 and 40 kg/m 2 were associated with an attenuated risk of major bleeding at 1-year in patients undergoing PCI and this association was consistent among HBR individuals.

The hidden impact of neuropathic pain after surgical fixation of wrist, hip, and ankle fractures: A cross-sectional retrospective study evaluating its prevalence and risk factors

BackgroundDysesthesia, electrical and burning sensations, in addition to allodynia are frequent symptoms of neuropathic pain. Despite the high frequency, scientific data on the development of neuropathic pain after surgery for fracture fixation are scarce. The goal of the present study was to determine the prevalence, risk factors, and evaluate potential associations among neuropathic pain, pain intensity, sociodemographic, and clinical variables after wrist, hip, and ankle fracture fixation. MethodsA cross-sectional retrospective study involving a cohort of 166 patients who underwent surgery for distal radius, proximal femur, malleolar fracture fixation was performed. Neuropathic pain was assessed one year after fracture fixation using the Doleur Neuropathique Questionnaire (DN4). ResultsThe incidence of neuropathic pain in our sample was 49 (29.5%). Predictors for the development of neuropathic pain included patients with a high body mass index (BMI), female gender, diabetes mellitus, long-term use of analgesics (especially using pain-modulating medication), patients who presented some fracture-related complication during the course of the treatment, who had limitations for daily activity, and who were away from work due to chronic pain. ConclusionIn our study, neuropathic pain after wrist, hip, and ankle fracture fixation was prevalent and associated with higher BMI values and amount of medication, in addition to higher proportions of female sex, absence from work, DM, limitation for daily activities, postoperative complications, and use of pain modulating medications.

Screening for Prediabetes and Diabetes in a National Network of Federally Qualified Health Centers: An Observational Study.

In 2021, the U.S. Preventive Services Task Force (USPSTF) recommended screening for prediabetes and diabetes among adults aged 35-70years with overweight or obesity. Studying dysglycemia screening in federally qualified health centers (FQHCs) that serve vulnerable patient populations is needed to understand health equity implications of this recommendation. To investigate screening practices among FQHC patients who would be eligible according to the 2021 USPSTF recommendation. Retrospective cohort study analyzing electronic health records from a national network of 282 FQHC sites. We included 183,329 patients without prior evidence of prediabetes or diabetes, who had ≥ 1 office visit from 2018-2020. Screening eligibility was based on age and measured body mass index (BMI). The primary outcome, screening completion, was ascertained using hemoglobin A1c or fasting plasma glucose results from 2018-2020. Among 89,543 patients who would be eligible according to the 2021 USPSTF recommendation, 53,263 (59.5%) were screened. Those who completed screening had higher BMI values than patients who did not (33.0 ± 6.7kg/m2 vs. 31.9 ± 6.2kg/m2, p < 0.001). Adults aged 50-64years had greater odds of screening completion relative to younger patients (OR 1.13, 95% CI: 1.10-1.17). Patients from racial and ethnic minority groups, as well as those without health insurance, were more likely to complete screening than White patients and insured patients, respectively. Clinical risk factors for diabetes were also associated with dysglycemia screening. Among patients who completed screening, 23,588 (44.3%) had values consistent with prediabetes or diabetes. Over half of FQHC patients who would be eligible according to the 2021 USPSTF recommendation were screened. Screening completion was higher among middle-aged patients, those with greater BMI values, as well as vulnerable groups with a high risk of developing diabetes. Future research should examine adoption of the 2021 USPSTF screening recommendation and its impact on health equity.

Assessment of Hypertensive Patients' Complex Metabolic Status Using Data Mining Methods.

Cardiovascular diseases are among the leading causes of mortality worldwide. Hypertension is a preventable risk factor leading to major cardiovascular events. We have not found a comprehensive study investigating Central and Eastern European hypertensive patients' complex metabolic status. Therefore, our goal was to calculate the prevalence of hypertension and associated metabolic abnormalities using data-mining methods in our region. We assessed the data of adults who visited the University of Debrecen Clinical Center's hospital (n = 937,249). The study encompassed data from a period of 20 years (2001-2021). We detected 292,561 hypertensive patients. The calculated prevalence of hypertension was altogether 32.2%. Markedly higher body mass index values were found in hypertensive patients as compared to non-hypertensives. Significantly higher triglyceride and lower HDL-C levels were found in adults from 18 to 80 years old. Furthermore, significantly higher serum glucose and uric acid levels were measured in hypertensive subjects. Our study confirms that the calculated prevalence of hypertension is akin to international findings and highlights the extensive association of metabolic alterations. These findings emphasize the role of early recognition and immediate treatment of cardiometabolic abnormalities to improve the quality of life and life expectancy of hypertensive patients.

Classical Prognostic Factors Predict Prognosis Better than Inflammatory Indices in Locally Advanced Cervical Cancer: Results of a Comprehensive Observational Study including Tumor-, Patient-, and Treatment-Related Data (ESTHER Study).

Systemic inflammation indices were found to be correlated with therapeutic outcome in several cancers. This study retrospectively analyzes the predictive role of a broad range of systemic inflammatory markers in patients with locally advanced cervical cancer (LACC) including patient-, tumor-, and treatment-related potential prognostic factors. All patients underwent definitive chemoradiation and pretreatment values of several inflammatory indices (neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio, monocyte/lymphocyte ratio, systemic immune inflammation index (SII), leukocyte/lymphocyte ratio, combination of platelet count and NLR, aspartate aminotransferase/platelet ratio index, aspartate aminotransferase/lymphocyte ratio index, systemic inflammatory response index, and aspartate transaminase/neutrophil ratio index) were calculated. Their correlation with local control (LC), distant metastasis-free (DMFS), disease-free (DFS), and overall survival (OS) was analyzed. One hundred and seventy-three patients were included. At multivariable analysis significant correlations were recorded among clinical outcomes and older age, advanced FIGO stage, lower hemoglobin levels, larger tumor size, and higher body mass index values. The multivariate analysis showed only the significant correlation between higher SII values and lower DMFS rates (p < 0.01). Our analysis showed no significant correlation between indices and DSF or OS. Further studies are needed to clarify the role of inflammation indices as candidates for inclusion in predictive models in this clinical setting.

СРАВНЕНИЕ ПОКАЗАТЕЛЕЙ ФИЗИЧЕСКОГО РАЗВИТИЯ И ФИЗИЧЕСКОЙ ПОДГОТОВЛЕННОСТИ ПЕРВОКУРСНИКОВ С РАЗНЫМ СОСТОЯНИЕМ ЗДОРОВЬЯ, ПЕРЕНЕСШИХ COVID-19

To study the "post-covid syndrome," as a natural consequence of the pathological course of the new coronavirus infection "covid-19," data from a retrospective analysis of the incidence and testing of motor abilities of freshmen in 2022 are presented. The incidence rate of covid-19 among 2022 freshmen was significantly higher than among 2021 freshmen and had two peaks in October 2021 and February 2022. The ratio of girls who had been ill and did not have covid-19 was significantly higher than in the group of boys. Among young men who had recovered from covid-19, 14.86% belonged to a special medical group, while among those who were not sick, only 4.27% belonged to a special medical group. In the group of girls who had had covid-19, 17.45% belonged to the special medical group, and 11.42% among those who were not sick. Among young men who had been ill and did not have covid-19, 68.92 and 68.29% of freshmen, respectively, had a normal level of body mass index (BMI); 13.51 and 14.63% − reduced BMI values, and 16.22 and 13.42% − high BMI values. Among girls, 64.98 and 69.84% of freshmen were characterized by normal BMI values; 21.52 and 19, 34% − reduced values, and 13.08 and 8.86% − high BMI. Comparison of physical fitness indicators of freshmen who had been ill and did not have covid-19 were performed in subgroups with comparable BMI values. In the group of boys and girls with normal body mass index values, there were no significant differences in physical development and physical fitness among students who had been ill and did not have covid-19. In boys and girls with an insufficient body mass index who had recovered from covid-19, the indicators of active orthostatic test were significantly worse than in those who were not sick. In boys with excessive BMI who have had covid-19, the indicators of the hand dynamometry index and resistance to hypoxia were significantly lower than among non-sick fellow students.

Diagnostic value of anthropometric indicators and body composition as indicators of aging rates and comorbidity in patients with cardiometabolic diseases

Objective — to assess anthropometric indicators and body composition in patients with certain cardiometabolic diseases depending on their aging rates and the number of existing comorbid pathologies.&#x0D; Materials and methods. Examinations involved 92 patients with cardiometabolic diseases, including arterial hypertension (AH), non‑alcoholic fatty liver disease, obesity, dyslipidemia, insulin resistance. Female prevailed among patients (62.0%), the mean age was 49.2 [41.4; 55.4] years. All patients were divided into groups depending on calendar age (CA): young &lt;45 years (n=32), middle age 45—59 years (n=49), elderly &gt;60 years (n=11), and also divided by the rates of aging: with accelerated age delta (Δ) &gt;0 years (n=14), with significantly slowed rates of ageing — Δ ≤–5 years (n=51) and intermediate ones — Δ ∈ (–5; 0] years (n=27). Anthropometric parameters and calculated indices were determined in all patients and included body mass index (BMI), waist circumference (WC), hip circumference (HC), WC/HC ratio, percentage of total fat (TF), percentage of skeletal muscle mass (SM), visceral fat (VF), weight‑adjusted waist index (WWI), a body shape index (ABSI) and abdominal volume index (AVI). As additional indicators of aging, the level of uric acid, the total mortality risk during the next 10 years (MR) and the level of global methylation (GM) of DNA were determined.&#x0D; Results. Significant differences between all groups divided according to CA were in BA and MR (p=0.0001 in all cases). Patients &lt;45 years of age compared to the elderly had significantly higher rates of aging (p=0.019) and significantly lower levels of BMI (p=0.039), WC (p=0.034), WWI (p=0.002) and AVI (p=0.032). WWI was the only marker that significantly increased in the middle‑aged group of patients (p=0.033) compared to young patients. Patients re‑divided into groups according to  did not differ in the levels of anthropometric indicators and body composition. However, patients with significantly slower rates of aging had significantly lower uric acid levels compared to the group with accelerated (p=0.0001) and intermediate rates of aging (p=0.024), and also had higher CA compared to patients in the intermediate group (p=0.026). Various indicators of aging were significantly associated with weight, BMI, VF, WC, WC/HC, WWI and AVI, but only WC and AVI were simultaneously associated with all markers of aging (uric acid, BA, MR, GM). Only WWI was associated with CA, in addition it had the strongest association with BA and MR compared to other indicators. Patients with 4—5 comorbid pathologies had worse weight (p=0.045), BMI (p=0.0001), WC (p=0.002), WC/HC (p=0.002), TF (p=0.004), SM (p=0.010), WWI (p=0.006), AVI (p=0.002), WWI (p=0.040) and aging rates (p=0.008).&#x0D; Conclusions. Among anthropometric and body composition parameters in patients with cardiometabolic pathology, WWI is probably the most effective one for monitoring premature aging, as it is associated with both CA, markers of aging and cardiometabolic parameters. The higher calendar age among patients with cardiometabolic pathologies was accompanied by higher values of BMI, WC, WWI and AVI, so control of these indicators may be useful for prevention of premature aging. Assessment of weight, BMI, WC, WC/HC, TF, SM, WWI and AVI is effective for predicting aging rates among patients with multimorbidity.