Modifying Effect of Single-Nucleotide Polymorphism on Blood Hg Level and Association between Blood Hg Level and Dietary Exposure to Hg LevelAbstract Number:2132 JI AE LIM*, Ho-Jang Kwon, Jung-Duck Park, Heon Kim, Yong-Dae Kim, Sang-Yong Eom, and Hyungryul Lim JI AE LIM* Dankook University College of Medicine, Korea, E-mail Address: [email protected] Search for more papers by this author , Ho-Jang Kwon Dankook University College of Medicine, Korea, E-mail Address: [email protected] Search for more papers by this author , Jung-Duck Park Chung-Ang University College of Medicine, Korea, E-mail Address: [email protected] Search for more papers by this author , Heon Kim Chungbuk University College of Medicine, Korea, E-mail Address: [email protected] Search for more papers by this author , Yong-Dae Kim Chungbuk University College of Medicine, Korea, E-mail Address: [email protected] Search for more papers by this author , Sang-Yong Eom Chungbuk University College of Medicine, Korea, E-mail Address: [email protected] Search for more papers by this author , and Hyungryul Lim Dankook University College of Medicine, Korea, E-mail Address: [email protected] Search for more papers by this author AbstractBackground: Recent studies have suggested that several genes that mediate mercury metabolism are polymorphic in humans.Objectives: We hypothesized those single-nucleotide polymorphisms (SNPs) in toxicokinetics genes may influence individual difference in mercury biomarker levels. We studied the potential modifying effects of toxicokinetics related SNPs on blood mercury level and association between blood Hg level and dietary exposure to Hg level.Methods: We selected samples of 528 adults from ‘the Korean research project on the integrated exposure assessment of hazardous materials for food safety (KRIEFS)’cohort. This cohort measured blood mercury level and dietary exposure to mercury level. We surveyed SNPS of samples with a Human Exome 12 v 1.2. Analysis results were conducted bonferroni correction. The blood mercury levels were compared by SNPS with linear regression model. And we conducted correlation analysis between blood Hg level and dietary exposure to Hg level by genotype.Results: linear regression analysis showed that three SNPs were statistically significant different in blood mercury level by genotype (cut off P< 2?10-7). TOP1MT (rs11544484) TT genotype (mean 37.1 µg/L) or TC genotype (mean 6.25 µg/L) had higher blood mercury levels than CC genotype (mean 6.05 µg/L). HLA-DQB1 (rs2858881) GG genotype (mean 23.8 µg/L) had higher blood mercury level than AG genotype (mean 5.25 µg/L) and AA genotype (mean 6.21 µg/L). FAT1 (rs74511500) GG genotype (mean 5.80 µg/L) had lower blood mercury level than GA+AA genotype (mean 8.09 µg/L). Significant correlation between blood Hg level and dietary exposure to Hg level were observed in CC genotype (R= 0.22, P=<0.0001) of TOP1MT (rs11544484), GA+AA genotype (R=0.30, P=0.005) of FAT1 (rs74511500), AA genotype (R=0.23, P=<0.0001) of HLA-DQB1 (rs2858881).Conclusion: Our findings suggest that some toxicokinetics related genetic polymorphism may influences blood mercury level.