By the establishment of science parks, Taiwan has achieved the ability to form high-tech industrial clusters and provided an environment for sustainable industrial development. This study analyzes the sustainable development strategy of the Central Taiwan Science Park (hereafter CTSP). The questions addressed here include: (1) What is the concept of sustainable development in the CTSP? and (2) How does the research respond to the debate on the significance of the CTSP? The research data have been collected using interviews and observation. According to the literature, eight criteria are identified and set up as a framework to code and analyze the data: “natural resources, accessibility regulatory regime, market demand, development level, proximity condition, parcel conditions, and financial compensation”. The framework is then used for evaluating the sustainability of science parks in the light of 17 core goals proposed by the United Nations as Sustainable Development Goals/SDGs for the world. Evaluation of these core goals in the CTSP development revealed the successful transformation of Taiwan’s political and economic structure. In this study, the analysis of the sustainable development generated by the science parks indicates Taiwan’s transition from state leadership (strong state, weak society) to state guidance (strong state, strong society). However, despite its contribution to the long-term development of Taiwan’s economy, the CTSP development has been accompanied by environmental downsides, risking the sustainability goals. In conclusion, the state’s role in making CTSP successful and sustainable, the determining role of regulatory regimes, and moving from state leadership to state guidance are emphasized.