Purpose: to analyze the causes of long-term deformations of prestressed concrete bridge spans and the problems associated with their prediction. To provide a brief overview of existing methods for predicting the long-term behavior of prestressed concrete bridges. The relevance of the problem is due to the need to ensure the reliability and durability of these structures, which are widely used in modern bridge construction. The objective of this paper is to identify factors that influence the development of long-term deformations and to develop approaches for their accurate prediction. Methods: the study examines the long-term deformations of prestressed concrete bridge spans and the problems associated with their prediction using existing bridge structures as examples. Existing methods for predicting long-term deformations in prestressed concrete are evaluated. In particular, the effects of high-strength reinforcement relaxation and the effects of concrete creep and shrinkage are analyzed. Results: accurate prediction of long-term deformations is a complex task that requires consideration of many factors, such as prestress losses, environmental conditions, material properties, and structural characteristics of bridges. The methods discussed in this paper, including the multiplier method and the approximate time interval method, demonstrate their effectiveness in evaluating long-term deformations. However, further research is needed to improve the prediction methods and increase the efficiency of prestressed concrete bridge design. Practical significance: provides design engineers with specific methods and approaches for evaluating the long-term behavior of prestressed concrete bridges. Application of these methods can reduce the risk of excessive deformations and deflections, ultimately ensuring the safety and reliability of bridge structures.