High Static Magnetic Field Research Articles

The Evolution of Cube Texture in Directionally Solidified Fe-3.0 wt. % Si Alloy Assisted by a High Static Magnetic Field

The Evolution of Cube Texture in Directionally Solidified Fe-3.0 wt. % Si Alloy Assisted by a High Static Magnetic Field

Effects of 16.8-22.0 T high static magnetic fields on the development of zebrafish in early fertilization.

Despite some existing studies on the safety of high static magnetic fields (SMFs), the effects of ultra-high SMFs above 20.0 T for embryonic development in early pregnancy are absent. The objective of this study is to evaluate the influence of 16.8-22.0 T SMF on the development of zebrafish embryos, which will provide important information for the future application of ultra-high field magnetic resonance imaging (MRI). Two-hour exposure to homogenous (0 T/m) 22.0 T SMF, or 16.8 T SMFs with 123.25 T/m spatial gradient of opposite magnetic force directions was examined in the embryonic development of 200 zebrafish. Their body length, heart rate, spontaneous tail-wagging movement, hatching and survival rate, photomotor response, and visual motor response (VMR) were analyzed. Our results show that these ultra-high SMFs did not significantly affect the general development of zebrafish embryos, such as the body length or spontaneous tail-wagging movement. However, the hatching rate was reduced by the gradient SMFs (p < 0.05), but not the homogenous 22.0 T SMF. Moreover, although the zebrafish larva activities were differentially affected by these ultra-high SMFs (p < 0.05), the expression of several visual and neurodevelopmental genes (p < 0.05) was generally downregulated in the eyeball. Our findings suggest that exposure to ultra-high SMFs, especially the gradient SMFs, may have adverse effects on embryonic development, which should cause some attention to the future application of ultra-high field MRIs. As technology advances, it is conceivable that very strong magnetic fields may be adapted for use in medical imaging. Possible dangers associated with these higher Tesla fields need to be considered and evaluated prior to human use. Ultra-High static magnetic field may affect early embryonic development. High strength gradient static magnetic field exposure impacted zebrafish embryonic development. The application of very strong magnetic fields for MR technologies needs to be carefully evaluated.

Design requirements for human UHF magnets from the perspective of MRI scientists

Abstract The highest magnetic field strength for human-sized magnetic resonance imaging (MRI) currently lies at 11.7 tesla. Given the opportunities for enhanced sensitivity and improved data quality at higher static magnetic fields, several initiatives around the world are pursuing the implementation of further human MRI systems at or above 11.7 tesla. In general, members of the MR research community are not experts on magnet technology. However, the magnet is the technological heart of any MR system, and the MRI community is challenging the magnet research and design community to fulfill the current engineering gap in implementing large-bore, highly homogeneous and stabile magnets at field strengths that go beyond the performance capability of niobium-titanium. In this article, we present an overview of magnet design for such systems from the perspective of MR scientists. The underlying motivation and need for higher magnetic fields are briefly introduced, and system design considerations for the magnet as well as for the MRI subsystems such as the gradients, the shimming arrangement, and the radiofrequency hardware are presented. Finally, important limitations to higher magnetic fields from physiological considerations are described, operating under the assumption that any engineering or economic barriers to realizing such systems will be overcome.&amp;#xD;

Modeling the stress and forces on multi-channel TMS coil arrays in high-field MRI scanners

Transcranial magnetic stimulation (TMS) is a non-invasive method for stimulating the cortex. Concurrent functional magnetic resonance imaging can show changes in TMS-induced activity in the whole brain, with the potential to inform brain function research and to guide the development of TMS therapy. However, the interaction of the strong current pulses in the TMS coil in the static main magnetic field of the MRI produces high Lorentz forces, which may damage the coil enclosure and compromise the patient’s safety. We studied the time-dependent mechanical behavior and durability of two multi-locus TMS (mTMS) coil arrays inside a high-field MRI bore with finite element modeling. In addition, coil arrays were built and tested based on the simulation results. We found that the current pulses produce shock waves and time-dependent stress distribution in the coil plates. The intensity and location of the maximum stress depend on the current waveform, the coil combination, and the transducer orientation relative to the MRI magnetic field. We found that 30% glass-fiber-filled polyamide is the most durable material out of the six options studied. In addition, novel insights for more durable TMS coil designs were obtained. Our study contributes to a comprehensive understanding of the underlying mechanisms responsible for the structural failure of mTMS coil arrays during stimulation within high static magnetic fields. This knowledge is essential for developing mechanically stable and safe mTMS-MRI transducers.

Ultra-high static magnetic fields altered the embryonic division and development in Caenorhabditis elegans via multipolar spindles

IntroductionUltra-high static magnetic fields (SMFs) have unique advantages in improving medical and academic research. However, the research on the early embryo exposure of ultra-high SMFs is minimal, extensive exploration is indispensable in living organisms. ObjectivesThe present study was aimed to study the effects of ultra-high SMFs on the early embryonic division and development of Caenorhabditis elegans (C. elegans). MethodsEarly adult parents containing fertilized eggs in vivo were exposed to SMFs at intensities ranging from 4 T to 27 T. The number of mitotic cells in the reproductive glands of the P0 worms, early embryonic cell spindle localization, embryo hatching and the reproductive as well as developmental indicators of F1 and F2 nematodes were examined as endpoints. ResultsOur results indicated that ultra-high SMFs has no obvious effect on the germ cell cycle, while 14 T and 27 T SMFs significantly increased the proportion of multi-polar spindle formation in early embryonic cells, and reduced the developmental rate and lifespan of C. elegans exposed at the embryonic stage. Spindle abnormalities of early embryonic cells, as well as the down-regulation of genes related to asymmetric embryonic division and the abnormal expression of the non-muscle myosin NMY-2 in the division grooves played a critical role in the slowing down of embryonic development induced by ultra-high SMFs. ConclusionsThis study provided novel information and a new sight for evaluating the biosafety assessment by exposure to ultra-high SMFs at the early embryonic stage in vivo.

On the future sustainable ultra-high-speed maglev: A superconductor magnet technology enabling high energy efficiency and robustness

The blooming ultrahigh-speed SC maglev (superconducting magnetically levitated train) prompts green travel worldwide. We utilized high-temperature superconductor (HTS) magnets and have developed an energy-economical SC maglev prototype (Energ. Convers. Manage. (291)117247). In this paper, as a continuation, we further improve and maximize the performance of its key part – the HTS magnets, especially in compact high magnetic field and energy density operating conditions, by innovating an HTS magnet technology named the Shunted Extreme-NI Concept. The operational energy-robustness, -density, and -economy of HTS magnets, compared to the conventional type, are improved by 96.8%, 66.7%, and 52.5%, respectively. For a full-scale maglev equipped with this technology, the estimated energy consumption per passenger kilometer can be further reduced to below 20% of that of airplanes under the same cruising speed of 1000 km/h. This work is dedicated to advancing the energy performances of HTS magnets, heading to the future sustainable maglev transportation.

Static magnetic fields in regenerative medicine.

All organisms on Earth live in the weak but ubiquitous geomagnetic field. Human beings are also exposed to magnetic fields generated by multiple sources, ranging from permanent magnets to magnetic resonance imaging (MRI) in hospitals. It has been shown that different magnetic fields can generate various effects on different tissues and cells. Among them, stem cells appear to be one of the most sensitive cell types to magnetic fields, which are the fundamental units of regenerative therapies. In this review, we focus on the bioeffects of static magnetic fields (SMFs), which are related to regenerative medicine. Most reports in the literature focus on the influence of SMF on bone regeneration, wound healing, and stem cell production. Multiple aspects of the cellular events, including gene expression, cell signaling pathways, reactive oxygen species, inflammation, and cytoskeleton, have been shown to be affected by SMFs. Although no consensus yet, current evidence indicates that moderate and high SMFs could serve as a promising physical tool to promote bone regeneration, wound healing, neural differentiation, and dental regeneration. All in vivo studies of SMFs on bone regeneration and wound healing have shown beneficial effects, which unravel the great potential of SMFs in these aspects. More mechanistic studies, magnetic field parameter optimization, and clinical investigations on human bodies will be imperative for the successful clinical applications of SMFs in regenerative medicine.

Effect of static magnetic field pretreatment on the structure and oil absorption properties of normal maize starch

In this work, we report the effect of static magnetic field (SMF) on normal maize starch (NMS) structure and oil absorption properties. The results showed that the untreated NMS had the total oil absorption of 83.90%, solubility of 19.00%, swelling power of 20.32 g/g, and amylose content of 26.95%. Besides, compared with untreated NMS, pretreatment with different SMF strengths significantly reduced the total oil absorption (61.78–78.12%), solubility (16.99–18.61%), swelling power (17.62–19.02 g/g), and amylose content (19.77–24.73%) of NMS. Besides, the SMF-pretreated NMS had a rough surface with more pits and pores, a denser particle structure, and a smaller specific surface area and particle size than untreated NMS. However, the high SMF intensity (50 mT) made NMS form a porous structure, leading to the highest oil absorption of NMS (78.12%), but still less than untreated NMS (83.90%). FT-IR, XRD, and DSC studies further showed that SMF pretreatment improved the structural ordering and thermal stability of NMS particles, inhibiting the oil absorption of NMS. To investigate whether SMF pretreatment could reduce starch-based fried food oil absorption, LF-NMR was used to determine the oil content of fried NMS treated with different SMF strengths. Results indicated the oil content of NMS after frying was significantly reduced by SMF pretreatment than untreated NMS, and the lowest was 0.2751 g/g for SMF-30. Therefore, SMF pretreatment can effectively reduce the oil absorption capacity of NMS before and after frying and serve as a prospective technology to reduce the oil content of starch-based fried foods.

Dynamics of Magnetization Under the Spin-Lock Pulse: General Solution of the Bloch Equation

Functional magnetic resonance imaging (fMRI) conventionally relies on hemodynamics response induced some seconds after neural activation. Therefore, the temporal limitations of fMRI is the main challenge and we focused on the spin-lock sequence, which identifies neural magnetic field using magnetic resonance between the spin-lock pulse and the measurement target. This potentially addresses limitations of the traditional fMRI such as low temporal resolution and high static magnetic field. To enhance spin-lock sequences, it is essential to analyze magnetization dynamics during the spin-lock pulse. This study improved our previous proposal by presenting the particular solution of the Bloch equation, which allows us to consider the effect of <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> relaxation. We also confirmed the novel solution with the comparison of numerical simulations without any approximation and discovered that the solution improved accuracy for <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M_y</i> and <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M_z</i> . The offset errors for <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M_y</i> and <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M_z</i> became smaller than 1 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> times to the thermal equilibrium magnetization and the magnitude of errors was reduced to 3.2975 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> and 1.3072 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> times compared to our previous proposal. This improvement contributes to acquisition-integrated spin-lock sequences. There are still drawbacks due to the rotating wave approximation in our new proposal, but, it is applicable when the frequency bandwidth of spin-lock resonance is narrow, or the measurement target, such as a steady-state induced response, can be approximated by a single-frequency sine wave.

The future search for low-frequency axions and new physics with the FLASH resonant cavity experiment at Frascati National Laboratories

We present a proposal for a new experiment, the FINUDA magnet for Light Axion SearcH (FLASH), a large resonant-cavity haloscope in a high static magnetic field which is planned to probe new physics in the form of dark matter (DM) axions, scalar fields, chameleons, hidden photons, as well as high frequency gravitational waves (GWs). Concerning the QCD axion, FLASH will search for these particles as the DM in the mass range (0.49–1.49)μeV, thus filling the mass gap between the ranges covered by other planned searches. A dedicated Microstrip SQUID operating at ultra-cryogenic temperatures will amplify the signal. The frequency range accessible overlaps with the Very High Frequency (VHF) range of the radio wave spectrum and allows for a search in GWs in the frequency range (100–300)MHz. The experiment will make use of the cryogenic plant and magnet of the FINUDA experiment at INFN Frascati National Laboratories near Rome (Italy); the operations needed to restore the functionalities of the apparatus are currently underway. We present the setup of the experiment and the sensitivity forecasts for the detection of axions, scalar fields, chameleons, hidden photons, and GWs.

Diffusion mechanism in liquid Al–Cu melt under high magnetic field

ABSTRACT High static magnetic field (HMF) is now a widely used technique to tailor materials. However, as one of the most fundamental properties in liquid alloy melts, atomic diffusion under HMF still lacks understanding. By using a novel gravity-assisted automatic docking device, the interdiffusion coefficient (IDC) in liquid Al–Cu alloy at various temperatures has been studied under HMF. It is found that HMF reduces the IDC. When HMF is larger than 5 T, the value of IDC remains constant at a certain temperature, which indicates HMF changes the diffusion mechanism from convective dominated mass transfer to a diffusive limited state in the liquid melt. For various temperatures, we find that a decrease of the frequency factor of atoms is the main reason for IDC decreasing under a certain HMF. The diffusion mechanism in liquid melt is similar to the vacancy mechanism in solids. This work provides a deep insight for atomic diffusion in a liquid melt by considering the interaction between temperature and HMF.

Intermittent high voltage electrostatic field and static magnetic field assisted modified atmosphere packaging alleviate mildew of postharvest strawberries after simulated transportation by activating the phenylpropanoid pathway

The mildew is a typical symptom of strawberries during storage. The effectiveness of intermittent high voltage electrostatic field combined with static magnetic field (HVEF-SMF) technique in inhibiting the mildew of strawberries (before and after simulation of transport vibrations) was investigated. Intermittent HVEF, SMF and HVEF-SMF treatments inhibited spoilage fungal growth on the surface of strawberries by increasing the membrane permeability and leakage of intracellular materials of spoilage fungal. The HVEF-SMF alleviated mildew in strawberries, which probably via the increase of antifungal compounds (total phenolics and lignin), phenylpropanoid biosynthetic enzyme activities (Phenylalanine ammonia-lyase, 4-coumarate-CoA ligase) and pathogenesis-related proteins enzymes activities (chitinase and β-1,3-glucanase). Overall, HVEF-SMF contributed to alleviating the mildew and disease incidence of strawberries, improving the levels of antimicrobial activity, as well as extending their shelf life from 6 d to 12 d. Therefore, HVEF-SMF treatment is a promising technology for alleviating postharvest mildew in strawberries after transportation.

Development of YBCO Patterned Multi-Filamentary Film Using Photolithography Method

High-temperature superconducting (HTS)-coated conductors (CCs) can be applied to magnets under low temperature and high magnetic field conditions, as well as in electric power equipment. Reducing the screening current and AC loss is an important topic for practical applications. In this study, we propose a multifilamentary YBCO thin film, fabricated by depositing YBCO on a substrate with elevated Zr stripes patterned by using photolithography techniques. While the thin film exhibited superconductivity, the crystal grain orientation was disturbed above the stripe, which locally inhibited the superconducting current flow. The results of this study indicate that a continuous YBCO film can be dividing into separate superconducting filaments by locally suppressing the good grain alignment required for a high intergrain <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">J</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> with Zr stripes between the STO substrate and the YBCO film.

Behavioral and neural responses to high-strength magnetic fields are reduced in otolith mutant mice.

Static high magnetic fields (MFs) interact with the vestibular system of humans and rodents. In rats and mice, exposure to MFs causes perturbations such as head movements, circular locomotion, suppressed rearing, nystagmus, and conditioned taste aversion acquisition. To test the role of otoconia, two mutant mouse models were examined, head-tilt Nox3het (het) and tilted Otop1 (tlt), with mutations, respectively, in Nox3, encoding the NADPH oxidase 3 enzyme, and Otop1, encoding the otopetrin 1 proton channel, which are normally expressed in the otolith organs, and are critical for otoconia formation. Consequently, both mutants show a near complete loss of otoconia in the utricle and saccule, and are nonresponsive to linear acceleration. Mice were exposed to a 14.1 Tesla MF for 30 min. After exposure, locomotor activity, conditioned taste aversion and c-Fos (in het) were assessed. Wild-type mice exposed to the MF showed suppressed rearing, increased latency to rear, locomotor circling, and c-Fos in brainstem nuclei related to vestibular processing (prepositus, spinal vestibular, and supragenual nuclei). Mutant het mice showed no response to the magnet and were similar to sham animals in all assays. Unlike het, tlt mutants exposed to the MF showed significant locomotor circling and suppressed rearing compared with sham controls, although they failed to acquire a taste aversion. The residual responsiveness of tlt versus het mice might reflect a greater semicircular deficit in het mice. These results demonstrate the necessity of the otoconia for the full effect of exposure to high MFs, but also suggest a semicircular contribution.

Raman Studies of Two-Dimensional Group-VI Transition Metal Dichalcogenides under Extreme Conditions

In the past decade, two-dimensional (2D) transition metal dichalcogenides (TMDs) have attracted increasing attention because of their striking physical properties and extensive applicability. Meanwhile, Raman spectroscopy has been demonstrated to be a feasible tool and is extensively employed in research on 2D TMDs. In recent years, the deployment of Raman spectroscopy under extreme conditions has elucidated the physical properties of TMDs. In this review, we focus on the extreme-condition Raman spectroscopy of typical group-VI TMDs, which are classified and discussed under the three extreme conditions of low temperature, high pressure and high magnetic field. The conclusion presents the most pressing challenges and attractive future opportunities in this rapidly developing research field.

Atomic imaging with a 12 T magnetic field perpendicular or parallel to the sample surface by an ultra-stable scanning tunneling microscope

We present the first nonmetallic scanning tunneling microscope (STM) featuring an ultra-stable tip-sample mechanical loop and capable of atomic-resolution imaging within a 12 T magnetic field that could be either perpendicular or parallel to the sample surface. This is also the first STM with an ultra-stable tip-sample mechanical loop but without a standalone scanner. The STM head is constructed only with two parts: an improved spider-drive motor and a zirconia tip holder. The motor performs both the coarse approach and atomic imaging. A supporting spring is set at the fixed end of the motor tube to decrease the tip-sample mechanical loop. The zirconia tip holder performs as the frame of the whole STM head. With the novel design, the STM head in three dimensions can be as small as 7.9 mm × 7.9 mm × 26.5 mm. The device's excellent performance is demonstrated by atomic-resolution images of graphite and NbSe2 obtained at 300 K and 2 K, as well as the high-resolution dI/dV spectrums of NbSe2 at variable temperatures. Low drift rates in the X-Y plane and Z direction further prove the imaging stability of our new STM. High-quality imaging of the Charge Density Wave (CDW) structure on a TaS2 surface shows the STM's good application capability. Continuous atomic images obtained in magnetic fields rangs from 0 T to 12 T with the direction of the magnetic field perpendicular or parallel to the sample surface show the STM's good immunity to high magnetic fields. Our results illustrate the new STM's broad application ability in extreme conditions of low temperature and high magnetic field.

Magnetic Field-Dependent Microstructure Evolution of Solidified Co39.2Ni39.2Al21.6 Eutectic Medium-Entropy Alloy

A (Fe, Cr)-free Co39.2Ni39.2Al21.6 eutectic medium-entropy alloy (EMEA) was designed and fabricated to study the microstructure and its evolution during slow solidification under different intensities of high static magnetic field (0 T, 5 T and 10 T). It was found that the original microstructure was characterized by FCC/BCC mixed herringbone eutectics consisting of two types of lamellar structures: a curved and wormy anomalous eutectic in the fringe, and a straight and long regular eutectic in the center. Nano-sized L10-type martensite layers are also distributed on the BCC lamellar as the martensitic transformation product. The FCC and BCC phases were enriched in Co and Al elements, respectively, while Ni element was distributed homogenously in both phases. With increasing magnetic field intensity, the herringbone eutectic structures remained stable, without the formation of a primary phase, while the phase constitution and the orientation relationships in the eutectic structures remained unchanged, with no obvious magnetically induced alignments. However, the lamellar spacing of the regular lamellar eutectic decreased significantly from 3.3 μm (0 T) to 1.93 μm (10 T); by contrast, the volume fraction of the anomalous eutectics increased considerably from 28.35% (0 T) to 55.14% (10 T), and the assumption that the imposed convection and destabilization of lamellar eutectics is controlled by the magnetic field is discussed in depth. Our results show a great potential for tailoring microstructures and properties by applying a strong magnetic field during the solidification process of EMEAs.

CHIMERA Fusion Technology Facility: Testing and Virtual Qualification

The Combined Heating and Magnetic Research Apparatus (CHIMERA) fusion technology test facility is under construction. The facility will be uniquely capable of semi-integral testing of fusion materials and component modules up to the size of the ITER test blanket module box, under combined conditions of in-vacuum high heat flux, static and pulsed magnetic fields, and high-temperature/high-pressure water cooling. This paper reports the high-level capabilities of the CHIMERA baselined design and the planned program of testing and describes the proposed strategy for use of simulations for virtual testing, qualification, and in-situ monitoring. The first step in testing of a component mock-up is to take data from as-built geometry and other measurements and transmit them to an integrated computational model that can closely mimic the physical asset and form a digital replica. Not only can this digital replica be queried in advance of physical testing in the facility, allowing optimization of the test program, but combined with subsequent test data, it also can deliver much greater insight into experimental results than can be obtained using test data alone. The digital replica is used as the basis for a digital twin, which is live coupled to the running experiment, and is under development as a proposed key facet of fusion reactor surveillance in-service. Physical mock-ups for testing can be subjected to in-vacuum heat flux up to 0.5 MW/m2 over the entire surface while within a strong horizontal magnetic field. The central field can be up to 4 T with a peak in the test region of 5 T. The same component mock-ups can also be subjected to repeated magnetic field pulses with ramp rate 12 T/s, which can simulate loading conditions of a plasma disruption. Facility upgrades are underway to include a liquid metal circulation loop to allow the study of magnetohydrodynamics effects and to add a high-heat-flux system using a very high-power continuous-wave laser to achieve divertor-relevant heat fluxes of 20 MW/m2 over the area of a small-scale mock-up. Four examples are given to illustrate the physical testing program that is currently foreseen.

High static magnetic field-assisted synthesis of Mn-doped ZnO diluted magnetic semiconductor via the hydrothermal method

ABSTRACT The magnetic field-assisted approach had been applied in the synthesis of Mn-doped ZnO diluted magnetic semiconductor via the hydrothermal method. The effect of high static magnetic field (HSMF) on the structures, morphologies and magnetic properties of the samples were characterised. X-ray diffraction and X-ray photoelectron analysis revealed that Mn ions had been doped in the hexagonal wurtzite ZnO and there were no any other detectable phases observed. Energy dispersive spectroscopy revealed that the content ratio of Zn to Mn was about 19:1. In addition, transmission electron microscopy and high-resolution transmission electron microscopy studies confirmed that Zn0.95Mn0.05O was nanorods in shape, and the growth rate of the nanorod was obviously restrained. While more oxygen vacancies (V O) had been introduced with increasing the magnetic flux density. Finally, magnetisation measurements implied that all of the Zn0.95Mn0.05O samples were room-temperature ferromagnetism and their magnetism was improved by the HSMF.

Effect of static magnetic field on marine mollusc Elysia leucolegnote.

Artificial magnetic fields are unavoidable environment for offshore marine organisms. With the substantially increasing submarine cables, the impact of magnetic field generated by cables on marine organisms has gradually attracted people's attention. However, there are few studies on the effect of magnetic field on molluscs. To explore whether magnetic fields could interfere with the physiological functions of offshore molluscs, here we systematically analyzed the change of metabolism and transcriptome of Elysia leucolegnote exposed to either geomagnetic field or 1.1 T static magnetic field. The blood glucose and lipid levels, as well as the activities of antioxidant enzymes in E. leucolegnote were significantly increased upon the exposure to high static magnetic field for 10days. Meanwhile, the activities of enzymes related to digestive performance and liver functions were decreased. Possible mechanisms were further revealed through comparative transcriptome analysis. A total of 836 differentially expressed genes were identified, 352 of which were up-regulated and 484 of which were down-regulated after exposure to the high static magnetic field. The up-regulated differential genes were mainly concentrated in lysosomal and apoptotic pathways, and down-regulated differential genes were mainly involved in digestive and immune systems including phagocytosis. This pattern was further confirmed by RT-qPCR analysis. In conclusion, prolonged exposure to a 1.1 T static magnetic field increased oxidative stress and blood glucose and lipid levels, and decreased immunity and physiological conditions in E. leucolegnote. The data we presented here provides a comprehensive view of metabolism change and gene expression pattern of E. leucolegnote exposed to static magnetic field. It may expand our knowledge on the magnetic field effects on offshore mollusc at molecular level, and contribute to clarification of the interaction between marine animals and artificial magnetic fields, which is certainly ecologically important.