To solve the problem that high-speed catamarans have excessive amplitude of vertical motion in rough sea conditions, an anti-pitching method based on incremental robust predictive control of catamarans is proposed, which takes into account the model uncertainty and input rate of appendage requirements. Thus, a high-speed catamaran vertical control model is established with T-foils and flaps serving as anti-pitching appendages, and the hydrodynamic coefficient uncertainties is analyzed, which is converted into a state space model with norm-bounded uncertainty to facilitate control system design; moreover, transforming the norm-bounded uncertainty model of a high-speed catamaran into an incremental model, which can increase the integral action to improve the anti-pitching performance. On this basis, the hybrid H2/H∞ robust predictive control method is proposed to achieve wave disturbance resistance capability and robust stability of the catamaran system, taking the rate of input of the anti-pitching appendages as the input constraints, and the linear matrix inequality (LMI) receding-horizon optimization is used to solve the incremental control input of appendages. Ultimately, the effectiveness of the proposed algorithm is verified by digital simulation.