High Socioeconomic Disadvantage Research Articles

AI-based approach to enable proactive identification of early lung cancer: A retrospective population health study and economic model.

10536 Background: Approximately 48,500 new cases of lung cancer are diagnosed each year in the UK with a five-year survival rate which lags behind other European countries. Most patients are diagnosed at stage III or IV disease, which has a significantly worse prognosis. The integration of real-world data and AI techniques presents a promising avenue for improvement, using novel solutions not achievable through traditional care models. This study explores proactive patient identification at scale, aligning with the "left shift" paradigm in population health. The approach uses innovative technologies and novel data sources to identify patients with early-stage disease, enhancing both clinical and economic outcomes. Importantly, these interventions should be feasible on a large scale without overburdening already stretched clinical services. Methods: A retrospective study of real-world data for an urban population with high socioeconomic disadvantage and health needs was undertaken. Two endpoints were determined: detection potential and health economic impact. For detection potential (DP), patients aged 40 and above who underwent chest X-rays (CXR) at a large academic medical centre between 2016-2022 were included. Natural Language Processing (NLP) analysed unstructured free-text data from Electronic Health Records, combined with ICD-10 codes, for predictive model (PM) development using Machine Learning (ML) classification techniques. The PM's performance was assessed using the area under the receiver operating characteristic curve (AUCROC). Health economic impact was evaluated through a theoretical extrapolation of DP. Assuming a 9% left shift from late (stage III or IV) to early (stage I or II) disease, a health economic model (HEM) compared the impact of the current care model to a potential future state facilitated by the digital medicine care model (DMCM). Results: 75,342 patients were included, with 755 lung cancer diagnoses occurring within 6 months of CXR. The PM achieved a peak AUROC of 0.75, exceeding the performance of currently used risk prediction models (Q Cancer Risk, Risk Assessment Tools). A 9% left shift equated to 4.5 years mean increase in survival. The DMCM was associated with a net healthcare cost benefit of £6k per patient diagnosed with lung cancer, improved quality-adjusted life years of £21M for the year 1 cohort over 10 years and increased economic productivity (from additional years in workforce) of £2.4M. Conclusions: The study demonstrates the practical utility of AI-supported early lung cancer detection at population scale. Real-world evidence is needed to prospectively validate the model as cost-effective, scalable, and efficient. Future work will seek to improve the model's performance against a broader at-risk patient population and explore its applicability to other late-presenting tumours.

Parents’ perceptions of the Tasmanian School Lunch Project - interim findings

Most Australian school students take a packed lunch to school(1). However, parents have reported many barriers to packing a healthy lunch(2). Subsequently, foods eaten during school hours are not consistent with the Australian Dietary Guidelines, with discretionary foods providing about 44% of energy consumed during this time(3). In addition, some children go to school without any food for lunch or money to buy lunch. The Tasmanian School Lunch Project provides free nutritious cooked lunches for Kinder to Year 10 students attending 30 government schools (15 commenced 2022, 15 commenced 2023) in areas of high socioeconomic disadvantage. The lunches were provided 1-3 days/week. The menu and recipes were designed by dietitians. This analysis aimed to describe parents’ perceptions of the School Lunch Project during the first year. Six of the 15 schools that commenced in term 2 2022 were invited, and agreed, to participate in the evaluation. During term 3 or 4 2022, parents completed online or written surveys (n = 159) and/or participated in discussion groups (n = 26) to share their thoughts on the menu, their concerns, likes, and willingness to pay. Survey data were analysed descriptively and open-ended survey responses and discussion group data thematically. During 2022, 78,832 nutritious cooked lunches were provided to 1,678 students. Most parents felt there was enough variety on the menu (66%) and the right amount of food was served (69%). Most students (79%) ate the lunches every day they were provided yet 52% of parents continued to provide a packed lunch. Parents enjoyed that their child was having a healthy lunch (66%) and trying new foods (74%). Some parents in the discussion groups indicated positive flow on effects at home with students trying new foods and sitting down together as a family to eat the evening meal. Half the parents (50%) had no concerns about the school providing lunches. The most commonly reported concerns were their child might not like the food (36%) or their child does not try new foods (8.6%). These concerns were also raised in the discussion groups. Most parents (93%) were prepared to pay for the lunches in future (median $3, range $1-$12) and 85% thought there should be a family discount. Parents acknowledged some payment was necessary for the sustainability of the program but some expressed concern for those who may struggle to pay. More direct communication with families about the meals offered, the availability of bread (from term 4 2022) for students who choose not to eat the cooked lunch or want more to eat, and allowing families time to adjust to the new lunch system, may address some of the concerns raised. Further data on parents’ perceptions of the school lunches will be collected during term 3 2023.

Associations of U.S. hospital closure (2007-2018) with area socioeconomic disadvantage and racial/ethnic composition

PurposeTo examine whether hospital closure is associated with high levels of area socioeconomic disadvantage and racial/ethnic minority composition. MethodsPooled cross-sectional analysis (2007–2018) of 6467 U.S. hospitals from the American Hospital Association’s Annual Survey, comparing hospital population characteristics of closed hospitals to all remaining open hospitals. We used multilevel mixed-effects logistic regression models to assess closure as a function of population characteristics, including area deprivation index ([ADI], a composite measure of socioeconomic disadvantage), racial/ethnic composition, and rural classification, nesting hospitals within hospital service areas (HSAs) and hospital referral regions. Secondary analyses examined public or private hospital type. ResultsOverall, 326 (5.0%) of 6467 U.S. hospitals closed during the study period. In multivariable models, hospitals in HSAs with a higher burden of socioeconomic disadvantage (per 10% above median ADI ZIP codes, AOR 1.05; 95% CI, 1.01–1.09) and Black Non-Hispanic composition (highest quartile, AOR 4.03; 95% CI, 2.62–6.21) had higher odds of closure. We did not observe disparities in closure by Hispanic/Latino composition or rurality. Disparities persisted for Black Non-Hispanic communities, even among HSAs with the lowest burden of disadvantage. ConclusionsDisproportionate hospital closure in communities with higher socioeconomic disadvantage and Black racial composition raises concerns about unequal loss of healthcare resources in the U.S.

Socioeconomic Disadvantage Predicts Decreased Likelihood of Maintaining a Functional Knee Arthroplasty Following Treatment for Prosthetic Joint Infection

BackgroundProsthetic joint infection (PJI) carries major morbidity and mortality as well as a complicated and lengthy treatment course. In patients who have high degrees of socioeconomic disadvantage, this may be a particularly devastating complication. Our study sought to evaluate the impact of socioeconomic deprivation on outcomes following treatment for PJI of the knee. MethodsWe conducted a retrospective review of revision total knee arthroplasty (TKA) procedures performed for the treatment of initial PJI between 2008 and 2020 at a single tertiary care center in the United States. The Area Deprivation Index (ADI) was used to quantify socioeconomic deprivation. The primary outcome measure was presence of a functional knee joint at the time of most recent follow-up defined as TKA components or an articulating spacer. A total of 96 patients were included for analysis. The median follow-up duration was 26.5 months. ResultsThere was no significant difference in the rate of treatment failure (P = .63). However, the proportion of patients who had a functional knee arthroplasty (in contrast to having undergone arthrodesis, amputation, or retention of a static spacer) declined significantly with increasing ADI index (81.8% for the least disadvantaged group, 58.7% for the middle group, 42.9% for the most disadvantaged group, P = .021). ConclusionsPatients who have a higher socioeconomic disadvantage as measured by ADI are less likely to maintain a functional knee arthroplasty following treatment for TKA PJI. These findings support continued efforts to improve access to care and optimize treatment plans for patients who have socioeconomic disadvantage.

Community-level social determinants of health and pregestational and gestational diabetes

Individual adverse social determinants of health are associated with increased risk of diabetes in pregnancy, but the relative influence of neighborhood or community-level social determinants of health is unknown. This study aimed to determine whether living in neighborhoods with greater socioeconomic disadvantage, food deserts, or less walkability was associated with having pregestational diabetes and developing gestational diabetes. We conducted a secondary analysis of the prospective Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be. Home addresses in the first trimester were geocoded at the census tract level. The exposures (modeled separately) were the following 3 neighborhood-level measures of adverse social determinants of health: (1) socioeconomic disadvantage, defined by the Area Deprivation Index and measured in tertiles from the lowest tertile (ie, least disadvantage [T1]) to the highest (ie, most disadvantage [T3]); (2) food desert, defined by the United States Department of Agriculture Food Access Research Atlas (yes/no by low income and low access criteria); and (3) less walkability, defined by the Environmental Protection Agency National Walkability Index (most walkable score [15.26-20.0] vs less walkable score [<15.26]). Multinomial logistic regression was used to model the odds of gestational diabetes or pregestational diabetes relative to no diabetes as the reference, adjusted for age at delivery, chronic hypertension, Medicaid insurance status, and low household income (<130% of the US poverty level). Among the 9155 assessed individuals, the mean Area Deprivation Index score was 39.0 (interquartile range, 19.0-71.0), 37.0% lived in a food desert, and 41.0% lived in a less walkable neighborhood. The frequency of pregestational and gestational diabetes diagnosis was 1.5% and 4.2%, respectively. Individuals living in a community in the highest tertile of socioeconomic disadvantage had increased odds of entering pregnancy with pregestational diabetes compared with those in the lowest tertile (T3 vs T1: 2.6% vs 0.8%; adjusted odds ratio, 2.52; 95% confidence interval, 1.41-4.48). Individuals living in a food desert (4.8% vs 4.0%; adjusted odds ratio, 1.37; 95% confidence interval, 1.06-1.77) and in a less walkable neighborhood (4.4% vs 3.8%; adjusted odds ratio, 1.33; 95% confidence interval, 1.04-1.71) had increased odds of gestational diabetes. There was no significant association between living in a food desert or a less walkable neighborhood and pregestational diabetes, or between socioeconomic disadvantage and gestational diabetes. Nulliparous individuals living in a neighborhood with higher socioeconomic disadvantage were at increased odds of entering pregnancy with pregestational diabetes, and those living in a food desert or a less walkable neighborhood were at increased odds of developing gestational diabetes, after controlling for known covariates.

Women's socioeconomic status and attitudes toward intimate partner violence in Eswatini: A multilevel analysis.

Attitudes supportive of spousal violence retards developmental efforts worldwide, and in particular in patriarchal African settings. It is important to curb this behavior by designing preventative evidence-based policies. This study examines the acceptance of intimate partner violence among women residing in Eswatini and determines whether attitudes supportive of intimate partner violence are associated with women's low socioeconomic status both at the individual- and community-level. Cross-sectional secondary data from two Eswatini Multiple Indicator Cluster Surveys (MICS) conducted in 2010 and 2014 with representative samples of 4,686 and 4,761 women, respectively were analyzed using descriptive statistics and multilevel (random effect) logistic regressions. Overall, the prevalence of acceptance of intimate partner violence declined significantly between 2010 and 2014 in Eswatini (29.0% vs. 19.8%, p<0.001). In both surveys, socioeconomic factors associated with women's supportive attitudes toward intimate partner violence were educational level, marital structure, and community socioeconomic disadvantage. Overall, primary or lower educational attainment, single/unmarried relationships, and women living in a community with a high socioeconomic disadvantage were key factors associated with supportive attitudes toward intimate partner violence. Secondary or higher education for individual women and a high proportion of women in the community with low socioeconomic disadvantage are important socioeconomic predictors of reducing women's supportive attitudes toward intimate partner violence. Therefore, further gains in non-supportive attitudes toward acceptance of intimate partner violence could be achieved through efforts and intervention in the education of individual women and improving women's socioeconomic status in the community.

Neighborhood Socioeconomic Disadvantage and Long-Term Outcomes After Pediatric Tracheostomy.

To determine whether long-term outcomes after pediatric tracheostomy are impacted by neighborhood socioeconomic disadvantage. A prospective cohort of children with tracheostomies was followed at an academic pediatric hospital between 2015 and 2020. Patients were grouped into low or high socioeconomic disadvantage using their neighborhood area deprivation index (ADI). Survival and logistic regression analyses determined the relationship between ADI group, decannulation, and mortality. A total of 260 children were included with a median age at tracheostomy of 6.6 months (interquartile range [IQR], 3.9-42.3). The cohort was 53% male (N = 138), 55% White race (N = 143), and 35% Black or African American (N = 90). Tracheostomy was most frequently indicated for respiratory failure (N = 189, 73%). High neighborhood socioeconomic disadvantage was noted for 66% of children (N = 172) and 61% (N = 158) had severe neurocognitive disability. ADI was not associated with time to decannulation (HR = 0.90, 95% confidence interval [95% CI]: 0.53-1.53) or time to death (HR = 0.92, 95% CI: 0.49-1.72). Neighborhood socioeconomic disadvantage was not associated with decannulation or mortality among children with a tracheostomy. These findings suggest that long-term outcomes after pediatric tracheostomy are less dependent on socioeconomic factors in an individual community. 3 Laryngoscope, 134:2415-2421, 2024.

Impact of Free Hospital-Provided Rideshare Service on Radiation Therapy Completion Rates: A Matched Cohort Analysis

Radiation therapy (RT) is generally given in consecutive daily sessions over multiple weeks. This poses challenges for patients who face barriers such as limited access to public or private transportation, limited financial resources, lack of social support, and long distances to healthcare facilities. Delayed or incomplete RT increases risk for worse clinical outcomes. The potential of rideshare service, which uses a private vehicle for hire arranged through a phone-based application or website, to facilitate timely RT is understudied. Retrospective data was collected on patients who received RT at a single institution from 2017-2022. Patient demographic and treatment characteristics were compared between those who did and did not utilize free hospital-provided rideshare service. RT completion rates were analyzed for a 1:1 matched non-rideshare cohort using optimal matching with the scaled Euclidean distance metric, to balance age, sex, race, performance status, number of fractions prescribed, Area Deprivation Index (ADI), distance to treatment center, year of diagnosis, treatment site, intent, and modality. ADI is a validated composite measure of community-level socioeconomic deprivation. Of 2,906 patients who underwent RT, 58 utilized free hospital-provided rideshare service. Rideshare utilizers had a lower median age (60 vs 66, p = .02), and were more likely to identify as Black or African American (60 vs 22%, p<.0001) compared to non-rideshare utilizers. Rideshare utilizers also had higher ADI scores (median 9 vs 5, p<.0001), indicating higher socioeconomic disadvantage, and travelled shorter distances for treatment (median 5.0 vs 14.7 miles, p<.0001). More rideshare utilizers underwent RT for curative intent (79 vs 50%, p<.0001), concordant with a higher number of fractions prescribed (median 28 vs 5, p<.0001) as well as longer treatment course duration (median 39 vs 13 days, p<.0001). The most common treatment sites were head and neck (31%) and breast / chest wall (22%) for rideshare utilizers, and pelvis (27%) and brain (21%) for non-rideshare utilizers (p<.0001). Volumetric modulated arc therapy followed by 3D conformal were the most common treatment modalities in both groups. The matched cohort analysis revealed that RT completion rates were significantly higher for rideshare vs non-rideshare utilizers at 96 vs 81% (p = .01) overall, and 98 vs 78% (p = .01) for patients undergoing treatment with curative intent. Even after adjustment for socioeconomic, clinical, and treatment characteristics, utilization of free hospital-provided rideshare service was associated with improved RT completion rates. These findings are notable as the majority of rideshare utilizers come from socioeconomically marginalized communities, and would otherwise be expected to face significant barriers to RT completion.

Reasons for hospitalisation in youth with type 1 diabetes, 2010-2019.

To determine the incidence of hospitalisation for all diagnoses among Australian youth with type 1 diabetes. We linked Australians aged under 20 years with type 1 diabetes on the National Diabetes Services Scheme (n = 45,685) to hospital admission data from 2010 to 2019. We determined relative risks (RR) of hospitalisation among those with type 1 diabetes in the states of Victoria and Queensland (n = 21,898) compared to the general population for 2010-2017 using Poisson regression. Australian youth with type 1 diabetes had increased risk for almost all reasons for hospitalisation compared to the general population, especially infections such as anogenital herpesviral infections (RR 54.83, 95% CI 33.21-90.53), and mental health disorders including personality disorders (RR 9.70, 95% CI 8.02-11.72). Among those with type 1 diabetes, over 60% of hospitalisations were directly related to diabetes, almost half of which were for ketoacidosis. Approximately 15% of ketoacidosis admissions occurred within 3 months of diabetes diagnosis. One quarter of those with admissions for ketoacidosis were readmitted for ketoacidosis within 12 months. Residence in areas of high socio-economic disadvantage was an independent risk factor for admission and readmission for ketoacidosis. Youth with type 1 diabetes are susceptible to a wide range of complications. Clinicians should consider screening and prevention for conditions such as infections and mental health disorders. Targeted support and education around glycaemic management should be considered in those at high risk for ketoacidosis admission including those living in areas of high socio-economic disadvantage.

Neighborhood-Level Socioeconomic Disadvantage Predicts Outcomes in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Malignancy.

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) improves survival in select patients with peritoneal metastases (PM), but the impact of social determinants of health on CRS/HIPEC outcomes remains unclear. A retrospective review was conducted of a multi-institutional database of patients with PM who underwent CRS/HIPEC in the USA between 2000 and 2017. The area deprivation index (ADI) was linked to the patient's residential address. Patients were categorized as living in low (1-49) or high (50-100) ADI residences, with increasing scores indicating higher socioeconomic disadvantage. The primary outcome was overall survival (OS). Secondary outcomes included perioperative complications, hospital/intensive care unit (ICU) length of stay (LOS), and disease-free survival (DFS). Among 1675 patients 1061 (63.3%) resided in low ADI areas and 614 (36.7%) high ADI areas. Appendiceal tumors (n = 1102, 65.8%) and colon cancer (n = 322, 19.2%) were the most common histologies. On multivariate analysis, high ADI was not associated with increased perioperative complications, hospital/ICU LOS, or DFS. High ADI was associated with worse OS (median not reached versus 49 months; 5 year OS 61.0% versus 28.2%, P < 0.0001). On multivariate Cox-regression analysis, high ADI (HR, 2.26; 95% CI 1.13-4.50; P < 0.001), cancer recurrence (HR, 2.26; 95% CI 1.61-3.20; P < 0.0001), increases in peritoneal carcinomatosis index (HR, 1.03; 95% CI 1.01-1.05; P < 0.001), and incomplete cytoreduction (HR, 4.48; 95% CI 3.01-6.53; P < 0.0001) were associated with worse OS. Even after controlling for cancer-specific variables, adverse outcomes persisted in association with neighborhood-level socioeconomic disadvantage. The individual and structural-level factors leading to these cancer disparities warrant further investigation to improve outcomes for all patients with peritoneal malignancies.

Using fluency and comprehension instruction with struggling readers to improve student reading outcomes in English elementary schools

This study reports results from a randomized controlled trial of a reading intervention program in English elementary schools implemented during Covid19. Trained staff delivered targeted reading fluency and comprehension instruction to small groups of eligible children aged 7–9 for at least 12-weeks. Twelve schools from four English districts with high socio-economic disadvantage participated, with a sample of 186 children. Positive effect sizes of +0.26 on overall reading scores were observed, on an independently designed standardised reading test. A process evaluation assessed implementation fidelity. This intervention shows excellent promise as a technique to improve overall reading (mainly through enhancing sentence level reading comprehension).

1210-P: Associations of Community-Level Social Determinants of Health and Hypertensive Disorders of Pregnancy

Objective: To determine whether community-level social determinants of health are associated with hypertensive disorders of pregnancy (HDP). Methods: This is a secondary analysis from the prospective Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be. We evaluated three community-level exposures using home addresses geocoded at the census-tract level: 1) socioeconomic disadvantage by the 2015 Area Deprivation Index (ADI); 2) food insecurity by the USDA Food Access Research Atlas; and 3) less walkability by the EPA National Walkability Score. The outcome was new onset HDP. Poisson regression was used to estimate adjusted relative risks (aRR). Results: Of 9,062 individuals, 33.6% were in the highest tertile of ADI, 24.5% lived with food insecurity, and 66.3% lived in a less walkable neighborhood. 13.0% were diagnosed with HDP. Individuals living in a community with higher socioeconomic disadvantage, (aRR T2: 1.26; 95% CI: 1.10, 1.44; and T3: 1.19; 95% CI: 1.02, 1.38), food insecurity (aRR: 1.15; 95% CI: 1.02, 1.29), and less walkability (aRR: 1.21; 95 CI: 1.07, 1.36) were at higher risk of developing HDP compared with those who did not. Conclusions: Community-level social determinants of health, including socioeconomic disadvantage, food insecurity, and low walkability, were associated with increased risk of HDP among nulliparous individuals. Disclosure T.Bank: None. W.Grobman: None. J.Wu: None. C.Lynch: None. K.K.Venkatesh: None.

Patients' Perspectives on Life and Recovery 1 Year After COVID-19 Hospitalization.

Many patients hospitalized for COVID-19 experience prolonged symptoms months after discharge. Little is known abou t patients' personal experiences recovering from COVID-19 in the United States (US), where medically underserved populations are at particular risk of adverse outcomes. Toexplore patients' perspectives on the impact of COVID-19 hospitalization and barriers to and facilitators of recovery 1year after hospital discharge in a predominantly Black American study population with high neighborhood-level socioeconomic disadvantage. Qualitative study utilizing individual, semi-structured interviews. Adult patients hospitalized for COVID-19 approximately 1year after discharge home who were engaged in a COVID-19 longitudinal cohort study. The interview guide was developed and piloted by a multidisciplinary team. Interviews were audio-recorded and transcribed. Data were coded and organized into discrete themes using qualitative content analysis with constant comparison techniques. Of 24 participants, 17 (71%) self-identified as Black, and 13 (54%) resided in neighborhoods with the most severe neighborhood-level socioeconomic disadvantage. One year after discharge, participants described persistent deficits in physical, cognitive, or psychological health that impacted their current lives. Repercussions included financial suffering and a loss of identity. Participants reported that clinicians often focused on physical health over cognitive and psychological health, an emphasis that posed a barrier to recovering holistically. Facilitators of recovery included robust financial or social support systems and personal agency in health maintenance. Spirituality and gratitude were common coping mechanisms. Persistent health deficits after COVID-19 resulted in downstream consequences in participants' lives. Though participants received adequate care to address physical needs, many described persistent unmet cognitive and psychological needs. A more comprehensive understanding of barriers and facilitators for COVID-19 recovery, contextualized by specific healthcare and socioeconomic needs related to socioeconomic disadvantage, is needed to better inform intervention delivery to patients that experience long-term sequelae of COVID-19 hospitalization.

Impact of free hospital-provided rideshare service on radiation therapy completion rates: A matched cohort analysis.

6530 Background: Radiation therapy (RT) is generally given in consecutive daily sessions over multiple weeks. This poses challenges for patients who face barriers such as limited access to public or private transportation, limited financial resources, lack of social support, and long distances to healthcare facilities. Delayed or incomplete RT increases risk for worse clinical outcomes. The potential of rideshare service, which uses a private vehicle for hire arranged through a phone-based application or website, to facilitate timely RT is understudied. Methods: Retrospective data was collected on patients who received RT at a single institution from 2017-2022. Patient demographic and treatment characteristics were compared between those who did and did not utilize free hospital-provided rideshare service. RT completion rates were analyzed for a 1:1 matched non-rideshare cohort using optimal matching with the scaled Euclidean distance metric, to balance age, sex, race, performance status, number of fractions prescribed, Area Deprivation Index (ADI), distance to treatment center, year of diagnosis, treatment site, intent, and modality. ADI is a validated composite measure of community-level socioeconomic deprivation. Results: Of 2,906 patients who underwent RT, 58 utilized free hospital-provided rideshare service. Rideshare utilizers had a lower median age (60 vs 66, p = .02), and were more likely to identify as Black or African American (60 vs 22%, p &lt; .0001) compared to non-rideshare utilizers. Rideshare utilizers also had higher ADI scores (median 9 vs 5, p &lt; .0001), indicating higher socioeconomic disadvantage, and travelled shorter distances for treatment (median 5.0 vs 14.7 miles, p &lt; .0001). More rideshare utilizers underwent RT for curative intent (79 vs 50%, p &lt; .0001), concordant with a higher number of fractions prescribed (median 28 vs 5, p &lt; .0001) as well as longer treatment course duration (median 39 vs 13 days, p &lt; .0001). The most common treatment sites were head and neck (31%) and breast / chest wall (22%) for rideshare utilizers, and pelvis (27%) and brain (21%) for non-rideshare utilizers (p &lt; .0001). Volumetric modulated arc therapy followed by 3D conformal were the most common treatment modalities in both groups. The matched cohort analysis revealed that RT completion rates were significantly higher for rideshare vs non-rideshare utilizers at 96 vs 81% (p = .01) overall, and 98 vs 78% (p = .01) for patients undergoing treatment with curative intent. Conclusions: Even after adjustment for socioeconomic, clinical, and treatment characteristics, utilization of free hospital-provided rideshare service was associated with improved RT completion rates. These findings are notable as the majority of rideshare utilizers come from socioeconomically marginalized communities, and would otherwise be expected to face significant barriers to RT completion.

Impact of High Neighborhood Socioeconomic Deprivation on Access to Accredited Breast Imaging Screening and Diagnostic Facilities

PurposeThe aim of this study was to evaluate the presence or absence of accredited breast imaging facilities in ZIP codes with high or low neighborhood socioeconomic deprivation. MethodsA retrospective ecological study design was used. Neighborhood socioeconomic disadvantage rankings at the ZIP code level were defined by the University of Wisconsin Neighborhood Atlas Area Deprivation Index. Outcomes included the presence or absence of FDA- or ACR-accredited mammographic facilities, accredited stereotactic biopsy or breast ultrasound facilities, and ACR Breast Imaging Centers of Excellence. US Department of Agriculture rural-urban commuting area codes were used to define urban and rural status. Access to breast imaging facilities in high-disadvantage (≥97th percentile) and low-disadvantage (≤3rd percentile) ZIP codes was compared using χ2 tests, stratified by urban or rural status. ResultsAmong 41,683 ZIP codes, 2,796 were classified as high disadvantage (1,160 rural, 1,636 urban) and 1,028 as low disadvantage (39 rural, 989 urban). High-disadvantage ZIP codes were more likely rural (P < .001) and less likely to have FDA-certified mammographic facilities (28% versus 35%, P < .001), ACR-accredited stereotactic biopsy (7% versus 15%, P < .001), breast ultrasound (9% versus 23%, P < .001), or Breast Imaging Centers of Excellence (7% versus 16%, P < .001). Among urban areas, high-disadvantage ZIP codes were less likely to have FDA-certified mammographic facilities (30% versus 36%, P = .002), ACR-accredited stereotactic biopsy (10% versus 16%, P < .001), breast ultrasound (13% versus 23%, P < .001), and Breast Imaging Centers of Excellence (10% versus 16%, P < .001). ConclusionsPeople living in ZIP codes with high socioeconomic disadvantage are less likely to have accredited breast imaging facilities within their ZIP codes, which may contribute to disparities in access to breast cancer care experienced by underserved groups living in these areas.

Race Associated With Increased Complication Rates After Total Knee Arthroplasty

BackgroundRacial and ethnic disparities have been suggested to be associated with poor outcomes after total knee arthroplasty (TKA). While socioeconomic disadvantage has been studied, analyses of race as the primary variable are lacking. Therefore, we examined the potential differences between Black and White TKA recipients. Specifically, we assessed 30-day and 90-day, as well as 1 year: (1) emergency department visits and readmissions; (2) total complications; (3) as well as risk factors for total complications. MethodsA consecutive series of 1,641 primary TKAs from January 2015 to December 2021 at a tertiary health care system were reviewed. Patients were stratified according to race, Black (n = 1,003) and White (n = 638). Outcomes of interest were analyzed using bivariate Chi-square and multivariate regressions. Demographic variables such as sex, American Society of Anesthesiologists classification, diabetes, congestive heart failure, chronic pulmonary disease, and socioeconomic status based on Area Deprivation Index were controlled for across all patients. ResultsThe unadjusted analyses found that Black patients had an increased likelihood of 30-day emergency department visits and readmissions (P < .001). However, in the adjusted analyses, Black race was demonstrated to be a risk factor for increased total complications at all-time points (P ≤ .0279). Area Deprivation Index was not a risk for cumulative complications at these time points (P ≥ .2455). ConclusionBlack patients undergoing TKA may be at increased risk for complications with more risk factors including higher body mass index, tobacco use, substance abuse, chronic obstructive pulmonary disease, congestive heart failure, hypertension, chronic kidney disease, and diabetes and were thus, “sicker” initially than the White cohort. Surgeons are often treating these patients at the later stages of their diseases when risk factors are less modifiable, which necessitates a shift to early, preventable public health measures. While higher socioeconomic disadvantage has been associated with higher rates of complications, the results of this study suggest that race may play a greater role than previously thought.

Hospitalizations from Birth to 28 Years in a Population Cohort of Individuals Born with Five Rare Craniofacial Anomalies in Western Australia

To describe trends, age-specific patterns, and factors influencing hospitalizations for five rare craniofacial anomalies (CFA). Data on livebirths (1983-2010; n=721,019) including rare CFA (craniofacial microsomia, mandibulofacial dysostosis, Pierre Robin sequence, Van der Woude syndrome, and fronto-nasal dysplasia), episodes of death, and demographic and perinatal factors were identified from the Western Australian (WA) Register of Developmental Anomalies, Death Registrations and Midwives Notification System. Information on incident craniofacial and non-craniofacial related admissions, length of hospital stay, and intensive care and emergency related admissions were identified using principal diagnosis and procedural codes were extracted from the Hospital Morbidity Data Collection and linked to other data sources. Associations of hospitalizations by age groups as well as demographic and perinatal factors were expressed as incidence rate ratio (IRR). The incident hospitalizations were three times as high for rare CFA (IRR 3.22 - 3.72) throughout childhood into adolescence than those without. Children with rare CFA had three to four times as many potentially preventable hospitalizations until 18 years of age than those without. Specifically, respiratory infections (IRR 2.13-2.35), ear infections (IRR 7.92 - 26.28), and oral health-related conditions contributed for most non-craniofacial admissions until the adolescence period. Higher incidence of non-craniofacial related hospitalizations was observed among Indigenous children, births with intrauterine growth restrictions and families with high socioeconomic disadvantage. Throughout childhood, individuals with rare CFA had higher hospital service use, specifically for potentially preventable conditions, than those without. These population level findings can inform new preventive strategies and early disease management targeted towards reducing preventable hospitalizations.

MP77-02 HIGH AREA DEPRIVATION INDEX IS ASSOCIATED WITH DE NOVO PROSTATE CANCER METASTASIS IN VETERANS

You have accessJournal of UrologyCME1 Apr 2023MP77-02 HIGH AREA DEPRIVATION INDEX IS ASSOCIATED WITH DE NOVO PROSTATE CANCER METASTASIS IN VETERANS Ananta Wadhwa, Lorna Kwan, Michael Lewis, Brent Rose, Jennifer Cullen, Nicholas Nickols, Kara Maxwell, Kosj Yamoah, and Isla Garraway Ananta WadhwaAnanta Wadhwa More articles by this author , Lorna KwanLorna Kwan More articles by this author , Michael LewisMichael Lewis More articles by this author , Brent RoseBrent Rose More articles by this author , Jennifer CullenJennifer Cullen More articles by this author , Nicholas NickolsNicholas Nickols More articles by this author , Kara MaxwellKara Maxwell More articles by this author , Kosj YamoahKosj Yamoah More articles by this author , and Isla GarrawayIsla Garraway More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003351.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Metastatic prostate cancer (PCa) is highly lethal with a 5-year survival rate of 30%. Individuals with specific germline mutations, a family or personal cancer history, and/or identifying as Black/African-American display higher risk of developing PCa, including metastatic PCa. Healthcare barriers, such as lack of insurance and/or lower socioeconomic status, also correlate with advanced stage diagnosis. We sought to determine if the Area Deprivation Index (ADI), a ranking of socioeconomic disadvantage including income, education, employment, and housing quality, was associated with de novo metastases and/or metastatic progression in a racially/ethnically diverse VA PCa cohort. METHODS: Veterans diagnosed and/or treated for PCa from 2000-2013 in the Greater Los Angeles VA Healthcare System were identified in accordance with an institutional review board approved protocol. Clinical, pathological, and demographic data were obtained from the electronic medical record and the Veterans Health Administration Corporate Data Warehouse. State ADI (decile rank of 1-10) was calculated based upon the 9-digit residential zip code. Multivariate analyses identified factors associated with de novo metastasis or metastatic progression. Kaplan-Meier (KM) analysis permitted survival comparison of de novo metastatic (M1) cases, or localized cases with metastatic progression (M0-MP). RESULTS: Of 2152 PCa cases identified, ADI could be determined in 1498 (69.6%). There were 1311 M0, 76 M1, 136 MX cases, and 57 M0 patients who experienced metastatic progression (M0-P). On multivariate analysis, state ADI decile rank ≥7 was significantly associated with de novo metastasis diagnosis (rank 7-8: OR=4.39 (1.26, 15.35); rank 9-10: OR=4.12 (1.05, 16.09)). State ADI rank was not associated with metastatic progression in M0 patients. There were no significant differences in PCa-specific survival by ADI Rank within M1 nor M0-P strata. CONCLUSIONS: Veterans residing in areas of high socioeconomic disadvantage (ADI rank ≥7) were >4 times more likely to be diagnosed with de novo metastasis, while no effects of ADI were observed on PCa-survival in M1 cases or M0-P cases. These results suggest that even in a relatively equal access healthcare system, potential social barriers indicated by high ADI may lead to delayed diagnosis. Future studies linking frequency of healthcare visits and/or screening to ADI may reveal potential strategies to mitigate this disparity in the VA population. Source of Funding: Research support for the investigators include National Institutes of Health K08CA215312, KNM; 5P50CA092131, R01 PAR-20-077, IPG); US Department of Defense (W81XWH211075, IPG; W81XWH-19-1-0435, KY); Prostate Cancer Foundation (PCF17CHAL04, IPG; 20YOUNG02, KNM; 18VALO10, KY, NGN), Burroughs Wellcome Foundation (1017184, KNM); Basser Center for BRCA at the University of Pennsylvania (KNM); Jean Perkins Foundation (IPG), STOP Cancer Foundation (IPG), and VA ORD CSR&D (NGN) © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1101 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ananta Wadhwa More articles by this author Lorna Kwan More articles by this author Michael Lewis More articles by this author Brent Rose More articles by this author Jennifer Cullen More articles by this author Nicholas Nickols More articles by this author Kara Maxwell More articles by this author Kosj Yamoah More articles by this author Isla Garraway More articles by this author Expand All Advertisement PDF downloadLoading ...

Patterns, trends, and factors influencing hospitalizations for craniosynostosis in Western Australia. A population-based study

Understanding hospital service use among children with a diagnosis of craniosynostosis (CS) is important to improve services and outcomes. This study aimed to describe population-level trends, patterns, and factors influencing hospitalizations for craniosynostosis in Western Australia. Data on live births (1990–2010; n = 554,624) including craniosynostosis, episodes of death, demographic, and perinatal factors were identified from the midwives, birth defects, hospitalizations, and death datasets. Information on craniosynostosis and non-craniosynostosis-related admissions, cumulative length of hospital stay (cLoS), intensive care unit, and emergency department–related admissions were extracted from the hospitalization dataset and linked to other data sources. These associations were examined using negative binomial regression presented as annual percent change and associations of hospitalizations by age groups, demographic, and perinatal factors were expressed as incidence rate ratio (IRR). We found an increasing trend in incident hospitalizations but a marginal decline in cLoS for craniosynostosis over the observed study period. Perinatal conditions, feeding difficulties, nervous system anomalies, respiratory, and other infections contributed to majority of infant non-CS-related admissions.Respiratory infections accounted for about twice the number of admissions for individuals with CS (IRRs 1.94–2.34) across all observed age groups. Higher incidence of non-CS hospitalizations was observed among females, with associated anomalies, to families with highest socioeconomic disadvantage and living in remote areas of the state. Conclusion: Marginal reduction in the cLoS for CS-related admissions observed over the 21-year period are potentially indicative of improved peri-operative care. However, higher incidence of respiratory infection-related admissions for syndromic synostosis is concerning and requires investigation.

The Impact of Neighborhood Factors on Physical Activity in Older Adults With Visual Impairment

To investigate the associations of neighborhood-level socioeconomic and environmental characteristics with physical activity in persons with glaucoma. Cross-sectional study (N=230). Home addresses were used to extract neighborhood factors (NFs): Area Deprivation Index, crime rate, and the proportion of racial and ethnic minorities, poverty, college graduates, and park area in their census tract. Participants' average number of daily steps and nonsedentary minutes were collected over 7 days using an accelerometer. Visual field (VF) loss was quantified as integrated VF sensitivity. Multivariable negative binomial regression models and additional models with an interaction term evaluated the effect of NF on physical activity and whether these relationships differed by VF loss severity. Participants were on average 70.6 years of age, 51.7% were male, and 27.8% were black. A higher Area Deprivation Index or poverty share was associated with fewer NSM (incidence rate ratio [IRR]=0.96 per 1 Area Deprivation Index decile increment, P=.01; IRR=0.92 per 10% poverty share increment, P=.02), while higher share of college graduates was associated with greater NSM (IRR=1.03 per 10% increment; P=.03). Stronger associations were noted between both high crime rate and poverty share with NSM in individuals with severe VF damage as opposed to no/mild VF damage (IRR=0.44, P=.001; IRR=0.81, P=.02). Select NFs (poverty share and crime rate) may disproportionately affect physical activity in patients with severe VF loss. Interventions to overcome activity limitations within the context of poverty and high socioeconomic disadvantage are important for addressing glaucoma-related disability, particularly in those with severe VF loss.