This study provided a unique Artificial intelligence (AI) model for the cost estimation of the foundation system for high-rise buildings. First, parametric data research was conducted, including 180 examples of foundation systems for high-rise building models related to criteria such as average column spacing, floor height, slap load, overall weight, base shear, and over. In addition, moment, gravity load, seismic load, design load, various columns (mid-edge-corner), soil profile, bearing capacity, GWT, excavation depth, and foundation systems are all factors to consider (shallow and deep footing). The research encompassed column spacing (5.0, 7.0, and 9.0 m) and the number of stories from 15 to 35, with an average cost decrease of 15%. The AI model utilizes extensive machine learning algorithms to analyze structural and geotechnical parameters. It provides a predictive tool that improves decision-making in the preliminary design. The methodology includes collecting data, training models utilizing innovative neural network techniques and validating them against current cost estimation models. The findings indicate that the AI model significantly improves the accuracy of cost estimations, with a precision rate of 95%, compared to traditional methods. Moreover, the model presents a potential cost savings of up to 15%. Construction designers and decision-makers may utilize the study’s findings to increase the accuracy of foundation system selection, lower costs and construction length, and improve overall project performance. Future work may involve applying this concept to infrastructure and substructure projects and collecting more data for benchmarking and empirical study.