High-quality Training Datasets Research Articles

Enhanced stereodivergent evolution of carboxylesterase for efficient kinetic resolution of near-symmetric esters through machine learning

Carboxylesterases serve as potent biocatalysts in the enantioselective synthesis of chiral carboxylic acids and esters. However, naturally occurring carboxylesterases exhibit limited enantioselectivity, particularly toward ethyl 3-cyclohexene-1-carboxylate (CHCE, S1), due to its nearly symmetric structure. While machine learning effectively expedites directed evolution, the lack of models for predicting the enantioselectivity for carboxylesterases has hindered progress, primarily due to challenges in obtaining high-quality training datasets. In this study, we devise a high-throughput method by coupling alcohol dehydrogenase to determine the apparent enantioselectivity of the carboxylesterase AcEst1 from Acinetobacter sp. JNU9335, generating a high-quality dataset. Leveraging seven features derived from biochemical considerations, we quantitively describe the steric, hydrophobic, hydrophilic, electrostatic, hydrogen bonding, and π-π interaction effects of residues within AcEst1. A robust gradient boosting regression tree model is trained to facilitate stereodivergent evolution, resulting in the enhanced enantioselectivity of AcEst1 toward S1. Through this approach, we successfully obtain two stereocomplementary variants, DR3 and DS6, demonstrating significantly increased and reversed enantioselectivity. Notably, DR3 and DS6 exhibit utility in the enantioselective hydrolysis of various symmetric esters. Comprehensive kinetic parameter analysis, molecular dynamics simulations, and QM/MM calculations offer insights into the kinetic and thermodynamic features underlying the manipulated enantioselectivity of DR3 and DS6.

TSAE-UNet: A Novel Network for Multi-Scene and Multi-Temporal Water Body Detection Based on Spatiotemporal Feature Extraction

The application of remote sensing technology in water body detection has become increasingly widespread, offering significant value for environmental monitoring, hydrological research, and disaster early warning. However, the existing methods face challenges in multi-scene and multi-temporal water body detection, including the diverse variations in water body shapes and sizes that complicate detection; the complexity of land cover types, which easily leads to false positives and missed detections; the high cost of acquiring high-resolution images, limiting long-term applications; and the lack of effective handling of multi-temporal data, making it difficult to capture the dynamic changes in water bodies. To address these challenges, this study proposes a novel network for multi-scene and multi-temporal water body detection based on spatiotemporal feature extraction, named TSAE-UNet. TSAE-UNet integrates convolutional neural networks (CNN), depthwise separable convolutions, ConvLSTM, and attention mechanisms, significantly improving the accuracy and robustness of water body detection by capturing multi-scale features and establishing long-term dependencies. The Otsu method was employed to quickly process Sentinel-1A and Sentinel-2 images, generating a high-quality training dataset. In the first experiment, five rectangular areas of approximately 37.5 km2 each were selected to validate the water body detection performance of the TSAE-UNet model across different scenes. The second experiment focused on Jining City, Shandong Province, China, analyzing the monthly water body changes from 2020 to 2022 and the quarterly changes in 2022. The experimental results demonstrate that TSAE-UNet excels in multi-scene and long-term water body detection, achieving a precision of 0.989, a recall of 0.983, an F1 score of 0.986, and an IoU of 0.974, significantly outperforming FCN, PSPNet, DeepLabV3+, ADCNN, and MECNet.

Development and comprehensive evaluation of a national DBCG consensus-based auto-segmentation model for lymph node levels in breast cancer radiotherapy

Background and purposeThis study aimed at training and validating a multi-institutional deep learning (DL) auto segmentation model for nodal clinical target volume (CTVn) in high-risk breast cancer (BC) patients with both training and validation dataset created with multi-institutional participation, with the overall aim of national clinical implementation in Denmark. Materials and methodsA gold standard (GS) dataset and a high-quality training dataset were created by 21 BC delineation experts from all radiotherapy centres in Denmark. The delineations were created according to ESTRO consensus delineation guidelines. Four models were trained: One per laterality and extension of CTVn internal mammary nodes. The DL models were tested quantitatively in their own test-set and in relation to interobserver variation (IOV) in the GS dataset with geometrical metrics, such as the Dice Similarity Coefficient (DSC). A blinded qualitative evaluation was conducted with a national board, presented to both DL and manual delineations. ResultsA median DSC > 0.7 was found for all, except the CTVn interpectoral node in one of the models. In the qualitative evaluation ‘no corrections needed’ were acquired for 297 (36 %) in the DL structures and 286 (34 %) for manual delineations. A higher rate of ‘major corrections’ and ‘easier to start from scratch’ was found in the manual delineations. The models performed within the IOV of an expert group, with two exceptions. ConclusionDL models were developed on a national consensus cohort and performed on par with the IOV between BC experts and had a comparable or higher clinical acceptance than expert manual delineations.

Two-step optimization for accelerating deep image prior-based PET image reconstruction.

Deep learning, particularly convolutional neural networks (CNNs), has advanced positron emission tomography (PET) image reconstruction. However, it requires extensive, high-quality training datasets. Unsupervised learning methods, such as deep image prior (DIP), have shown promise for PET image reconstruction. Although DIP-based PET image reconstruction methods demonstrate superior performance, they involve highly time-consuming calculations. This study proposed a two-step optimization method to accelerate end-to-end DIP-based PET image reconstruction and improve PET image quality. The proposed two-step method comprised a pre-training step using conditional DIP denoising, followed by an end-to-end reconstruction step with fine-tuning. Evaluations using Monte Carlo simulation data demonstrated that the proposed two-step method significantly reduced the computation time and improved the image quality, thereby rendering it a practical and efficient approach for end-to-end DIP-based PET image reconstruction.

Automatic detection of earthquake triggered landslides using Sentinel-1 SAR imagery based on deep learning

ABSTRACT Earthquake Triggered Landslides (ETLs) are serious secondary hazards of earthquakes, causing severe casualties and property losses, and their rapid, automated and accurate detection is of great value. Due to the all-day and all-weather imaging capability of Synthetic Aperture Radar (SAR), ETL detection using SAR images is promising but faces the problem of insufficient accuracy. In this study, we proposed a deep learning-based ETL detection method to address this problem. Firstly, published ETL inventories and SAR images are combined to generate high-quality training datasets. Then, a landslide detection network of Multi-level Features Effective Weighting and Fusion (MFEWF) is proposed to effectively extract and fuze multi-level landslide features to identify SAR pixels within ETLs. Finally, the ETL boundary is determined based on these identified SAR pixels. This method is verified through three earthquake cases: the 2017 Mainling, China earthquake, the 2018 Palu, Indonesia earthquake and the 2018 Papua New Guinea earthquake. Results show that our method can effectively identify landslide boundaries with high accuracy (88.8%, 81.4% and 82.4% for the three cases), obviously outperforming other deep learning frameworks (e.g. DeepLabV3+). Using Sentinel-1 imagery to achieve such high accuracy in landslide detection, this study will improve emergency response to landslide disasters following earthquakes.

(Invited) Machine Learning in Chemistry: Reactive Force Fields for Carbon Structure Formation

Machine learning (ML) became a premier tool for modeling chemical processes and materials properties. ML interatomic potentials have become an efficient alternative to computationally expensive quantum chemistry simulations. In the case of reactive chemistry designing high-quality training data sets is crucial to overall model accuracy. To address this challenge, we develop a general reactive ML interatomic potential through unbiased active learning with an atomic configuration sampler inspired by nanoreactor molecular dynamics. The resulting model is then applied to study five distinct condensed-phase reactive chemistry systems: carbon solid-phase nucleation, graphene ring formation from acetylene, biofuel additives, combustion of methane and the spontaneous formation of glycine from early-earth small molecules. In all cases, the results closely match experiment and/or previous studies using traditional model chemistry methods. Importantly, the model does not need to be refit for each application, enabling high throughput in silico reactive chemistry experimentation.

MCPL: Multi-model co-guided progressive learning for multimodal aspect-based sentiment analysis

Multimodal Aspect-Based Sentiment Analysis (MABSA) aims to combine image and text information to extract aspect terms from sentences and predict aspect-based sentiment polarities. Previous joint approaches have either viewed this task as collapsed label sequence annotation or modelled each subtask as a unified index sequence generation task, overlooking the explicit relation among its subtasks. This type of method cannot effectively integrate the strengths of task-specific models and adapt to difficult joint prediction tasks. To address this problem, we propose a Multi-model Co-guided Progressive Learning (MCPL) strategy that leverages task-specific models and the correlations among downstream tasks to expand high-quality training datasets, and provides progressive supervision signals to enhance the model’s ability to adapt from simple to difficult tasks. Based on MCPL, we construct a Phase-wise Progressive Learning (PPL) module for MABSA, in which three Task Affinity-based Pseudo-label Generation (TAPG) modules are proposed for task-specific label expansion. The TAPG modules leverage the task correlations among three MABSA downstream tasks for co-guided teaching, and the PPL module utilises their gradual relationship from aspect term extraction to perform sentiment classification and then joint prediction for progressive learning. Experiments on widely used public datasets demonstrate that the proposed MCPL method achieves excellent performance on the three subtasks of MABSA and outperforms most state-of-the-art methods. The source code is publicly available at https://github.com/qujiaqi-babu/MCPL.

A robust synthetic data generation framework for machine learning in high-resolution transmission electron microscopy (HRTEM)

Machine learning techniques are attractive options for developing highly-accurate analysis tools for nanomaterials characterization, including high-resolution transmission electron microscopy (HRTEM). However, successfully implementing such machine learning tools can be difficult due to the challenges in procuring sufficiently large, high-quality training datasets from experiments. In this work, we introduce Construction Zone, a Python package for rapid generation of complex nanoscale atomic structures which enables fast, systematic sampling of realistic nanomaterial structures and can be used as a random structure generator for large, diverse synthetic datasets. Using Construction Zone, we develop an end-to-end machine learning workflow for training neural network models to analyze experimental atomic resolution HRTEM images on the task of nanoparticle image segmentation purely with simulated databases. Further, we study the data curation process to understand how various aspects of the curated simulated data—including simulation fidelity, the distribution of atomic structures, and the distribution of imaging conditions—affect model performance across three benchmark experimental HRTEM image datasets. Using our workflow, we are able to achieve state-of-the-art segmentation performance on these experimental benchmarks and, further, we discuss robust strategies for consistently achieving high performance with machine learning in experimental settings using purely synthetic data. Construction Zone and its documentation are available at https://github.com/lerandc/construction_zone.

An Empirical Study on the Effect of Training Data Perturbations on Neural Network Robustness.

The vulnerability of modern neural networks to random noise and deliberate attacks has raised concerns about their robustness, particularly as they are increasingly utilized in safety- and security-critical applications. Although recent research efforts were made to enhance robustness through retraining with adversarial examples or employing data augmentation techniques, a comprehensive investigation into the effects of training data perturbations on model robustness remains lacking. This paper presents the first extensive empirical study investigating the influence of data perturbations during model retraining. The experimental analysis focuses on both random and adversarial robustness, following established practices in the field of robustness analysis. Various types of perturbations in different aspects of the dataset are explored, including input, label, and sampling distribution. Single-factor and multi-factor experiments are conducted to assess individual perturbations and their combinations. The findings provide insights into constructing high-quality training datasets for optimizing robustness and recommend the appropriate degree of training set perturbations that balance robustness and correctness, and contribute to understanding model robustness in deep learning and offer practical guidance for enhancing model performance through perturbed retraining, promoting the development of more reliable and trustworthy deep learning systems for safety-critical applications.

A deep learning-based toolkit for 3D nuclei segmentation and quantitative analysis in cellular and tissue context.

We present a new set of computational tools that enable accurate and widely applicable 3D segmentation of nuclei in various 3D digital organs. We have developed an approach for ground truth generation and iterative training of 3D nuclear segmentation models, which we applied to popular CellPose, PlantSeg and StarDist algorithms. We provide two high-quality models trained on plant nuclei that enable 3D segmentation of nuclei in datasets obtained from fixed or live samples, acquired from different plant and animal tissues, and stained with various nuclear stains or fluorescent protein-based nuclear reporters. We also share a diverse high-quality training dataset of about 10,000 nuclei. Furthermore, we advanced the MorphoGraphX analysis and visualization software by, among other things, providing a method for linking 3D segmented nuclei to their surrounding cells in 3D digital organs. We found that the nuclear-to-cell volume ratio varies between different ovule tissues and during the development of a tissue. Finally, we extended the PlantSeg 3D segmentation pipeline with a proofreading tool that uses 3D segmented nuclei as seeds to correct cell segmentation errors in difficult-to-segment tissues.

Ground-truth-free Deep Learning for 3-D Seismic Denoising and Reconstruction with Channel Attention Mechanism

Seismic denoising methods using supervised methods rely on a large number of high-quality paired training datasets to reach satisfactory performances. There are two ways to generate labels for network training: one is to simulate the synthetic data using the wave equation, and the other is to utilize denoised data obtained via conventional methods. However, using these labels will limit the networks' noise attenuation performance compared with using large volumes of noise-free data as labels. Here, we propose a ground-truth-free way for three-dimensional (3-D) seismic data processing. First, we use the 3-D patch scheme to divide the noisy seismic data into many fixed-size blocks and then flatten the obtained 3-D patches to expand the training set and capture more higher-order waveform characteristics from the input noisy data. Next, the obtained training dataset is sent into the proposed deep learning (DL) network, where the encoder blocks compress the feature map to extract the waveform features, and the decoder blocks reconstruct the denoised feature map. Notably, the convolutional bottleneck attention module (CBAM) and efficient channel attention (ECA) module are applied to guide the network to focus on signal fluctuation features with fewer network parameters. In addition, the concatenation mechanism is used to enable deep networks to reuse shallow-layer waveform features and mitigate overfitting during training. Finally, the unpatching scheme is used to reconstruct the denoised 3-D seismic data. Numerical experiments demonstrate that the proposed method outperforms benchmark approaches in terms of signal-to-noise ratio (SNR) improvement and useful signal preservation.

Digital-twin-driven intelligent tracking error compensation of ultra-precision machining

In ultra-precision machining (UPM), linear axis tracking affects contour accuracy and final machining quality. Traditional error modeling is complicated by the identification of numerous unknown parameters linked to nonlinear characteristics in the linear feed axes. To fill this gap, this study proposed a digital-twin-driven framework integrating the developed G-code interpreter and the deep learning model to achieve real-time tracking error compensation for UPM. To enhance the prediction accuracy of the tracking error of each axis of UPM machines, Bayesian hyperparameter optimization and feature importance analysis were conducted in the proposed TCN-BiLSTM model using high-quality training datasets from well-designed experiments. Ultimately, validation of the proposed system on a three-axis ultra-precision milling machine demonstrated its excellent performance. The experimental results showed that the optimized TCN-BiLSTM model exhibited an excellent capacity to predict the tracking error of the X-axis and Y-axis with minimal mean absolute error values of 0.000009 and 0.000023, respectively. Implementing the customized application reduced X-axis and Y-axis tracking errors by approximately 45–75% and 40–70%, respectively. This study first validates the feasibility of deep learning to improve accuracy in the UPM field, which will provide significant insight into speeding up the digitalization and intellectualization of the UPM scenario.

A high-quality dataset featuring classified and annotated cervical spine X-ray atlas

Recent research in computational imaging largely focuses on developing machine learning (ML) techniques for image recognition in the medical field, which requires large-scale and high-quality training datasets consisting of raw images and annotated images. However, suitable experimental datasets for cervical spine X-ray are scarce. We fill the gap by providing an open-access Cervical Spine X-ray Atlas (CSXA), which includes 4963 raw PNG images and 4963 annotated images with JSON format (JavaScript Object Notation). Every image in the CSXA is enriched with gender, age, pixel equivalent, asymptomatic and symptomatic classifications, cervical curvature categorization and 118 quantitative parameters. Subsequently, an efficient algorithm has developed to transform 23 keypoints in images into 77 quantitative parameters for cervical spine disease diagnosis and treatment. The algorithm’s development is intended to assist future researchers in repurposing annotated images for the advancement of machine learning techniques across various image recognition tasks. The CSXA and algorithm are open-access with the intention of aiding the research communities in experiment replication and advancing the field of medical imaging in cervical spine.

A novel full-resolution convolutional neural network for urban-fringe-rural identification: A case study of urban agglomeration region

Monitoring urbanization processes is important because they are often accompanied by intensive landscape pattern transitions and pluralistic socioeconomic changes. To effectively monitor urban expansion and support regional planning, it is essential to develop a fast, accurate and universal urban–rural classification model, especially identifying the dynamic spatial patterns of urban, urban–rural fringe and rural areas. Although deep learning can effectively detect land cover changes, its applications in urban–rural identification have received little attention due to a lack of high-quality training datasets. In this study, we develop a novel transferable full-resolution convolutional neural network (FR-Net) to identify urban-fringe-rural areas. A large-scale training dataset was constructed using field surveys and aerial photography, and a data cube was stacked by multiple typical socio-natural indicators. We took the Beijing-Tianjin-Hebei (BTH) urban agglomeration region in China as a case study and identified spatiotemporal evolutions of urban-fringe-rural areas from 2000 to 2020. The results indicated that over the past two decades, the urban–rural fringe expanded outward with urban areas, and both areas gradually increased, with an inverted U-shaped growth rate. Accurate identification of these fringes can benefit regional urban–rural planning and social governance. Based on the identification results, complex socio-ecological impacts of urbanization could be further explored. Testing demonstrated that the developed FR-Net model has high accuracy and robustness. Our developed open-source FR-Net model exhibits transferability and can be applied to multi-scale urbanized areas.

Parameterization and Performance Analysis of a Scalable, near Real-Time Packet Capturing Platform

The rapid evolution of technology has fostered an exponential rise in the number of individuals and devices interconnected via the Internet. This interconnectedness has prompted companies to expand their computing and communication infrastructures significantly to accommodate the escalating demands. However, this proliferation of connectivity has also opened new avenues for cyber threats, emphasizing the critical need for Intrusion Detection Systems (IDSs) to adapt and operate efficiently in this evolving landscape. In response, companies are increasingly seeking IDSs characterized by horizontal, modular, and elastic attributes, capable of dynamically scaling with the fluctuating volume of network data flows deemed essential for effective monitoring and threat detection. Yet, the task extends beyond mere data capture and storage; robust IDSs must integrate sophisticated components for data analysis and anomaly detection, ideally functioning in real-time or near real-time. While Machine Learning (ML) techniques present promising avenues for detecting and mitigating malicious activities, their efficacy hinges on the availability of high-quality training datasets, which in turn poses a significant challenge. This paper proposes a comprehensive solution in the form of an architecture and reference implementation for (near) real-time capture, storage, and analysis of network data within a 1 Gbps network environment. Performance benchmarks provided offer valuable insights for prototype optimization, demonstrating the capability of the proposed IDS architecture to meet objectives even under realistic operational scenarios.

Understanding YTHDF2-mediated mRNA degradation by m6A-BERT-Deg.

N6-methyladenosine (m6A) is the most abundant mRNA modification within mammalian cells, holding pivotal significance in the regulation of mRNA stability, translation and splicing. Furthermore, it plays a critical role in the regulation of RNA degradation by primarily recruiting the YTHDF2 reader protein. However, the selective regulation of mRNA decay of the m6A-methylated mRNA through YTHDF2 binding is poorly understood. To improve our understanding, we developed m6A-BERT-Deg, a BERT model adapted for predicting YTHDF2-mediated degradation of m6A-methylated mRNAs. We meticulously assembled a high-quality training dataset by integrating multiple data sources for the HeLa cell line. To overcome the limitation of small training samples, we employed a pre-training-fine-tuning strategy by first performing a self-supervised pre-training of the model on 427760 unlabeled m6A site sequences. The test results demonstrated the importance of this pre-training strategy in enabling m6A-BERT-Deg to outperform other benchmark models. We further conducted a comprehensive model interpretation and revealed a surprising finding that the presence of co-factors in proximity to m6A sites may disrupt YTHDF2-mediated mRNA degradation, subsequently enhancing mRNA stability. We also extended our analyses to the HEK293 cell line, shedding light on the context-dependent YTHDF2-mediated mRNA degradation.

Wavelet-Improved Score-Based Generative Model for Medical Imaging.

The score-based generative model (SGM) has demonstrated remarkable performance in addressing challenging under-determined inverse problems in medical imaging. However, acquiring high-quality training datasets for these models remains a formidable task, especially in medical image reconstructions. Prevalent noise perturbations or artifacts in low-dose Computed Tomography (CT) or under-sampled Magnetic Resonance Imaging (MRI) hinder the accurate estimation of data distribution gradients, thereby compromising the overall performance of SGMs when trained with these data. To alleviate this issue, we propose a wavelet-improved denoising technique to cooperate with the SGMs, ensuring effective and stable training. Specifically, the proposed method integrates a wavelet sub-network and the standard SGM sub-network into a unified framework, effectively alleviating inaccurate distribution of the data distribution gradient and enhancing the overall stability. The mutual feedback mechanism between the wavelet sub-network and the SGM sub-network empowers the neural network to learn accurate scores even when handling noisy samples. This combination results in a framework that exhibits superior stability during the learning process, leading to the generation of more precise and reliable reconstructed images. During the reconstruction process, we further enhance the robustness and quality of the reconstructed images by incorporating regularization constraint. Our experiments, which encompass various scenarios of low-dose and sparse-view CT, as well as MRI with varying under-sampling rates and masks, demonstrate the effectiveness of the proposed method by significantly enhanced the quality of the reconstructed images. Especially, our method with noisy training samples achieves comparable results to those obtained using clean data. Our code at https://zenodo.org/record/8266123.

High School and Undergraduate Student Volunteers as an Imperfect Solution to Machine Learning Geoscience Research Needs

AbstractThe machine learning revolution presents geoscientists with exciting new opportunities for research, but is constrained by the need for large, high quality training data sets. Simultaneously, undergraduate and graduate program admissions have become increasingly competitive, pressuring high school and undergraduate students to differentiate themselves through involvement in research at earlier stages. Aligning these two interests provides mutually beneficial opportunities for both geoscientists and early‐stage students. We describe our experiences working with 20 early‐stage students to build a large training data set digitized from satellite images of meltwater drainage patterns on ice sheets. The intent of this Perspective is to share our experience and lessons learned with other machine learning researchers who, like us, may have minimal experience mentoring young volunteer researchers but may seek such partnerships for the first time in response to their machine learning training data set needs. These partnerships enabled creation of a powerful new machine learning model that would have otherwise been infeasible. Student benefits varied with their commitment and proactiveness, ranging from exposure to geoscience research and a resume line item to strong letters of recommendation and ongoing connections with geoscience researchers at an elite university lab. Many students were attracted to the project solely out of interest in machine learning, so the opportunity reached students who would not otherwise have conducted research in geoscience. Still, without incentives for researchers to engage less‐privileged students, our experience suggests that mutually beneficial partnerships between researchers and early‐stage students may exacerbate issues of inequality and lack of diversity within the geosciences.

Transfer learning to leverage larger datasets for improved prediction of protein stability changes

Amino acid mutations that lower a protein's thermodynamic stability are implicated in numerous diseases, and engineered proteins with enhanced stability can be important in research and medicine. Computational methods for predicting how mutations perturb protein stability are, therefore, of great interest. Despite recent advancements in protein design using deep learning, in silico prediction of stability changes has remained challenging, in part due to a lack of large, high-quality training datasets for model development. Here, we describe ThermoMPNN, a deep neural network trained to predict stability changes for protein point mutations given an initial structure. In doing so, we demonstrate the utility of a recently released megascale stability dataset for training a robust stability model. We also employ transfer learning to leverage a second, larger dataset by using learned features extracted from ProteinMPNN, a deep neural network trained to predict a protein's amino acid sequence given its three-dimensional structure. We show that our method achieves state-of-the-art performance on established benchmark datasets using a lightweight model architecture that allows for rapid, scalable predictions. Finally, we make ThermoMPNN readily available as a tool for stability prediction and design.

Deep autoencoders and multivariate analysis for enhanced hypertension detection during the COVID-19 era

<abstract> <p>The incidence of hypertension has increased dramatically in both elderly and young populations. The incidence of hypertension also increased with the outbreak of the COVID-19 pandemic. To enhance hypertension detection accuracy, we proposed a multivariate outlier removal method based on the deep autoencoder (DAE) technique. The method was applied to the Korean National Health and Nutrition Examination Survey (KNHANES) database. Several studies have identified various risk factors for chronic hypertension. Chronic diseases are often multifactorial rather than isolated and have been associated with COVID-19. Therefore, it is necessary to study disease detection by considering complex factors. This study was divided into two main parts. The first module, data preprocessing, integrated external features for COVID-19 patients merged by region, age, and gender for the KHNANE-2020 and Kaggle datasets. We then performed multicollinearity (MC)-based feature selection for the KNHANES and integrated datasets. Notably, our MC analysis revealed that the "COVID-19 statement" feature, with a variance inflation factor (VIF) of 1.023 and a p-value < 0.01, is significant in predicting hypertension, underscoring the interrelation between COVID-19 and hypertension risk. The next module used a predictive analysis step to detect and predict hypertension based on an ordinal encoder (OE) transformation and multivariate outlier removal using a DAE from the KNHANES data. We compared each classification model's accuracy, F1 score, and area under the curve (AUC). The experimental results showed that the proposed XGBoost model achieved the best results, with an accuracy rate of 87.78% (86.49%–88.1%, 95% CI), an F1 score of 89.95%, and an AUC of 92.28% for the COVID-19 cases, and an accuracy rate of 87.72% (85.86%–89.69%, 95% CI), an F1 score of 89.94%, and an AUC of 92.23% for the non-COVID-19 cases with the DAE_OE model. We improved the prediction performance of the classifiers used in all experiments by developing a high-quality training dataset implementing the DAE and OE in our method. Moreover, we experimentally demonstrated how the steps of the proposed method improved performance. Our approach has potential applications beyond hypertension detection, including other diseases such as stroke and cardiovascular disease.</p> </abstract>