Natural refrigerants like CO2 are playing a significant role in making refrigeration and heat pump systems climate-friendly by slowly phasing out the high global warming refrigerants like hydrofluorocarbons (HFCs). However, the efficiency of a transcritical CO2 refrigeration system declines significantly when the ambient temperature increases, primarily attributed to the high-pressure lift and the losses incurred during expansion. To remedy this issue, this paper presents a novel rotary gas pressure exchanger (PXG) device, which simultaneously achieves high differential pressure expansion work recovery and the “free compression” of the portion of the flash gas in a compact, rotary machine. For this, a PXG device is designed, fabricated, and tested to achieve free compression of CO2 over the entire differential pressure of approximately 70 bar between a receiver and a gas cooler. This is one of the highest free-pressure lift provided by any device to date in CO2 refrigeration. However, there is a small pressure loss of approximately 1–2 bar in the system due to viscous and inertia losses in the piping and in the PXG itself, which needs to be overcome by an external booster device. Results on a baseline PXG integrated system with two low lift booster compressors are presented, which show up to 60 bar free pressure lift and up to 18.2 % COP improvement provided by PXG. Additionally, key performance characteristics of the PXG, like the expansion work recovery, the mass boost ratio, direct fluid-to-fluid contact, and no pass-through operation are experimentally quantified. This work also presents a novel method to integrate two low lift ejectors with PXG to eliminate the need for separate low lift compressors. The low lift ejectors are designed, fabricated, and tested in-house, followed by their integration with the PXG device. A new type of transcritical CO2 refrigeration system is designed to integrate these low lift ejectors with PXG, and experiments are conducted at various evaporator thermal duties and gas cooler exit temperatures, simulating varying ambient temperature conditions. A novel control system to control the gas cooler pressure to optimal thermodynamic levels using PXG rotational speed is demonstrated experimentally. Further, automated control of high-pressure low lift ejector mass flow using an in-built needle design has been successfully demonstrated to optimise PXG mass boost performance. The LP low lift ejector achieved a successful pressure lift of 3.8 bar, and the HP low lift ejector showed a lift of 5.7 bar on the top of 42 bar free pressure lift provided by PXG for up to 5.8 kg/min mass flow delivered by free PXG compression. The results from this study demonstrate that the PXG device provides a significant energy efficiency improvement to the transcritical CO2 refrigeration system, and the novel low lift ejectors, when integrated with PXG, provide a successful method to maximise PXG’s thermodynamic potential.