Direct seawater splitting is a promising strategy for the production of green hydrogen to address water shortage and environmental concerns. However, the primary obstacle in direct seawater splitting is directly related to the high selectivity and durability of oxygen evolution reaction (OER) electrocatalysts. In this study, we developed sulfur-doped multimetal (Ni, Fe, and Co) borophosphates (BPOs) as high-performance OER catalysts for alkalized seawater electrolytes. The incorporated sulfur atoms act as precursors to enhance the corrosion resistance, as they form negatively charged polyanionic surface layers that block the chloride ions. The best catalyst demonstrates an overpotential of 278 mV in alkaline freshwater and 292 mV in alkalized seawater electrolytes when subjected to a current density of 100 mA cm−2. The overpotential disparity between the two media was only 14 mV, suggesting that the material has substantial resistance to chloride corrosion. Furthermore, excellent electrochemical durability was attained for the sulfurized and amorphized multi-metal BPOs, highlighting their high potential as promising catalysts for seawater oxidation.