The objective of this study was to explore the relationship between high performance management practices (HPMP) and affective commitment (AC) through mediating mechanism of job satisfaction (JS). Questionnaires were distributed among 260 employees of five banks (Habib Bank Limited, Faysal Bank, Bank Alfalah limited, Summit Bank and Standard Chartered Bank) using non probability convenient sampling technique. Kenny (2012) contemporary approach for mediation was used to find out relationship between the variables. Results showed that HPMP have significant and positive relationship with AC. Similarly, the results also showed that there is positive relationship between HPMP and JS. From the results it is concluded that JS partially mediates the relationship between HPMP and AC.