This study analyzes and optimizes the structural design of three-dimensional (3D) reinforced concrete framestructures to minimize the amount of two main materials, including concrete and steel reinforcement, used inreinforced concrete frames. Jaya algorithm was developed based on evolutionary algorithms to build the structural optimization model. The objective function (minimum material cost) with variables being column andbeam cross-sections was set up. In which, the constraints related to the maximum internal force and displacement being in the structural members satisfy limited strength and serviceability requirements. A subroutine written in Python was used to connect the optimization process to the structural analysis software, ETABS. The 3D reinforced concrete frame of a three-story building was selected for cost and design optimization analysis. In which, the optimization problem was solved in cases of three different maximum numbers of iterations, including 20, 35, and 50. In each iteration level, a setting of five independent runs was performed. The subroutine proved to be fast, robust, and convenient manner for solving optimization problems in designing 3D reinforced concrete frames. In which, the best optimal cost might be obtained after twenty iterations and the better convergence behavior occurred at higher numbers of iterations. The study results showed that, for this reinforced concrete frame, applying optimal design led to a materials cost reduction (success rate) by 33.67% compared to that of the conventional design. This success rate would fluctuate according to different nations’ design codes.
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