High Longevity Research Articles

A Review of Grouper Fisheries Management in the Southeastern and Caribbean U.S.: Challenges, Successes, and Future Directions

Groupers (Epinephelidae) are ecologically important mesopredators that support valuable fisheries across the globe. Many groupers display slow growth and maturity, high longevity, ontogenetic habitat shifts, spawning-related migrations and aggregations, and protogynous hermaphroditism, which make them susceptible to overexploitation. In this review, I synthesize available information related to the management of grouper fisheries across the southeastern and Caribbean U.S. I highlight current management challenges, such as managing multispecies reef fish fisheries with growing recreational fishing effort. I discuss management interventions with limited success, such as establishing marine protected areas to improve the populations of groupers that display protogynous hermaphroditism. I also highlight management successes, such as recovering historically depleted grouper stocks, and ecosystem-based considerations in grouper stock assessments. I discuss how climate change and anthropogenic effects are expected to affect groupers. Lastly, I provide examples of stakeholder involvement in monitoring and management efforts directed at grouper stocks. The purposes of this review are to demonstrate the complexities of managing grouper fisheries and provide a road map for future research and conservation efforts into these economically and ecologically relevant fishes within and beyond the region.

Phenotypic upregulation of hexocylceramides and ether-linked phosphocholines as markers of human extreme longevity.

Centenarians and their relatives possess a notable survival advantage, with higher longevity and reduced susceptibility to major age-related diseases. To date, characteristic omics profiles of centenarians have been described, demonstrating that these individuals with exceptional longevity regulate their metabolism to adapt and incorporate more resilient biomolecules into their cells. Among these adaptations, the lipidomic profile stands out. However, it has not yet been determined whether this lipidomic profile is specific to centenarians or is the consequence of extreme longevity genetics and is also present in centenarians' offspring. This distinction is crucial for defining potential therapeutic targets that could help delay the aging process and associated pathologies. We applied mass-spectrometry-based techniques to quantify 569 lipid species in plasma samples from 39 centenarians, 63 centenarians' offspring, and 69 noncentenarians' offspring without familial connections. Based on this profile, we calculated different indexes to characterize the functional and structural properties of plasma lipidome. Our findings demonstrate that extreme longevity genetics (centenarians and centenarians' offspring) determines a specific lipidomic signature characterized by (i) an enrichment of hexosylceramides, (ii) a decrease of specific species of ceramides and sulfatides, (iii) a global increase of ether-PC and ether-LPC, and (iv) changes in the fluidity and diversity of specific lipid classes. We point out the conversion of ceramides to hexosylceramides and the maintenance of the levels of the ether-linked PC as a phenotypic trait to guarantee extreme longevity. We propose that this molecular signature is the result of an intrinsic adaptive program that preserves protective mechanisms and cellular identity.

Branching out: Material Flow Analysis of Cascading Utilization in Domestic and Imported Wood Products for Strategic Carbon Reduction in South Korea

This study employs a material flow analysis (MFA) to examine the usage patterns of domestic and imported wood resources in South Korea, analyzing the significant differences in utilization, and their impacts on carbon storage. We found a contrast between manufacturing and industrial uses of domestic and imported wood. Imported wood products with high economic value and longevity are primarily used in sustainable construction and manufacturing. In contrast, domestic wood is primarily utilized in lower-value wood-based boards and energy production, with a shorter lifespan and lower carbon storage potential. This study outlined the economic and environmental value chains by wood origin, highlighting their industrial linkages and utilization pathways. Consequently, tailored strategies are essential to promote sustainable wood resource use and advance climate mitigation. Recommendations have been provided for policy instruments to enhance wood resource management sustainability and climate change mitigation.

Adaptive Hyperactivity and Biomarker Exploration: Insights from Elders in the Blue Zone of Sardinia.

Background/Objectives: Adaptive hyperactivity characterized by increased activity levels and novelty-seeking traits without mood disorders is prevalent among older adults in Sardinia's "blue zone," an area with high longevity. This study aims to evaluate the adaptive nature of hyperactivity concerning quality of life, social rhythms, and mood symptoms in individuals from this region, particularly among elderly adults over 80. Methods: This observational cross-sectional study included adults and older adults over 80 from Sardinia's blue zone. This study included a sample of patients followed at the Center for Consultation Psychiatry and Psychosomatics for Bipolar Disorder of the University Hospital of Cagliari and a homogeneous comparison sample of patients without psychiatric pathologies, referred to the Dermatology Clinic of the same hospital, for a period of 6 months, from February to August 2024. The general sample, divided into two parts-cases, represented by patients with psychiatric pathology, and controls, patients without psychiatric pathology-was divided in turn into three sub-groups: "adults" (18-64 years), young elders (65-79), and old elders (over 80 years). The participants underwent psychiatric interviews and completed the Mood Disorder Questionnaire (MDQ), Patient Health Questionnaire (PHQ-9), SF-12, and Brief Social Rhythm Scale (BSRS). Data were compared with national and regional normative data. Results: Older adults in the blue zone demonstrated higher MDQ positivity (22.58%) compared to the national averages (0.87%), without corresponding increases in dysregulated rhythms, depressive symptoms, or reduced quality of life. Younger old persons (65-79 years) showed increased rhythm dysregulation (BSRS score: 20.64 ± 7.02) compared to adults (17.40 ± 6.09, p = 0.040), but this trend was not observed in the oldest group (80+ years). No significant differences were found in the CH3SH and (CH3)2S levels between groups. Conclusions: The hyperactivity observed in older adults from Sardinia's blue zone appears adaptive and not linked to social rhythm dysregulation, depressive symptoms, or a diminished quality of life, suggesting resilience factors which may contribute to longevity. These findings support the potential classification of such hyperactivity as beneficial rather than pathological, warranting further research into biomarkers and psychoeducational interventions to prevent the onset of bipolar disorders in predisposed individuals.

Enhancing multi-type fault diagnosis in lithium-ion battery systems: Vision transformer-based transfer learning approach

Ensuring the accurate diagnosis of internal short circuit (ISC) faults and consistency anomalies is crucial for maintaining the high safety and longevity of battery systems. The challenge lies in the high similarity between the features of ISC faults and consistency anomalies, which can complicate accurate fault diagnosis. This study introduces a multi-fault diagnostic model that leverages the Vision Transformer (ViT) and employs simulated data to accurately pinpoint ISC faults and intricate consistency anomalies, such as capacity and state of charge anomalies, achieving an impressive accuracy rate of up to 100 %. The process begins with an in-depth analysis of fault mechanisms to extract and differentiate multi-fault features using a mean difference model. Subsequently, the ViT's exceptional ability to capture temporal information, which aids in the accurate identification of fault features. The integration of transfer learning with experimental data further refines the real-world diagnosis accuracy. The results confirm the robustness of the proposed method, highlighting its potential to substantially mitigate safety hazards in battery systems and enhance operational reliability.

Flow Cytometry Sorting for Random Access in DNA Data Storage: Encapsulation for Enhanced Stability and Sequence Integrity of DNA.

As digital data undergo explosive growth, deoxyribonucleic acid (DNA) has emerged as a promising storage medium due to its high density, longevity, and ease of replication, offering vast potential in data storage solutions. This study focuses on the protection and retrieval of data during the DNA storage process, developing a technique that employs flow cytometry sorting (FCS) to segregate multicolored fluorescent DNA microparticles encoded with data and facilitating efficient random access. Moreover, the encapsulated fluorescent DNA microparticles, formed through layer-by-layer self-assembly, preserve structural and sequence integrity even under harsh conditions while also supporting a high-density DNA payload. Experimental results have shown that the encoded data can still be successfully recovered from encapsulated DNA microparticles following de-encapsulation. We also successfully demonstrated the automated encapsulation process of fluorescent DNA microparticles using a microfluidic chip. This research provides an innovative approach to the long-term stability and random readability of DNA data storage.

Strategies for Mitigating Phosphoric Acid Leaching in High-Temperature Proton Exchange Membrane Fuel Cells.

High-temperature proton exchange membrane fuel cells (HT-PEMFCs) have become one of the important development directions of PEMFCs because of their outstanding features, including fast reaction kinetics, high tolerance against impurities in fuel, and easy heat and water management. The proton exchange membrane (PEM), as the core component of HT-PEMFCs, plays the most critical role in the performance of fuel cells. Phosphoric acid (PA)-doped membranes have showed satisfied proton conductivity at high-temperature and anhydrous conditions, and significant advancements have been achieved in the design and development of HT-PEMFCs based on PA-doped membranes. However, the persistent issue of HT-PEMFCs caused by PA leaching remains a challenge that cannot be ignored. This paper provides a concise overview of the proton conduction mechanism in HT-PEMs and the underlying causes of PA leaching in HT-PEMFCs and highlights the strategies aimed at mitigating PA leaching, such as designing crosslinked structures, incorporation of hygroscopic nanoparticles, improving the alkalinity of polymers, covalently linking acidic groups, preparation of multilayer membranes, constructing microporous structures, and formation of micro-phase separation. This review will offer a guidance for further research and development of HT-PEMFCs with high performance and longevity.

Understanding Nanoscale Interactions between Minerals and Microbes: Opportunities for Green Remediation of Contaminated Sites.

In situ contaminant degradation and detoxification mediated by microbes and minerals is an important element of green remediation. Improved understanding of microbe-mineral interactions on the nanoscale offers promising opportunities to further minimize the environmental and energy footprints of site remediation. In this Perspective, we describe new methodologies that take advantage of an array of multidisciplinary tools─including multiomics-based analysis, bioinformatics, machine learning, gene editing, real-time spectroscopic and microscopic analysis, and computational simulations─to identify the key microbial drivers in the real environments, and to characterize in situ the dynamic interplay between minerals and microbes with high spatiotemporal resolutions. We then reflect on how the knowledge gained can be exploited to modulate the binding, electron transfer, and metabolic activities at the microbe-mineral interfaces, to develop new in situ contaminant degradation and detoxication technologies with combined merits of high efficacy, material longevity, and low environmental impacts. Two main strategies are proposed to maximize the synergy between minerals and microbes, including using mineral nanoparticles to enhance the versatility of microorganisms (e.g., tolerance to environmental stresses, growth and metabolism, directed migration, selectivity, and electron transfer), and using microbes to synthesize and regenerate highly dispersed nanostructures with desired structural/surface properties and reactivity.

Molecular Dynamics Study of Adhesion-Related Structural Properties for PVDF-HFP Polymer Binders

The current lithium-ion battery (LIB) market is expanding rapidly. Binders are essential to maintaining the high capacity and longevity of batteries. These binders can be classified into organic binders used for cathodes and aqueous binders used for anodes. Among them, Poly(vinylidene fluoride) (PVDF) binder is a representative organic binder that offers excellent electrochemical stability. To solve low adhesive force and weak mechanical strength of conventional PVDF binders, hexafluoropropylene (HFP) is added to improve these properties. However, the present poly(vinylidene fluoride-hexafluoropropylene) (PVDF-HFP) binders still show lower adhesive force than other polymeric binders, and therefore further research works are necessary.In this study, we employ classical molecular dynamics (MD) simulations to investigate the structural properties of the PVDF-HFP copolymers. To create realistic disordered PVDF-HFP polymers, we develop a computational scheme that can randomly arrange the angles and sequences of the constituent polymer chains. By varying the ratio of randomly arranged PVDF-HFP copolymers to 0/100, 5/95, 10/90, 15/85, and 20/80, we build a solution model that mimics the HFP concentration of PVDF-HFP (0–20%, Sigma Aldrich) used in the actual experiments. N-methyl-2-pyrrolidone (NMP) used as solvents. To create a large-scale model, we utilize the Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) and set parameters by using OPLS force field. This allows us to build a simulation model containing approximately 40,000 atoms consisting of 10 PVDF-HFP polymers and 1500 NMP monomers.After creating the simulation model, approximately eight steps of molecular dynamics simulation are performed by referring to the process of making the actual polymer film. In this process, NMP molecules are evaporated to produce a polymer film consisting only of PVDF-HFP polymers. Then we perform the adhesion analysis by applying forces to five polymer film models with different composition ratios in various conditions. Throughout these processes, we find the characteristic changes depending on the composition ratio. Finally, we will present the possible routes that can lead to the enhanced adhesive properties of PVDF-HFP, which is a key requirement to the development of high performance binders.

Exploring the Nb-Ti-W-O System for Use as Li-Ion Battery Anodes

While much attention in recent years has been given to high performance Li-ion batteries for electrical vehicles, other applications such as medical devices require a unique set of properties that demand a different set of material considerations such as long lifetimes and extremely high safety. Anodes for such batteries must be carefully selected to properly achieve these goals. The most commonly industrially utilized anode material, graphite, is not suitable for medical applications due to particle fracture and Li dendrite growth at high rates. Currently utilized medical device anode materials obtain this high performance by sacrificing energy density.Herein a new set of Nb based materials for use as anodes are presented that do not need to make such a sacrifice as they display high longevity along with high energy densities. The Nb-Ti-W pseudoternary features many promising single-phase compositions that could be used as anodes for such devices. These compositions derive from crystal structures that are found on both the Nb2O5-WO3 and Nb2O5-TiO2 pseudobinaries1, though they posses a more diverse range of chemical compositions. These compositions feature high performance discharge capacities of up to 300 mAh/g. Some materials also display robust capacity retentions of up to 98% after 10 cycles. The materials were also tested at 37 °C to simulate operation within the human body. At these temperatures, improvements were found in electrochemical performance for nearly all compositions, notably demonstrating a large improvement in capacity retention regardless of crystal structure. References (1) Rehman, S.; Sieffert, J. M.; Lang, C. J.; McCalla, E. NbyW1-yOz and NbxTi1-xOz pseudobinaries as anodes for Li-ion batteries. Electrochimica Acta 2023, 439. DOI: 10.1016/j.electacta.2022.141665.

Comparative genomics reveals convergent signals associated with the high metabolism and longevity in birds and bats.

Birds and bats have long lifespans relative to their body size compared with non-flying animals. However, the genomic basis associated with longer lifespan of flying species despite their higher metabolism was unclear. In this study, we hypothesized that genes involved in the regulation of metabolism and lifespan changed with the acquisition of flight and searched for genes that show specific evolutionary patterns in flying species. As a result, we identified several genes that show different evolutionary rates in bird and bat lineages. Genes in pathways involved in lifespan regulation were conserved in birds, while they evolved at an accelerated rate in bats. We also searched for genes in which convergent amino acid substitutions occurred in birds and bats and found such substitutions in genes involved in cancer, reactive oxygen species control and immunity. Our study revealed genomic changes associated with the acquisition of flight in birds and bats and suggested that multiple genes involved in the regulation of lifespan and metabolism support both high metabolism and longevity in flying species.

Applying Lessons from the Blue Zones on Campus: How Environment Impacts Health

The Blue Zones, locations with exceptionally high longevity, are enviable places to reside as many residents live long, healthy lives. Similarities exist between the Blue Zones regarding the residents’ behaviors and environmental conditions. These similarities, specifically related to physical activity, nutrition, and social connection, among others, promote a culture of wellness. Universities are a unique location in which a culture of wellness, designed specifically based on lessons from the Blue Zones, may be infused to promote well-being. Using the socioecological model, strategies can be implemented to mimic the Blue Zones on a college campus. For example, emphasizing education on health and wellness at the individual level, facilitating community around wellness at the interpersonal level, improving campus walkability at the community level, and advocating for on-campus dining options that are enjoyable and nutritious at the policy level would benefit students, faculty, and staff. Academic communities could benefit from implementing the recommendations provided. Collecting data on the impact is critical so that benefits may be evaluated, and information shared.

A Study on Materials Used and Longevity of Implant-Supported Prostheses

ABSTRACT Objective: This retrospective research was directed to investigate the longevity and maintenance requirements of implant-supported prostheses in subjects treated at a tertiary care center. Methods: Patient records of individuals who received implant-supported prostheses between January 2018 and December 2020 were retrospectively analyzed. Demographic information, implant type, prosthetic design, and follow-up data were collected. The primary outcomes assessed were prosthetic survival rates and the incidence of complications requiring maintenance interventions. Statistical analysis was performed to identify associations between demographic and clinical variables and the observed outcomes. Results: The research included 150 subjects with an average follow-up duration of 3 years. The overall survival rate of implant-supported prostheses was 90%, with 20% requiring maintenance interventions. Common complications included peri-implantitis (10%), prosthetic fracture (6%), and screw loosening (4%). Significant associations were found between smoking status and peri-implantitis (P < 0.05) and between prosthetic design and prosthetic fracture (P < 0.01). Conclusion: Implant-supported prostheses demonstrated a high overall longevity rate, with a subset of subjects requiring maintenance interventions due to complications. Peri-implantitis, prosthetic fracture, and screw loosening were the most prevalent complications, emphasizing the importance of tailored patient care and risk stratification.

BASIC PENTACYSTEINE1 regulates ABI4 by modification of two histone marks H3K27me3 and H3ac during early seed development of Medicago truncatula.

The production of highly vigorous seeds with high longevity is an important lever to increase crop production efficiency, but its acquisition during seed maturation is strongly influenced by the growth environment. An association rule learning approach discovered MtABI4, a known longevity regulator, as a gene with transcript levels associated with the environmentally-induced change in longevity. To understand the environmental sensitivity of MtABI4 transcription, Yeast One-Hybrid identified a class I BASIC PENTACYSTEINE (MtBPC1) transcription factor as a putative upstream regulator. Its role in the regulation of MtABI4 was further characterized. Overexpression of MtBPC1 led to a modulation of MtABI4 transcripts and its downstream targets. We show that MtBPC1 represses MtABI4 transcription at the early stage of seed development through binding in the CT-rich motif in its promoter region. To achieve this, MtBPC1 interacts with SWINGER, a sub-unit of the PRC2 complex, and Sin3-associated peptide 18, a sub-unit of the Sin3-like deacetylation complex. Consistent with this, developmental and heat stress-induced changes in MtABI4 transcript levels correlated with H3K27me3 and H3ac enrichment in the MtABI4 promoter. Our finding reveals the importance of the combination of histone methylation and histone de-acetylation to silence MtABI4 at the early stage of seed development and during heat stress.

Exploring role of microbatteries in enhancing sustainability and functionality of implantable biosensors and bioelectronics

Microbatteries are emerging as a sustainable, miniaturized power source, crucial for implantable biomedical devices. Their significance lies in offering high energy density, longevity, and rechargeability, facilitating uninterrupted health monitoring and treatment within the body. The review delves into the development of microbatteries, emphasizing their miniaturization and biocompatibility, crucial for long-term, safe in-vivo use. It examines cutting-edge manufacturing techniques like physical and chemical vapor deposition, and atomic layer deposition, essential for the precision manufacture of the microbatteries. The paper contrasts primary and secondary batteries, highlighting the advantages of zinc-ion and magnesium-ion batteries for enhanced stability and reduced reactivity. It also explores biodegradable batteries, potentially obviating the need for surgical extraction post-use. The integration of microbatteries into diagnostic and therapeutic devices is also discussed, illustrating how they enhance the efficacy and sustainability of implantable biosensors and bioelectronics.

Green modifications for rendering cotton fabric with antibacterial, anti-mite, and mosquito-repellent functions using single natural eugenol

Cotton fabrics are widely used in everyday life; however, increasing their versatility through green modifications remains a challenge. The current mainstream approach merely physically attaches the additives onto the fibers, resulting in low binding affinity. In this study, novel cotton fabrics (Cotton-Si-EU) with long-lasting antibacterial, anti-mite, and mosquito-repellent properties were facilely fabricated in a green procedure. In contrast to conventional coating and physical addition methods, the eugenol graft modification ensured the safety, environmental friendliness and long-lasting functionality of the Cotton-Si-EU. In addition, Cotton-Si-EU fabrics retained the softness, comfort, breathability, and moisture absorption originating from the cotton fabric. Cotton-Si-EU also showed over 99.99% antibacterial, 73% anti-mite, and 75% mosquito repellent rates, simultaneously destroying microorganisms and insects through oxidative stress, inhibiting enzyme activity, affecting cell structure, and other mechanisms. More importantly, after 50 washing cycles, the fabrics still exhibited durable antibacterial properties higher than the AAA requirements, indicating high functional longevity. In addition, good cytocompatibility, hemocompatibility, and negligible skin irritation demonstrated excellent biological safety. Therefore, this study is of great significance in providing a reference for modifying cotton fabrics using an infinite number of natural products after screening, which will broaden the application scope and improve the safety level of functional cotton fabrics.

Implantable Cardiac Devices in Patients with Brady- and Tachy-Arrhythmias: An Update of the Literature.

Implantable cardiac devices are a vital treatment option in the management of tachy/brady-arrhythmias and heart failure with conduction disease. In the recent years, these devices have become increasingly sophisticated, with high implantation success rates and longevity. However, these devices are not without risks and complications, which need to be carefully considered before implantation. In an era of rapidly evolving cardiac device therapies, this review article will provide an update on the literature and outline some of the emerging technologies that aim to maximise the efficiency of implantable devices and reduce complications. We discuss novel pacing techniques, including alternative pacing sites in anti-bradycardia and biventricular pacing, as well as the latest evidence surrounding leadless device technologies and patient selection for implantable device therapies.

Metal oxide-based nanocomposites as advanced electrode materials for enhancing electrochemical performance of Supercapacitors: A comprehensive review

In recent years, the escalating use of nonrenewable fossil fuels has emerged as a significant threat to global sustainability, prompting the need for renewable, cost-effective, and eco-friendly energy storage solutions. Supercapacitors (SCs) are notable for their high power density (PD), cycle stability, and swift charge/discharge rates, although they fall short in energy density (ED) compared to traditional batteries. The performance of SCs is greatly influenced by the electrode materials used, highlighting the importance of material innovation in tackling the challenges posed by increasing fossil fuel consumption. Transition metal oxides (TMOs), known for their redox activity in energy storage, have been thoroughly investigated for their exceptional specific capacitance, which ranges from 100 to 2000F g−1, surpassing that of electrical double-layer capacitors (EDLCs). TMOs such as ruthenium oxide (RuO2), manganese oxide (MnO2), nickel oxide (NiO), cobalt oxide (Co3O4), tin oxide (SnO2), zinc oxide (ZnO), tungsten oxide (WO3), and vanadium pentoxide (V2O5) are widely researched for their high theoretical capacitance, affordability, and longevity. This review emphasizes the groundbreaking potential of metal oxide nanocomposites (NCs) formed by combining them with graphene, carbon nanotubes (CNTs), and polymers, leading to synergistic enhancements in electrical conductivity, surface area, and charge storage capacity. This thorough review not only presents an in-depth analysis of current research but also sheds light on potential future developments, contributing to the ongoing progress in the field of advanced electrode materials for energy storage.

EXPLORATION OF THE PACKING ELEMENT OF THE ANNULAR BOP

The article delved into exploring various structural configurations of clamping nodes in universal preventers, examining both conical and spherical designs. Anti-discharge equipment is essential for averting well blowouts by sealing well openings and maintaining back pressure during drilling, operation, and testing phases. The reliability and durability of this equipment must undergo rigorous testing to ensure safety. Universal preventers not only manage the wellhead but also facilitate pipeline rotation, vertical movement, and additional pipeline insertion into the well. They effectively seal the wellhead even with identical pipe parts. The sequence of technological processes must be carefully chosen and monitored when selecting preventers to ensure high reliability, longevity, and operational efficiency in oil and gas well activities. One of the critical components in anti-discharge equipment is the clamp knot. Let's delve into the clamp knot of universal preventers. The clamp comprises numerous metal inserts evenly spaced along its length, creating a tight seal at the wellhead by compressing the flexible clamp element. Hydraulic pressure drives a piston to close and open the clamping element. As a result, the clamping element of the universal preventer experiences varying loads in direction and magnitude. A spherical structural design in the clamping element provides better resistance to changing stresses compared to a conical design due to its spherical surface, resulting in uniform force distribution. However, this structural design's drawback is increased wear on the elastic sealing joint due to friction during pipeline movement. Additionally, pressure forces during piston upward movement impact the sealing element's tightness, functionality, and lifespan. Keywords: Anti-discharge equipment, locking element, universal preventer, conical locking device.

Association of Race and Ethnicity With High Longevity Deceased Donor Kidney Transplantation Under the US Kidney Allocation System

Rationale & ObjectiveThe US Kidney Allocation System (KAS) prioritizes candidates with ≤20% Estimated Post-Transplant Survival (EPTS) for high longevity kidneys defined by a ≤20% Kidney Donor Profile Index (KDPI). Use of EPTS in the KAS deprioritizes candidates with older age, diabetes, and longer dialysis durations. We assessed whether this use also disadvantages racial-ethnic minority candidates, who are younger but more likely to have diabetes and longer durations of kidney failure requiring dialysis. Study DesignObservational cohort study. Setting& Participants: Adult candidates for and recipients of kidney transplantation represented in the Scientific Registry of Transplant Recipients from January 2015 through December 2020. ExposureRace and ethnicity. OutcomesAge-adjusted assignment to ≤20% EPTS, transplantation of a ≤20% KDPI kidney, and post-transplant survival in longevity matched recipients by racial-ethnicity. Analytic ApproachMultivariable logistic regression, Fine-Gray competing risks survival analysis, and Kaplan-Meier and Cox Proportional Hazards methods. ResultsThe cohort included 199,444 candidates (7% Asian, 29% Black, 19% Hispanic/Latino, 43% White) listed for deceased donor kidney transplantation. Non-White candidates had significantly higher rates of diabetes, longer dialysis duration, and were younger than White candidates. Adjusted for age, Asian, Black, and Hispanic/Latino candidates had significantly lower odds of having a ETPS score ≤20% (OR 0.86, [0.81, 0.91], 0.52 [0.50, 0.54], and 0.49, [0.47, 0.51]), and were less likely to receive a ≤20% KDPI kidney (subHR 0.70 [0.66, 0.75], 0.89 [0.87, 0.92], and 0.73 [0.71, 0.76]), compared to White candidates. Among recipients with ≤20% EPTS scores transplanted with a ≤20% KDPI deceased donor kidney, Asian and Hispanic recipients had lower post-transplant mortality (HR 0.45 [0.27, 0.77], and 0.63 [0.47, 0.86]) and Black recipients had higher but not statistically significant post-transplant mortality (HR 1.22 [0.99, 1.52]) compared to White recipients. LimitationsProvider reported race-ethnicity data and 5-year post transplant follow-up period. ConclusionsThe US kidney allocation system is less likely to identify racial-ethnic minority candidates as having a ≤20% EPTS score which triggers allocation of high longevity deceased donor kidneys. These findings should inform the OPTN about how to remedy racial/ethnic disparities introduced through KAS’s current approach of allocating allografts with longer predicted longevity to recipients with longer estimated post-transplant survival.