High Loading Capability Research Articles

Advancement in Soft Hydrogel Grippers: Comprehensive Insights into Materials, Fabrication Strategies, Grasping Mechanism, and Applications.

Soft hydrogel grippers have attracted considerable attention due to their flexible/elastic bodies, stimuli-responsive grasping and releasing capacity, and novel applications in specific task fields. To create soft hydrogel grippers with robust grasping of various types of objects, high load capability, fast grab response, and long-time service life, researchers delve deeper into hydrogel materials, fabrication strategies, and underlying actuation mechanisms. This article provides a systematic overview of hydrogel materials used in soft grippers, focusing on materials composition, chemical functional groups, and characteristics and the strategies for integrating these responsive hydrogel materials into soft grippers, including one-step polymerization, additive manufacturing, and structural modification are reviewed in detail. Moreover, ongoing research about actuating mechanisms (e.g., thermal/electrical/magnetic/chemical) and grasping applications of soft hydrogel grippers is summarized. Some remaining challenges and future perspectives in soft hydrogel grippers are also provided. This work highlights the recent advances of soft hydrogel grippers, which provides useful insights into the development of the new generation of functional soft hydrogel grippers.

Polymeric Microbubble Shell Engineering: Microporosity as a Key Factor to Enhance Ultrasound Imaging and Drug Delivery Performance.

Microbubbles (MB) are widely used as contrast agents for ultrasound (US) imaging and US-enhanced drug delivery. Polymeric MB are highly suitable for these applications because of their acoustic responsiveness, high drug loading capability, and ease of surface functionalization. While many studies have focused on using polymeric MB for diagnostic and therapeutic purposes, relatively little attention has thus far been paid to improving their inherent imaging and drug delivery features. This study here shows that manipulating the polymer chemistry of poly(butyl cyanoacrylate) (PBCA) MB via temporarily mixing the monomer with the monomer-mimetic butyl cyanoacetate (BCC) during the polymerization process improves the drug loading capacity of PBCA MB by more than twofold, and the in vitro and in vivo acoustic responses of PBCA MB by more than tenfold. Computer simulations and physisorption experiments show that BCC manipulates the growth of PBCA polymer chains and creates nanocavities in the MB shell, endowing PBCA MB with greater drug entrapment capability and stronger acoustic properties. Notably, because BCC can be readily and completely removed during MB purification, the resulting formulation does not include any residual reagent beyond the ones already present in current PBCA-based MB products, facilitating the potential translation of next-generation PBCA MB.

A robust polyaniline hydrogel electrode enables superior rate capability at ultrahigh mass loadings

Simultaneously achieving high mass loading and superior rate capability in electrodes is challenging due to their often mutually constrained nature, especially for pseudocapacitors for high-power density applications. Here, we report a robust porous polyaniline hydrogel (PPH) prepared using a facile ice-templated in situ polymerization approach. Owing to the conductive, robust, and porous nanostructures suitable for ultrafast electron and ion transport, the self-supporting pure polyaniline hydrogel electrode exhibits superior areal capacitance without sacrificing rate capability and gravimetric capacitance at an ultrahigh mass loading and notable current density. It achieves a high areal capacitance (15.2 F·cm−2 at 500 mA·cm−2) and excellent rate capability (~92.7% retention from 20 to 500 mA·cm−2) with an ultrahigh mass loading of 43.2 mg cm−2. Our polyaniline hydrogel highlights the potential of designing porous nanostructures to boost the performance of electrode materials and inspires the development of other ultrafast pseudocapacitive electrodes with ultrahigh loadings and fast charge/discharge capabilities.

Fabrication of thermo-responsive microcapsule pesticide delivery system from maleic anhydride-functionalized cellulose nanocrystals-stabilized pickering emulsion template

The overuse of pesticides has shown their malpractices. Novel and sustainable formulations have consequently attracted abundant attention but still appear to have drawbacks. Here, we use a maleic anhydride-functionalized cellulose nanocrystals-stabilized Pickering emulsions template to prepare thermo-responsive microcapsules for a pesticide delivery system via radical polymerization with N-isopropyl acrylamide. The microcapsules (MACNCs-g-NIPAM) are characterized by the microscope, SEM, FTIR, XRD, TG-DTG, and DSC techniques. Imidacloprid (IMI) is loaded on MACNCs-g-NIPAM to form smart release systems (IMI@MACNCs-g-NIPAM) with high encapsulation efficiency (~88.49%) and loading capability (~55.02%). The IMI@MACNCs-g-NIPAM present a significant thermo-responsiveness by comparing the release ratios at 35°C and 25°C (76.22% vs 50.78%). It also exhibits advantages in spreadability, retention and flush resistance on the leaf surface compared with the commercial IMI water-dispersible granules (CG). IMI@MACNCs-g-NIPAM also manifest a significant advantage over CG (11.12 mg/L vs 38.90 mg/L for LC50) regarding activity tests of targeted organisms. In addition, IMI@MACNCs-g-NIPAM has shown excellent biocompatibility and low toxicity. All the benefits mentioned above prove the excellent potential of IMI@MACNCs-g-NIPAM as a smart pesticide formulation.

Hybrid Mn Atomic Clusters/Single-Dispersed Atoms with Dual Antioxidant Activities for a Chemiluminescent Immunoassay.

Single-dispersed atoms (SDAs) as catalysts have drawn extensive attention due to their ultimate atom utilization efficiency and desirable catalytic capability. Atomic clusters (ACs) with potential multiple enzyme-like activities also display great practicability in catalysis-based biosensing. In this work, hybrid Mn ACs/SDAs were implanted in the frameworks of defect-engineered MIL 101(Cr) modulated by excess acetic acid, with a high loading capability of 13.9 wt %. Distinctively, Mn SDAs display weak superoxide dismutase (SOD)-like activity for specifically eliminating superoxide anion (O2•-), while Mn ACs/SDAs display both catalase-like and SOD-like activities for remarkable elimination of total reactive oxygen species (ROS) due to the cooperative effect of the two atom-scale catalytic sites. Thus, Mn ACs/SDAs can efficiently inhibit the chemiluminescent (CL) emission of multiple ROS-mediated luminol systems with a superior quenching rate of 85.5%. To validate the practicability of Mn ACs/SDAs for a sensitive CL assay, an immunoassay method was established to detect acetamiprid by using Mn ACs/SDAs as signal quenchers, which displayed a quantification range of 10 pg mL-1-25 ng mL-1 and a detection limit of 3.3 pg mL-1. This study paves an avenue for developing ACs/SDAs with multiple antioxidant activities that are suitable for application in biosensing.

Evaluation of the Antibacterial, Anti-Inflammatory, And Bone-Promoting Capacity of UiO-66 Loaded with Thymol or Carvacrol.

Oral infectious diseases have a significant impact on the health of oral and maxillofacial regions, as well as the overall well-being of individuals. Carvacrol and thymol, two isomers known for their effective antibacterial and anti-inflammatory properties, have gained considerable attention in the treatment of oral infectious diseases. However, their application as topical drugs for oral use is limited due to their poor physical and chemical stability. UiO-66, a metal-organic framework based on zirconium ion (Zr4+), exhibits high drug loading capability. Carvacrol and thymol were efficiently loaded onto UiO-66 with loading rates of 79.60 ± 0.71% and 79.65 ± 0.76%, respectively. The release rates of carvacrol and thymol were 77.82 ± 0.87% and 76.51 ± 0.58%, respectively, after a period of 72 h. Moreover, Car@UiO-66 and Thy@UiO-66 demonstrated excellent antibacterial properties against Candida albicans, Escherichia coli, and Staphylococcus aureus with minimum bactericidal concentrations (MBC) of 0.313 mg/mL, 0.313 mg/mL, and 1.25 mg/mL, respectively. Furthermore, based on the results of the CCK8 cytotoxicity assay, even at concentrations as high as 1.25 mg/mL, Car@UiO-66 and Thy@UiO-66 exhibited excellent biocompatibility with a relative cell survival rate above 50%. These findings suggest that Car@UiO-66 and Thy@UiO-66 possess favorable biocompatibility properties without significant toxicity towards periodontal membrane cells. Additionally, in vivo studies confirmed the efficacy of Car@UiO-66and Thy@UiO-66 in reducing inflammation, promoting bone formation through inhibition of TNF-a and IL6 expression, enhancement of IL10 expression, and acceleration of bone defect healing. Therefore, the unique combination of antibacterial, anti-inflammatory, and osteogenic properties make Car@UiO-66 and Thy@Ui O-66 promising candidates for the treatment of oral infectious diseases and repairing bone defects.

Hollow mesoporous calcium peroxide nanoparticles for drug-free tumor calcicoptosis therapy

Calcium ions (Ca2+) participate in the regulation of cellular apoptosis as a second messenger. Calcium overload, which refers to the abnormal elevation of intracellular Ca2+ concentration, is a factor that can lead to cell death. Here, based on the unique biological effects of Ca2+, hollow mesoporous calcium peroxide nanoparticles (HMCPN) were developed by a facile hydrolysis-precipitation method for drug-free tumor calcicoptosis therapy. The average pore size of the optimized HMCPN17 is 6.4 nm, and the surface area is 81.3 m2/g, which enables HMCPN17 with high drug loading capability. The Ca2+ release from HMCPN17 is much faster at pH 6.8 than that at pH 7.4, which can be ascribed to the acid-triggered conversion of HMCPN17 to Ca2+ and H2O2, indicating a pH-responsive decomposition behavior of HMCPN17. The high drug loading contents of doxorubicin (DOX) and/or sorafenib (SFN) indicate that HMCPN17 can be employed as a generic drug delivery system (DDS). The in vitro and in vivo results reinforce the high calcicoptosis therapeutic efficacy of tumors by our HMCPN17 without drug loading, which can be attributed to the efficient accumulation in tumors and the ability of H2O2 and Ca2+ production at acidic TME. Our HMCPN17 has broad application prospect for construction of multi-drug-loaded composite nanomaterials with diversified functions for the treatment of tumors. Statement of significanceThe combination of hollow mesoporous nanomaterials and calcium peroxide nanoparticles has a wide range of applications in the synergistic treatment of tumors. In this study, hollow mesoporous calcium peroxide nanoparticles (HMCPN) were developed based on a simple hydrolysis-precipitation method for tumor calcicoptosis therapy without drug loading. The high drug loading contents of DOX and/or SFN indicate that our HMCPN can serve as a generic DDS. The experimental results demonstrated the high calcicoptosis therapeutic efficacy of HMCPN on tumors even without drug loading.

Facile preparation of zwitterionic core-shell nanogels for dual-functional coatings: Combining antifouling and antibacterial features in silicon implant model surface modification

To develop surface-coating technology for fabricating functionalized biomedical implant and overcome implant-associated bacterial infections, this study presented an innovative antifouling and antibacterial dual-functional nanogel coating methodology for engineering silicon-based biomedical implants/biochips. Firstly, zwitterionic core-shell PAA@(GMA/SBMA) nanogels were designed and prepared via reflux-precipitation polymerization and were characterized through NMR, FTIR, DLS, AFM and TEM. The nanogels exhibited uniform and spherical morphology, salt-ion responsiveness, and high lysozyme loading capability. Subsequently, the PAA@(GMA/SBMA) nanogels were covalently grafted onto the surface of silicon wafers, via an epoxy-amine ring-opening reaction, to prepare nanogel-coated silicon wafers (Si@nanogels). A comprehensive array of characterization techniques, including SEM-EDS, contact angle measurements, and XPS, validated the effective nanogel-coating. These coatings demonstrated notable resistance to protein adsorption, highlighting their robust antifouling properties. Upon loading with the antibacterial agent lysozyme, the nanogel coating displayed remarkable antibacterial efficacy against both Gram-negative (E. coli) and Grampositive (S. aureus) bacteria and effectively inhibited biofilm formation. Furthermore, the nanogel coatings exhibited good biocompatibility and dynamic stability, thus facilitating the surface-mediated adhesion and growth of fibroblast 3T3 cells. Significantly, this work provided a facile, economic and efficient surface modification approach to fabricate nanogel-coated antifouling/antibacterial dual-functional biomedical implant model towards potential clinical applications.

Construction of bupivacaine-loaded gelatin-based hydrogel delivery system for sciatic nerve block in mice.

Peripheral nerve blockade (PNB) is a common treatment to relieve postoperative pain. However, local anesthetics alone have a short duration of action and severe side effects during postoperative analgesia. In order to overcome these limitations, the present study reported an injectable hydrogel with a drug slow-release profile for regional nerve blockade. The injectable hydrogel was prepared by crosslinking with gelatin and NHS-PEG-NHS, which was degradable in the physiological environment and displayed sustainable release of anesthetics locally, thus improving the disadvantage of the high toxicity of local anesthetics. In this regard, we conducted a series of in vitro characterizations and proved that the hydrogel has a porous three-dimensional mesh structure with high drug loading capability, and sustainable drug release profile. And cytotoxicity experiments confirmed the good biocompatibility of the hydrogel. It was shown that using the animal sciatic nerve block model, the analgesic effect was greatly improved in vivo, and there was no obvious evidence of permanent inflammation or nerve damage in the block site's sections. This locally slow-release platform, combined with local anesthetics, is therefore a promising contender for long-acting analgesia.

Ultrastable Iodinated Oil-Based Pickering Emulsion Enables Locoregional Sustained Codelivery of Hypoxia Inducible Factor-1 Inhibitor and Anticancer Drugs for Tumor Combination Chemotherapy.

Tumor hypoxia-associated drug resistance presents a major challenge for cancer chemotherapy. However, sustained delivery systems with a high loading capability of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE exhibited facile injectability for intratumoral administration, great radiopacity for in vivo examination, excellent physical stability (>1 mo), and long-term sustained release capability of both hydrophilic drugs (i.e., acriflavine and doxorubicin). We found that the codelivery of acriflavine and doxorubicin from the PE promoted the local accumulation and retention of both drugs using an acellular liver organ model and demonstrated significant inhibition of tumor growth in a 4T1 tumor-bearing mouse model, improving the chemotherapeutic efficacy through the synergistic effects of direct cytotoxicity with the functional suppression of HIF-1 pathways of tumor cells. Such an iodinated oil-based PE provides a great injectable sustained delivery platform of hydrophilic drugs for locoregional chemotherapy.

Enhanced efficacy of β-carotene loaded solid lipid nanoparticles optimized and developed via central composite design on breast cancer cell lines

β-carotene is obtained from both plants and animals and has been the subject of intense research because of its provitamin-A, antioxidant, and anticancer effects. Its limited absorption and oxidative degradation significantly reduce its antitumor efficacy when taken orally. In our study, we utilize a central composite design to develop “bio-safe and highly bio-compatible” solid lipid nanoparticles (SLNs) by using only the combination of palmitic acid and poloxamer-407, a block co-polymer as a surfactant. The current research aim to develop and characterize SLNs loaded with β-carotene to improve their bioavailability and therapeutic efficacy. In addition, the improved cytotoxicity of solid lipid nanoparticles loaded with β-carotene was screened in-vitro in human breast cancer cell lines (MCF-7). The nanoparticles exhibits good stability, as indicated by their mean zeta potential of −26.3 ± 1.3 mV. The particles demonstrated high drug loading and entrapment capabilities. The fabricated nanoparticle's prolonged release potential was shown by the in-vitro release kinetics, which showed a first-order release pattern that adhered to the Higuchi model and showed a slow, linear, and steady release over 48 h. Moreover, a diffusion-type release mechanism was used to liberate β-carotene from the nanoparticles. For six months, the nanoparticles also showed a notable degree of physical stability. Lastly, using the MTT assay, the anti-cancer properties of β-carotene-loaded solid lipid nanoparticles were compared with intact β-carotene on MCF-7 cell lines. The cytotoxicity tests have shown that the encapsulation of β-carotene in the lipid bilayers of the optimized formulation does not interfere with the anti-cancer activity of the drug. When compared to standard β-carotene, β-carotene loaded SLNs showed enhanced anticancer efficacy and it is a plausible therapeutic candidate for enhancing the solubility of water-insoluble and degradation-sensitive biotherapeutics like β-carotene.

Switched CMOS current source compared to enhanced Howland circuit for bio-impedance applications.

Bio-impedance Spectroscopy (BIS) is a technique that allows tissue analysis to diagnose a variety of diseases, such as medical imaging, cancer diagnosis, muscle fatigue detection, glucose measurement, and others under research. The development of CMOS integrated circuit front-ends for bioimpedance analysis is required by the increasing use of wearable devices in the healthcare field, as they offer key features for battery-powered wearable devices. These features include high miniaturization, low power consumption, and low voltage power supply. A key circuit in BIS systems is the current source, and one of the most common topology is the Enhanced Howland Current Source (EHCS). EHCS is also used when the current driver is driven by a pseudo-random signal like discrete interval binary sequences (DIBS), which, due to its broadband nature, requires high performance operational amplifiers. These facts lead to the need for a current source more compatible with DIBS signals, ultra-low power supply, standard CMOS integrated circuit, output current amplitude independent of input voltage amplitude, high output impedance, high load capability, high output voltage swing, and the possibility of tetra-polar BIS analysis, that is a pseudotetra-polar in the case of EHCS. The objective of this work is to evaluate the performance of the Switching CMOS Current Source (SCMOSCS) over EHCS using a Cole-skin model as a load using SPICE simulations (DC and AC sweeps and transient analysis). The SCMOSCS demonstrated an output impedance of more than 20 MΩ, a ± 2.5 V output voltage swing from a +3.3 V supply, a 275 μA current consumption, and a 10 kΩ load capacity. These results contrast with the + 1.5 V output voltage swing, the 3 kΩ load capacity, and the 4.9 mA current of the EHCS case.

High-Stroke, High-Output-Force, Fabric-Lattice Artificial Muscles for Soft Robots.

Artificial muscles, providing safe and close interaction between humans and machines, are essential in soft robotics. However, their insufficient deformation, output force, or configurability usually limits their applications. Herein, this work presents a class of lightweight fabric-lattice artificial muscles (FAMs) that are pneumatically actuated with large contraction ratios (up to 87.5%) and considerable output forces (up to a load of 20kg, force-to-weight ratio of over 250). The developed FAMs consist of a group of active air chambers that are zigzag connected into a lattice through passive connecting layers. The geometry of these fabric components is programmable to convert the in-plane lattice of FAMs into out-of-plane configurations (e.g., arched and cylindrical) capable of linear/radial contraction. This work further demonstrates that FAMs can be configured for various soft robotic applications, including the powerful robotic elbow with large motion range and high load capability, the well-fitting assistive shoulder exosuit that can reduce muscle activity during abduction, and the adaptive soft gripper that can grasp irregular objects. These results show the unique features and broad potential of FAMs for high-performance soft robots.

Holmium (III)-doped multifunctional nanotheranostic agent for ultra-high-field magnetic resonance imaging-guided chemo-photothermal tumor therapy

Ultra-high-field (UHF) MRI has shown great advantages over low-field magnetic resonance imaging (MRI). Despite being the most commonly used MRI contrast agents, gadolinium chelates perform poorly in high magnetic fields, which significantly weakens their T1 intensity. In comparison, the rare element Holmium (Ho)-based nanoparticles (NPs) have demonstrated great potential as T2-weighted MRI contrast agents in UHF MRI due to their extremely short electron relaxation times (∼ 10−13s). In this study, a multifunctional nanotherapeutic probe was designed for UHF MRI-guided chemotherapy and photothermal therapy. The Ho (III)-doped mesoporous polydopamine (Ho-MPDA, HM) nanosphere was loaded with the chemotherapeutic drug mitoxantrone (MTO) and then coated with 4T1 cell membranes to enhance active targeting delivery to breast cancer. The prepared nanotherapeutic probe MTO@HMM@4T1 (HMM@T) exhibited good biocompatibility, high drug-loading capability and great potential as Ho (III)-based UHF MRI contrast agents. Moreover, the biodegradation of HMM@T in response to the intratumor pH and glutathione (GSH) promotes MTO release. Near-infrared (NIR) light irradiation of HM induced photothermal therapy and further enhanced drug release. Consequently, HMM@T effectively acted as an MRI-guided tumor-targeting chemo-photothermal therapy against 4T1 breast cancer. Statement of significanceUltra-high-field (UHF) MRI has shown great advantages over low-field magnetic resonance imaging (MRI). Although gadolinium chelates are the most commonly used MRI contrast agents in clinical practice, they exhibit a significantly decreased T1 relaxivity at UHF. Holmium exhibits outstanding UHF magnetic resonance capabilities in comparison with gadolinium chelates currently used in clinic. Herein, a theranostic nanodrug (HMM@T) was designed for UHF MRI-guided chemo-photothermal therapy. The nanodrug possessed remarkable UHF T2 MRI properties (r2 = 152.13 mM−1s−1) and high drug loading capability of 18.4 %. The biodegradation of HMM@T NPs under triple stimulations of pH, GSH, and NIR led to an efficient release of MTO in tumor microenvironment. Our results revealed the potential of a novel UHF MRI-guided multifunctional nanosystem in cancer treatment.

Three Dimensional Low-Tortuosity Carbon Fibers Enable High-Areal-Capacity and Long-Durability Battery

Increasing the thickness of lithium-ion battery electrodes enables significant improvement in energy density and reducing the manufacturing cost. However, the existing barriers such as manufacturing challenges, performance issues, and scalability impede the development of fabricating thick electrodes. Here, we demonstrate a three dimension, low-tortuosity, and metal current collector free carbon fiber (CF) electrode which works as an integrated host substrate for LiNi0.5Mn0.3Co0.2O2 (NMC 532) cathode materials, similarly, the paired anode. The low tortuosity (~ 1.7) aligned microchannels of CF provide a good electron conductivity (~ 0.23 S cm-1), low Li+ diffusion resistance (~ 22 Ω), and high reversibility (91% over 500 cycles at C/3) compared to ~ 0.01 S cm-1, ~ 34 Ω, and 50% over 50 cycles for 100 µm slurry-casting graphite electrode with tortuosity of 2.9, respectively. The large porosity (~ 60%) enables CF a high mass loading capability of NMC 532 (> 70 mg cm-2) which provides a theoretical areal capacity ~ 14 mAh cm-2. The practical design of NMC 532/CF versus CF thick cells, with NMC 532 mass loading 32 mg cm-2, and theoretical areal capacity ~ 5.5 mAh cm-2 show an initial discharge areal capacity 4.1 mAh cm-2 at C/3 (1.5 mA cm-2), a capacity retention of 90.4% (500 cycles), 78.1% (1000 cycles), and 65.5% (1500 cycles). Furthermore, the post-analysis of long-term cycled NMC 532 particles, with consistent morphology of pristine particles, demonstrates lessen thermal stress across the electrodes. Our work presents a well-aligned microstructure for thick lithium-ion electrodes with practical level, scalable manufacturing, high areal capacity, and long-term electrochemical durability.

Study on developing a multi-integrated textile system: investigating the liquid loading and release performances of hollow fiber yarns

Textile fabrics have a long history of use for a wide range of applications that satisfying the needs of livelihood. In this era of modernization and high technological advancements, the use of textiles has spread to include using man-made and nonconventional textiles. Among them, hollow fiber-based textiles have great application prospects due to their high surface-area-to-volume ratio, high loading capability, high active surface area and high permeability of the porous layer. Herein, the liquid loading and release performances of various hollow fiber yarns with different parameters (i.e. spinning methods, yarn count, loading amount, releasing rate, etc.) under optimized negative pressure are presented. Results showed that the hollow fiber vortex spun yarn (with yarn count Ne 10/1) had the highest loading ability under negative pressure. Moreover, the amount of liquid loaded into the yarns first increased rapidly and then the rate became slower with an increase of loading time and finally tended to a stable value. In addition, as the release time increases, the amount of liquid released from the hollow fiber yarns became higher and the release rate became lower. These findings provide an important foundation for the development of the multi-integrated textile system, which is comprises the controllable loading and delivery of various types of active substances and chemicals.

Black Phosphorus/V3C2 MXene Layered Heterostructure as a Sustainable Cathode Material for Li-Ion Battery: An Ab Initio Study

Layered heterostructures have been recognized as next generation cathode materials for ion batteries owing to their high mobility and ion loading capability. Herein, we report black phosphorus (BP)/MXene layered heterostructures (BP/V3C2, BP/V3C2N2, BP/V3C2O2, and BP/V3C2Cl2) and their computational investigation for Li-ion battery. First-principles calculations have been carried out for Li ion intercalation followed by computing open-circuit voltage (ranges from 1.08 to 2.17 V for BP/V3C2, 3.78 to 1.79 V for BP/V3C2N2, 2.97 to 2.04 V for BP/V3C2O2, and 1.84 to 2.12 V for BP/V3C2Cl2), adsorption energy (−1.87 eV per Li atom for BP/V3C2, −2.49 eV per Li-atom for BP/V3C2N2, −2.25 eV per Li atom for BP/V3C2O2, and −1.92 eV per Li-atom for BP/V3C2Cl2), and diffusion barrier. Notably, the optimized BP/V3C2 layered heterostructure exhibits 630.320 mAh g–1 Li storage capacity which is significantly higher than the earlier reported 2D cathode materials. Our simulated results indicate that BP/V3C2, BP/V3C2N2, BP/V3C2O2, and BP/V3C2Cl2 layered heterostructures can be considered as favorable cathode materials for sustainable Li-ion batteries.

Thymol-Nanoparticles as Effective Biocides against the Quarantine Pathogen Xylella fastidiosa.

Quarantine pathogens require the investigation of new tools for effective plant protection. In particular, research on sustainable agrochemicals is the actual challenge. Plant extracts, essential oils, and gels are natural sources of efficient biocides, such as aromatic secondary metabolites. Thymol is the major phenolic constituent of thyme and oregano essential oils, and it can inhibit many pathogenic microbes. Thymol nanoparticles were obtained through adsorption on CaCO3 nanocrystals, exploiting their carrier action. High loading efficiency and capability were reached as verified through UV and TGA measurements. We report the first study of thymol effect on Xylella fastidiosa, conducing both fluorometric assay and in vitro inhibition assay. The first test confirmed the great antibacterial effect of this compound. Finally, an in vitro test revealed an interesting synergistic action of thymol and nanocarriers, suggesting the potential application of thymol-nanoparticles as effective biocides to control Xylella fastidiosa infection.

Ethanol-mediated synthesis of γ-cyclodextrin-based metal-organic framework as edible microcarrier: performance and mechanism

Here, an ethanol-mediated method was introduced to fabricate γ-cyclodextrin-based metal–organic frameworks (γ-CD-MOFs) as microcarriers for epigallocatechin-3-gallate (EGCG). Through adjusting ethanol gas diffusion temperature and ethanol liquid feed speed, we achieved control of crystallization efficiency and crystals size without extra surfactants. Under the sequential regulatory by ethanol in two phases, the obtained γ-CD-MOFs with cubic shape exhibited excellent crystallinity, high surface area, and uniform size distribution. Through the interplay of hydrogen bonding, hydrophobic interactions and π stacking, EGCG molecules could be stored efficiently within cavities and tunnels of the γ-CD-MOFs with high load capability of 334 mg g−1. More importantly, the incorporation of EGCG within frameworks wouldn’t disintegrate the unique body-centered cubic structure of γ-CD-MOFs, in turn, would improve the thermostability and antioxidative activity of EGCG. Significantly, all food-grade materials ensured the γ-CD-MOFs high acceptance and applicability for food and biomedical applications.

Angular bandwidth for the non-focusing stimulated Brillouin scattering pulse compression

Laser pulse duration compression by stimulated Brillouin scattering (SBS) with a non-focusing scheme is a suitable candidate for high energy sub-nanosecond pulse generation owing to its high load capability and simple structure. The angular deviation of the feedback seed from the pump light path has a serious impact on the non-focusing SBS pulse compression. In this paper, we study the influence of this effect both numerically and experimentally. Firstly the pulse compression characteristics of 20th-order super-Gaussian-shaped pulses with 5 ns duration are analyzed theoretically. Then an experiment was carried out with a single-frequency high power Nd:glass laser system at the frequency-doubled wavelength of 527 nm which delivers 5 ns super-Gaussian-shaped pulses with single pulse energy over 10 J. Heavy fluorocarbon liquid FC-40 was used as the active SBS medium. The compressed pulse duration of sub-400 ps with an energy efficiency of ∼ 50 % is obtained when the laser is normally incident on the rear cell window. ± 4° deviation between the feedback Stokes light and pump laser halves the energy efficiency and doubles the compressed pulse duration. The experimental results agree well with the numerical calculations. The results of this paper will provide a basis for the design of self-pumped SBS pulse compressor and pave a way for higher energy sub-nanosecond pulse generation in the future.