High Level Of Interaction Research Articles

Imidazopyridine Hydrazine Conjugates as Potent Anti‐TB Agents with their Docking, SAR, and DFT Studies

AbstractNovel imidazopyridines hydrazine conjugates were designed and synthesized for their anti‐tubercular (anti‐TB) activity. A cytotoxicity assay was conducted with Vero cells to determine the safety profile of the most effective compounds. It was found that compound (IA3) (MIC=0.78 μM) and (IA8) (MIC=1.12 μM) were nearly 3.7 and 2.5 times more active than pyrazinamide. Based on Density functional theory (DFT), these molecules exhibited better charge transfer between molecular orbital's, which made them suitable for biological applications. Molecular docking on Mycobacterium tuberculosis InhA bound to NITD‐916 (PDB: 4R9S) revealed that compounds possessed greater binding affinity towards proteins. In addition, the most active anti‐TB compounds (IA3) and (IA8) exhibited high levels of interaction with the target protein and exceptional safety profile, suggesting they may prove to be effective leads for new drugs.

Communal nesting shapes the sex-dependent glutamatergic response to early life stress in the rat prefrontal cortex

IntroductionEarly social environment, either positive or negative, shapes the adult brain. Communal nesting (CN), a naturalistic setting in which 2-3 females keep their pups in a single nest sharing care-giving behavior, provides high level of peer interaction for pups. Early social isolation (ESI) from dam and siblings represents, instead, an adverse condition providing no peer interaction.MethodsWe investigated whether CN (enrichment setting) might influence the response to ESI (impoverishment setting) in terms of social behavior and glutamate system in the medial prefrontal cortex (mPFC) of adult and adolescent male and female rats.ResultsPinning (a rewarding component of social play behavior) was significantly more pronounced in males than in females exposed to the combination of CN and ESI. CN sensitized the glutamate synapse in the mPFC of ESI-exposed male, but not female, rats. Accordingly, we observed (i) a potentiation of the glutamatergic neurotransmission in the mPFC of both adolescent and adult males, as shown by the recruitment of NMDA receptor subunits together with increased expression/activation of PSD95, SynCAM 1, Synapsin I and αCaMKII; (ii) a de-recruiting of NMDA receptors from active synaptic zones of same-age females, together with reduced expression/activation of the above-mentioned proteins, which might reduce the glutamate transmission. Whether similar sex-dependent glutamate homeostasis modulation occurs in other brain areas remains to be elucidated.DiscussionCN and ESI interact to shape social behavior and mPFC glutamate synapse homeostasis in an age- and sex-dependent fashion, suggesting that early-life social environment may play a crucial role in regulating the risk to develop psychopathology.

Sociocultural risks of resource extraction for the low-carbon energy transition: Evidence from the Global South

The ongoing global transition to low-carbon energy relies on access to energy transition minerals (ETMs), bringing to life new mining projects. This shift is particularly impacting the Global South, due to high levels of interaction of mineral deposits with territories of Indigenous peoples and peasants, weak governance and remoteness. Focusing on the sustainability and justice of energy transitions, previous research has identified a range of environmental and social impacts of ETM mining across Global South countries. We argue that current research overlooks impacts of energy transition-related mining on tangible and intangible cultural heritage of land-connected people. This paper seeks to address this gap by examining the intersection of ETM mining and sociocultural practices in the Global South from spatial, governance and justice perspectives. Based on an extensive literature review, this article critically addresses key themes in the literature on the social aspects of energy transitions and uses cases from Ghana, the Democratic Republic of Congo (DRC), Chile, and Papua New Guinea (PNG) to demonstrate the immediate and long-term sociocultural impacts associated with ETM mining. It is important to foster an all-encompassing approach to planetary just energy transitions that places equal weight on ensuring cultural alongside environmental, economic and social sustainability.

The effect of retirement eligibility on mental health in the United Kingdom: Heterogeneous effects by occupation.

I investigate heterogeneity across occupational characteristics in the effect of retirement eligibility on mental health in the United Kingdom. I use K-means clustering to define three occupational clusters, differing across multiple dimensions. I estimate the effect of retirement eligibility using a Regression Discontinuity Design, allowing the effect to differ by cluster. The effects of retirement eligibility are beneficial, and greater in two clusters: one comprised of white-collar jobs in an office setting and another of blue-collar jobs with high physical demands and hazards. The cluster with smaller benefits mixes blue- and white-collar uncompetitive jobs with high levels of customer interaction. The results have implications for the distributional effect of raising the retirement age.

The Role of Whatsapp Business in Increasing Consumer Engagement by Implementing Dewa Eka Prayoga Marketing Techniques

The development of digital communication technology has changed the marketing paradigm, with WhatsApp Business becoming one of the popular platforms companies use to interact with customers. Effective marketing techniques such as those developed by Dewa Eka Prayoga, a well-known practitioner in the field of marketing, have become a concern in efforts to increase consumer engagement. This research aims to investigate the role of WhatsApp Business in increasing consumer engagement by applying Dewa Eka Prayoga marketing techniques. This research focuses on understanding the extent to which WhatsApp Business and Dewa Eka Prayoga's marketing techniques can increase consumer interaction and engagement. This research uses a quantitative research method with data collection using a questionnaire. The respondents were randomly selected from the target population of WhatsApp Business users who have used the Dewa Eka Prayoga marketing technique. The questionnaire was structured based on consumer involvement dimensions and the effectiveness of marketing techniques, and it was analyzed using descriptive and inferential statistical methods. This research analysis shows that WhatsApp Business significantly increases consumer engagement when applied with the Dewa Eka Prayoga marketing technique. The high level of interaction between companies and consumers via WhatsApp Business positively influences consumer perceptions, as well as increases the level of consumer satisfaction and loyalty. This research concludes that WhatsApp Business is an effective tool for increasing consumer engagement when used together with Dewa Eka Prayoga's marketing techniques. Companies can use this platform to strengthen consumer relationships, expand marketing reach, and increase customer loyalty.

Untangling the truth: User engagement with misinformation in toothache-related Facebook posts.

Social media is a platform for sharing views on aspects of life, including oral health. This study aimed to characterize Facebook posts related to toothache information. Two independent investigators retrieved 500 English-language posts with the highest level of interaction using CrowdTangleTM and analyzed their facticity, motivation, author's profile, content, sentiment, and type of post. Data were analysed descriptively and using Pearson's Chi-square and Mann-Whitney U tests and multiple logistic regression models. Most posts were produced by regular users and were not financially motivated, although commercial posts had significantly higher total interaction among users. While link- or video-containing posts (OR = 1.66) and posts with positive sentiments (OR = 1.53) were associated with users' total interaction, older (OR = 1.81) and link- or video-containing posts (OR = 2.04) were associated with overperforming scores. Misinformation was positively associated with financial motivation (OR = 2.03) and positive sentiments (OR = 3.79). This study highlights the importance of addressing the spread of misinformation related to oral health on social media and taking steps to ensure that accurate and reliable information is readily available. Toothache-related misinformation was associated with positive sentiments and financial motivation. Links, videos, and positive sentiments awakened greater user engagements with toothache-related posts.

Dreaming of new musical interaction – the interactive music in the project Dream

ABSTRACT Dream was an online live performance in early 2021 and was a collaboration between several partners, among them Royal Shakespeare Company, the Philharmonia Orchestra, Marshmallow Laser Feast, Manchester International Festival and EPIC Games. The stated goal of Dream was to explore new ways of interacting with audiences while bridging the disciplines of theatre, music, video games and other forms of digital media. The musical goals were to enable a high level of musical interactivity while at the same time coupling that with the use of high-quality recorded orchestral music. This article is not a study of the Dream project as a whole, but focuses on the interactive music that was generated in realtime by the actors and powered by Reactional Music. Apart from briefly discussing the technology itself, this article will describe and analyse some of the working processes involved in composing interactive music, as well as discuss some of the future implications of the use of technology from the video game industry in new areas such as live performances and audience interaction. The aim of this is to see if it’s possible to envision what kind of new artistic output that can come from these new technological environments.

Experimental analysis of a photovoltaic self-consumption system for the offices of a local company

The article analyzes the prospect of a solution for the mutual interaction of a photovoltaic generator and the local electrical grid, within the context of electrifying the offices of a hydrocarbon storage facility. The idea is to examine the operational performance of a system that enables the maximum self-consumption of energy generated by a small-scale photovoltaic system installed on the facility's site. Such a system could prove beneficial for multiple consumers operating in a complex energy environment. The issue is scrutinized based on experimental data from a real case in Dakar, Senegal. An installation with a photovoltaic system of approximately 17 kWp peak power is monitored for a year to assess the reliability of the self-consumption photovoltaic system for a broader application. The data encompasses both the functioning of the photovoltaic system and its interaction with the electrical grid. The potential use of this solution in the context of promoting self-consumption policies to reduce electricity consumption expenses is discussed and analyzed, revealing a relatively high level of interaction with the electrical grid. Despite maintenance costs, the photovoltaic system proves to be cost-effective.

Microalgae bio-reactive façade: Location and weather-based systematic optimization

This article explores the design of microalgae biofaçade thanks to a numerical model describing the system’s thermal and biological behavior. Design options (single vs. double glazing, radiation-selective film, culture reservoir thickness) and operation strategies (light transmission, microalgae strain, sparged air origin, boiler fumes reuse) are screened systematically. The context for this investigation was the city of Marseille over a 10-year period (2013 to 2022) for which detailed meteorological data were available (air temperature, wind velocity and orientation, cloud cover, at a 3-hour resolution). These investigations revealed a very high level of interaction between the parameters (assessed by H2 Friedman index), making the system notoriously complicated to design and optimize. Nevertheless, some conclusions can be drawn. In France, fitting double glazing equipped with a greenhouse radiation-selective film is essential to harness as much heat as possible (＋16.7 % and ＋6.5 % of operation duration over year 2018, respectively). Similarly, a thermophilic strain is not relevant because overheating events are inexistent in well-designed systems. Further refinements, such as the origin of the air blown into the culture reservoir and the reuse of combustion fumes from the boiler (＋2.1 % performance), were evaluated from a technical point of view. However, their implementation would also be subjected to other considerations, such as the financial costs and environmental benefits. Finally, the model was applied to design the most efficient possible microalgae biofaçade system in the case of a hypothetical official building renovation.

Privacy computing meets metaverse: Necessity, taxonomy and challenges

Metaverse, the core of the next-generation Internet, is a computer-generated holographic digital environment that simultaneously combines spatio-temporal, immersive, real-time, sustainable, interoperable, and data-sensitive characteristics. It cleverly blends the virtual and real worlds, allowing users to create, communicate, and transact in virtual form. With the rapid development of emerging technologies including augmented reality, virtual reality and blockchain, the metaverse system is becoming more and more sophisticated and widely used in various fields such as social, tourism, industry and economy. However, the high level of interaction with the real world also means a huge risk of privacy leakage both for individuals and enterprises, which has hindered the wide deployment of metaverse. Then, it is inevitable to apply privacy computing techniques in the framework of metaverse, which is a current research hotspot. In this paper, we conduct comprehensive research on the necessity, taxonomy and challenges when privacy computing meets metaverse. Specifically, we first introduce the underlying technologies and various applications of metaverse, on which we analyze the challenges of data usage in metaverse, especially data privacy. Next, we review and summarize state-of-the-art solutions based on federated learning, differential privacy, homomorphic encryption, and zero-knowledge proofs for different privacy problems in metaverse. Finally, we show the current security and privacy challenges in the development of metaverse and provide open directions for building a well-established privacy-preserving metaverse system. For easy access and reference, we integrate the related publications and their codes into a GitHub repository: .

Interaction Assessment of a Social-Care Robot in Day center Patients with Mild to Moderate Cognitive Impairment: A Pilot Study

As dementia-induced impairments of daily functioning escalate, novel cognitive stimulation techniques utilizing technological advances, like social robots, have surfaced. This study examines the interaction level of the EBO social-care robot with day center patients in Cáceres, Extremadura, Spain. The study uses systematic video analysis as a method of interaction assessment. This observational pilot study was performed on patients above 65 with mild to moderate cognitive impairment (Minimental State Examination ≥\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\ge $$\\end{document} 21) receiving cognitive therapy at the AZTIDE social and health center. Two individualized 10–15 min sessions, replicating the Wizard of Oz technique, were conducted per participant, with the human operator’s commands being unnoticeably executed by the EBO robot. Of the six participants involved, all maintained complete eye contact with the robot, with 83.3%\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\%$$\\end{document} of the interactions recording maximum attention. Participants felt comfortable and calm, rating conversational factors such as attentiveness and naturalness as ’good’ or ‘excellent’. The high interaction level with the EBO robot suggests it as a promising tool for cognitive stimulation in patients with mild to moderate cognitive impairment. The systematic video evaluation also appears effective in assessing user–robot interaction, thus underscoring its potential utility in future social robotics research.

The role of trust as an informal social mechanism for contract enforcement among young women microenterprises in financial markets in sub-Saharan Africa

PurposeThe main purpose of this paper is to establish whether trust plays a significant mediating role in the relationship between access to microcredit and survival of young women microenterprises in under-developed financial markets in sub-Saharan Africa. The main focus of this paper is to specifically test whether relational social capital built by young women from homogeneous and heterogeneous groups can be more effective in promoting economic exchange in under-developed financial markets since interpersonal trust has recently been found to harbor group collusion, especially among kins. Overall, the paper distinguishes trust among individuals based on their age, gender and ethnic diversity.Design/methodology/approachThis study used structural equation model to test whether trust significantly mediates the relationship between access to microcredit and survival of young women microenterprises using Analysis of Moments Structures (AMOS) based on recommendations by Hair et al. (2022) and Baron and Kenny (1986).FindingsThe findings from this study revealed that trust significantly and positively mediate the relationship between access to microcredit and survival of young women microenterprises in under-developed financial markets in sub-Saharan Africa. Trust developed from relational social capital among young women from homogeneous and heterogeneous groups create a stronger basis for economic exchange in under-developed financial markets.Research limitations/implicationsWhile this study generates a positive evidence on the impact of access to microcredit on survival of young women microenterprises, the results cannot be over emphasized and generalized because the data were collected from only a single developing country. Future research may extend the current study to include other developing countries to make a more justified comprehensive analysis.Practical implicationsThe findings from this study highlights the importance of using a blend of social policy guided by norms combined with formal regulations as an informal contract enforcement mechanism to achieve efficient economic exchange in under-developed financial markets. Relational social capital formed on the basis of informal norms among groups from diverse population can supplement formal laws to enforce contractual obligations in microcredit access, especially among youthful microentrepreneurs, who seems to have stronger relational behaviors than adults. Financial institutions such as banks should use informal contract enforcement system to increase the scope of financial inclusion of young microentrepreneurs, especially in unbanked rural communities in sub-Saharan Africa, Uganda inclusive where formal laws are weak and sometimes not functional. The findings also show that younger people have a stronger relationship behavior than adults. Therefore, policy should create structures that can promote social activities among youth. Governments in sub-Saharan Africa, Uganda inclusive through their respective Ministry of Gender, Labour and Youth Affairs should create youth clubs that can increase interaction and relational social capital among the younger population to derive economic empowerment. sub-Saharan African governments, Uganda inclusive should rely more on social policy based on relational social capital as a missing link to promote and achieve economic development.Originality/valueThis paper provides an evidence on the unique role of age, gender and ethnicity in information sharing and exchange based on social policy in the financial market to limit group collusion. The authors indicate that diversity in relational social capital among young women microentrepreneurs prohibit strategic defaults, which promotes access to microcredit for survival of women micro small and medium enterprises (MSMEs) through socialization. High level of interaction among younger women microentrepreneurs from homogeneous and heterogeneous groups allow them to close the information gap to timely meet borrowing contractual obligations to derive economic benefits. The paper shows that younger women have more trust than older women while searching for economic value through socialization. In fact, social policy can wholly supplement formal policy to promote growth and survival of young women microenterprises, especially in sub-Saharan Africa, Uganda inclusive.

Blended and online learning: what works and why in primary and secondary schools. Evidence from Northern Ireland

ABSTRACT Data from a sample of teachers, parents and pupils in Northern Ireland about their experiences of blended and online learning during the pandemic has thrown light on effective practice and some of the reasons for this. After an initial period of uncertainty and confusion, most of the five schools studied found ways to provide regular online lessons which in many cases had high levels of interaction between teachers and pupils and in some cases between pupils. This was true also in schools which had high levels of pupil disadvantage measured through entitlement to free school meals. The reasons for the emergence of good practice were the prior investment in ICT facilities for every school, the support provided through educational authorities and local teacher networks, and the quality of leadership in schools.

An Investigation of the Intercultural Sensitivity Levels of Summer Work and Travel Programme Students

A variety of programmes and schemes make travel more affordable and attractive for young people. They provide opportunities to experience intercultural communication first-hand to those who could not have imagined without being involved in such institutionalized schemes. One such programme is Work & Travel which is offered in the USA. Young people who gain hands-on experience in the USA can potentially gain intercultural skills. A few studies have focused on to what extent this experience could live up to the expectations (1 reference). There is a lack of research on the impact of Summer Work and Travel (SWT) participants and the factors affecting their levels of intercultural sensitivity, especially in the Turkish context. Therefore, the current study aims to measure the intercultural sensitivity (IS) of the SWT participants from Türkiye and the factors which impact their level of IS. The sequential mixed method was used, and the quantitative data was first gathered via a five-point Likert scale with 129 participants. Semi-structured interviews with ten volunteering participants followed the quantitative data collection phase. It was concluded from the data analysis that the participants in the SWT experience had a high level of IS. While some participants had less confidence due to their insufficient language proficiency, they reported that they became more confident as they improved their language skills and adapted to the intercultural environment. The researchers also concluded that the high IS might have resulted from the participants’ high level of daily interaction with people from different cultures and at the social events they attended.

The Proteomic Analysis of Cancer-Related Alterations in the Human Unfoldome.

Many proteins lack stable 3D structures. These intrinsically disordered proteins (IDPs) or hybrid proteins containing ordered domains with intrinsically disordered protein regions (IDPRs) often carry out regulatory functions related to molecular recognition and signal transduction. IDPs/IDPRs constitute a substantial portion of the human proteome and are termed "the unfoldome". Herein, we probe the human breast cancer unfoldome and investigate relations between IDPs and key disease genes and pathways. We utilized bottom-up proteomics, MudPIT (Multidimensional Protein Identification Technology), to profile differentially expressed IDPs in human normal (MCF-10A) and breast cancer (BT-549) cell lines. Overall, we identified 2271 protein groups in the unfoldome of normal and cancer proteomes, with 148 IDPs found to be significantly differentially expressed in cancer cells. Further analysis produced annotations of 140 IDPs, which were then classified to GO (Gene Ontology) categories and pathways. In total, 65% (91 of 140) IDPs were related to various diseases, and 20% (28 of 140) mapped to cancer terms. A substantial portion of the differentially expressed IDPs contained disordered regions, confirmed by in silico characterization. Overall, our analyses suggest high levels of interactivity in the human cancer unfoldome and a prevalence of moderately and highly disordered proteins in the network.

Transcriptomic Analysis of Metastatic Colorectal Tumor with Low Mutational Burden

Objective: To identify potential drug targets for metastasis colorectal cancer (CRC) patients with low mutational burden by examining differences in immune-related gene expression. Methods: For this study, 623 samples were collected from The Cancer Genome Atlas (TCGA) database, comprising tumor mutational burden (TMB), RNA sequencing (RNA-Seq), and clinical data. Differential gene expression analysis, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the identified genes were conducted using the R package. Additionally, a comparative analysis of immune infiltrating cell composition in metastatic and non-metastatic groups was performed. Hub genes, exhibiting high levels of interaction, were selected using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database. The Drug Gene Interaction Database (DGIdb) was then utilized to estimate drugs targeting the identified hub genes. Results: The transcriptome data of 326 colorectal cancer patients with low TMB were analyzed, comprising 58 patients with metastasis and 268 patients without metastasis. Among the differential expression in 1,111 genes for patients with metastasis compared to those without metastasis, 733 genes were upregulated, and 378 genes were downregulated. KEGG and GO enrichment analysis indicated significant differences in gene expression in CRC metastatic patients with low TMB compared to non-metastasis patients with low TMB. Enriched pathways included humoral immuneresponse, immunoglobulin production, and regulation of AMPA receptor activity. Two genes related to interleukin-12 were identified through secondary enrichment for immune-related genes. Analysis of tumor-infiltrating immune cell data revealed significant differences in memory-activated T cell CD4 and T cell CD8. Conclusions: This analysis of RNA sequencing data and immune-filtrating cell data revealed significant differences between metastatic colorectal cancer patients with low TMB and their non-metastatic counterparts. These distinctions suggest the possibility of identifying more effective drugs or therapies for metastatic colorectal cancer patients with low TMB.

High interaction potential of online-only courses with breakout sessions-results of apilot study

The flipped classroom (FC) is nowadays apopular principle of blended student-centered learning. Students first prepare basic knowledge at home and subsequently meet for consolidation and amore in-depth look at acertain topic. During the COVID-19 pandemic, several groups developed approaches to also transform the characteristic FC second session into an online-only format. Herein, we present apilot study on establishing an online-only FC format with elements of collaborative learning and its evaluation by medical students. The FC design related to diseases of the salivary glands was transformed into an online-only event. After studying the basic information online, supported by self-made interactive videos and/or lecture recordings, students met in avideo conference enriched by breakout sessions, interactive demonstration of the related clinical examination including ultrasound, and aformative assessment. Aquestionnaire with 27items was answered by participants to evaluate the concept and the event. Use of common hard- and software systems led to atechnically stable video conference. Atotal of 55students completed the questionnaire and were included into data analysis. During the breakout sessions, lively interaction between participants was observed. The evaluation of both the event itself and the related learning progress showed good results despite the lack of preparation beforehand in 27% of participants. Online-only FC designs can result in high satisfaction. High quality of online preparation, asolid technical platform, accurate time management, and areasonable selection of topics are the main parameters contributing to successful course design. Nowadays, embedding medical imaging can be realized in appropriate quality for educational purposes. The implementation of breakout sessions and voting tools enables collaborative online learning with high levels of interaction and satisfaction for both teachers and students.

Influence of starch-protein interactions on the digestibility and chemical properties of a 3D-printed food matrix based on salmon by-product proteins

This study evaluated the influence of starch-protein interactions on the chemical properties and digestibility of a 3D-printed gel based on salmon by-product protein. Changes in the starch-protein interactions of the stable cornstarch (CS, 15%) and salmon protein isolate (SPI, 4%–12%) printable gels during the in vitro gastrointestinal digestion process were studied by principal component analysis. Protein-rich printed gels increased resistant starch content by 18.05%. Changes in chemical properties and the starch-protein concentration of the gels during the digestion process were highly correlated. The CS-SPI gels in the gastric and intestinal phases exhibited lower α-helix/β-sheet ratio and fluorescence intensity values, whereas surface hydrophobicity increased. This resulted in more ordered structures with a high level of molecular interaction that inhibited enzymatic hydrolysis. This study provides crucial information about the transformations of starch-protein interactions during the digestibility of 3D-printed food matrices as an alternative source of nutrients with a high nutritional quality.

Research on the application of digital media technology in museum exhibition design: A case study of the national museum of Singapore

There is a profound transformation in museum exhibition design. The ubiquitous digital media technology is driving the rapid evolution and development of museums. This trend is particularly evident in the need for diverse presentation methods to facilitate a high level of interaction and integration between audiences and exhibits. This research aims to explore the application of digital media technology in museum exhibition design, with the National Museum of Singapore as the research object. Through an in-depth examination of the digitalized exhibition projects in the National Museum of Singapore, insights can be acquired into how these technologies have changed the exhibition methods of museums and enriched the visitors’ experience. This thesis will focus on the application, impact, and potential future development trends of digital media technology in museum exhibition design. The findings of this study can serve as valuable experiences and insights for other museums in the application of digital media technology.

Effect of Inquiry Based Learning on Academic Achievement of Students at Higher Secondary Level

Introduction: This study aims to investigate the impact of Inquiry-Based Learning (IBL) on the academic achievement of students in accounting at the higher secondary school level. The research objective was to assess the effectiveness of IBL compared to traditional teaching methods. Methodology: The study involved forming control and experimental groups based on pre-test scores. Over eight weeks, lesson plans were implemented using IBL for the experimental group, while the control group received instruction through traditional methods. Pre-tests served as post-tests and for retention. Ethical considerations were adhered to throughout the research process. Results/Findings: Analysis using t-test revealed that students taught with IBL demonstrated significantly higher academic achievement compared to those taught with traditional methods. This suggests that IBL is more effective in enhancing learning outcomes in accounting at the higher secondary school level. Future Direction: It is recommended that teachers incorporate IBL more frequently in accounting classrooms at the higher secondary level. Additionally, fostering high levels of interaction through questioning is encouraged to promote student involvement, learning enhancement, and motivation.