High-intensity Resistance Exercise Research Articles

Acute effects of the sequence of concurrent high-intensity resistance and endurance exercises in recreational athletes

This study aimed to assess the acute effects of the sequence of concurrent training (CT) on physiological, neuromuscular, and perceptive parameters in recreational athletes. Eighteen active men (mean ± SD: 22.00 ± 2.00 years; 79.40 ± 9.87 kg and 175.62 ± 6.35 cm) performed two CT sessions consisting of repeated sprint endurance exercise followed by resistance exercise (E-R) or the reverse sequence (R-E) in a randomized order. The E exercise consisted of 6x30s of cycling “all-out” interspersed by 15s of passive recovery, while the R exercise consisted of 3x15 repetitions near failure (1 repetition in reserve) of back squat exercise with rest intervals of 45s. Height in CMJ, heart rate (HR), rating of perceived exertion (RPE) after each exercise, and at the final of the session (sRPE) were recorded. The R-E sequence showed a higher HR at 10s, 1min and 6min (p < .05) post E exercise compared to R exercise. Significant protocol x time interactions were observed for sRPE (p < .001) being higher after the R-E sequence compared to E-R sequence. RPE was significantly higher (p < .01) after E exercise compared to R exercise in both sequences, without differences between the E exercises. However, there were significant differences between the R exercises (p < .01) being higher in the R-E sequence. Our results suggest that the order of exercises during CT affects the second exercise when performed in a R-E sequence, with more cardiovascular stress and higher perceived exertions.

Fetal Heart Rate During Moderate To High Intensity Resistance Exercise In Pregnant Individuals

Fetal Heart Rate During Moderate To High Intensity Resistance Exercise In Pregnant Individuals

Design of the VOILA-intervention study: A 12-week nutrition and resistance exercise intervention in metabolic or mobility compromised Dutch older adults and the response on immune-metabolic, gut and muscle health parameters

BackgroundExercise and nutrition interventions can slow ageing-induced decline in physiology. However, effects are heterogeneous and usually studied separately per outcome domain. In the VOILA study, we simultaneously study various health outcomes relevant for older adults and the inter-individual heterogeneity in response to a lifestyle intervention. MethodsVOILA is a 12-week lifestyle intervention in 3 groups of older adults (≥60 years), with compromised mobility (n=50), compromised metabolic health (n=50), or recovering from total knee replacement (TKR, n=70, of which 20 randomized to standard care only). The intervention includes high-intensity resistance exercise training thrice weekly, nutritional counselling, and nutritional supplements every morning and evening (including 20-25g whey protein and (evening only) 5.5g Biotis™ GOS). We measure immune-metabolic, gut health, muscle mass and physical functioning at baseline and after completion of the intervention/standard care. An additional reference group of healthy older adults (n=50) will undergo baseline measurements only. DiscussionImprovements in various physiological systems are expected, but with differences between groups/individuals. This study will provide insights into how the physiological state of older adults influences the extent of lifestyle-induced health improvements to create better tailored interventions to attenuate biological ageing and improve the health span of subgroups and individuals.

Remote Ischemic Preconditioning Does Not Attenuate Arterial Stiffening Following Acute High-Intensity Resistance Exercise

Remote Ischemic Preconditioning Does Not Attenuate Arterial Stiffening Following Acute High-Intensity Resistance Exercise

High-intensity resistance training and collagen supplementation improve patellar tendon adaptations in professional female soccer athletes.

We investigated whether 10 weeks of pre-season soccer training (including high-intensity resistance exercise) with hydrolysed collagen (COL) supplementation would confer greater changes in patellar tendon (PT) mechanical and material properties compared with placebo (PLA) in professional female soccer athletes. Eleven athletes from the first team squad of a Football Association Women's Championship soccer club volunteered to participate in this study (age, 25.7±4.2 years; height, 1.68±0.04m; mass, 64.0±4.6kg). Participants were pair-matched for baseline knee extensor maximum isometric voluntary contraction torque, age, height and mass and were randomly assigned to the COL group (n=6) or PLA group (n=5). Participants were given 30g COL or energy-matched (36.5g maltodextrin and 8.4g fructose) PLA, plus 500mg vitamin C before each training session, which consisted of high-intensity lower-limb resistance exercise, plyometric or pitch-based exercise 3 days/week for 10weeks during the pre-season period. We assessed knee extensor maximum isometric voluntary contraction torque and PT properties using isokinetic dynamometry and ultrasonography before and after the intervention. The PT stiffness [COL, +15.4%±3.1% (d=0.81) vs. PLA, +4.6%±3.0% (d=0.32), P=0.002] and Young's modulus [COL, +14.2%±4.0% (d=0.65) vs. PLA, +3.4%±2.8% (d=0.15), P=0.004] increased more in COL than in PLA. There was a main effect of training on PT cross-sectional area (P=0.027), but no interaction effect (P=0.934). To conclude, 10 weeks of pre-season soccer training (incorporating high-intensity resistance exercise) with 30g COL increased PT stiffness and Young's modulus more than training alone in professional female soccer athletes. This has positive implications for improving athletic performance and mitigating injury risk.

Study protocol for the ROLEX-DUO randomised placebo-controlled trial: ROmosozumab Loaded with EXercise – DUal effects on bone and muscle in postmenopausal Osteoporosis and Osteopenia

IntroductionNovel strategies are needed to address the rising burden of osteoporosis and fragility fractures. High-intensity resistance and impact (HiRIT) exercise has shown benefit in improving bone density in postmenopausal women...

Acute Effects of High-Intensity Resistance Exercise on Recognition of Relational Memory, Lactate, and Serum and Plasma Brain-Derived Neurotrophic Factor.

Baumgartner, NW, Belbis, MD, Kargl, C, Holmes, MJ, Gavin, TP, Hirai, DM, and Kao, S-C. Acute effects of high-intensity resistance exercise on recognition of relational memory, lactate, and serum and plasma brain-derived neurotrophic factor. J Strength Cond Res XX(X): 000-000, 2024-Acute aerobic exercise improves memory, but this phenomenon is understudied in response to resistance exercise (RE) despite evidence that RE-induced increases in lactate and brain-derived neurotrophic factor (BDNF) play mechanistic roles in memory performance. To determine the acute effect of RE on lactate, BDNF, and their associations with object and relational memory, blood lactate, and serum and plasma BDNF were taken from 36 adults (average age 23.64 ± 3.89 years; 18 woman) before and immediately after 42 minutes of high-intensity RE and a rest condition on counterbalanced days. Subjects then immediately studied a series of paired objects and completed object and relational recognition tasks. Results revealed a condition by trial interaction, previously studied objects were remembered less accurately following RE (d = 0.66) but recognition occurred faster (d = 0.28), indicating a speed-accuracy tradeoff following RE. There was no effect of either intervention on relational recognition performance. Lactate (d = 3.68) and serum BDNF (d = 0.74) increased following RE, whereas there was no time-related change in lactate and serum BDNF following rest. However, changes in lactate and BDNF did not predict any measures of object (rs < 0.25, ps > 0.16) or relation recognition (rs < 0.28, ps > 0.13). Collectively, these findings suggest that acute high-intensity RE selectively improves the processing speed of recognizing objects at the cost of less accurate recognition of previously studied objects. Furthermore, changes in object and relational memory performance are unlikely driven by acute increases in lactate or BDNF following high-intensity RE.

Effects of different exercise modes and intensities on cognitive performance, adult hippocampal neurogenesis, and synaptic plasticity in mice.

Exercise can induce beneficial improvements in cognition. However, the effects of different modes and intensities of exercise have yet to be explored in detail. This study aimed to identify the effects of different exercise modes (aerobic and resistance) and intensities (low and high) on cognitive performance, adult hippocampal neurogenesis and synaptic plasticity in mice. A total of 40 C57BL/6J mice were randomised into 5 groups (n = 8 mice per group): control, low-intensity aerobic exercise, high-intensity aerobic exercise, low-intensity resistance exercise, and high-intensity resistance exercise. The aerobic exercise groups underwent treadmill training, while the resistance exercise groups underwent ladder climbing training. At the end of the exercise period, cognitive performance was assessed by the Y-maze and Barnes maze. In addition, adult hippocampal neurogenesis was evaluated immunohistochemically by 5-bromo-2'-deoxyuridine (BrdU)/ neuronal nuclei (NeuN) co-labeling. The levels of synaptic plasticity-related proteins in the hippocampus, including synaptophysin (SYP) and postsynaptic density protein 95 (PSD-95), were analyzed by western blotting. Our results showed no significant differences in cognitive performance among the groups. However, high-intensity aerobic exercise significantly increased hippocampal adult neurogenesis relative to the control. A trend towards increased adult neurogenesis was observed in the low-intensity aerobic group compared to the control group. No significant changes in synaptic plasticity were observed among all groups. Our results indicate that high-intensity aerobic exercise may be the most potent stimulator of adult hippocampal neurogenesis.

The Effect of Exercise on Intraocular Pressure and Glaucoma.

A review of the literature found that certain types of exercise and physical activity result in transient reductions in intraocular pressure and may have a beneficial effect on glaucoma severity and progression. Glaucoma is the most common cause of irreversible vision loss worldwide. Raised intraocular pressure (IOP) is the most important risk factor for the disease. Exercise is known to result in changes in IOP. The purpose of this review was to investigate the effect of exercise on IOP and glaucoma. A comprehensive search of multiple literature databases was performed. Medline, EMBASE, and Cochrane libraries were used to search for the relevant terms. 16 original studies were selected for the review. Exercise of varying intensity and type has differing effects on IOP. Moderate-intensity aerobic exercise results in transient reductions in IOP, while high-intensity resistance exercise and weight-lifting lead to transient elevations in IOP. There is evidence to suggest that exercise and higher levels of fitness may be protective against the development of glaucoma. In addition, increased daily physical activity may be associated with less visual field progression in patients with glaucoma. While secondary causes of glaucoma are included in some of the studies discussed in this review, the findings are largely applicable to primary open angle glaucoma. Exercise may be a beneficial lifestyle modification in the management of glaucoma; however, further longitudinal studies are required to validate this.

Dehydration Decreases Slow Wave Sleep After Heavy Resistance Exercise

Purpose: The purpose of this study was to examine the effects of hydration status on sleep and recovery measurement before and after high volume resistance exercise. It was hypothesized that dehydration decreases sleep and recovery measurements following exercise. Methods: Eight resistance-trained men (age, 21±2 years; weight, 82.0±12.6 kg; height, 177.3±6.9 cm) performed a series of bilateral leg press and knee extensions (RE, 5 sets of 10 repetitions at 80% of 1 repetition maximum). Participants completed one trial in a euhydrated state (EUH; urine specific gravity (USG) &lt; 1.020) and the other in a dehydrated state (DEH: USG ≥ 1.020) which was separated by 2 weeks. For the DEH trial, participants were restricted from consuming fluids for 24 hours prior to the RE and were only permitted to drink 1.5 L of water post-exercise for the remainder of the day. For the EUH trial, participants were instructed to consume fluid for 24 hours prior to and 24 hours post RE to maintain euhydration. Sleep and recovery measurements were collected from a wearable sleep device that participants wore the night before (PRE) and after RE (POST). Repeated measures ANOVAs were used to identify the differences between EUH and DEH. Effect size (ES) was calculated with resulting effects identified as either small (0.2-0.49), medium (0.5-0.79), or large (&gt;0.8) effects. Results: Slow wave sleep (SWS) (POST EUH, 1.4±0.5 hr; POST DEH, 1.0±0.5 hr; ES=0.8; p=0.028) and %SWS (POST EUH, 21.8±3.7 %; POST DEH, 14.3±6.4 %; ES=1.4; p=0.016) were greater in DEH compared to EUH at the night following RE. Also, SWS decreased at POST compared to PRE in DEH (PRE DEH, 1.4±0.3hr; ES=1.0; p=0.028), but not in EUH (PRE EUH, 1.2±0.6 hr; p=0.061). Sleep duration, sleep effciency, sleep disturbance, sleep deprivation, rapid eye movement sleep (REM), %REM, light sleep, resting heart rate, and heart rate variability were not different between EUH and DEH ( p&gt;0.05). Conclusion: Dehydration decreases slow wave sleep following heavy RE, which potentially impairs recovery from exercise as SWS is important for physiological recovery. Therefore, it is critical to maintain euhydration to maximize recovery following an acute bout of RE. This study was funded by National Strength and Conditioning Association (NSCA). This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

SOLVING THE HIGH-INTENSITY MUTLIMODAL TRAINING PRESCRIPTION PUZZLE: A SYSTEMATIC MAPPING REVIEW

INTRODUCTION &amp; AIMS High-Intensity Multimodal Training (HIMT) refers to all styles of high-intensity combined aerobic, resistance and/or bodyweight exercise. Previous heterogeneity in exercise prescription and reporting in HIMT reduces the understanding of which factors should be commonly considered when prescribing HIMT (e.g., exercise volume, intensity, duration). Previous studies have demonstrated positive effects of HIMT on health and performance outcomes. However, methodological disparities limit comparisons between findings. This systematic mapping review examines the prescriptive considerations and health and performance outcomes of HIMT in the context of training. METHODS A systematic literature search was conducted using Ovid Medline, SPORTDiscus and Cochrane Library databases and additional sources to identify studies up until February 2023. A total of 37090 records were retrieved, of which 221 were included for review. 247 individual HIMT protocols were included for categorical analysis against the Consensus on Exercise Reporting Template (CERT) and Applied Research Model for the Sport Sciences. RESULTS A total of 85 unique terms were used to describe HIMT. Included studies most commonly prescribed HIMT using a consistent exercise selection and circuit format. Exercise intensity was inconsistently reported on and a large proportion of studies incorrectly prescribed ‘high-intensity’ exercise according to ACSM definitions (i.e., &amp;lt;77% HRmax). Participation location, supervision and participation format were the most commonly reported non-training variables. The most frequently reported outcomes were cardiovascular health, perceptual outcomes, body composition and biochemical outcomes. A large proportion of previous HIMT research was experimental in design. CONCLUSIONS Previous HIMT research demonstrates a lack of standardisation in reporting. Future studies should seek to follow guidelines such as the CERT to improve reporting rigour. Additionally, forthcoming research should attempt to actively involve practitioners in implementation studies to improve ecological validity among interventions. REGISTRATION This review adhered to PRISMA-ScR guidelines. Preregistration: osf.io/yknq4.

The Frailty Reduction via Implementation of Exercise, Nutrition, and Deprescribing (FRIEND) Trial: Study Protocol and Recruitment Results.

Virtually all adults in aged care facilities are frail, a condition which contributes to falls, cognitive decline, hospitalisation, and mortality. Polypharmacy, malnutrition, sedentariness, and sarcopenia are risk factors amenable to intervention. The Asia-Pacific Frailty Management Guidelines recommend anabolic exercise and the optimisation of medications and nutrition. However, no study has evaluated this best practice intervention triad in aged care. The Frailty Reduction via the Implementation of Exercise, Nutrition, and Deprescribing (FRIEND) Trial (ANZCTR No.ACTRN12622000926730p) is a staged 6-month translational trial evaluating resident outcomes, staff/caregiver knowledge, and institutional implementation in a Townsville aged care facility. Residents received high-intensity resistance exercise and balance training and medication and nutrition optimisation co-implemented by investigators (exercise physiologist, geriatrician, pharmacist, and nutritionist) and facility staff. Staff and caregivers completed comprehensive education modules and training. We report the trial protocol and recruitment results. 29 residents (21 female, age: 88.6 ± 6.3 years) were recruited. At baseline, the residents were frail (frailty scale nursing home (FRAIL-NH); 6.3 ± 2.4/14), cognitively impaired (Montreal Cognitive Assessment; 13.8 ± 6.8/30), functionally impaired (Short Physical Performance Battery; 4.9 ± 3.1/12, 6 min walk distance; 222.2 ± 104.4 m), and were prescribed numerous medications (15.5 ± 5.9). Two residents died and one withdrew before the intervention's commencement. Thirty family members and 19 staff (carers, allied health assistants, nurse managers, registered nurses, lifestyle-leisure officers, kitchen/hospitality staff, and senior leadership) were recruited to receive frailty education modules. The FRIEND trial is currently being implemented with results expected in mid-2024. This is the first trial to evaluate the implementation of the best practice frailty guidelines including anabolic exercise and medication/nutritional optimisation in residential aged care.

Differences in the recovery response from high-intensity and high-volume resistance exercise on force, reactive agility, and cognitive function

PurposeThis study compared the recovery response of physical performance and cognitive function between high volume, low intensity (HV) and high intensity, low volume (HI) resistance training in resistance trained men.MethodsEight recreationally resistance trained men (27.8 ± 1.6 y; 85.5 ± 11.2 kg; 178.4 ± 8.3 cm), with at least one-year of resistance training experience (6.4 ± 3.9 y) participated in this cross-over design study. Participants were randomly assigned to either HV (6-sets of 15–20 repetitions at 60% of the participant’s one-repetition maximum (1RM), 1-min rest between sets) or HI (6-sets of 3–5 repetitions at 90% 1RM, 3-min rest between sets). Following a one-week recovery period, participants reported back to the laboratory and performed the other training session. Cognitive function (SCAT5), physical performance (isometric mid-thigh pull), and reactive agility measures were assessed at baseline, immediately-post (IP) and at 30- (30P) and 60-minutes post-exercise.ResultsParametric analysis revealed no differences in peak force (p = 0.423), and the rate of force development at 200 ms (p = 0.827) and 250 ms (p = 0.797) between HI and HV. However, magnitude-based inference (MBI) analysis indicated that peak force was possibly decreased at 30P following HI and that reactive agility was likely negatively impacted at IP following HV. Friedman analysis indicated a significant decline (p = 0.035) in delayed memory during HV at IP and 30P.ConclusionsResults of this study indicate that participants engaging in HV resistance training are more susceptible to experiencing performance declines in reaction time and cognitive function than HI training. These findings shed light on differences in physical and cognitive function recovery from HI and HV training programs.

Prehabilitative high-intensity interval training and resistance exercise in patients prior allogeneic stem cell transplantation

Physical capacity prior allogeneic stem cell transplantation (allo-HCT) has been shown as a relevant prognostic factor for survival after transplant. Therefore, we evaluated feasibility and preliminary efficacy of a high-intensity interval training (HIIT) and moderate to high-intensity resistance exercise (RE) to increase physical capacity in patient’s prior allo-HCT. In this multicentre single arm pilot study, a supervised exercise program was performed twice weekly for 4–12 weeks prior allo-HCT, depending on the individual time remaining. Outcomes were feasibility (recruitment, adherence, safety), physical capacity (cardiorespiratory fitness [VO2peak], muscle strength) and patient reported outcomes (physical functioning, fatigue). Thirty patients were intended, 16 could be included, and 14 completed post intervention assessment (75% male, 55 ± 11 years). The study was stopped early due to a low recruitment rate. Nine patients (64%) reached the initial minimum planned number of eight exercise sessions. Individual adherence was high with 92% for HIIT and 85% for RE. 87% of all performed exercise sessions were completed without complaints and VO2peak increased significantly from 20.4 to 23.4 ml/kg/min. The low recruitment rate suggests that initiation of the intervention concept immediately before allo-HCT is feasible only in a small number of patients. In particular, the timeframe directly prior allo-HCT seems too short for exercise interventions, although the exercise program was designed to improve outcomes in a very short time frame. HIIT and RE were feasible, effective and well accepted by the included patients.

Changes in Arterial Stiffness in Response to Blood Flow Restriction Resistance Training: A Narrative Review.

Arterial stiffness naturally increases with age and is a known predictor of cardiovascular morbimortality. Blood flow restriction (BFR) training involves decreasing muscle blood flow by applying a strap or a pneumatic cuff during exercise. BFR induces muscle hypertrophy even at low intensities, making it an appealing option for older, untrained individuals. However, BFR use in patients with cardiovascular comorbidities is limited by the increased pressor and chronotropic response observed in hypertensive elderly patients. Furthermore, the impact of BFR on vascular function remains unclear. We conducted a comprehensive literature review according to PRISMA guidelines, summarizing available data on the acute and long-term consequences of BFR training on vascular function. Although evidence is still scarce, it seems that BFR has a mild or neutral long-term impact on arterial stiffness. However, current research shows that BFR can cause an abrupt, albeit transient, increase in PWV and central blood pressure. BFR and, preferably, lower-body BFR, should be prescribed with caution in older populations, especially in hypertensive patients who have an exacerbated muscle metaboreflex pressor response. Longer follow-up studies are required to assess the chronic effect of BFR training on arterial stiffness, especially in elderly patients who are usually unable to tolerate high-intensity resistance exercises.

Therapeutic Photobiomodulation Before Strenuous Exercise Attenuates Shoulder Muscle Fatigue.

Photobiomodulation therapy (PBMT) applied as a preconditioning treatment before exercise has been shown to attenuate fatigue and improve skeletal muscle contractile function during high-intensity resistance exercise. Practical implications for preconditioning muscles with PBMT before fatiguing exercise include a safe and noninvasive means to enhance performance and reduce the risk of musculoskeletal injury. To examine the muscle fatigue-attenuating effects of PBMT on performance of the shoulder external-rotator muscle group when applied as a preconditioning treatment before high-intensity, high-volume resistance exercise. Sham-controlled, crossover design. Laboratory. Twenty healthy men (n = 8) and women (n = 12) between the ages of 18 and 30 years. Photobiomodulation therapy was administered using a near-infrared laser (λ = 810/980 N·m, 1.8 W/cm2, treatment area = 80-120 cm2) to the shoulder external-rotator muscles at a radiant exposure of 10 J/cm2. Participants performed 12 sets of isokinetic shoulder exercise. Each set consisted of 21 concentric contractions of internal and external rotation at 60°/s. The sets were subdivided into 3 blocks of exercise (block 1: sets 1-4; block 2: sets 5-8; block 3: sets 9-12). Normalized peak torque (N·m/kg), average peak torque (N·m), total work (N·m), and average power (W). During the last block of exercise (sets 9-12), all performance measures for the active PBMT condition were 6.2% to 10% greater than the sham PBMT values (P < .02 to P < .001). Photobiomodulation therapy attenuated fatigue and improved muscular performance of the shoulder external rotators in the latter stages of strenuous resistance exercise.

Muscle Mass and Muscle Strength Following 6 Weeks of Blood Flow Restriction Combined with Low-Intensity Strength Training in Overweight Adolescents

Background and Study purpose. Blood flow restriction training is a new training technique that involves low-intensity exercise and can generate physiological changes equivalent to high-intensity exercise. The aim of this study is to assess the impact of blood flow restriction in conjunction with low-intensity resistance exercise on muscle mass and muscle strength among overweight adolescents, in comparison to conventional resistance exercise. Materials and methods. The study involved two randomized groups: an experimental group, which performed 40% of one repetition maximum (1RM) resistance exercise combined with 60% of arterial occlusion pressure (AOP), and a traditional resistance exercise group, which performed 70% of 1RM resistance exercise. All participants underwent pre-test and post-test evaluations for body composition, 1RM, and muscle circumference. The training program lasted for six weeks and consisted of upper and lower body training, including exercises such as leg press, leg curl, arm curl, and arm extension. Results. The group that underwent low-load blood flow restriction (LLBFR) training showed a notable increase in muscle mass (p&lt;0.049) as well as arm and leg circumference (p&lt;0.047 and p&lt;0.046, respectively) compared to before the training program, similar to the results of high-intensity resistance exercise. Conclusions. Combining blood flow restriction with low-intensity resistance training is a potentially effective approach to increase muscle size and strength, especially in overweight adolescents. Moreover, this type of training can decrease the amount of exercise load, making it a feasible option for individuals who may not tolerate high loads due to certain medical conditions or other limitations.

"We want more": perspectives of sarcopenic older women on the feasibility of high-intensity progressive resistance exercises and a whey-protein nutrition intervention.

This qualitative study is nested within a 12-week pilot randomized-controlled, two-arm trial involving high-intensity progressive resistance training (PRT) or PRT with a multi-nutrient, whey-protein supplementation (PRT+WP) in sarcopenic older adults (trial registration no: TCTR20230703001). The aim was to investigate sarcopenic participants' perceptions and barriers to this multi-modal intervention strategy that may accelerate "real-world" implementation. Eighteen older adults (one man) with possible sarcopenia were invited to join the study, of whom 16 women were randomized to a thrice-weekly PRT (n = 8) program (80% of 1-repetitive maximum, six resistance band exercises) only or PRT plus daily weekday milk-based WP supplementation (PRT+WP, n = 8). Muscle strength (handgrip and 5-times sit-to-stand), mass (dual-energy X-ray absorptiometry), performance (Short Physical Performance Battery and stair ascent-descent), and nutrition status (Mini Nutritional Assessment) were assessed for changes. We randomly selected eight women for the semi-structured interview. Post-intervention, eight (50%) women were sarcopenia-free, six (38%) remained in possible sarcopenia, one (6%) improved to sarcopenia, and one (6%) deteriorated from possible to severe sarcopenia. There were no significant between-group differences, but significant within-group improvements (p < 0.05) were detected for handgrip strength (PRT+WP 5.0 kg, d = 0.93; PRT 6.1 kg, d = 0.55), 5-times sit-to-stand time (PRT 2.0 s, d = 1.04), nutrition score (PRT+WP 3.44, d = 0.52; PRT 1.80, d = 0.44), and stair ascent time (PRT+WP 0.97 s, d = 0.77; PRT 0.75 s, d = 0.97). Our thematic analyses identified four main themes, namely, (1) perceived benefits, (2) sustaining behavior changes, (3) challenges in participating, and (4) improved wellbeing. Participants expressed how they initially were skeptical and doubted that they could complete the exercises or tolerate the milk-based WP supplements. However, they reported positive experiences and benefits felt from strength gains, increased confidence, and better physical abilities. Participants were surprised by the zero adverse effects of WP supplements. The women wanted more nutritional information and structured, guided exercise programs and suggested a community-based implementation. In conclusion, our findings showed PRT was well received and may support reduced risks of sarcopenia. No added benefits were seen with the addition of WP supplementation, but a larger sample is required to address this question. Overall, older (previously sarcopenic) Malay women indicated that they want more multi-modal programs embedded in their community.

Effect of Blood Flow Restriction in Low-Intensity Resistance Training of the Quadriceps Femoris Muscle on Joint Position Sense and Threshold to Detect Passive Motion in Patients with Knee Osteoarthritis

Backgrounds: The functional ability of knee OA (KOA) patients is mainly affected by muscle weakness and poor proprioception function. Quadriceps femoris strengthening exercises can improve proprioceptive function in patients with KOA, whereas low-intensity resistance exercises with Blood Flow Restriction have been shown to produce hypertrophy and increase muscle strength equivalent to high-intensity resistance exercises. However, prescriptions for exercise with BFR are still very diverse, and only a few studies show the effects of BFR training on proprioceptive function in patients with KOA. This study aims to determine the impact of BFR in LI-RT of the quadriceps femoris muscle on joint position sense and threshold to detect passive motion in patients with KOA. Methods: This randomized control trial study designed a clinical experiment with a before and after test. The research enrolled 28 people with KOA grades 2 and 3. The JPS and TTDPM, which reflect proprioceptive function, were measured before and after 6 weeks of exercise. This study's statistical analysis utilized the Monte Carlo test, independent t-test, and paired t-test. The effect size was noticed using Cohen's-d calculation to investigate the statistical influence of alterations further. The significance level was less than 0.05. Results: The mean age of the control group was 61.43 ± 5.70 years old, and the treatment group was 57.71 ± 5.25 years old. There were significant improvements in JPS and TTDPM results before and after training in each group (p &lt; 0,05). There was no significant difference in JPS and TTDPM results between the two groups on the post-test on delta values (p&gt; 0,05). Conclusions: The addition of BFR in LI-RT for 6 weeks did not affect JPS and TTDPM in patients with KOA.

Older females but not males exhibit increases in cerebral blood velocity, despite similar pulsatility increases after high-intensity resistance exercise.

Sex differences in resting cerebral hemodynamics decline with aging. Acute resistance exercise (RE) is a hypertensive challenge that might reveal sex-dependent abnormalities in cerebral hemodynamics. Thus, we hypothesized cerebral blood velocity and pulsatility responses to RE would be sex-dependent in older adults. Fourteen older females and 11 males [50-68 years] completed a high-intensity unilateral isokinetic knee flexion/extension exercise. Measurements were collected at baseline, immediately, 5-and 30-min post-RE. Blood pressure was measured via finger photoplethysmography. Mean middle cerebral artery blood velocity (MCAv) and pulsatility were assessed via transcranial Doppler ultrasound. Carotid pulsatility was obtained via duplex ultrasound. MCAv increased immediately after RE in older females (mean difference (d)= 6.02, 95% CI: 1.66 to 10.39 cm. s-1, p<0.001) but not in males (d= -0.72, 95% CI: -3.83 to 5.27 cm.s-1, p=0.99). Followed by similar reductions 5-min post-RE in older females (d= -4.40, 95% CI: -8.81 to -0.10 cm.s-1, p=0.045) and males (d= -6.41, 95% CI: -11.19 to -1.62 cm.s-1, p=0.003). MCAv pulsatility increased similarly in older females (d= 0.24, 95% CI: 0.11 to 0.40, p<0.001) and males (d=0.38, 95% CI: 0.20 to 0.53, p<0.001), persisting 5-min post-RE. Older females showed smaller increases in carotid pulsatility immediately after RE (d= 0.18, 95% CI: 0.03 to 0.38, p=0.01) than males (d=0.48, 95% CI: 0.26 to 0.68, p<0.001). An exercise-mediated hypertensive stimulus revealed differential sex responses in MCAv and carotid pulsatility but not in cerebral pulsatility. Cerebral pulsatility findings suggests a similar sex susceptibility to cerebrovascular abnormalities following an exercise-mediated hypertensive stimulus in older adults.