High Intensity Pulsed Magnetic Field Research Articles

Effectiveness of Sanatorium Treatment Programs for Women with Chronic Endometritis: a Prospective Randomized Study

INTRODUCTION. The problem of recurrent antibiotic-resistant urogenital infections is increasing, and standard therapy is becoming ineffective. Sanatorium-resort treatment of chronic inflammatory diseases of the pelvic organs in women allows us to solve these problems with the help of natural and preformed physical factors.
 AIM. To study the clinical effectiveness of comprehensive sanatorium treatment programs in patients with chronic endometritis.
 MATERIALS AND METHODS. A prospective randomized trial included 73 patients, aged 35 ± 10 years, diagnosed with chronic endometritis. The control group (n = 25) received «basic» therapy with amplipulstherapy, sodium chloride baths. The comparison group (n = 24) received «basic» therapy and manual therapy. The main group (n = 24) received «basic» therapy, high-intensity pulsed magnetic field and manual therapy. Diagnostic criteria: immunohistochemical examination of the endometrium, echographic examination, dopplerometry of pelvic vessels, laser Doppler flowmetry.
 RESULTS AND DISCUSSION. After treatment, an increase in the uterine arterial perfusion index was noted in all groups compared with baseline values. The median indicator increased in the study groups by 2.36 times, 2.4 times, and 2.6 times, respectively (p 0.05). The decrease in the maximum peak speed in the comparison group and the main group exceeded the indicators of the control group (p 0.001). The systolic-diastolic ratio decreased in the comparison group and the main group (p 0.05). A decrease in stagnation in the venular microcirculation, a normotonic type of microcirculation, improvement in endothelial function (p 0.01) were revealed in the main group.
 CONCLUSION. An algorithm has been developed. In case of endometrial hypoplasia, decreased uterine perfusion, increased uterine artery resistance index, «basic» therapy is recommended, including sodium chloride baths and amplipulstherapy. With an increase in the maximum peak blood flow rate, an increase in the systolic-diastolic ratio, it is necessary to add a course of manual therapy to the «basic» therapy. When detecting violations of venous outflow, it is recommended to include high-intensity pulsed magnetic therapy.

Application of high-intensity pulsed magnetotherapy in the medical rehabilitation of children with degree scoliose (methodological recommendations)

In the medical rehabilitation of children with scoliosis, a fairly wide range of physiotherapy technologies (sinusoidal modulated currents, interference currents, laser therapy, combined use of hypobarotherapy and electrical muscle stimulation, low-intensity magnetic therapy, biofeedback therapy) are used. At the same time, the search for the most effective methods of physiotherapy aimed at stimulating muscle tone, local blood circulation and metabolic and trophic processes in bone and muscle tissues continues. One of the promising methods is high-intensity pulsed magnetic therapy (HIMT), which is a therapeutic effect of a pulsed magnetic field (PMF) with a pulse repetition rate of about 0.5 Hz, a duration not exceeding several milliseconds and an amplitude reaching 1500 mT or more on the working surface of the inductor. The guidelines substantiate the use of this method in the medical rehabilitation of children with scoliosis of the II degree on the basis of the revealed favorable effect of a high-intensity pulsed magnetic field on the dynamics of the orthopedic status, strength endurance of the trunk muscles, cardio-respiratory parameters and microcirculation in children with scoliosis of the II degree. The effectiveness, necessity and expediency of including high-intensity pulsed magnetic therapy in the program of medical rehabilitation of children with II degree scoliosis has been proved. The methodological recommendations are addressed to traumatologists — orthopedists, physiotherapists, physical therapy doctors, physical and rehabilitation medicine doctors, reflexologists, pediatricians, and other specialists of medical organizations.

Effect of high intensity pulsed magnetic field (30 T) on microstructure and tribological properties of Ni-based coatings

Pulsed magnetic fields can improve ferromagnetic and paramagnetic materials by improving their stress structure, domain variation, phase structure distribution and grain size of both solid and molten metals. Therefore, we strengthened the Ni-based wear-resistant coating by using the high-intensity (30 T) pulsed magnetic field equipment independently developed by our research group. The results show that the magnetic domains appeared as sheet domains and showed sinusoidal distribution after pulsed magnetic field intensification. The crystal structure is improved, the residual compressive stress is increased and the tribological coefficient is decreased. This study provides a new perspective on the design of high-strength metal base coatings for various applications.

Effect of pulsed magnetic field on retained austenite of quenched 8Cr4Mo4V steel under cryogenic condition

High-intensity pulsed magnetic field was applied to modify the microstructure and mechanical propertis of quenched 8Cr4Mo4V bearing steel under the cryogenic environment. The microstructual transformation in 8Cr4Mo4V bearing steel was investigated by X-ray diffraction (XRD), Vibrating sample magnetometer (VSM) and Electron Backscatter Diffraction (EBSD) and so on. The results revealed that individual deep cryogenic treatment (DCT) promote the transformation from retained austenite (RA) in quenched steel to martensite. However, this phase transformation will be inhibited by coupling high-intensity magnetic field with deep cryogenic treatment (MDCT). For instance, the relative reduction of RA content in DCT samples was 10 ± 2%, while that in MDCT samples was 3 ± 3%. Furthermore, the modified Williamson-Hall method was utilized to estimate the dislocation characteristics based on XRD profile analysis. It exhibited that the proportion of edge dislocation significantly decrease from 61.8% to 43.7% by DCT, while this type of dislocation remains almost unchanged after MDCT. Moreover, the microhardness of quenched 8Cr4Mo4V steel became more uniform after MDCT than that of DCT. It can be indicated that the martensite transformation is blocked and carbon cluster is dissolved under the condition of coupling pulsed magnetic field treatment.

High Intensity Pulsed Magnetic Field Application in Patients with Chronic Prostatitis Complicated by Erectile Dysfunction: а Randomized Prospective Study

INTRODUCTION. Chronic prostatitis is one of the most common urological nosologies, the third most common diagnosis in men under 50 years old. Existing scientific sources testify to the effectiveness of various physiotherapeutic interventions in patients with infectious-inflammatory diseases of the male reproductive system, complicated by erectile dysfunction. AIM. The aim of the study was the scientific substantiation of high-intensity pulsed magnetic field application in patients with chronic prostatitis complicated by erectile dysfunction. MATERIAL AND METHODS. The study included 60 patients randomized into two groups. The first group (30 people) received high-intensity pulsed magnetic field; the second group (30 people) received drug therapy. RESULTS AND DISCUSSION. It was shown that the high clinical results of high-intensity pulsed magnetic field application were based on the compensation of local blood circulation conditioned by the improvement of the prostate blood flow according to the ultrasound of the prostatic vessels as well as by the elimination of the penile blood supply deficiency due to the improvement of the arterial vessels tone and elimination of venous stasis according to laser doppler flowmetry. CONCLUSION. An innovative method has been developed to treat patients with chronic prostatitis complicated by erectile dysfunction using high-intensity pulsed magnetic field.

A method for increasing the yield of the suitable product of humic acids from raw materials using pulse-magnetic processing

The paper studied the effect of high-intensity pulsed magnetic fields (PMF) on extraction of humic acids in order to increase the yield of the suitable product. It is proposed to add to the technological chain of reactions for the precipitation of humic acids the operation of PMF processing of raw materials at the stage of the brawn coal suspension in alkali (the first experiment) or the alkaline extraction suspension (the second experiment).Pulse-magnetic processing the brawn coal suspension in alkali and the alkaline extraction suspension was carried out at magnetic field intensities H=0.09 106 A/m and H=0.82 106 A/m with the frequency of the discharge circuit f=40 kHz and the number of pulses n=1. The experiments have shown that when humic acids are obtained by water-alkaline extraction followed by their precipitation in an acid medium, for the highest yield of the product it is necessary to add the operation of pulse-magnetic processing a raw material at the magnetic field intensity of 0.82 106 A/m at the stage of the brawn coal suspension in alkali. It can be assumed that a high-intensity PMF contributes to the transfer of humic acids to a state conducive to their more efficient precipitation and extraction.

FT-IR Analysis of Structural Changes in Ketoprofen Lysine Salt and KiOil Caused by a Pulsed Magnetic Field.

High-intensity, low-frequency magnetic fields (MFs) have been widely used in the treatment of diseases and in drug delivery, even though they could induce structural changes in pharmacological molecules. Morphological changes in ketoprofen and KiOil were investigated through Fourier-transform infrared spectroscopy (FT-IR). Unsupervised principal component analysis was carried out for data clustering. Clinical validation on 22 patients with lower back pain was managed using diamagnetic therapy plus topical ketoprofen or KiOil. The Numerical Rating Scale (NRS) and Short-Form Health Survey 36 (SF-36) were used to evaluate clinical and functional response. Ketoprofen showed clear clustering among samples exposed to MF (4000–650 cm−1), and in the narrow frequency band (1675–1475 cm−1), results evidenced structural changes which involved other excipients than ketoprofen. KiOil has evidenced structural modifications in the subcomponents of the formulation. Clinical treatment with ketoprofen showed an average NRS of 7.77 ± 2.25 before and an average NRS of 2.45 ± 2.38 after MF treatment. There was a statistically significant reduction in NRS (p = 0.003) and in SF-36 (p < 0.005). Patients treated with KiOil showed an average NRS of 7.59 ± 2.49 before treatment and an average NRS of 1.90 ± 2.26 after treatment (p < 0.005). SF-36 showed statistical significance for all items except limitations due to emotional problems. A high-intensity pulsed magnetic field is an adjunct to topical treatment in patients with localized pain, and the effect of MF does not evidence significant effects on the molecules.

Changes in the Structure of the Benzylpenicillin Sodium Salt Molecule under the Pulsed Magnetic Field

The study aims at the Fourier spectra of an antibiotic exposed to a high-intensity pulsed magnetic field. The applied frequency was f = 40 kHz, with a number of pulses n = 1, at intensities of the pulsed magnetic field H = 0.09 × 106 А/m, Н = 0.50 × 106 А/m, Н = 0.82 × 106 А/m. It was assumed that under the conditions of the pulsed magnetic field there might be a change in the structure of the drug molecule. The research has revealed that an increase in the pulsed magnetic field power leads first to a decrease in the intensity of the band in the Fourier spectrum, and then to its increase. In addition, changes were recorded in the amide group of benzylpenicillin sodium salt molecules depending on the intensity of the pulsed magnetic field applied to the antibiotic.

ВОЗДЕЙСТВИЕ ИМПУЛЬСНОГО МАГНИТНОГО ПОЛЯ ВЫСОКОЙ НАПРЯЖЕННОСТИ НА ДЕРМАЛЬНЫЕ ФИБРОБЛАСТЫ ЧЕЛОВЕКА В КУЛЬТУРЕ

The influence of pulsed magnetic fields (PMF) with different values of field intensity H, discharge current frequency f and a number of pulses n on dermal fibroblasts was studied in vitro. A specialized pulse-magnetic installation «PMI-Bio» and a measuring stand for creating and monitoring the specified parameters of the PMF were created. Four series of experiments with longitudinal and transverse action of the PMF at a field intensity of 3.76⋅106 – 8.7⋅106 A/m (500 and 1000 J) were carried out. It was found that the longitudinal action of the PMF at 500 J does not lead to cell death, preserves all their structural components, and is safe for primary fibroblast cultures. The use of high-intensity pulsed magnetic fields (HI PMF) at 1000 J in both longitudinal and transverse directions leads to a violation of cell adhesion to the culture plastic and changes in the structure of dermal fibroblasts, up to their death.

The substantiation of the application of the high-intensity pulsed magnetic field for the combined treatment of biliary sludge

The objective of the present study was to evaluate the effectiveness of the application of the high-intensity pulsed magnetic field in the combination with the intake of mineral water (MW) and rational pharmacotherapy as the components of the combined treatment of biliary sludge. The study included 117 patients presenting with biliary sludge (BS) who were randomly allocated to three groups. Group 1 was comprised of 38 patients and served as the control group. These patients received medicamentous therapy (hymecromone - 200 mg 3 times daily during two weeks and ursodeoxycholic acid at a dose of 10-15 mg/kg a day during a period from 3 to 6 months). The second group consisted of 40 patients and served as the group of comparison. The patients of this group received medicamentous therapy in the combination with the intake of 'Sernovodskaya' hydrocarbonate-chloride-sulphate sodium mineral water (from a spring in the Chechen republic). The third group was composed of 39 patients and constituted the main study group. These patients completed a course of therapy with the use of the high-intensity pulsed magnetic field applied to the gall bladder region. Each patient underwent 10 sessions of magnetic therapy after the completion of the treatment with hymecromone and 'Sernovodskaya' mineral water. The treatment was carried out with simultaneous monitoring dynamics of the clinical symptoms of biliary sludge, the ultrasound examination of the abdominal organs with the evaluation of the contractile function of the gall bladder, the level of bilirubin in the cystic bile, bile acids, cholesterol, and cholate-cholesteric coefficient. The combined treatment of the patients suffering from BS including the application of the high-intensity pulsed magnetic field alleviated the clinical symptoms of the disease much faster than medicamentous therapy combined with the intake of 'Sernovodskaya' mineral water. Moreover, it promoted the restoration of the motor activity of the gall bladder and accelerated the evacuation of the hyperechoic particles. The course of the combined treatment of the patients presenting with biliary sludge including the application of the high-intensity pulsed magnetic field in the combination with the intake of mineral water (MW) and rational pharmacotherapy significantly relieved abdominal pains, alleviated the symptoms of biliary dyspepsia, and improved the motor function of the biliary tract. These therapeutic effects persisted as long as 3 months. The results of the present study give evidence of the necessity of prescription of an optimum dose of ursodeoxycholic acid to the patients suffering from biliary sludge.

In vivo pulsed magneto-motive ultrasound imaging using high-performance magnetoactive contrast nanoagents.

Previously, pulsed magneto-motive ultrasound (pMMUS) imaging has been introduced as a contrast-agent-assisted ultrasound-based imaging modality capable of visualizing biological events at the cellular and molecular level. In pMMUS imaging, a high intensity pulsed magnetic field is used to excite cells or tissue labeled with magnetic nanoparticles. Then, ultrasound (US) imaging is used to monitor the mechanical response of the tissue to an externally applied magnetic field (i.e., tissue displacement). Signal to noise ratio (SNR) in pMMUS imaging can be improved by using superparamagnetic nanoparticles with larger saturation magnetization. Metal-doped magnetic nanoparticles with enhanced tunable nanomagnetism are suitable candidates to improve the SNR and, therefore, sensitivity of pMMUS imaging, which is essential for in vivo pMMUS imaging. In this study, we demonstrate the capability of pMMUS imaging to identify the presence and distribution of zinc-doped iron oxide nanoparticles in live nude mice bearing A431 (human epithelial carcinoma) xenograft tumors.

Spectral Domain Magneto-Optical Magnetometry

In this work we present a new concept for measuring high intensity pulsed magnetic fields (h (t)) through the spectral analysis of spin excitations in a saturated yttrium-iron garnet (YIG) thin film grown on a gadolinium gallium garnet (GGG) substrate. The spectrum of spin excitations, generated in the sample by picosecond h (t), was determined with the help of a magnetooptical (MO) Faraday probe in the guided wave regime of lightwave propagation. This technique, compared to the standard MO cells, allows one to avoid saturation effects because the amplitude of h (t) is measured in the frequency domain, and allows us to realize the analysis in real time taking advantage of strong a MO signal.

Self-Diffusion Studies in CuBTC by PFG NMR and MD Simulations

Self-diffusion and relaxation time studies of C3 to C6 hydrocarbons adsorbed in the microporous metal−organic framework CuBTC were performed by nuclear magnetic resonance (NMR) in the temperature range of 193−373 K. The presence of paramagnetic copper species in the solid CuBTC framework leads to short longitudinal (T1) and transverse (T2) relaxation times of the hydrocarbons with typical values of T1 ≲ 10 ms and T2 ≲ 3 ms. Under these conditions, pulsed field gradient (PFG) NMR self-diffusion studies could only be performed at short observation times using the primary spin echo sequence with high-intensity pulsed magnetic field gradients. The obtained temperature dependent self-diffusion coefficients were analyzed using an Arrhenius approach. The activation energies of the alkanes are in the range of 6.5−8.5 kJ/mol, increasing slightly with increasing number of carbon atoms. Significantly higher values were found for propene (13.2 kJ/mol) and 1-butene (15.0 kJ/mol). These tendencies are consistent with corresponding measurements of heats of adsorption and with data obtained in molecular dynamics (MD) simulations. The MD simulations show a strong dependence of the heat of adsorption and diffusion on loading and temperature. This is caused by the preferential adsorption of small alkanes such as propane and butane in the side pockets of the CuBTC structure at low loading and temperature.

International Conference on Transcranial Magnetic and Direct Current Stimulation

International Conference on Transcranial Magnetic and Direct Current Stimulation

An improved approach to calibrating high magnetic field gradients for pulsed field gradient experiments

Probes capable of generating short high intensity pulsed magnetic field gradients are commonly used in diffusion studies of systems with very short T 2. Traditional methods of calibrating magnetic field gradients present unique challenges at ultrahigh field strengths and are often inapplicable. Currently the most accurate method of determining magnetic gradient strength is to use the known diffusion coefficient of a standard sample and determine gradient strength from the echo attenuation plot of a diffusion experiment, however, there are problems with finding suitable standards for high intensity gradients. Here, we show that molecules containing at least two receptive nuclei (i.e. one with high and one with low gyromagnetic ratios) are excellent systems for calibrating high intensity gradients.

Unidirectionally Solidified Al-Cu Eutectic Alloy under High Intensity Pulsed Magnetic Field

The pulsed electric current produced by discharging of capacitors pass through the double solenoids with ferrosilicon core, the instant strong pulsed magnetic field with the oscillating and declining characters was made between two ferrosilicon cores. The effect of high-pulsed magnetic field on the unidirectionally solidified Al-Cu eutectic microstructure with 10µm/s withdrawn velocity was investigated. Under the high intensive pulsed magnetic field, the Al-Cu eutectic solidified morphology experience three evolution stages that are regular columnar structure to breaking off fine grain, coarsening dendrite to newly regularization columnar structure with increasing of 0～15.5J charge energy. It is found that rich copper phase evidently come out inter eutectic cells and the eutectic spacing decrease in newly regularization specimen. The induced electric field caused by high pulsed magnetic field in metallic melt brought into oscillating solute electro-migration in front of solidification interface, which has the effect of promoting solute diffusion and reducing the constitutionally supercooling region.

スプレードライ造粒粉末を用いてパルス磁場中成形したＮｄ‐Ｆｅ‐Ｂ系焼結磁石の磁気特性

Nd-Fe-B alloy powder was granulated by a spray drying method using an organic binder in order to improve the powder flowability during feeding and compacting. In this experiment, whether or not the degree of magnetic orientation of primary particles in granulated powders is raised by applying high intensity pulsed magnetic field in compacting was studied, in order to improve magnetic properties of sintered magnets. It was found that the orientation of particles (remanences) was improved remarkably by applying high intensity pulsed magnetic field in initial process of compaction of granulated powders, so that magnetic properties of magnets are superior to those of magnets when applying only static magnetic field in compacting. The observation of granulated powders after applying magnetic field shows that granulated powders were destructed more easily by such high intensity pulsed field. The orientation of primary particles in granulated powders depends strongly on the apparent density of powders when applying pulsed field. It was very effective for improving magnetic properties of magnets using granulated powders to apply pulsed field when powders fed in die cavity are free for orientation. By means of controlling the binding strength of binder and timing of pulsed magnetic field, magnetic characteristics of magnets using granulated powders became almost equal to that of magnet using raw powder.

Characterization of a Laser Plasma in a Pulsed Magnetic Field. Part II: Time-Resolved Emission and Absorption Studies

Temporally resolved emission and absorbance measurements were made in order to investigate the dynamic effects of a high-intensity pulsed magnetic field on a laser plasma. Temporally resolved emission studies were spatially resolved so that the effects of the magnetic field on plasma propagation both along and normal to the magnetic field could be probed. The mechanism of interaction of the field was investigated by observing plasma emission in spatial zones most likely to be influenced by an induced secondary current in the plasma. Spatial and temporal discrimination of emission enhancements indicated that radial compression was due to static magnetic field interactions with the laser plasma and that mild Joule-heating from the small induced current was most likely responsible for emission enhancements later in time. Spatially integrated absorbance measurements in the decaying plasma showed a decrease in absorbance as a result of the magnetic confinement; this is attributed to an increased rate of condensation of the atoms in the vapor cloud produced by the pinched plasma. More efficient coupling of energy from the magnetic field to the plasma would require low-pressure operation in a controlled atmosphere and/or a pulsed magnetic field having a greater d B/d t.

FeAlO3: new production methods and study of its magnetization in very high intensity pulsed magnetic fields

The first production method proceeds from the use of the intermediate vacancy spinel phase γ-(Fe 0.50 Al 0.50 ) 2 O 3 , while the second one consists in treating the amorphous residue to the oxalic salt decomposition at 1380 o C. The study of magnetization in high magnetic fields did not allow us to obtain saturation of the material. Experiments on FeAlO 3 monocrystallite production are in progress to study the magnetic structure and explain the high magnetic anisotropy of this compound

On the fading of relativistic tracks in K-5 nuclear emulsion at high temperature

Evolution in time of the latent image fading of relativistic tracks in K-5 emulsions is investigated at a temperature typical of exposures in high intensity pulsed magnetic fields. The fading is significantly non-exponential and strong enough to cause systematic shifts and relatively wide scatters of the estimated track parameters. Plates subjected to preheating show a more regular and hence predictable fading behaviour, as well as a weaker overall fading.