High-intensity Interval Training Program Research Articles

Effect of an eight-week high-intensity interval training programme on circulating sphingolipid levels in middle-aged adults at elevated cardiometabolic risk (SphingoFIT)-Protocol for a randomised controlled exercise trial.

Evidence indicates that sphingolipid accumulation drives complex molecular alterations promoting cardiometabolic diseases. Clinically, it was shown that sphingolipids predict cardiometabolic risk independently of and beyond traditional biomarkers such as low-density lipoprotein cholesterol. To date, little is known about therapeutic modalities to lower sphingolipid levels. Exercise, a powerful means to prevent and treat cardiometabolic diseases, is a promising modality to mitigate sphingolipid levels in a cost-effective, safe, and patient-empowering manner. This randomised controlled trial will explore whether and to what extent an 8-week fitness-enhancing training programme can lower serum sphingolipid levels of middle-aged adults at elevated cardiometabolic risk (n = 98, 50% females). The exercise intervention will consist of supervised high-intensity interval training (three sessions weekly), while the control group will receive physical activity counselling based on current guidelines. Blood will be sampled early in the morning in a fasted state before and after the 8-week programme. Participants will be provided with individualised, pre-packaged meals for the two days preceding blood sampling to minimise potential confounding. An 'omic-scale sphingolipid profiling, using high-coverage reversed-phase liquid chromatography coupled to tandem mass spectrometry, will be applied to capture the circulating sphingolipidome. Maximal cardiopulmonary exercise tests will be performed before and after the 8-week programme to assess patient fitness changes. Cholesterol, triglycerides, glycated haemoglobin, the homeostatic model assessment for insulin resistance, static retinal vessel analysis, flow-mediated dilatation, and strain analysis of the heart cavities will also be assessed pre- and post-intervention. This study shall inform whether and to what extent exercise can be used as an evidence-based treatment to lower circulating sphingolipid levels. The trial was registered on www.clinicaltrials.gov (NCT06024291) on August 28, 2023.

Evaluation of a High Intensity Interval Training (HIIT) Program for Military Personnel Receiving Inpatient Treatment for a Substance Use Disorder

This study aimed to evaluate a high intensity interval training (HIIT) program delivered in an inpatient treatment setting serving military personnel. This recreational therapy (RT) program assessed the impact of a single session (60-minute) HIIT program on participant affect and state-anxiety. Using a single-group pretest-posttest design, 58 data sets were collected from participants (N = 20). Results indicated an increase in positive affect (z = -.6.52, p < .001), a decrease in negative affect (z = -2.64, p < .01), and a significant reduction in anxiety, t (57) = 1.99, p = .05 following the intervention. The program also resulted in a significant elevation in heart rate, t (57) = -25.89, p < .001 with most participants reaching moderate to high intensity physical activity levels. On a scale of 1–10, participants rated their likelihood of participating in HIIT post-discharge at 6.28 (SD = 2.43). Additional qualitative data provides valuable insight on the perceived benefits to participants and offers suggestions for future program development and research in this area.

Applicability of a supramaximal high-intensity interval training program for older adults previously not engaged in regular exercise; analyses of secondary outcomes from the Umeå HIT Study

This analysis of secondary outcomes investigated the applicability of supramaximal high-intensity interval training (HIT) with individually prescribed external intensity performed on stationary bicycles. Sixty-eight participants with a median (min; max) age of 69 (66; 79), at the time not engaged in regular exercise were randomized to 25 twice-weekly sessions of supramaximal HIT (20-min session with 10 × 6-s intervals) or moderate-intensity training (MIT, 40-min session with 3 × 8-min intervals).The primary aim was outcomes on applicability regarding; adherence to prescribed external interval intensity, participant reported positive and negative events, ratings of perceived exertion (RPE 6–20), and affective state (Feeling Scale, FS -5–5). A secondary aim was to investigate change in exercise-related self-efficacy (Exercise Self-Efficacy Scale) and motivation (Behavioural Regulations in Exercise Questionnaire-2).Total adherence to the prescribed external interval intensity was [median (min; max)] 89 % (56; 100 %) in supramaximal HIT, and 100 % (95; 100 %) in MIT. The supramaximal HIT group reported 60 % of the positive (112 of 186) and 36 % of the negative (52 of 146) events. At the end of the training period, the median (min; max) session RPE was 15 (12; 17) for supramaximal HIT and 14 (9; 15) for MIT. As for FS, the median last within-session rating was 3 (−1; 5) for supramaximal HIT and 3 (1; 5) for MIT. Exercise-related motivation increased (mean difference in Relative Autonomy Index score = 1.54, 95 % CI [0.69; 2.40]), while self-efficacy did not change (mean difference = 0.55, 95 % CI [-0.75; 1.82]), regardless of group.This study provide support for supramaximal HIT in supervised group settings for older adults.

How does rest Interval duration affect performance? An experiment on high-intensity sprint exercises

Introduction: The purpose of this study was to examine the effects of interval and high-intensity sprint training (RST) with different rest intervals on the respiratory function, aerobic and anaerobic power. (2) Materials and Methods: The study involved the voluntary participation of 20 male participants. The participants were divided into two groups: 2IRG (2-minute rest between repeated sprints) and 4IRG (4-minute rest between repeated sprints). The changes in the respiratory function, aerobic, and anaerobic power parameters were examined in the 2IRG and 4IRG athletes who performed two training sessions per week for 4 weeks. (3) Results: The findings indicated that there was no improvement in the respiratory function among the athletes, but there was a significant improvement in aerobic and anaerobic power parameters. However, this improvement was similar in both the 2IRG and 4IRG groups. (4) Conclusions: A 4-week high-intensity interval training program with two RST sessions per week was insufficient to elicit improvements in the respiratory function. However, RST protocols with 2-minute and 4-minute rest intervals provided similar aerobic and anaerobic benefits.

High-intensity interval training improves respiratory and cardiovascular adjustments before and after initiation of exercise.

Purpose: High-intensity interval training (HIIT) may induce training-specific physiological adaptations such as improved respiratory and cardiovascular adjustments before and after the onset of high-intensity exercise, leading to improved exercise performance during high-intensity exercise. The present study investigated the effects of HIIT on time-dependent cardiorespiratory adjustment during maximal exercise and before and after initiation of high-intensity exercise, as well as on maximal exercise performance. Methods: 21 healthy male college students were randomly assigned to HIIT group (n = 11) or control group (n = 10). HIIT group performed training on a cycle ergometer once a week for 8 weeks. The training consisted of three bouts of exercise at 95% maximal work rate (WRmax) until exhaustion. Before and after the HIIT program, dynamic cardiorespiratory function was investigated by ramp and step exercise tests, and HIIT-induced cardiac morphological changes were assessed using echocardiography. Results: HIIT significantly improved not only maximal oxygen uptake and minute ventilation, but also maximal heart rate (HR), systolic blood pressure (SBP), and time to exhaustion in both exercise tests (p < 0.05). Time-dependent increases in minute ventilation (VE) and HR before and at the start of exercise were significantly enhanced after HIIT. During high-intensity exercise, there was a strong correlation between percent change (from before to after HIIT program) in time to exhaustion and percent change in HRmax (r = 0.932, p < 0.001). Furthermore, HIIT-induced cardiac morphological changes such as ventricular wall hypertrophy was observed (p < 0.001). Conclusion: We have demonstrated that HIIT at 95% WRmax induces training-specific adaptations such as improved cardiorespiratory adjustments, not only during maximal exercise but also before and after the onset of high-intensity exercise, improvement of exercise performance mainly associated with circulatory systems.

Recovery After High-Intensity Interval Training in Professional Soccer Players: Passive-Active Combination Recovery Technique

Objective: The aim of this study is to investigate which of the passive recovery (PR), active recovery (AR) and passive-active combination recovery (PAR) techniques applied after the end of high-intensity interval training (HIIT) was more effective in professional super league soccer players. Method: 28 trained professional male soccer players (age: 24.79±2.75 years, height: 180.50±5.81 cm, weight: 74.18±5.47 kg) from the Türkiye Super League team participated in this study voluntarily. Before the study, participants were assigned to 3 groups according to heart rate (HR) and lactic acid (La) levels. Each HIIT load intensity was determined according to the Karvonen method. HIIT sessions were performed for 5 repetitions of 2 minutes (1 set = 5x2 minutes) and a 30-second rest was given between repetitions. At the end of the set, a 2-minute recovery period was applied. Three different recovery techniques, PR, AR and PAR, were applied alternately to each group at the end of the HIIT programs. Participants' HR and La values were taken at the end of HIIT and recovery techniques. Differences between the obtained data were determined by repeated measures one-way ANOVA and multiple comparison tests. P&lt;0.05 level was considered significant in all tests. Results: Although there was no significant difference in La levels between groups (p&gt;0.05), significant differences were observed between HR and loading intensities (p&lt;0.05). According to the results of multiple comparisons, the recoveries in HR and La levels were found to be significant in favor of the PAT group (p&lt;0.05). Discussion: It can be thought that football players increase the mitochondrial biogenesis, oxidative and lipid oxidation capacities of skeletal muscles due to adaptations to HIIT and similar heavy workouts. Depending on these developments in the athletes' condition, it can be said that all three recovery techniques affect the decrease of HR and La in the two-minute period. Conclusion: PR and PAR techniques were effective in reducing HR levels. AR and PAR techniques were effective in reducing La levels. Therefore, it can be said that the PAR technique is more effective in reducing both HR and La levels together.

Moderate-intensity constant or high-intensity interval training? Metabolic effects on candidates to undergo bariatric surgery

Background & aimsBariatric surgery is highly effective against obesity. Pre-surgical exercise programs are recommended to prepare the candidate physically and metabolically for surgery-related rapid weight loss. However, the ideal exercise prescription in this population is unknown. This study aimed to compare the metabolic effects of moderate-intensity constant (MICT) vs. a high-intensity interval training (HIIT) program in candidates to undergo bariatric surgery. Methods and resultsTwenty-five candidates (22 women) to undergo sleeve gastrectomy aged from 18 to 60 years old were recruited. At baseline, we measured body composition, physical activity levels, grip strength, and aerobic capacity. Further, we assessed metabolic function through glycemia and insulinemia (both fasting and after oral glucose tolerance test (OGTT)), homeostatic model assessment for insulin resistance (HOMA-IR), lipid profile, glycated haemoglobin (HbA1c), transaminases, fibroblast growth factor 21 (FGF21), growth differentiation factor 15 (GDF15), apelin, and adiponectin. Afterward, participants were randomized into MICT (n = 14) or HIIT (n = 11). Both training programs consisted of 10 sessions (2–3 times/week, 30 min per session) distributed during 4 weeks before the surgery. After this, all outcomes were measured again at the end of the training programs and 1 month after the surgery (follow-up). A mixed effect with Tukey's post-hoc analysis was performed to compare values at baseline vs. post-training vs. postsurgical follow-up. Both training programs increased aerobic capacity after training (p < 0.05), but only after MICT these changes were kept at follow-up (p < 0.05). However, only MICT decreased fat mass and increased total muscle mass and physical activity levels (p < 0.05). Metabolically, MICT decreased insulinemia after OGTT (p < 0.05), whereas HIIT increased adiponectin after training and GDF15 at follow-up (both p < 0.05). ConclusionsBoth MICT and HIIT conferred benefits in candidates to undergo bariatric surgery, however, several of those effects were program-specific, suggesting that exercise intensity should be considered when preparing these patients. Future studies should explore the potential benefits of prescribing MICT or HIIT in a customized fashion depending on a pretraining screening, along with possible summatory effects by combining these two exercise programs (MICT + HIIT). Clinical trial registrationInternational Traditional Medicine Clinical Trial Registry, N° ISRCTN42273422.

High-intensity interval training enhances mRNA expression of IGF1Ea in rat Achilles tendon.

High-intensity interval training (HIIT) reportedly enhances the functional properties of the musculoskeletal system. However, the effects of HIIT on tendons remain unclear. Sixteen male rats were randomly assigned to the control (Con) or HIIT group (n = 8 in each group). Rats in the HIIT group executed the HIIT program consisting of 2.5min treadmill running and 4.5min rests between the bouts, 5days per week for 9weeks. Running speed, number of sets, and inclination were incrementally increased during the training period. Histological analysis revealed no apparent morphological changes in the extracellular matrix structure or nuclei of tenocytes between the groups. Real-time reverse transcription polymerase chain reaction analysis revealed thatIgf1EamRNA expression was enhanced in the HIIT group. Furthermore,Igfbp5mRNA expression tended to be higher in the HIIT group. The 9-week HIIT program enhanced tenogenic Igf1Ea mRNA expression.

Pre and Post-high-intensity Interval Training Delays Colon Tumor Onset in a Syngeneic Mouse Model.

High-intensity interval training (HIIT) can trigger transient anti-tumor cytotoxicity through the mobilization of natural killer cells (NK cells) and myokines. Yet, the effects of HIIT on tumor development and microenvironment are unclear. Male C57/BL6 mice were administered either MC38 of syngeneic colon cancer cells or vehicle in a single subcutaneous injection. Before injection, the training group completed four weeks of the HIIT program (progressive swimming training, 3/week, 10-12 min, 4-6% of body weight for overload). Following injection, trained mice continued to exercise for two additional weeks. Pre and post-HIIT training was effective in preventing tumor onset (p=0.0065), maintaining body weight gain, and counteracting splenomegaly by 40% compared to the tumor group. However, HIIT had no impact on suppressing tumor growth, modifying final tumor volume, or significantly changing tumor proliferation (Ki-67), connective tissue content, or DNA double-strand damage detected by phospho-histone gamma-H2AX (γ-H2AX). Pre and post-HIIT program is feasible for mice carrying a subcutaneous syngeneic tumor and effective in delaying tumor burden; however, HIIT did not alter colon tumor endpoints.

Evaluation of the Left Ventricular Myocardium Using Layer-Specific Strain Analysis in Adolescent Athletes Performing High-Intensity Interval Training.

High-intensity interval training (HIIT) has been demonstrated to be an efficient way of improving physical performance in adolescent athletes compared to conventional training modalities. The objective of this study was to evaluate the impact of HIIT on the myocardial function of adolescent athletes, specifically focusing on left ventricular (LV) function, using conventional echocardiography and layer-specific strain (LSS) analysis. A total of 19 male adolescent athletes (with mean age of 16.83 ± 1.29years) participating in various football clubs were recruited for this study. During the course of 8weeks, these adolescent male athletes engaged in HIIT program centered around running. Upon completion of HIIT program, a treadmill exercise test was conducted. Subsequently, conventional and LSS echocardiography were conducted to acquire the evaluation of LV myocardial function. Interventricular septum thickness and ventricular mass index were significantly increased post high-intensity interval training (p < 0.005). After the HIIT, the treadmill exercise test demonstrated a significant increase in test duration and metabolic equivalent compared to the pre-training values (p < 0.005). Post high-intensity interval training, LSS analysis revealed significantly improved LV circumferential strain values in the basal and mid-segments of the left ventricle when compared to the pre-training measurements (p < 0.005). The implementation of high-intensity interval training led to an enhancement of circumferential LSS in the LV, indicating a favorable physiological adaptation and improved efficiency of the myocardium.

Muscular fitness profiles in relation to the response in body fat during school-based high-intensity intervention.

We aimed to assess the equivalence of the muscular fitness (MF) between body fat percentage (BFP) responders (Rs<inf>BFP</inf>) and non-responders (NRs<inf>BFP</inf>) to school-based high-intensity interval training (HIIT). Adolescents aged 16 (N.=73, 42.5% of males) were identified as Rs<inf>BFP</inf> (N.=45) or NRs<inf>BFP</inf> (N.=28). MF was assessed based on hand strength (HS), abdominal muscle strength (ABS), and leg power (VJ). Profile analysis showed distinct patterns of MF changes in both response categories. Despite the presence of parallelism (Wilks' Λ=0.979, Pillai's V=0.212, P=0.473), a gradient of increasing changes (HS-ABS-VJ) was found in the Rs<inf>BFP</inf>, while a gradient of decreasing changes was shown in the NRs<inf>BFP</inf>, and a significant level of inequality (F<inf>(1,71)</inf>=7.823, P=0.047, partial eta-squared [η2<inf>p</inf>] 0.041). One-way analysis showed a significant and moderate effect on VJ (F<inf>(1,71)</inf>=7.080, P=0.010, η2<inf>P</inf>=0.091), a close to significant effect on ABS (F<inf>(1,71)</inf>=3.300, P=0.074, η2<inf>P</inf>=0.044) and lack of an effect on HS (F<inf>(1,71)</inf>=0.699, P=0.406, η2<inf>P</inf>=0.010). The test of equal means across the condition categories (separately for Rs<inf>BFP</inf> and NRs<inf>BFP</inf>) indicated that there was no multivariate statistically significant within-group effect (F<inf>(2, 70)</inf>=0.517, P=0.599). The findings may help teachers assess the potential and indirect changes in muscle performance after employing a body weight intervention (based on the HIIT program). A more targeted approach to treating adolescents with excessive BF, in parallel with improving MF, can be individually tailored.

The Influence of the HIIT and Aerobic Training Programs on Body Composition.

Purpose: According to studies, the increased risk of obesity in today's general population is mainly caused by insufficient physical activity. In this study, we compared the effect of two types of endurance training. High-intensity interval training (HIIT) and aerobic (continuous) load training and their impact on selected aspects of body composition. Methods: This study included women (n = 14; 32 years old; height 166.3cm; weight 62.5kg) divided into two groups of seven participants. The tested groups were selected by a deliberate selection of 7 probands, training thrice a week for ten weeks. An entrance and exit examination was conducted using non-invasive techniques (anthropometric measurements, body composition analysis – bioimpedance analysis). A paired T-test (p &lt; 0.05) was used for parameter analysis. Cohen's d was used to assess material significance. Results: Despite the small sample of tested women, better results were achieved in the group implementing the high-intensity interval training. However, these data do not allow for assessing a statistically significant difference between the two types of training methods in reducing the percentage of body fat. Changes in monitored parameters were thus evaluated as statistically insignificant. Conclusion: Despite the relevant results, better results were achieved in the HIIT intervention program. The limiting factors of the study were a small research sample with a deliberate selection and insufficient possibility to control eating habits. Furthermore, it is necessary to pay attention to the higher readiness and motivation of the participants. High-intensity interval training, thanks to its variability and low time requirement, proved to be a suitable exercise program for changing body composition not only in people with obesity but also in the adult population in general.

High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study

IntroductionA novel high-intensity interval training (HIIT) programme has demonstrated feasibility for patients with intermittent claudication (IC). The aim of this study was to explore patient perspectives of the HIIT programme to inform refinement and future research. MethodsAll patients screened and eligible for the ‘high intensity interval training in patients with intermittent claudication (INITIATE)’ study, were eligible to take part in a semi-structured interview. A convenience subsample of patients was selected from three distinct groups: 1) those who completed the HIIT programme, 2) those who prematurely discontinued the HIIT programme and 3) those who declined the HIIT programme. Interviews considered patients views of the programme and experiences of undertaking and/or being invited to undertake it. Interviews were audio recorded, transcribed verbatim and analysed via thematic analysis. ResultsEleven out of 31 participants who completed the programme and twelve out of 38 decliners were interviewed. No participants who withdrew from the programme agreed to interview. The three key themes were; personal reflections of the programme; programme facilitators and barriers; and perceived benefits. Completers enjoyed taking part, reported symptomatic improvement and would complete it again. Practical and psychological barriers exist, such as transport and motivation. Changes to the programme were suggested. ConclusionFindings support the acceptability of this novel HIIT programme, which in combination with the feasibility findings, suggest that a fully powered randomised controlled trial, comparing HIIT to usual-care supervised exercise programmes is warranted.

Effects of a Cycling versus Running HIIT Program on Fat Mass Loss and Gut Microbiota Composition in Men with Overweight/Obesity.

High-intensity interval training (HIIT) can efficiently decrease total and (intra-)abdominal fat mass (FM); however, the effects of running versus cycling HIIT programs on FM reduction have not been compared yet. In addition, the link between HIIT-induced FM reduction and gut microbiota must be better investigated. The aim of this study was to compare the effects of two 12-wk HIIT isoenergetic programs (cycling vs running) on body composition and fecal microbiota composition in nondieting men with overweight or obesity. Sixteen men (age, 54.2 ± 9.6 yr; body mass index, 29.9 ± 2.3 kg·m -2 ) were randomly assigned to the HIIT-BIKE (10 × 45 s at 80%-85% of maximal heart rate, 90-s active recovery) or HIIT-RUN (9 × 45 s at 80%-85% of maximal heart rate, 90-s active recovery) group (3 times per week). Dual-energy x-ray absorptiometry was used to determine body composition. Preintervention and postintervention fecal microbiota composition was analyzed by 16S rRNA gene sequencing, and diet was controlled. Overall, body weight, and abdominal and visceral FM decreased over time ( P < 0.05). No difference was observed for weight, total body FM, and visceral FM between groups (% change). Conversely, abdominal FM loss was greater in the HIIT-RUN group (-16.1% vs -8.3%; P = 0.050). The α-diversity of gut microbiota did not vary between baseline and intervention end and between groups, but was associated with abdominal FM change ( r = -0.6; P = 0.02). The baseline microbiota profile and composition changes were correlated with total and abdominal/visceral FM losses. Both cycling and running isoenergetic HIIT programs improved body composition in men with overweight/obesity. Baseline intestinal microbiota composition and its postintervention variations were correlated with FM reduction, strengthening the possible link between these parameters. The mechanisms underlying the greater abdominal FM loss in the HIIT-RUN group require additional investigations.

The effects of high intensity interval training on quality of life: a systematic review and meta-analysis

Abstract Aim This study aimed to ascertain the impact of high intensity interval training (HIIT) on physical, mental, and overall quality of life (QoL) through a comprehensive systematic review and meta-analysis. Subject and methods A systematic search for relevant trials was performed via PubMed, the Cochrane Library and Web of science as well as the manual screening of prior meta-analyses and their respective reference lists (PROSPERO reference: CRD42022326576). Adult controlled trials investigating the effects of a &gt;2-week HIIT intervention with an eligible non-intervention control group were considered. As the primary outcome, studies were required to include at least one measure of physical and/or mental and/or overall QoL, on any validated QoL domain, pre and post intervention. Results Twenty-two studies with twenty-four effect sizes were included; seventeen comparing HIIT and overall QoL, fourteen comparing HIIT and physical QoL and thirteen studies comparing HIIT and mental QoL. There was a statistically significant improvement in physical (SMD= 0.405, 95% CI: 0.110- 0.700, p= 0.007), mental (SMD= 0.473, 95% CI: 0.043 –0.902, p=0.031) and overall QoL (SMD= 0.554, 95% CI 0.210-0.898, p=0.002) following a program of HIIT. Secondary analysis of 5 studies comparing HIIT against moderate intensity continuous training demonstrated no significant difference in improvement between the two modes (SMD= -0.094, CI= -0.506-0.318, p=0.655). Conclusion Engaging in HIIT produces statistically significant improvements in physical, mental, and overall quality of life in clinical and non-clinical populations at a small to moderate effect size. Furthermore, HIIT appears as effective as MICT in improving overall QoL, offering a more time-efficient exercise option.

High-intensity interval training programs and their impact on endurance performance in handball players: A systematic review

Abstract Study aim: This systematic review aimed to identify and analyze the available evidence about the effects of high-intensity interval training (HIIT) interventions on endurance performance in handball players. Material and methods: The search for relevant literature was conducted across prominent databases, including PubMed, Scopus, SPORTDiscus, and Web of Science Core Collection. The eligibility criteria focused on healthy handball players, without restrictions on age, sex, or competitive level, who were exposed to HIIT interventions, either alone or in combination with other training methods. The methodological assessment employed the RoB2 and ROBINS scales. A screening process was executed, evaluating 434 titles, leading to the inclusion of 17 eligible studies in this systematic review, comprising a total of 369 participants. Results: Most studies on HIIT in handball involved tier-two athletes (trained/developmental) and mostly men. The training frequency typically implemented was twice per week, with a duration between 4 and 12 weeks, with different types of HIIT. There was considerable variation in outcomes across the included studies, with most of them demonstrating a significant positive impact of HIIT on improving endurance performance when compared to controls. Conclusion: In conclusion, the predominant focus of the overall analyzed studies was on the effects of different HIIT interventions in obtaining positive performance adaptations assessed by field-based tests in handball players.

Home-based high-intensity interval training for people with Parkinson's: Protocol for the HIIT-Home4Parkinson's randomized, controlled feasibility study.

High-intensity interval training (HIIT) is feasible and beneficial for some people with Parkinson's (PwP), although adherence to extended programs may be problematic. PwP face barriers to exercise such as lack of time, expense, and difficulty with travel logistics due to motor symptoms. HIIT based in the home setting if practical, could therefore be apposite for PwP by overcoming these barriers. However, until now, no home-based HIIT program for PwP has been developed. Cocreated by PwP, clinicians, and family members, the HIIT-Home4Parkinson's (HH4P) program is an innovative, 12-week home-based HIIT program for PwP. This protocol describes a feasibility study designed to assess the feasibility and safety of the HH4P program, explore outcomes that may be sensitive to change, and inform the implementation of a potential full trial. Using a randomized controlled parallel group design, 24independently mobile people with Parkinson's of mild to moderate disease severity will be randomized 1:1 to either the HH4P program plus usual care, or usual care alone. Both groups will be assessed at baseline, and upon the completion of the program. Outcomes will include feasibility and safety factors such as recruitment, completion, adverse events, and intervention fidelity with qualitative evaluation along with mechanistic, physiological, and clinical outcomes. Results of this study will inform the rationale and methodological considerations for a full trial with long-term follow-up. Ultimately, further establishing the practicality and utility of home-based HIIT could provide an important exercise option for PwP, potentially leading to extended participation and increased health and well-being for this population.

Changing the game in the fitness industry: effectiveness of high-intensity interval training for girth, vital signs, and BMI

The High-Intensity Interval Training program quickly became one of the most popular exercise regiments due to its ability to improve health by significantly impacting the body. This experimental study focused on determining the effectiveness of a 1-month High-Intensity Interval Training program to 10 selected clients which are classified as overweight and obese. Based on the findings, it was found that after participating in High-Intensity Interval Training for one month, most of the participants successfully reduced body measurements, vital signs, and body mass index. In terms of girth measurements, participants’ abdomen, chest and waist circumference improved significantly; while forearm and the legs have a slight significant difference. Based on blood pressure, it was observed that High-Intensity Interval Training may positively help to keep blood pressure in the normal range. However, no evidence to imply that this particular program can regulate it. Lastly, based on the pre- and post-test scores of the clients, it was observed that High-Intensity Interval Training program has a significant effect on the improvement on their girth measurement, vital signs, and body mass index. Performing a similar study to support or repudiate the claims of this study is highly recommended.

Effects of Exercise Intensity during the Detraining Period on Changed Muscle Hypertrophy- and Mitochondrial Biogenesis-Related Proteins after High-Intensity Interval Training

This study investigated whether different exercise intensities during detraining could maintain muscle hypertrophy and mitochondrial biogenesis signaling pathways activated high-intensity interval training (HIIT) in the flexor pollicis longus and soleus muscles of Sprague-Dawley rats. Fiver groups were studied: non-exercise ([NEG], n=6), HIIT only ([CTG], n=6), resting control ([CD], n=6), low-intensity exercise (LID, n=6), moderate-intensity exercise ([MID], n=6). The HIIT program consisted of 30-minute sessions of 24 m/min for eight weeks. During detraining (two weeks), LID and MID groups exercise three times per week at 8 m/min and 16 m/min, respectively. Muscle hypertrophy and mitochondrial biogenesis-related protein expression in the flexor pollicis longus and soleus muscles were analyzed using Western blotting. Compared to NEG, PI3K was higher in the CTG and LID in the flexor pollicis longus, while Akt and p-mTOR signaling pathways were significantly activated in MID and CTG. In the soleus muscle, p-AMPK expression was higher in CD and MID than in NEG, and FNDC5 was upregulated in LID compared to CTG and CD. These findings suggest that moderate-intensity exercise during detraining may help maintain HIIT-induced muscle hypertrophy signaling, while low-intensity exercise may contribute to sustaining HIIT-activated aerobic metabolism in skeletal muscle.

COMPARISON OF MORNING AND EVENING HIGH-INTENSITY INTERVAL TRAINING (HIIT) ON SELECTED PARAMETERS IN BADMINTON PLAYERS

In this study, we delve into the realm of high-intensity interval training (HIIT) and its impact on the performance of collegiate badminton players, emphasizing the importance of timing in implementing such training. A total of 45 male college badminton players, aged 18 to 21, regularly engaging in five days of exercise per week for at least one year, participated in the research conducted at Government Degree College (GDC), Qila Didar Singh, Gujranwala, Punjab, Pakistan. The participants exhibited a mean age of 19.48 ± 1.29 years, a height of 170.31 ± 7.15 cm, a weight of 64.37 ± 6.59 kg, and a BMI of 22.22 ± 2.12. The research protocols comprised a ten-minute warm-up followed by ten minutes of HIIT, with measurements taken during the morning (09:30-10:30 a.m.) and evening (05:00-06:00 p.m.) sessions. Evaluation of aerobic fitness, speed, and agility utilized the 20m shuttle run test, Sprint time over 20m, and SEMO agility test. Results revealed significant differences in scores between morning and evening HIIT programs (p &lt; .05). However, no significant disparities were noted in the performance times of these tests between the two time frames (p &gt; .05). In conclusion, this study suggests that HIIT training can enhance badminton players' performance, irrespective of whether it is conducted in the morning or evening.