High-intensity Anaerobic Exercise Research Articles

Effect of three months high-intensity anaerobic treadmill-based exercise on intuitive decision-making capability

Background. Quick decision making capability is critical for handling critical situation. Intuitive decision making is most desirable for situations requiring quick and heedful decisions. Decision making, just like other cognitive skills can be modified through several factors like physical activity. In this study we aim to decipher the effects of high-intensity treadmill-based exercise on intuitive ability. Methods. A prospective cohort design with convenience sampling with a sample of 80 participants from various gym centres. Following ethical approval and informed consent, participants were divided in to either no exercise (NE) (n = 38) condition or treadmill-based exercise (TBE) group (n = 42). Data on socio-demographic characters, self-reported mental health history and IDM scores were obtained. Data were obtained at baseline and after 34 sessions of treadmill-based exercise for TBE and 12 weeks of normal physical activity for NE group. Mixed-factor ANOVA, paired t-test and regression analysis was used utilizing SPSS version 21. Results. A significant improvement in IDM scores was observed in TBE group after 34 exercise sessions as compared to NE group (p < .01). A significant interaction of time points and group was also revealed through mixed-factor ANOVA (p < .01). Socio-demographic characters and mental health history had no significant impact on IDM scores. Chi-square analysis of the IDM sub-categories showed a significant increase in intuitive decision making individuals in the TBE group post intervention (p < .01). Conclusion. Exercise training can be used as a potential training tool for improving decision making outcomes in critical settings.

Interval training has more negative effects on sleep in adolescent speed skaters: a randomized cross controlled trial.

Sleep is an essential component of athletic performance and recovery. This study aimed to investigate the effects of different types of high-intensity exercise on sleep parameters in adolescent speed skaters. Eighteen male adolescent speed skaters underwent aerobic capacity testing, Wingate testing, and interval training in a randomized crossover design to assess strength output, heart rate, and blood lactate levels during exercise. Sleep quality after each type of exercise was evaluated using the Firstbeat Bodyguard 3 monitor. The results showed that Wingate testing and interval training led to decreased sleep duration, increased duration of stress, decreased RMSSD, and increased LF/HF ratio (p < 0.01). Conversely, aerobic capacity testing did not significantly affect sleep (p > 0.05). The impact of interval training on sleep parameters was more significant compared to aerobic capacity testing (p < 0.01) and Wingate testing (p < 0.01). High-intensity anaerobic exercise has a profound impact on athletes' sleep, primarily resulting in decreased sleep duration, increased stress duration, decreased RMSSD, and increased LF/HF ratio.

Thermographic Changes following Short-Term High-Intensity Anaerobic Exercise.

Current studies report thermographic changes following aerobic or resistance exercise but not short, vigorous anaerobic exercise. Therefore, we investigated body surface temperature changes using thermal imaging following a short session of anaerobic exercise. We studied three different regions of interest (ROIs): the legs, chest, and forehead. Thermal imaging for each participant was performed before and immediately after completing a Wingate anaerobic test and every minute during a 15 min recovery period. Immediately after the test, the maximum temperature was significantly higher in all ROIs (legs, p = 0.0323; chest, p = 0.0455; forehead, p = 0.0444) compared to pre-test values. During the recovery period, both legs showed a significant and continuous temperature increase (right leg, p = 0.0272; left leg, p = 0.0382), whereas a non-significant drop was noted in the chest and forehead temperatures. Additionally, participants with a lower anaerobic capacity exhibited a higher delta increase in surface leg temperature than participants with higher anaerobic capacities, with a minimal change in surface leg temperature. This is the first study to demonstrate body surface temperature changes following the Wingate anaerobic test. This temperature increase is attributed to the high anaerobic mechanical power outputs achieved by the leg muscles and the time taken for temperature reduction post-exercise.

The Effects of Various Modes of High-Intensity Anaerobic Exercise on Dynamic Balance Performance

The Effects of Various Modes of High-Intensity Anaerobic Exercise on Dynamic Balance Performance

Racial Differences in Blood Pressure and Autonomic Recovery Following Acute Supramaximal Exercise in Women.

Despite the growing popularity of high-intensity anaerobic exercise, little is known about the acute effects of this form of exercise on cardiovascular hemodynamics or autonomic modulation, which might provide insight into the individual assessment of responses to training load. The purpose of this study was to compare blood pressure and autonomic recovery following repeated bouts of acute supramaximal exercise in Black and White women. A convenience sample of twelve White and eight Black young, healthy women were recruited for this study and completed two consecutive bouts of supramaximal exercise on the cycle ergometer with 30 min of recovery in between. Brachial and central aortic blood pressures were assessed by tonometry (SphygmoCor Xcel) at rest and 15-min and 30-min following each exercise bout. Central aortic blood pressure was estimated using brachial pressure waveforms and customized software. Autonomic modulation was measured in a subset of ten participants by heart-rate variability and baroreflex sensitivity. Brachial mean arterial pressure and diastolic blood pressure were significantly higher in Blacks compared to Whites across time (race effect, p = 0.043 and p = 0.049, respectively). Very-low-frequency and low-frequency bands of heart rate variability, which are associated with sympathovagal balance and vasomotor tone, were 22.5% and 24.9% lower, respectively, in Blacks compared to Whites (race effect, p = 0.045 and p = 0.006, respectively). In conclusion, the preliminary findings of racial differences in blood pressure and autonomic recovery following supramaximal exercise warrant further investigations of tailored exercise prescriptions for Blacks and Whites.

Effects of High-Intensity Anaerobic Exercise on the Scavenging Activity of Various Reactive Oxygen Species and Free Radicals in Athletes.

High-intensity exercise in athletes results in mainly the production of excess reactive oxygen species (ROS) in skeletal muscle, and thus athletes should maintain greater ROS scavenging activity in the body. We investigated the changes in six different ROS-scavenging activities in athletes following high-intensity anaerobic exercise. A 30-s Wingate exercise test as a form of high-intensity anaerobic exercise was completed by 10 male university track and field team members. Blood samples were collected before and after the exercise, and the ROS-scavenging activities (OH•, O2•−, 1O2, RO• and ROO•, and CH3•) were evaluated by the electron spin resonance (ESR) spin-trapping method. The anaerobic exercise significantly increased RO• and ROO• scavenging activities, and the total area of the radar chart in the ROS-scavenging activities increased 178% from that in pre-exercise. A significant correlation between the mean power of the anaerobic exercise and the 1O2 scavenging activity was revealed (r = 0.72, p < 0.05). The increase ratio in OH• scavenging activity after high-intensity exercise was significantly greater in the higher mean-power group compared to the lower mean-power group (n = 5, each). These results suggest that (i) the scavenging activities of some ROS are increased immediately after high-intensity anaerobic exercise, and (ii) an individual’s OH• scavenging activity responsiveness may be related to his anaerobic exercise performance. In addition, greater pre-exercise 1O2 scavenging activity might lead to the generation of higher mean power in high-intensity anaerobic exercise.

Effect of a Sugar-Free Branched Chain Amino Acid-Containing Sports Drink on Acute High Intensity Anaerobic Performance

Purpose: BioSteel® high performance sports drink (HPSD) is an enticing alternative to carbohydrate-containing sports drinks that are often associated with side effects such as gastrointestinal discomfort or post-consumption hypoglycemia. BioSteel® HPSD is carbohydrate-free and provides bioavailability of branched-chain amino acids (BCAAs) and other necessary cofactors that aid in BCAAs digestion. Here, we investigated the efficacy of BioSteel® HPSD to improve high-intensity anaerobic exercise performance in young adults. Methods: A modified Wingate anaerobic test (mWAnT) was performed by fourteen healthy college students. Each subject underwent a total of nine trials, with each trial consisting of four bouts of cycling for 10 seconds / bout. The crossover design had each subject consume either BioSteel® HPSD, placebo, or water 30 minutes prior to the onset of exercise for three trials each, respectively. Results: Participants consuming BioSteel® HPSD had significantly improved average power output expressed as an average of all bouts and all trials. Analyzing exercise performance as a function of separate 10 second bouts revealed significantly higher power output (bouts 1 and 4) and peak power (bout 1) in the BioSteel® HPSD consuming group. Despite this increased power output, subjects consuming BioSteel® HPSD did not fatigue faster or to a greater extent, as evidenced by fatigue index. Translation of power output to distance travelled indicated a significantly increased distance traveled by the subjects who drank BioSteel® HPSD. Conclusion: Collectively, our data demonstrate that BioSteel® HPSD has a positive effect on acute anaerobic performance.

Abstract 10585: Racial Differences in Arterial Stiffness Following Acute Bouts of Anaerobic Exercise

African Americans (AA) experience an exaggerated hemodynamic response during recovery from aerobic exercise compared to Caucasian Americans (CA). There is also evidence that local arterial stiffness increases and systemic vasculature stiffness decreases following aerobic exercise. Despite the growing popularity of high-intensity anaerobic exercise, no study has examined racial differences in arterial stiffness following maximal anaerobic exercise between AA and CA women. Purpose: To compare local and systemic arterial stiffness during recovery from repeated bouts of maximal anaerobic exercise in young, healthy AA and CA women. Methods: Twenty (AA: n=8, age = 22±1yrs, BMI = 24.7±0.8 kg/m 2 ; CA: n=12, age = 22±1 yrs, BMI = 22.9 ±0.7 kg/m 2 ) healthy women without hypertension completed two bouts of maximal anaerobic exercise on a cycle ergometer with 30 minutes of recovery between bouts. Hemodynamic measurements were taken at resting, and 5 (P5-post-EX1), 15 (P15 post-EX1), and 30 minutes (P30 post-EX1) following a maximal anaerobic exercise test on cycle ergometer, and 5 (P5 post-EX2), 15 (P15 post-EX2), and 30 (P30 post-EX2) minutes following the second maximal anaerobic exercise test. Local carotid arterial compliance (AC) was assessed using ultrasonography and systemic arterial stiffness was assessed by augmentation index (AIx@75) and segmental arterial stiffness assessed by central Pulse Wave Velocity (cPWV) using SphygmoCor. Data were analyzed by 2 by 7 (race *time) repeated measures ANOVA. Results: See Table 1. Conclusion: There is less variation in local carotid arterial compliance in AA women compared to CA women following repeated bouts of maximal anaerobic exercise despite similar systemic or segmental arterial stiffness. Racial differences in arterial distensibility between AA and CA women in response to maximal anaerobic exercise may be limited to localized changes in the predominantly elastic carotid artery.

Chronic Ingestion of Bicarbonate-Rich Water Improves Anaerobic Performance in Hypohydrated Elite Judo Athletes: A Pilot Study.

In combat sports, anaerobic power and anaerobic capacity determine sport performance and the dominant metabolic pathways. The decline in performance during exercise that is attributed to the cumulative effects of fatigue, including excessive accumulation of metabolites, depletion of energy substrates, and water and electrolyte disturbances, seems to be of greatest significance. In our experiment, we evaluated the effectiveness of three weeks of bicarbonate-rich water ingestion on anaerobic performance in a state of hydration and dehydration in elite judo athletes. Eight male, elite judo athletes participated in two single-blind, repeated-measures trials. They were assigned to two hydration protocols, ingesting low mineralized table water and bicarbonate-rich water. Anaerobic performance was evaluated by two 30 s Wingate tests for lower and upper limbs, respectively, under conditions of hydration as well as exercise-induced dehydration. Resting, post-ingestion, and post-exercise concentrations of bicarbonate (HCO3), urine osmolality (UOSM), urine specific gravity (UGRAV), and lactate (La) were measured. The current investigation assessed two related factors that impair anaerobic performance—hypohydration and buffering capacity. High-bicarbonate water ingestion improved buffering capacity, and we demonstrated the potential role of this mechanism and its phenomenon in masking the adverse effects of dehydration in the context of repeated high-intensity anaerobic exercise (HIAE).

Fermented soybean beverage improves performance and attenuates anaerobic exercise oxidative stress in Wistar rat skeletal muscle

BackgroundHigh intensity exercises can damage active muscles due to mechanical and oxidative stress. Dietary supplements can mitigate muscle damage, especially vegetable products with high content of antioxidant compounds, such as soybean. We aimed to evaluate the effects of a fermented soy-based beverage on oxidative stress and exercise performance in animals submitted to resistive exercise. MethodsThe soybean fermented product was prepared with soybean extract fermented by Kefir grains and then the content of flavonoids, phenolic compounds and antioxidant activity were analyzed using the ABTS test. Animals were divided into sedentary (control-C, soybean-S, and soybean-kefir-SK) and exercised (exercise-E, soybean-SE, and soybean-kefir-SKE) groups. After 8 weeks of treatment all animals were euthanized. ResultsBlood lactate was high (>7 mmol/l) in all exercised groups. The SKE group performed the highest number of jumps in training sessions, when compared to the other groups (E: 28.20 ± 2.29; SE: 29.20 ± 2.72; SKE: 41.27 ± 1.76; jump/min; p < 0.05). In addition, the SKE group developed hypertrophy of the gastrocnemicus muscle (E: 1.46 ± 0.003; SE: 1.46 ± 0.005; SKE: 1.51 ± 0.005; g/cm; p < 0.05), with less oxidative stress. The soybean fermented beverage had a high antioxidant effect (SK IR50: 4.13 ± 0.57; S IR50: 6.53 ± 0.35; p < 0.05) and increased flavonoids content (SK: 0.96 ± 0.04 mg/g; S: 0.095 ± 0.038 mg/g; p < 0.01). ConclusionHigh flavonoids content soy-based drink fermented with kefir blunted oxidative stress on skeletal muscle, resulting in improvement of the physical performance in animals trained through high intensity anaerobic exercise.

The potential use of lactate blockers for the prevention of COVID-19 worst outcome, insights from exercise immunology

Following the decline in Physical Activity (PA) due to COVID-19 restrictions in the form of government mandated lockdowns and closures of public spaces, the modulatory effect of physical exercise on immunity is being heavily revisited. In an attempt to comprehend the wide discrepancy in patient response to COVID-19 and the factors that potentially modulate it, we summarize the findings relating PA to inflammation and immunity. A distinction is drawn between moderate intensity and high intensity physical exercise based on the high lactate production observed in the latter. We hypothesize that, the lactate production associated with high intensity anaerobic exercise is implicated in the modulation of several components of the innate and adaptive immunity. In this review, we also summarize these immunomodulatory effects of lactate. These include increasing serum IL-6 levels, the main mediator of cytokine storms, as well as affecting NK cells, Macrophages, Dendritic cells and cytotoxic T-lymphocytes. The implications of high lactate levels in athletic performance are highlighted where athletes should undergo endurance training to increase VO2 max and minimize lactate production. Tumor models of hypoxia were also reported where lactate levels are elevated leading to increased invasiveness and angiogenesis. Accordingly, the novel lactate blocking strategy employed in cancer treatment is evaluated for its potential benefit in COVID-19 in addition to the readily available beta-blockers as an antagonist to lactate. Finally, we suggest the diagnostic/prognostic purpose of the elevated lactate levels that can be determined through sweat lactate testing. It is the detrimental effect of lactate on immunity and its presence in sweat that qualify it to be used as a potential non-invasive marker of poor COVID-19 outcome.

Effect of Modified High Intensity Interval Training on Fat Loss

Exercise has multiple health benefits and is a critical component in managing overweight and obesity. High Intensity Interval Training (HIIT) involves brief high-intensity anaerobic exercise followed by rest or very low intensity exercise. 24 men and women (age 18–60 years) volunteered to participate in a 6 weeks of modified HIIT exercises program where whole body functional training exercises was provided. Their body weight, body mass index, waist to hip ratio and skin fold fat were measured at the beginning and at the end of the 6 weeks duration . Statistical significance was found between the variables at p < 0.05. The results showed that a Modified HIIT exercise Program based on Body weight training results in considerable decrease in level of sub-cutaneous adiposity up to 77.8%. Obesity and overweight have become complex pandemic disorders where in physical inactivity and lack of time to exercise plays a major role leading to various complications. Reduction in adiposity through structured exercises protocols will improve body composition and Cardio-metabolic health . Novel interventions such as modified HIIT serve as the perfect pathway to address the time factor and enhancement of physical activity as well.

Racial Differences In Cardiovascular Responses Following Acute Bouts Of Anaerobic Exercise

Despite the growing popularity of high-intensity anaerobic exercise, few studies have examined the acute effects of this form of exercise on cardiovascular hemodynamics, or potential racial differences in these responses. In addition, post exercise hypotension may be absent in African Americans (AA) following aerobic exercise, consistent with their higher risk for hypertension. It is unknown whether AA and Caucasian Americans (CA) would exhibit different blood pressures following acute bouts of anaerobic exercise. PURPOSE: To assess hemodynamic changes in healthy, young AA and CA women following repeated bouts (two) of maximal anaerobic exercise. METHODS: Eight young, healthy AA women and 9 CA women completed this study. Vascular and hemodynamic measurements were taken at rest, and 5 (P5-1st), 15 (P15-1st), and 30 minutes (P30-1st) following a maximal anaerobic exercise test on cycle ergometer, and 5 (P5-2nd), 15 (P15-2nd), and 30 (P30-2nd) minutes following the second maximal anaerobic exercise test. Brachial systolic (SBP), diastolic (DBP) blood pressures, central aortic SBP, DBP and mean arterial blood pressure (aortic MAP) were measured. Carotid arterial stiffness (beta-stiffness index) were obtained using ultrasonography. RESULTS: Data were presented in Table 1 as mean ± standard error. Resting DBP and aortic DBP were significantly different between AA and CA (§ p<0.05). There was a significant race by time interaction for aortic MAP (* p<0.05). And there was a trend towards significance in race by time interaction for beta stiffness index (p=0.06). CONCLUSION: Acute bouts of anaerobic exercise increase aortic MAP in young AA but not in CA, and it may be related to increases in arterial stiffness in AA. The heightened BP and vascular responses to exercise stimulus may play a role in the pathogenesis of hypertension in AA. Supported by New England ACSM New Investigator Award to HY.Table 1: Hemodynamic responses to two acute bouts of maximal anaerobic exercise.

Renal Vascular Responsiveness to Sympathetic Activation is Not Affected by Prior High Intensity Anaerobic Exercise

Renal Vascular Responsiveness to Sympathetic Activation is Not Affected by Prior High Intensity Anaerobic Exercise

Citrus Aurantium and caffeine complex versus placebo on biomarkers of metabolism: a double blind crossover design

BackgrouondThe purpose of this study was to examine resting the metabolic response to the ingestion of a complex containing Citrus Aurantium + Caffeine (CA + C) and if its consumption influences metabolic recovery following a high-intensity anaerobic exercise bout in habitual caffeine users.MethodsTen physically active males (25.1 ± 3.9 years; weight 78.71 ± 9.53 kg; height 177.2 ± 4.6 cm; body fat 15.5 ± 3.13%) participated in this study. This study was performed in a double-blind, randomized crossover fashion consisting of two exhaustive exercise protocols. On each visit the participants consumed either a CA + C (100 mg of CA and 100 mg of C) or placebo (dextrose) capsule. After consumption, participants were monitored throughout a 45-min ingestion period, then completed a repeated Wingate protocol, and were then monitored throughout a 45-min recovery period. Metabolic function was measured through blood glucose, plasma insulin, plasma triglycerides, and plasma catecholamines: epinephrine (E) and norepinephrine (NE). Biomarkers were taken at four different time points; Ingestion period: baseline (I1), post-ingestion period (I2); Recovery period: immediately post-exercise (R1), post-recovery period (R2).ResultsA repeated measures ANOVA revealed significant time-dependent increases in plasma E and NE at I2 only in the CA + C trial (p < 0.05), and a significant decrease in blood glucose at I2 in the PLA trial (p < 0.05); however, no meaningful changes in glucose was observed following CA + C ingestion. No changes in insulin or triglycerides were observed during the ingestion period. No trial-dependent differences were observed in the Recovery period. All biomarkers of metabolic recovery were equivalent when evaluating R1 v R2. Participants recovered in a similar time-dependent manner in all markers of metabolism following the PLA and CA + C trials.ConclusionThe findings of this study suggested that normal recommended dosages of 100 mg CA + 100 mg C is sufficient to promote glucose sparing at rest, with modest increases in SNS activity; however, the individual role of CA or C in this response cannot be determined.

Effects of immediate post-exercise recovery after a high intensity exercise on subsequent cycling performance

The aim of the study is to investigate the comparative effect of compression sleeves, rest and active recovery on performance and immediate recovery from high-intensity cycling performance (HICP). Eight recreationally trained male cyclists completed three trials, each separated by one week. Each trial consisted of two 10-min high intensity exercise task (30-20-10 s maximal HICP bouts with 3 min 1 W/kg recovery) separated by application one of the three 24-min recovery strategies (active – cycling 1W/kg, ACT; passive – supine position, PAS; passive – sitting with compression sleeves; PAS+CS). Applied recovery strategy effectiveness was assessed via changes in blood lactate clearance (LA), acid-base changes and performance parameters (fatigue index, FI; peak power, PP and relative peak power). Fatigue index was significantly improved by ACT for 30s and 20s HICP. There was a significant decrease in FI for PAS + CS (p = 0.041) and PAS (p = 0.026) showing a negative impact of PAS + CS and PAS for keeping PP during 10s task. The rate of decrease in plasma LA concentration over the 24-min recovery period was significantly higher in ACT (0.50 ± 0.1 mmol/min) compared to PAS and PAS+CS (0.31 ± 0.07 mmol/l, p = 0.001, 0.37 ± 0.09 mmol/min, p = 0.024, respectively). The passive recovery strategies decreased the ability of keeping repeated maximal intensity cycling performance in contrast to active recovery. The use of compression calf sleeves has no significant additional effect on plasma lactate clearance after high intensity anaerobic exercise above resting condition.

Caffeine and Citrate Aurantium Supplementation Alter Resting Cardiac Autonomic Function but Not During Recovery

PURPOSE: To examine the combined effects of the pre exercise complex Citrate Aurantium and Caffeine (CA+C) on cardiac autonomic activity following ingestion and immediately after high-intensity anaerobic exercise in habitual caffeine users. METHODS: Ten physically active males (25.1± 3.9 years; mass 78.7± 9.5kg) who habitually consume caffeine (≥ 1 serving a day [95mg] 4 days a week) participated. This was a double-blind crossover design, where either a CA+C or a placebo capsule was consumed followed by a 45-min ingestion period, a repeated Wingate protocol, and a 45-min recovery period. Cardiac autonomic activity was assessed through Heart Rate (HR), plasma epinephrine (E) and norepinephrine (NE), and markers of Heart Rate Variability (HRV): root mean squared of successive R-R differences (RMSSD); Standard Deviation of R-R intervals (SDNN); High-Frequency (HF); Low-Frequency (LF); and its ratio (LF:HF). Markers were taken at four time points: pre-Ingestion (PRE-ig), 40-45-min post (Post- ig); Wingate recovery (PRE-rcv), 40-45-min post recovery (Post-rcv). RESULTS: Markers that violated normality were naturally log transformed prior to further analysis (ln). Pre-planned comparisons were performed to assess differences between pre and post time points as well as the corresponding time point of the other trial within their respected phase. During the CA+C trial, an increase in HR, lnSDNN, lnLF, EPI, and NE were observed at Post-ig when compared to Pre-ig (p≤0.05). Significant differences were observed in all markers, except LF:HF, during the CA+C and PLA trials from the Pre-rcv to Post-rcv (p≤0.05). CONCLUSION: The consumption of CA+C stimulates sympathetic activity during rest (e.g. ingestion phase) without influencing parasympathetic activity. CA+C provides no influence over cardiac autonomic recovery.

Influence of waterpipe smoking on cardiac autonomic function at rest and following high-intensity anaerobic exercise

Background: Waterpipe (WP) smoking has been linked to reduced birth weight, genetic damage, and respiratory and cardiovascular disease, possibly via enhanced exposure to carbon monoxide and volatile aldehydes. Objective: The effect of long-term WP smoking on cardiac autonomic function at rest and following exercise was investigated. Methods: Twenty males volunteered and were divided into two groups: WP smokers (WPS) and non-smokers (NSmk). Heart rate variability (HRV) at rest and following (10 mins) Wingate test was examined. Additionally, heart rate recovery (HRR) at 1 (HRR1), 2 (HRR2) and 5 mins (HRR5) post-Wingate test were considered. Results: At rest, the WPS group exhibited a significantly greater heart rate and lower standard deviation of RR intervals. The WPS group experienced a significantly greater peak heart rate while the post-Wingate recovery of HRV, HRR1, and HRR2 were similar between groups. In contrast, HRR5 for the WPS group was significantly greater than for the NSmk group. Conclusions: Long-term WP smoking resulted in an altered resting cardiac autonomic state exemplified by reduced overall HRV, specifically, a decline in vagal activity and/or relative increase in sympathetic activity that may persist during anaerobic exercise but not during early recovery.

Cancer and Exercise: Warburg Hypothesis, Tumour Metabolism and High-Intensity Anaerobic Exercise.

There is ample evidence that regular moderate to vigorous aerobic physical activity is related to a reduced risk for various forms of cancer to suggest a causal relationship. Exercise is associated with positive changes in fitness, body composition, and physical functioning as well as in patient-reported outcomes such as fatigue, sleep quality, or health-related quality of life. Emerging evidence indicates that exercise may also be directly linked to the control of tumour biology through direct effects on tumour-intrinsic factors. Beside a multitude of effects of exercise on the human body, one underscored effect of exercise training is to target the specific metabolism of tumour cells, namely the Warburg-type highly glycolytic metabolism. Tumour metabolism as well as the tumour–host interaction may be selectively influenced by single bouts as well as regularly applied exercise, dependent on exercise intensity, duration, frequency and mode. High-intensity anaerobic exercise was shown to inhibit glycolysis and some studies in animals showed that effects on tumour growth might be stronger compared with moderate-intensity aerobic exercise. High-intensity exercise was shown to be safe in patients; however, it has to be applied carefully with an individualized prescription of exercise.

The influence of citrus aurantium and caffeine complex versus placebo on the cardiac autonomic response: a double blind crossover design

BackgroundThe purpose of this study was to examine the resting cardiac autonomic nervous system’s response to the ingestion of a complex containing Citrus aurantium + Caffeine (CA + C) and its influence on recovery following a high-intensity anaerobic exercise bout in habitual caffeine users.MethodsTen physically active males (25.1 ± 3.9 years; weight 78.71 ± 9.53 kg; height 177.2 ± 4.6 cm; body fat 15.5 ± 3.13%) participated in this study, which consisted of two exhaustive exercise protocols in a randomized crossover design. On each visit the participants consumed either a CA + C (100 mg of CA and 100 mg of C) or placebo (dextrose) capsule. After consumption, participants were monitored throughout a 45-min ingestion period, then completed a repeated Wingate protocol, and were then monitored throughout a 45-min recovery period. Cardiac autonomic function (Heart Rate (HR) and Heart Rate Variability (HRV)) and plasma epinephrine (E) and norepinephrine (NE) were taken at four different time points; Ingestion period: baseline (I1), post-ingestion period (I2); Recovery period: immediately post-exercise (R1), post-recovery period (R2). Heart rate variability was assessed in 5-min increments.ResultsA repeated measures ANOVA revealed significant time-dependent increases in HR, sympathetic related markers of HRV, and plasma E and NE at I2 only in the CA + C trial (p < 0.05); however, no meaningful changes in parasympathetic markers of HRV were observed. Participants recovered in a similar time-dependent manner in all markers of HRV and catecholamines following the PLA and CA + C trials.ConclusionThe consumption of CA + C results in an increase of sympathetic activity during resting conditions without influencing parasympathetic activity. CA + C provides no influence over cardiac autonomic recovery.