Poor-quality diets are a major risk factor for non-communicable diseases. Few studies in Mexico have tested whether higher expenditures are needed to purchase high quality food. The objective of the study was to assess how dietary quality for food purchases was associated with household food at home expenditures. This study is a secondary analysis of cross-sectional data from the National Household Income and Expenditure Survey (ENIGH 2018). The study includes 74,469 households with information on food and beverages purchases in Mexico in 2018. Quarterly household food expenditures by adult equivalent (AE) for all food groups that were scored in the Global Dietary Quality Score (GDQS) for food purchases expressed in dollars/quarterly/AE. Adjusted generalized linear models were used to evaluate the association between GDQS for food purchases (expressed in tertiles: low-, mid-, and high-), and quarterly food expenditures. The analyses were performed at the national level, by place of residence and income quintile. At the national level, the difference in food expenditures between the high- and the low-GDQS group was +$13.85 dollars/AE. By place of residence, the difference between the high- and the low-GDQS group was +$17.31 dollars/AE in urban and +$5.12 dollars/AE in rural areas. For income quintile 1 (lowest) there was statistical difference of -$4.79 dollars/AE and for quintile 5 (highest) +$43.25. Quality of food purchases can be associated with higher or lower expenditures depending on the specific food purchased. High GDQS is associated with lower expenditures among the lowest-income households as they purchase less expensive options compared to high-income households.