Purpose: This study analyzes the relationship between self-esteem and gratitude tendency of university stu-dents during the corona 19 era of human disaster. From the end of 2019, TV programs, radio, and social media platforms have covered the novel corona virus infection(Corona 19) as the most important article. The stress caused by the COVID-19 epidemic showed a significant negative correlation with the quality of life, and positive psychological capital had a significant modulating effect, so it was necessary to develop a program to mediate the lowered quality of life. So at this moment, university students in their twenties living with the task of self-formation suggest that they have a high probability of developing depression through the loss of meaningful objects and distortion of their self-experience. Since gratitude has a positive correlation with psychological well-being and negative emotions such as anxiety, depression, and jealousy, it has a great influence on university student s daily life. Method: In this study, the following hypothesis was established to find out what differences are there be-tween gratitude tendency according to the characteristics of university students(gender, grade, religion), and also to examine the relationship between the self-esteem and gratitude tendency of university students. H1: Depending on the characteristics of university students, there will be a significant difference between gratitude tendency. H2: University students self-esteem will have a significant correlation with gratitude tendency. To measure self-esteem among the main variables of this study, the self-esteem item developed by Korean scho-lars was used based on the self-esteem scale developed by Rosenberg(1965). Results: Difference analysis(t-test and ANOVA) was conducted to find out the difference between the grati-tude tendency(Hypothesis 1) according to the characteristics of university students, and the characteristics of university students generally include gender, grade, and religion. The difference between gratitude tendency was significant only in gender and religion actually. As a result of the analysis, in terms of gender, female stu-dents showed a relatively high gratitude tendency, and in religion or not, students with religion showed higher gratitude tendency. As a result of conducting a correlation analysis on the self-esteem and gratitude tendency of university students(Hypothesis 2), significant correlations were found for both self-esteem factors. As a result of the analysis, positive self-esteem shows a positive(+) correlation with gratitude tendency, and negative self-esteem shows a negative(-) correlation with gratitude tendency. Conclusion: This study will be able to suggest a basic plan to ensure that university students can spend their time smoothly without psychological wandering and departure due to the limitations of daily life caused by corona virus infection(corona 19) during career decision period.