Anthropometric measurements of the human knee, have differences in the women's and the men's knee. Total Knee Arthroplasty (TKA), aim is to relieve pain in an osteoarthritic knee, to improve the functional range of movements, and thereby improve the quality of life, of the patient. In this study, which was specically done for women patients with primary tri-compartmental osteoarthritis of the knee, the implant design for total knee arthroplasty was either “Standard CR Flex Knee” or “Gender-Specic CR High-Flex Knee”. This prospective study had a recruitment period of 2 years and a minimum follow-up period of 1 year and was done between March 2018 to February 2021. 23 female subjects aged between 51 to 80 years, were recruited in the “Standard CR Flex Knee” group and 25 female subjects aged between 51 to 80 years, were recruited in the “GenderSpecic CR High-Flex Knee” group. 60.42% (n=29) had a right sided involvement and remaining 39.58% (n=19) had a left sided involvement. Post-operative Knee Society Clinical Rating System (KSS), mean clinical outcome for “Standard CR Flex” and “Gender-Specic CR High-Flex Knee” were scored as 87.5 and 92.0 points respectively. With regard to the mean functional outcome, as per KSS both the groups averaged 85.0 points. Thus, this study could not establish any potential additional benets, by opting for the “Gender-Specic CR High-ex knee prosthesis”. Both the “Standard CR Flex Knee” and the “Gender-Specic CR High-Flex Knee” TKA yielded nearly similar clinico-functional outcomes.