Higher ESS Research Articles

Research on the Application of Mathematics in Finance

Abstract. Mathematics is a fundamental science and a problem-solving method that plays an important role in revealing the essential laws of the development of certain things. It has rigorous logic, high abstractness, and wide applicability. This brings great difficulties to enterprises, especially high school mathematics because it involves a wide range of knowledge points and complex calculations. Among them, the formation of financial mathematics has greatly promoted the development of China's financial industry. Moreover, in solving financial problems, relevant knowledge and theories of mathematics can be used to analyze and explore financial laws, and the application effect is significant, for example, using deterministic mathematical method and nondeterministic mathematical method to solving question about financial investment and returns; building securities investment portfolio model or asset valuation model to calculating and expressing some economic models. Based on this, this article discusses the application of mathematical knowledge to several financial problems, analyzes the current problems, and looks forward to the future of financial mathematics.

Realization of the humanitarian potential of a higher mathematics course in the professional training of technical university students

Introduction. The next stage of globalization of relations is being formed – the creation of a digital economy, including smart manufacturing, smart finance, telemedicine, etc. The UNESCO Science Report: the Race Against Time for Smarter Development – Executive Summary, published in 2021, calls this phase the “fourth industrial revolution.” The development and basis of this revolution in the fields of science and engineering is directly related to digital technologies such as artificial intelligence, robotics, blockchain technology, which intersect with nano- and biotechnologies, and cognitive sciences. Scientific institutions and higher education systems are actively involved in this process as direct participants and as training institutions. Mathematical training is rightfully considered the methodological basis of most educational and special disciplines. The purpose of the study is to reveal the humanitarian potential of a higher mathematics course in the professional training of a technical university student. Materials and methods. In accordance with the provisions of the system-activity and information approaches, the authors have developed a questionnaire to identify preferences in realizing the humanitarian potential of the higher mathematics course at a technical university. Respondents are asked to rank the proposed six statements that characterize the mathematical preparation of students. 368 people took part in the survey, among them students of bachelor's degree (136 people), specialty (124 people), master's degree (78 people) and postgraduate studies (30 people) of St. Petersburg Mining University. The method of summarizing and grouping statistical observation materials was used. Results. The highest rating of 3.74 was occupied by the contradiction between the awareness of the leading role of mathematics in the development of logical thinking and at the same time the predominance of theoretical facts over their practical application in the university course of higher mathematics. This statement was noted as the most significant by 20% of students, 27% of undergraduates and 24% of graduate students. The other two, in terms of the severity of the contradiction, have a rating of 3.55 (mastering the content of a higher mathematics course is accompanied by objective difficulty due to the high abstractness of the subject) and 3.56 (insignificant inclusion of heuristic methods in the content of the course). In the context of constantly increasing requirements for the quality of engineering education, the problem of increasing the role of mathematical knowledge can be solved through didactic support of the educational and cognitive process in the classroom and as part of students’ independent work. In a multi-component educational activity, the basic dominants (spatial, logical, numerical and symbolic) are highlighted and the methodological features of their implementation in the student’s mathematical preparation are revealed. Conclusion. The humanitarian potential of the higher mathematics course presupposes a system of measures aimed at the priority development of intellectual and general cultural qualities of students. The realization of humanitarian potential involves the formation of a student's value attitude towards himself, the world around him and his activities in it. The realization of the humanitarian potential of the discipline in the training of a future engineer is possible through the organization of symbolic activities by means of practice-oriented tasks and educational cases of an applied nature.

Associations of sleep disorders with serum neurofilament light chain levels in Parkinson’s disease

BackgroundSleep disorders are a prevalent non-motor symptom of Parkinson’s disease (PD), although reliable biological markers are presently lacking.ObjectivesTo explore the associations between sleep disorders and serum neurofilament light chain (NfL) levels in individuals with prodromal and early PD.MethodsThe study contained 1113 participants, including 585 early PD individuals, 353 prodromal PD individuals, and 175 healthy controls (HCs). The correlations between sleep disorders (including rapid eye movement sleep behavior disorder (RBD) and excessive daytime sleepiness (EDS)) and serum NfL levels were researched using multiple linear regression models and linear mixed-effects models. We further investigated the correlations between the rates of changes in daytime sleepiness and serum NfL levels using multiple linear regression models.ResultsIn baseline analysis, early and prodromal PD individuals who manifested specific behaviors of RBD showed significantly higher levels of serum NfL. Specifically, early PD individuals who experienced nocturnal dream behaviors (β = 0.033; P = 0.042) and movements of arms or legs during sleep (β = 0.027; P = 0.049) showed significantly higher serum NfL levels. For prodromal PD individuals, serum NfL levels were significantly higher in individuals suffering from disturbed sleep (β = 0.038; P = 0.026). Our longitudinal findings support these baseline associations. Serum NfL levels showed an upward trend in early PD individuals who had a higher total RBDSQ score (β = 0.002; P = 0.011) or who were considered as probable RBD (β = 0.012; P = 0.009) or who exhibited behaviors on several sub-items of the RBDSQ. In addition, early PD individuals who had a high total ESS score (β = 0.001; P = 0.012) or who were regarded to have EDS (β = 0.013; P = 0.007) or who exhibited daytime sleepiness in several conditions had a trend toward higher serum NfL levels.ConclusionSleep disorders correlate with higher serum NfL, suggesting a link to PD neuronal damage. Early identification of sleep disorders and NfL monitoring are pivotal in detecting at-risk PD patients promptly, allowing for timely intervention. Regular monitoring of NfL levels holds promise for tracking both sleep disorders and disease progression, potentially emerging as a biomarker for evaluating treatment outcomes.

Impacts of Land Use Intensity on Ecosystem Services: A Case Study in Harbin City, China

Land use intensity (LUI) is an important indicator for assessing human activities, and quantitatively studying the impact of LUI on ESs can help to realize the scientific management of urban ecosystems as well as sustainable development. In this study, we quantified five important ecosystem service bundles in the study area with the aid of the R-language “kohonen” package and used bivariate spatial autocorrelation modeling to examine the effects of LUI on the ESs in Harbin City from 2000 to 2020. These ESs include food supply (FP), water conservation (WC), soil conservation (SC), carbon storage (CS), water purification (WP), and habitat quality (HQ). The results show the following: (1) The LUI in Harbin City had a trend from 2000 to 2020 of “decreasing and then growing”, with a spatial distribution pattern of “high in the west and low in the east.” (2) Except for FP, all other ESs exhibit a similar spatial pattern of “west-low-east-high”; WC and WP exhibit a trend of continuous increase, SC exhibits a trend of decreasing and then increasing, and CS and HQ are generally more stable, with less fluctuation. The built-up area is situated in the high-value area of LUI, and the area exhibits a significant expansion trend. (3) Ecological conservation bundles, FP–WP synergistic bundles, ecological transition bundles, CS–WP–HQ synergistic bundles, and FP bundles are the five ecosystem service bundles that were discovered in Harbin. (4) From 2000 to 2020, there is a predominately “low LUI-high ESs” and “high LUI-low ESs” aggregation type, with a substantial positive correlation between LUI and FP and a significant negative correlation between LUI and other ESs. Harbin City should strengthen the management of ESs in the western part of the city and, at the same time, maintain the favorable ecological conditions in the ecological barriers of Zhangguangcai Range and Xiaoxing’an Mountains.

Ключевые аспекты развития экономической безопасности в практике регионального управления (часть 2)

The development of the economic security of the region (ESR) is a key factor in increasing the resilience of the regional economy to modern challenges and threats, as indicated by the Strategy of Economic Security of Russia until 2030. Conditions for restricting sales and supplies, and destruction of existing logistics chains make the task of developing the ESR especially urgent. At the same time, the high abstractness of the concept of economic security raises new questions for researchers, including what the development of economic security is, how this development can be ensured, etc. The development of economic security implies the management of this development. However, neither the scientific community nor the practice of regional management has yet developed a holistic view of the ESR management system. In this regard, the subject of the study is the management of economic security from the positions of "as it is now" and "as it should be". For this purpose, the article analyzes the established management and monitoring practices, the possibilities of interaction of subjects and the institutional environment of the development of the ESR. The conducted research is presented in two parts. The second part of the article summarizes the key elements of the ESR management system. The article introduces the concept of maturity of the ESR management system as a measure of awareness and readiness of the management system for the successful implementation of security tasks, suggests a way to assess it based on the identified elements of the institutional environment and the Strategy of the development of the ESR. The minimum conditions for the development of the ESR are presented. The practical significance of the results lies in the possibility of their application by regional authorities to improve the management system, monitoring and development of the economic security of the region.

Not Only Excessive Daytime Sleepiness but Also Depression Symptoms, Chronological Age and Onset-Age Were Associated with Impulsivity in Narcolepsy Type 1 Patients.

ObjectiveTo detect the factors associated with total and subscales impulsivity scores in narcolepsy and further explore the non-linear relationship between these factors and impulsivity score.MethodsOne hundred and fifty-eight narcolepsy type 1 (NT1) patients were involved in this cross-sectional study. Patients completed questionnaires evaluating impulsivity symptoms (Barratt impulse scale-11, BIS-11), depression symptoms (Center for Epidemiologic Studies Depression Scale for Children, CES-DC or Self-Rating Depression Scale, SDS) and sleepiness (Epworth Sleepiness Scale, ESS). Parameters from polysomnography and multiple sleep latency test were also collected. Linear regression analysis was performed to detect the factors associated with total and subscales impulsivity scores. Then, generalized additive models and smooth curve fitting were performed to explore the non-linear relationship between chronological age and impulsivity scores.ResultsFactors associated with higher total impulsivity score were higher ESS, older onset and adolescents. Factors associated with higher attentional impulsivity score were higher ESS, older onset and adolescents. Factors associated with higher motor impulsivity score were higher ESS, younger onset and depression symptoms. Factors associated with higher non-planning impulsivity score were adolescents, older onset and depression symptoms. A non-linear relationship between age and impulsivity scores (total impulsivity score, attentional impulsivity score and non-planning impulsivity score) was detected in NT1 patients.ConclusionNot only excessive daytime sleepiness but also onset-age, depression symptoms and chronological age were associated with impulsivity in NT1 patients. The non-linear relationship between age and impulsivity scores suggested brain and mental development alterations in NT1 patients.

A Constructivist Ontology Relation Learning Method.

From the perspective of philosophy, ontology relations denote ultimate semantic relations of related knowledge concepts. Beyond doubt, it is still a very difficult problem on how to automatically depict and construct ontology relations because of its high abstractness. Some latest research attempted to realize ontology relation learning by learning abstract hierarchies or similarities among knowledge concepts. Inspired by the requirements of associative semantic cognition like in the human brain, a constructivist ontology relation learning (CORL) method is put forward in this study by borrowing the idea of the constructivist learning theory. Wherein, two following points are supposed: 1) each symbol knowledge is looked as a token of representing certain abstract pattern and 2) each pattern denotes a type of relation structures on other patterns, or a directly observed event data, such as physical sensing data, natural image, sound data, text word etc. So, ontology relation could be considered as the associative support degrees from other knowledge concepts to the target concept, which reflects how one knowledge ontology can be demarcated by other knowledge concepts. Then, the knowledge network can be employed to represent an entire domain knowledge system. Meanwhile, an associative random walk mechanism (ARWM) on knowledge network can be considered to explain the semantic generative process of every document. Thus, CORL can be realized by integrating ARWM into an extended latent Dirichlet allocation (LDA) model. Some theoretical and experimental analysis are done. The corresponding results demonstrate that CORL can obtain effective associative semantic relations among concept words, and gain some novel characteristics in better representing knowledge ontology than existing methods.

Obstructive Sleep Apnea Syndrome Comorbidity Phenotypes in Primary Health Care Patients in Northern Greece.

Background: Obstructive sleep apnea syndrome (OSAS) is a significant public health issue. In the general population, the prevalence varies from 10% to 50%. We aimed to phenotype comorbidities in OSAS patients referred to the primary health care (PHC) system. Methods: We enrolled 1496 patients referred to the PHC system for any respiratory- or sleep-related issue from November 2015 to September 2017. Some patients underwent polysomnography (PSG) evaluation in order to establish OSAS diagnosis. The final study population comprised 136 patients, and the Charlson comorbidity index was assessed. Categorical principal component analysis and TwoStep clustering was used to identify distinct clusters in the study population. Results: The analysis revealed three clusters: the first with moderate OSAS, obesity and a high ESS score without significant comorbidities; the second with severe OSAS, severe obesity with comorbidities and the highest ESS score; and the third with severe OSAS and obesity without comorbidities but with a high ESS score. The clusters differed in age (p < 0.005), apnea–hypopnea index, oxygen desaturation index, arousal index and respiratory and desaturation arousal index (p < 0.001). Conclusions: Predictive comorbidity models may aid the early diagnosis of patients at risk in the context of PHC and pave the way for personalized treatment.

Standardized database of 400 complex abstract fractals.

In experimental settings, characteristics of presented stimuli influence cognitive processes. Knowledge about stimulus features is important to manipulate or control the influence of stimuli. To date, there are a lack of standardized data incorporating such information for complex abstract stimuli. Thus, we provide norms for a database of 400 abstract and complex stimuli. Grey-scaled fractals were rated by 512 participants on the stimulus features of abstractness, animacy, verbalizability, complexity, familiarity, favorableness, and memorability. Moreover, 111 participants labeled the fractals, enabling us to calculate indices of naming agreement and modal names. Overall, the results confirmed high abstractness and low verbalizability of the provided stimuli. To establish external validation for selected stimulus features, we evaluated (a) classifier probability of a deep neural network labeling the fractals, negatively correlated with ratings of abstractness and positively with verbalizability and naming agreement; (b) data compression rate of fractal image files, positively correlated with the rating of complexity; and (c) performance of 212 participants in a recognition-memory task, positively correlated with the rating of memorability. The present work fills the gap of a standardized database for abstract stimuli and provides a database with valid norms for abstract and complex stimuli based on ratings and external validation measures. This database can be used to control and manipulate these stimulus features in experimental settings using abstract stimuli. Such a database is essential in experimental research using abstract stimuli for instance to control for verbal influence and strategy or to control for novelty and familiarity.

Pleural Metastasis of High-Grade Endometrial Stromal Sarcoma With YWHAE Gene (17p13.3) Rearrangement, A Rare Case Report

Abstract Introduction/Objective Endometrial stromal sarcoma (ESS), a rare malignant neoplasm of endometrial stroma, accounts for less than 1% of all uterine tumors. High grade ESS (HGESS) is aggressive and commonly relapses even after surgical and neoadjuvant therapy. Abdominal and pelvic regions are common sites of metastasis, however, distant metastases to the liver, lung, vertebrae, and brain have been reported. Methods/Case Report We encountered a 49-year-old female who presented with shortness of breath, found to have a left pleural effusion and multiple pleural masses. She initially presented three years ago with heavy irregular menses and left pelvic pain for one year. D&amp;C revealed prominent small spindle cells for which a stromal nodule and low-grade or malignant process was probable. CT scan showed an enlarged uterus. Hysterectomy with bilateral salpingo- oophorectomy, bilateral pelvic and para-aortic lymph node dissection, and partial omentectomy were performed. The uterus revealed an intramural 7 cm mass with a serpiginous growth pattern and lymphovascular invasion. Tumor cells were plump to spindled with areas of high cellularity, rounded nuclei, increased atypia and mitosis. Atypical areas were positive for cyclin D1, focally positive for CD10, and negative for ER, PR, SMA, desmin, AE1/3 and CAM5.2. FISH studies showed rearrangement of YWHAE gene (17p13.3) and no rearrangement of JAZF1 or PHF1 gene regions. Findings supported the diagnosis of HGESS. The patient received post-operative chemotherapy. Biopsy of the current pleural lesion revealed a nonspecific malignant spindle cell neoplasm positive for BCL1, CD56, CD117, CD99, TLE1 and INI1, while negative for AE1/3, CAM5.2, EMA, ER, PR, CK5/6, calretinin, SMA, desmin and S100. The CD10 stain was inconclusive. FISH studies showed rearrangement of YWHAE gene (17p13.3) and no rearrangement involving JAZF1 or PHF1 gene regions. No rearrangement of the SS18 gene region was observed and synovial sarcoma was excluded. Overall findings support the diagnosis of metastatic HGESS. Results (if a Case Study enter NA) NA Conclusion HGESS, a rare tumor with a nonspecific immunostain profile, has the ability to metastasize to rare body sites, such as the pleura in our case. Display of spindle cell morphology is a nonspecific finding that raises broad differential diagnoses. In women, with or without a history of uterine neoplasm, HGESS is a clinically worthwhile diagnosis to be mindful of.

Discovery Learning with Link Map and Motivation on Calculus

Calculus has a high abstractness so calculus requires the ability to think in solving mathematical problems. Calculus is one of the fields of mathematics that is full of calculations and formulas, so it needs the motivation to be happy and interested in calculus. This study aims to analyze discovery leaning with link maps and learning motivation on calculus. This research is quantitative descriptive with research variables including discovery learning, link maps and academic abilities of students. The study is conducted at Universitas Kanjuruhan Malang with 105 students. The research data is obtained from the results of the students’ academic ability test, the results of student worksheets on discovery learning and link maps and learning motivation with questionnaires. Data analysis uses multiple linear regressions assisted by SPSS. The results show that discovery learning with link maps has a positive effect on students’ academic abilities. In addition, motivation influences on discovery learning with link maps and student academic abilities. If students have high motivation and the ability to find their own concepts, the results of the concept last a long time in students’ memory, the students’ thinking ability and memory of students in understanding mathematical concepts, therefore it can solve mathematics problems better. Discovery learning with link maps gives students better academic abilities.

Automated analysis of lexical features in frontotemporal degeneration

We implemented an automated analysis of lexical aspects of semi-structured speech produced by healthy elderly controls (n = 37) and three patient groups with frontotemporal degeneration (FTD): behavioral variant FTD (n = 74), semantic variant primary progressive aphasia (svPPA, n = 42), and nonfluent/agrammatic PPA (naPPA, n = 22). Based on previous findings, we hypothesized that the three patient groups and controls would differ in the counts of part-of-speech (POS) categories and several lexical measures. With a natural language processing program, we automatically tagged POS categories of all words produced during a picture description task. We further counted the number of wh-words, and we rated nouns for abstractness, ambiguity, frequency, familiarity, and age of acquisition. We also computed the cross-entropy estimation, where low cross-entropy indicates high predictability, and lexical diversity for each description. We validated a subset of the POS data that were automatically tagged with the Google Universal POS scheme using gold-standard POS data tagged by a linguist, and we found that the POS categories from our automated methods were more than 90% accurate. For svPPA patients, we found fewer unique nouns than in naPPA and more pronouns and wh-words than in the other groups. We also found high abstractness, ambiguity, frequency, and familiarity for nouns and the lowest cross-entropy estimation among all groups. These measures were associated with cortical thinning in the left temporal lobe. In naPPA patients, we found increased speech errors and partial words compared to controls, and these impairments were associated with cortical thinning in the left middle frontal gyrus. bvFTD patients' adjective production was decreased compared to controls and was correlated with their apathy scores. Their adjective production was associated with cortical thinning in the dorsolateral frontal and orbitofrontal gyri. Our results demonstrate distinct language profiles in subgroups of FTD patients and validate our automated method of analyzing FTD patients' speech.

Improving the question formulation in Delphi‐like surveys: Analysis of the effects of abstract language and amount of information on response behavior

AbstractProspective surveys are a common research mode used to establish a profound decision base for R&amp;D investments, technological innovation, and policy making. The challenge faced by participants of such surveys, particularly if conducted via impersonal survey modes (e.g., mail or online surveys), is the limited ability to clarify contextual issues. Related research in socio‐psychology refers to language vagueness as abstractness, cautioning that abstract language and the way people interpret information are related. We apply Construal Level Theory and the Linguistic Category Model from linguistic sciences to the context of prospective surveys and examine the effects of abstract language and its related amount of information on panelists' response behavior. Based upon 32,000 observations, our research reveals that higher abstractness and greater amount of information reduce the clarity of the respondents' assessments of survey questions. In particular, abstract language and lengthy questions lead to less extreme assessments and a reduced response variance of panelists.

M126. THE MAIN AND INTERACTIVE EFFECTS OF ADULT STRESSFUL LIFE EVENTS WITH GENOMIC AND EXPOSOMIC LIABILITY FOR SCHIZOPHRENIA ON MENTAL AND PHYSICAL HEALTH: A PROSPECTIVE COHORT STUDY

BackgroundEvidence suggests that the impact of adult stressful life events (SLE) on health depends on an individual’s environmental and genetic predisposition to psychopathology. However, the influence of the genomic and exposomic (the sum of exposures) liabilities for schizophrenia on the association between SLE and health outcomes in the general population has not been studied. The current longitudinal study therefore aims to evaluate whether the association of recent SLE with mental as well as physical health is moderated by polygenic risk score for schizophrenia (PRS-S) and the exposome score for schizophrenia (ES-S, an aggregated environmental exposure score, akin to PRS-S).MethodsData from four waves of the Netherlands Mental Health Survey and Incidence Study-II (NEMESIS-II), a prospective survey in the Dutch general population aged 18 – 64, was used. The baseline data (T0) of NEMESIS-II, including 6646 participants, were collected from 2007 to 2009 and were followed up at year 3 (T1), year 6 (T2), and year 9 (T3). The Short-Form-36 Health Survey was used to repeatedly assess mental and physical health. Repeated assessment of SLE were based on the Brugha Life events section. Guided by our previous work, ES-S was constructed as the weighted sum of important baseline environmental factors, which were previously associated with schizophrenia. A subsample of 3099 participants (at T0) were genotyped and PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis, adjusted for the first three population principal components. The analyses were conducted using random intercept multilevel regression models with age, sex, and education included as a priori covariates. Models were clustered for multiple assessments per individual, and the random intercept of mental or physical health at T-1 was added to the model to control for previous health status. We evaluated the main effects of SLE, ES-S, and PRS-S, and tested the moderating effects of ES-S and PRS-S on the impact of SLE on physical and mental health. As sensitivity analyses, we repeated the analyses using lagged SLE at T-1.ResultsSLE and ES-S were associated with decreased mental (SLE: β = -2.53, P <0.001; ES-S: β = -2.93, P <0.001) and physical health (SLE: β = -2.62, P < 0.001; ES-S, β = -3.10, P < 0.001), while PRS-S was only associated with decreased mental health (β = -1.02, P <0.001) and not with physical health (β = -0.57, P = 0.061). ES-S moderated the association of SLE with mental health (β = -0.87, P = 0.002) but not with physical health (β = -0.60, P = 0.069). There was no evidence for gene–environment correlation between SLE and PRS-S (OR = 1.02, P = 0.527); and PRS-S did not moderate the association of SLE with mental (β = -0.38, P = 0.241) or physical health (β = -0.44, P = 0.252). The sensitivity analyses with lagged SLE at the previous time point converged with the results. SLE at T-1 was associated with mental (β = -0.90, P < 0.001) and physical health (β = -1.87, P < 0.001). ES-S moderated the association of SLE at T-1 with mental (β = -0.52 P = 0.029) but not physical health (β = -0.45, P = 0.116). PRS-S did not moderate the association of SLE at T-1 with mental (β = -0.03, P = 0.917) or physical health (β = 0.43, P = 0.233).DiscussionIn support of the diathesis-stress model, we have provided novel evidence showing that exposure to adult SLE, particularly in individuals with high ES-S, is associated with decreased mental health. However, we did not find evidence for a gene-environment interaction in the context of SLExPRS-S. Our findings also add to the literature showing that genomic and exposomic liability for schizophrenia is pleiotropically associated with health outcomes in the general population.

Pre-Race Sleep Management Strategy and Chronotype of Offshore Solo Sailors.

PurposeTo evaluate chronotype and the sleep management strategy adopted by sailors before the offshore solo sailing race “Mini Transat La Boulangère”. As secondary aim, we assessed whether adopting pre-race sleep management strategy influences performance at race.Materials and MethodsForty-two solo sailors completed questionnaires on sleep quality, sleepiness, chronotype and an ad hoc questionnaire on the pre-race sleep management strategy adopted. Arrival times, separately for each race’s leg, were provided by the race organization team.ResultsSolo sailors present mainly with a morning-type (40%) and intermediate-type (60%) chronotype, while none have an evening-type chronotype. Fifty-five percent of sailors adopted pre-race sleep management strategy. Sailors that adopted strategy have travelled more miles in offshore compared to sailors that did not adopt strategy (p<0.05). Significant differences emerged in rMEQ scores, with sailors that adopted strategy presenting lower score compared to sailors that did not adopt sleep strategy (p<0.05), as well as in chronotype distribution with morning-type sailors that are less likely to adopt pre-race sleep management strategy compared to intermediate type sailors (p<0.05). No differences emerged in final arrival times and in arrival time at leg1 and leg2. The most commonly adopted strategy (52% of sailors) consists of sleep extension, followed by the polyphasic sleep (26%), and sleep deprivation (22%) strategy. Sailors trained in polyphasic sleep have higher ESS than sailors trained in sleep deprivation (p<0.05).ConclusionMorning-type chronotype is overrepresented in this large cohort of solo sailors compared to the general population; moreover, chronotype seems to influence the adoption of sleep management strategy. A little over half of solo sailors participating in the Mini Transat trained in sleep management strategy before the race; however, neither the general adoption of pre-race sleep management strategy nor the adoption of a specific sleep strategy seems to significantly influence final arrival times.

Is Screening Positive for Sleep Apnea Associated With a Higher Rate of Miscarriage? [33J

INTRODUCTION: The purpose of this study was to evaluate whether positive questionnaire-based screening for obstructive sleep apnea (OSA) was associated with higher rates of miscarriage (SAB). METHODS: Secondary analysis of a prospective observational study of participants enrolled in an OSA screening study between 2010–2012. This analysis received an IRB exemption. A screening questionnaire with standard Epworth (ESS), Berlin (BQ), and novel items was administered at a prenatal care visit. The results of women who completed the survey in the first trimester (1T) were assessed for association with SAB. RESULTS: In a cohort of 213 women screened in the 1T, 30% (n=64) had elevated BQ or ESS scores, 18.8% (n=40) had high ESS scores and 14.6% (n=31) had elevated BQ scores suggestive of risk of OSA. 3.29% (n=7) had high ESS and BQ scores. Women who had both elevated ESS and BQ scores were more likely to experience SAB than those who had elevated scores on one or neither (P=.018). Women who reported snoring (P=.042) or hypertension (P=.013) in the 1T were more likely to experience SAB than women who did not. In contrast, women who reported napping in the 1T were less likely to experience SAB than women who did not (P=.045). CONCLUSION: Elevated BQ and ESS scores are statistically significantly associated with SAB. Snoring, naps and hypertension were the only individual questions from the BQ and ESS with statistically significant associations with SAB. Further investigation into this topic is warranted.

Action Recognition Scheme Based on Skeleton Representation With DS-LSTM Network

Skeleton-based human action recognition has been a popular research field during the past few years. With the help of cameras equipping deep sensors, such as the Kinect, human action can be represented by a sequence of human skeleton data. Inspired by the skeleton descriptors based on Lie group, a spatial–temporal skeleton transformation descriptor (ST-STD) is proposed in this paper. The ST-STD describes the relative transformations of skeletons, including the rotation and translation during movement. It gives a comprehensive view of the skeleton in both spatial and temporal domain for each frame. To capture the temporal connections in the skeleton sequence, a denoising sparse long short term memory (DS-LSTM) network is proposed in this paper. The DS-LSTM is designed to deal with two problems in action recognition. First, to decrease the intra-class diversity, the spatial–temporal auto-encoder (STAE) is proposed in this paper to generate representations with higher abstractness. The denoising constraint and the sparsity constraint are applied on both spatial and temporal domain to enhance the robustness and to reduce action misalignment. Second, to model the action sequence, a three-layer LSTM structure is trained with STAE representations for temporal modeling and classification. The experiments are carried out on four popular datasets. The results show that our approach performs better than several existing skeleton-based action recognition methods, which prove the effectiveness of our method.

Can Your Advertisement Go Abstract Without Affecting Willingness to Pay?

ABSTRACT Advertising can focus on concrete product attributes or on lifestyle expressions and abstract benefits. In the context of print advertising for luxury brands, the authors explored the relationship among advertising style (product-based versus lifestyle-building), advertising language (abstract versus concrete), and consumers9 willingness to pay through the lens of construal level theory, which analyzes the way consumers interpret the brand. The study found that lifestyle branding was related to high language abstractness; product-based branding was related to language concreteness; and construal level was a mediator, enhancing willingness to pay when low. The use of abstract language and lifestyle-based advertising therefore requires careful consideration.

PREVALENCE OF ADULT ADD IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA

SESSION TITLE: Comorbid Diseases and Sleep Apnea SESSION TYPE: Original Investigations PRESENTED ON: 10/10/2018 07:30 AM - 08:30 AM PURPOSE: The association between obstructive sleep apnea and attention deficit disorder is well characterized in children. However there is a paucity of literature about the association between OSA and adult ADD. The aim of this study was to see if there is a higher prevalence of ADD in adult patients with OSA. METHODS: All patients referred to our sleep center for a diagnostic polysomnogram were administered an adult ADD screening questionnaire and Epworth scale ESS. Sleep apnea was defined as AHI >15. ADD was considered + if patients had a score of 4 or more in Part A of the ADHD questionnaire. RESULTS: A total of 196 patients were included - 120Males M and 76Females F. 58% of patients were diagnosed with moderate OSA. Prevalence of ADD was 19%. There was no difference in prevalence of adult ADD between those with and without OSA (20% vs 18%; p = 0.71). Prevalence of ADD using a AHI cutoff of 5 was also not different (18.2%). Comparing patients with and without sleep apnea there was no difference in age 55 +- 15 vs 55 +/- 12. Prevalence of OSA was higher in M vs F - 67% vs 47%; p = 0.001. ESS was higher in OSA + group (11 +/- 5 vs 9 +/- 5). In patients with OSA, patients with + ADD were younger 50 +/- 12 vs 56 +/- 12. Prevalence of ADD was 27% in F vs 13% in M however this difference was not statistical significance. No ethnic differences were seen in ADD prevalence in OSA between Hispanic and Caucasian 25% C vs 23% H. BMI was similar between those with and without ADD 38 +/- 7 vs 36 +/- 9. OSA severity was milder in those with ADD 38 +/- 19 vs 48 +/- 25; p 0.02. ESS scores were higher in OSA patients with ADD 14 +/- 6 vs 11 +/- 5; p < 0.05. CONCLUSIONS: Prevalence of ADD in patients with OSA is 20% and is not different than those without OSA in a cohort of patients referred to a sleep center. Patients with OSA who screened positive for ADD were younger and had milder OSA and higher ESS. CLINICAL IMPLICATIONS: Adult ADD may not be more common in patients with OSA but specific clinical characteristics may help identify the subset of patients who may have comorbid ADD. Further research may be informative in studying the effect of CPAP therapy in improving ADD symptoms. DISCLOSURES: No relevant relationships by Akshar Aiyer, source=Web Response Speaker/Speaker's Bureau relationship with astra zeneca Please note: $5001 - $20000 Added 11/02/2017 by Shyamsunder Subramanian, source=Web Response, value=Consulting fee Speaker/Speaker's Bureau relationship with boehringer ingelheim Please note: $5001 - $20000 Added 11/02/2017 by Shyamsunder Subramanian, source=Web Response, value=Consulting fee Speaker/Speaker's Bureau relationship with genentech Please note: $5001 - $20000 Added 11/02/2017 by Shyamsunder Subramanian, source=Web Response, value=Consulting fee Speaker/Speaker's Bureau relationship with teva Please note: $5001 - $20000 Added 03/02/2018 by Shyamsunder Subramanian, source=Web Response, value=Consulting fee Speaker/Speaker's Bureau relationship with sunovion Please note: $1001 - $5000 Added 03/02/2018 by Shyamsunder Subramanian, source=Web Response, value=Consulting fee No relevant relationships by Alishah Suleman, source=Web Response Speaker/Speaker's Bureau relationship with Sunovian Please note: $5001 - $20000 Added 11/20/2017 by Salim Surani, source=Web Response, value=Honoraria Advisory Committee Member relationship with Astra Zeneca Please note: $5001 - $20000 Added 11/20/2017 by Salim Surani, source=Web Response, value=Consulting fee No relevant relationships by Zoya Surani, source=Web Response No relevant relationships by Joseph Varon, source=Web Response

Regional differences in endoscopic sinus surgery in Finland: a nationwide register-based study

ObjectivesEndoscopic sinus surgery (ESS) is a common operation typically performed due to chronic rhinosinusitis (CRS). There are limited data on the nationwide ESS rate and factors contributing to its regional...