A first theoretical attempt is made to understand the characteristics of dust acoustic shock waves (DASWs) in a polarized electron-depleted plasma with a mixed nonextensive high energy–tail ion distribution and to examine the impact of the generalized nonthermal polarization force on DASWs in an electron-depleted dusty plasma. First, a short numerical investigation illustrating the behavior of the mixed nonextensive high energy–tail (or Cairns–Tsallis) ion distribution and the domain of validity of its two parameters (q and [Formula: see text]) is carried out. Next, the generalized nonthermal polarization acting on dust grain in electron-depleted dusty plasma is determined within the context of Tsallis’ statistical mechanics. The behavior of this generalized polarization force is significantly affected by the nonextensive character of the nonthermal ions. Specifically, we have shown that, for both space and experimental dusty plasmas, the magnitude of the polarization force (in the case where [Formula: see text]) decreases as the nonextensivity of the nonthermal ions becomes significant. As an application, we have analyzed the changes caused by the nonthermal nonextensive polarization force on the main characteristics of DASW (viz. phase velocity, polarity, amplitude, width, etc.). Numerical results showed that our plasma model supports rarefactive and compressive DASWs that are significantly affected by the effects of nonthermal ion nonextensivity and polarization force. In particular, we have shown that for large values of the nonthermal parameter [Formula: see text], the increase in q allows the transition from rarefactive to compressive DASW structures. The present theoretical investigation is helpful to fully understand electrostatic disturbances in space and experimental dusty plasmas.