The regeneration of hazardous waste plastics are prerequisites for the sustainable development, and treatment of waste high density polyethylene (HDPE) industrial drums poses a significant challenge in the field of waste plastic recycling. In this study, a multi-step collaborative system was established for the decontamination and classification process of hazardous waste industrial drums. The yield of recycled HDPE particles exceeds 80 wt%. Through multiple experimental verifications, the optimal addition amount of antifoaming agent is 0.6 wt%, achieving the best balance between antifoaming effect and consumption. The motion process of antifoaming agent microdroplets in a static mixer was simulated. And also, through large-scale statistical analysis, the stability and reliability of physical properties and environmental safety of recycled HDPE particles were verified, supporting their reuse in various fields. In sum, this study proposes a feasible physical recycling strategy for hazardous waste HDPE industrial drums, and provides basic data from industrial practice and technical insights.