The plasma membrane is the membrane that serves as a boundary between the interior of a cell and its extracellular environment. Lipid rafts are microdomains within a cellular membrane that possess decreased fluidity due to the presence of cholesterol, glycolipids, and phospholipids containing longer fatty acids (Karp, 2005). These domains are involved in many different plasma membrane functions, including cell signalling. Knowledge of the structure and function of the plasma membrane is required in order to comprehend complex cellular processes such as migration and signal transduction. This knowledge is often acquired during university through introductory biology courses or cell/molecular biology core courses. Since active learning has been shown to facilitate student learning (Bonwell & Eison, 1991), it follows that this style of teaching may enhance lectures based on the topic of the plasma membrane. Unfortunately, few plasma membrane specific activities exist for university-level classes. Thus, I developed an activity titled Sank My Lipid modeled after the board game titled Sank My from Milton Bradley and Hasbro Games. Taylor and Busto (2004) suggested the use of the Battleship game to teach plotting of coordinates for students in grades three through four. The Battleship game can also be used as a tool for older students. Hence, You Sank My Lipid Rafts was carried out in a third year course titled Honours Cell and Molecular Biology (Medical Science 351, Bachelor of Health Sciences Program) at the University of Calgary (Calgary, Alberta, Canada). The Bachelor of Health Sciences Program is a pre-medical stream program designed to introduce high-calibre students to various aspects of health and health research. U.S. college equivalents of MDSC 351 would be second and third year cell biology core courses or medical school cell biology modules. Class size was 55, but this activity can be adapted for larger or smaller numbers of students. Student feedback regarding the exercise was positive. * The Game Objectives * Overall: To facilitate understanding of the structure and function of the plasma membrane Specific Course Objectives 1. Describe the functions of the plasma membrane. 2. Describe the types and roles of plasma membrane lipids, carbohydrates, and proteins. 3. Describe the importance and maintenance of membrane fluidity. 4. Describe the mechanisms employed by cells to transport materials across membranes: simple diffusion, diffusion through channels, facilitated diffusion, and active transport. * To serve as a form of assessment and feedback Synopsis The class is divided into two groups. Each group has an equal number of lipid rafts positioned on a grid. Students answer multiple choice questions based on the plasma membrane. If the students answer correctly as a group, they pick a square that may correspond with the location of a lipid raft of the opposing team. One group wins when it has sunk the other group's rafts. Target Audience * Second and third year undergraduate students Materials Instructor * overhead projector and screen * transparency markers * transparency of raft grids * transparency of questions/answers * handouts (group raft locations/grid) Students * pen * notepaper Setup & Preparation This game requires preparation of plasma membrane multiple choice questions. Figure 1 includes a sample of questions created for and used in this activity. An array of multiple choice questions requiring a range of processing (e.g., from straight recall to problem-solving) was used. Further information on proper multiple choice design can be found in Davis, 1993. Handouts include a sheet of paper with two grids: one with the rafts of the current group, one blank so group members can record hits on rafts of the opposing group. …