It is well-known that fruit processing beverage wastewater is one of the severely contaminated industrial wastewaters containing high BOD concentration. This makes it difficult to maintain the proper DO concentration needed in conventional aerobic wastewater treatment process unless the high BOD concentration is properly reduced by pretreatment processes such as anaerobic digestion. In this study, a full-scale high-efficiency bioreactor was applied to cope with the high BOD loading in fruit processing beverage wastewater as a pretreatment of the activated sludge process. The high-efficiency bioreactor, which has multiple draft-tubes for both internal circulation of mixed liquors and aeration, has a merit of requiring small land area for installation. The results of the full-scale high-efficiency bioreactor for fruit processing beverage wastewater treatment were compared with those of anaerobic filter. It was found that the high-efficiency bioreactor was greatly effective in aeration, maintaining a DO level of 2.47 mg/L on average. Substantial removal of pollutants were achieved in the high-efficiency bioreactor, which were 89.9% for BOD, 86.2% for CODMn, 57% for SS,78.9% for T-N, and 80.3% for T-P, while those of an aerobic filter were 45.5% for BOD, 43.1% for CODMn, 50.8% for SS, 55.3% for T-N, and 59.6% for T-P. Thus, it has been demonstrated that the high-efficiency bioreactor had good stability and suitability for the treatment of fruit processing beverage wastewater, as a pretreatment of conventional aerobic wastewater treatment.