The seismic behavior of square concrete-filled steel tubular (SCFST) column-composite beam single-side bolted joints has not been fully investigated. To address this gap, both experimental and numerical studies were conducted, focusing on the impact of various parameters. This research entailed constructing and testing nine prototypes of SCFST column-composite beam single-side bolted joints, scaled to a 1/2 zoom ratio, under conditions simulating seismic loads. Variables considered in these tests included the presence of stiffener ribs, bidirectional stirrups, the section height of the steel beam, and the axial compression ratio. A finite element model was developed and its accuracy was affirmed through comparison with the experimental outcomes. The analysis encompassed several aspects: the hysteretic response, skeleton curves, strain, ductility, stiffness degradation, and energy dissipation. The findings revealed that the design of bidirectional stirrups is crucial, especially under high axial compression ratios (n = 0.8), in preventing compression-flexure failures at the column ends. The hysteresis curves of the specimens manifested in two distinct shapes: spindle-shaped with bidirectional stirrups and bow-shaped without them. Enhancements such as the addition of stiffener ribs or an increase in the steel beam’s height resulted in a more comprehensive hysteresis curve, and improvements in the initial rotational stiffness, flexural bearing capacity, and energy dissipation capability of the specimens were observed. Notably, even when the beam-column bending capacity ratio in the SCFST column-composite beam single-side bolted joint reached 1.5, the joint’s energy absorption was predominantly governed by the beam’s energy dissipation.