The ratio of diffuser inlet to nozzle exit area (Ad/Ae) is one of the most important parameters in designing and evaluating the performance of a high-altitude test facility (HATF). Typically, at motor pressures near start or operating pressure of the diffuser, the vacuum chamber pressure oscillates at a high Ad/Ae, which may be dangerous for the HATF. In the present study, the effect of the Ad/Ae on the starting and breakdown performance of a second throat exhaust diffuser (STED) has been investigated experimentally using a HATF supplied by high-pressure cold air apparatus. Upon examining the overall performance of the diffuser, it is observed that with an increase in Ad/Ae, the oblique sealing shock wave at the diffuser inlet undergoes significant changes in location and strength. This leads to a further reduction of the flow total pressure and a stronger separation of the flow along the diffuser. Consequently, flow instability arises during starting or breakdown phases near the STED starting or operating pressure. By frequency analysis, it is observed that as Ad/Ae increases, the number of oscillatory modes of the vacuum chamber pressure increases and the dominant frequency of the oscillations in these transient situations becomes larger. Additionally, there is a significant decrease in nozzle pressure related to the onset of pressure oscillations. Furthermore, with an increase in Ad/Ae from 1.27 to 7.81, the minimum starting pressure and breakdown pressure of STED increase by 20.33% and 28.47%, respectively. Also, the hysteresis range in performance of STED vanishes at high Ad/Ae values.