Heterocycles In Reactions Research Articles

Синтез 5-арил-4-ацил-3-гидрокси-1- карбоксиметил-3-пирролин-2-онов

5-Aryl-1,4-disubstituted terahydropyrrole-2,3-diones are five-membered nitrogen heterocycles containing in the first alkyl position or an aryl functionalized substituent and in the fourth position in another state of nature an acyl residue. Trahydropyrrole-2,3-diones constitute a significant class of available and stable substances. Along with this, they easily enter into reactions with various nucleophilic reagents due to the highly reactive carbonyl group in the third position of the heterocycle. The presence of the latter, as well as the carbonyl group of the side chain, makes it possible to form various condensed systems from heterocycles in reactions with binucleophilic reagents. The synthesis of biologically active substances based on 1,4,5-trisubstituted tetrahydropyrrole-2,3-diones is one of the promising ways of using this class of compounds. Previously, it was found that 1,4,5-trisubstituted 3-hydroxy-3-pyrin-2-ones have anti-inflammatory, analgesic, antimicrobial, nootropic, antiplatelet and antiviral activity. We set the task to obtain 5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones, in the first position of the heterocycle there is a carboxymethyl substituent. By setting up a three-component reaction of acylpyruvic acid ether with aromatic aldehydes and glycine in dioxane in dioxane. The structure of the compound was established on the basis of IR and 1H NMR spectroscopy data. Based on the data of 1H NMR spectroscopy and a positive reaction with an alcoholic solution of iron(III) chloride, the predominant presence of compounds in the enol form was established. The article presents the proposed mechanism and schemes of the formula for the synthesis of 5-aryl-4-acyl-3-hydroxy-1-carboxymethyl-3-pyrrolin-2-ones, their physicochemical and spectral characteristics, as well as the yields of the reaction products.

ChemInform Abstract: Sulfenyl Halides in the Synthesis of Heterocycles. Part 4. Heterocyclization in Reactions of Alkenes with Sulfenylating Reagents Based on Di(2‐pyridyl) Disulfide.

AbstractAn efficient and convenient methodology for the formation of 2,3‐dihydro[1,3]thiazolo[3,2‐a]pyridinium derivatives is developed, which is based on the interaction of alkenes with sulfenylating reagents generated by the action of sulfuryl chloride or antimony pentachloride on di(2‐pyridyl)disulfide (I).

Sulfenyl halides in the synthesis of heterocycles. 4*. Heterocyclization in reactions of alkenes with sulfenylating reagents based on di(2-pyridyl) disulfide

Sulfenylating reagents have been obtained by the action of sulfuryl chloride or antimony pentachloride on di(2-pyridyl) disulfide. Their interaction with alkenes proceeds as addition-cyclization with ring closure by the nitrogen atom of the pyridine fragment of the sulfur-containing electrophile with the formation of 2,3-dihydro[1,3]thiazolo[3,2-a]pyridinium derivatives.

ChemInform Abstract: Directions of Heterocyclization in Reactions of 4,6‐Dimethyl‐2‐pyrimidinesulfenyl Chloride with 2‐Allylphenol.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform Abstract: Sulfenyl Halides in the Synthesis of Heterocycles. Part 1. Heterocyclization in Reactions of 1‐Phenyl‐5‐tetrazolesulfenyl Chloride with Arylolefins.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Sulfenyl halides in the synthesis of heterocycles. 1. Heterocyclization in reactions of 1-phenyl-5-tetrazolesulfenyl chloride with arylolefins

2,3-Dihydrothiazolo[3,2-d]tetrazolium perchlorates have been synthesized by the interaction of 1-phenyl-5-tetrazolesulfenyl chloride with styrene and with (E)-1-phenylpropene in nitromethane in the presence of lithium perchlorate.

Directions of Heterocyclization in Reactions of 4,6-Dimethyl-2-pyrimidinesulfenyl Chloride with 2-Allylphenol

Directions of Heterocyclization in Reactions of 4,6-Dimethyl-2-pyrimidinesulfenyl Chloride with 2-Allylphenol

ChemInform Abstract: Pteridin‐4(3H)‐ones and Related Compounds: Synthesis via Intermolecular Aza‐Wittig Reaction—Heterocyclization and Crystal Structure.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Polyhalovinyl Sulfones as Polyfunctional Electrophilic Substrates in Reactions with Nucleophiles

Abstract In the present review the results of investigations of the chemical properties of polyhalovinyl sulfones are summarized. The main accent is made on their ability to react with nucleophiles at different electrophilic sites depending on the nature and the number of halogen substituents as well as on the nucleophile. Special attention is given to the halophilic reduction of these electrophiles by soft nucleophiles. The synthetic potential of polyhalovinyl sulfones as synthons for various heterocycles in reactions with polydentate S- and N-nucleophiles is also demonstrated.

ChemInform Abstract: Formation of Nitrogen‐Containing Heterocycles in Reactions of O‐Nitrenes. Structure and Properties of Alkoxyaziridines

ChemInformVolume 21, Issue 50 Reviews ChemInform Abstract: Formation of Nitrogen-Containing Heterocycles in Reactions of O-Nitrenes. Structure and Properties of Alkoxyaziridines YU. P. ARTSYBASHEVA, YU. P. ARTSYBASHEVA Leningr. gos. univ., Leningrad 199164, USSRSearch for more papers by this authorB. V. IOFFE, B. V. IOFFE Leningr. gos. univ., Leningrad 199164, USSRSearch for more papers by this author YU. P. ARTSYBASHEVA, YU. P. ARTSYBASHEVA Leningr. gos. univ., Leningrad 199164, USSRSearch for more papers by this authorB. V. IOFFE, B. V. IOFFE Leningr. gos. univ., Leningrad 199164, USSRSearch for more papers by this author First published: December 11, 1990 https://doi.org/10.1002/chin.199050369Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume21, Issue50December 11, 1990 RelatedInformation

Formation of nitrogen heterocycles in reactions of O-nitrenes. Structures and properties of alkoxyaziridines (review)

The results of research on the synthesis of 1-alkoxyaziridines and 1-alkoxypyrrolines with the hypothetical participation of O-nitrenes generated by oxidation of o-alkylhydroxylamines are correlated.