We consider degenerate Monge-Ampere equations on compact Hessian manifolds. We establish compactness properties of the set of normalized quasi-convex functions and show local and global comparison principles for twisted Monge-Ampere operators. We then use the Perron method to solve Monge-Ampere equations whose RHS involves an arbitrary probability measure, generalizing works of Cheng-Yau, Delanoe, Caffarelli-Viaclovsky and Hultgren-Onnheim. The intrinsic approach we develop should be useful in deriving similar results on mildly singular Hessian varieties, in line with the Strominger-Yau-Zaslow conjecture.