Herpes Zoster Scars Research Articles

Cutaneous Sarcoidosis Masquerading as Papular Amyloidosis Revealed Post--Hair Removal.

Cutaneous Sarcoidosis Masquerading as Papular Amyloidosis Revealed Post--Hair Removal.

Post-herpetic abdominal pseudohernia – An uncommon/under-recognized complication of a common disease, herpes zoster – A case report

Acute zoster pain and post-herpetic neuralgia are the most common and nagging complications after herpes zoster. Sometimes, temporary paresis of the segmental nerves follows herpes zoster resulting in zoster paresis or muscle zoster. Here, we report a case of zoster paresis manifesting as post-herpetic abdominal pseudohernia. A 55-year-old male presented to the dermatology outpatient department with the complaints of intense pain, burning sensation, and paresthesia over the left side of his abdomen. He had a history of herpes zoster over the same site 2 weeks back. Then, he noticed a swelling over the left side of his abdomen, associated with bloating, decreased appetite, and easy satiety. Examination revealed hyperpigmented scars of herpes zoster in the T9-T11 dermatome along with an ipsilateral bulge of size 20 × 15 cm over the same site. The skin overlying the bulge was lax. The swelling increased in size following coughing and Valsalva maneuver. An ultrasonogram of the abdomen ruled out a ventral hernia. One should be aware of this entity, when examining patients with abdominal bulge along with herpes zoster scars, to avoid unnecessary surgeries.

A clinical and epidemiological study on discoid lupus erythematosus

<p class="abstract"><strong>Background:</strong> Discoid lupus erythematosus (DLE) is the commonest form of cutaneous lupus erythematosus.The objective of our study is to analyze the clinical and epidemiological aspects of DLE.</p><p class="abstract"><strong>Methods:</strong> All clinically diagnosed cases of DLE attending the dermatology OPD from October 2010 to September 2012were included in the study. A detailed history, complete physical examination, biopsy for confirmation and other relevant investigations were done in all cases.<strong></strong></p><p class="abstract"><strong>Results:</strong> The incidence was 4.79 per 10000 cases (51 of 106368 dermatology patients) showing female to male ratio of 4.1:1. Localized type was more common than the disseminated type. Few lesions (less than five) in a localized area without head and neck involvement were also classified as localized type in this study. Mucosal, verrucous, tumid and lupus panniculitis were the variants of DLE encountered. The sites involved were face, scalp, trunk, upper and lower limb in descending order of frequency. Antinuclear antibody (ANA) was positive in 22 of 30 cases done (73%). The systemic involvement was seen in 15 patients all of whom were diagnosed as systemic lupus erythematosus (SLE). Squamous cell carcinoma was seen in 2 cases of disseminated DLE.</p><p class="abstract"><strong>Conclusions:</strong> Majority of patients had disease onset at 3<sup>rd</sup> to 5<sup>th</sup> decade showing female predominance. When compared to localized type, disseminated type was found more frequently in males. Early onset and severe disease was noted among offspring born to a patient suffering from disseminated DLE. Serious morbidity like lupus nephritis was observed only in 1 case. The occurrence of DLE over the herpes zoster scar was an interesting observation.</p>

Herpes Zoster Scars

A 30-year-old man presented with a unilateral painful eruption of grouped vesicles in the right upper eyelid and right glabella area 8 months ago. The vesicles coalesced to form bullous lesions in 48 hours. The patient had chickenpox at the age of 4 years. A diagnosis of herpes zoster involving the ophthalmic branch of the right trigeminal nerve was made. The patient was treated with oral acyclovir 800 mg, five times a day. The lesions resolved in 14 days but the post-herpetic neuralgia lasted for 3 months. The patient was left with atrophic scars in the right glabellum. Herpes zoster, also known as shingles, is caused by reactivation of endogenous latent varicella-zoster virus that resides in a sensory dorsal root ganglion of the spinal cord or the extramedullary cranial nerve ganglion usually after primary infection with varicella-zoster virus (i.e., varicella or chickenpox). Clinically, herpes zoster is characterized by a painful, unilateral vesicular eruption in a restricted dermatomal distribution. Herpes zoster may involve the eyelids and glabella when the ophthalmic branch of the trigeminal nerve is affected. Appearance of skin lesions at the side of the nose represents involvement of the nasociliary branch of ophthalmic nerve (Hutchinson’s sign) and predicts a higher likelihood of ocular involvement. Herpes zoster may be complicated by scarring, as is illustrated in the present case. Of academic interest, lesions of molluscum contagiosum, granuloma annulare, granulomatous folliculitis, psoriasis, cutaneous sarcoidosis, prurigo nodularis, lichen planus, lichen sclerosis et atrophicus, morphea, lymphoma, Kaposi’s sarcoma, and lichenoid graft-versus-host disease have been reported in preexisting herpes zoster scars [1]. This is known as Wolf ’s isotopic response which refers to the occurrence of a new skin disorder at the site of another, unrelated, and already healed skin disease.

Sarcoid tissue reaction on herpes zoster scars in a myelodysplastic syndrome patient: Wolf's isotopic response

Journal of the European Academy of Dermatology and VenereologyVolume 23, Issue 4 p. 475-477 Sarcoid tissue reaction on herpes zoster scars in a myelodysplastic syndrome patient: Wolf's isotopic response D Watanabe, Corresponding Author D Watanabe Correspondence: D Watanabe. E-mail: [email protected]Search for more papers by this authorT Kuhara, T Kuhara Department of Dermatology, Aichi Medical University, Nagakute, Aichi, Japan Tel: +81 561 62 3311 (ext. 2161); Fax: +81 561 63 9914Search for more papers by this authorN Ishida, N Ishida Department of Dermatology, Aichi Medical University, Nagakute, Aichi, Japan Tel: +81 561 62 3311 (ext. 2161); Fax: +81 561 63 9914Search for more papers by this authorY Tamada, Y Tamada Department of Dermatology, Aichi Medical University, Nagakute, Aichi, Japan Tel: +81 561 62 3311 (ext. 2161); Fax: +81 561 63 9914Search for more papers by this authorY Matsumoto, Y Matsumoto Department of Dermatology, Aichi Medical University, Nagakute, Aichi, Japan Tel: +81 561 62 3311 (ext. 2161); Fax: +81 561 63 9914Search for more papers by this author D Watanabe, Corresponding Author D Watanabe Correspondence: D Watanabe. E-mail: [email protected]Search for more papers by this authorT Kuhara, T Kuhara Department of Dermatology, Aichi Medical University, Nagakute, Aichi, Japan Tel: +81 561 62 3311 (ext. 2161); Fax: +81 561 63 9914Search for more papers by this authorN Ishida, N Ishida Department of Dermatology, Aichi Medical University, Nagakute, Aichi, Japan Tel: +81 561 62 3311 (ext. 2161); Fax: +81 561 63 9914Search for more papers by this authorY Tamada, Y Tamada Department of Dermatology, Aichi Medical University, Nagakute, Aichi, Japan Tel: +81 561 62 3311 (ext. 2161); Fax: +81 561 63 9914Search for more papers by this authorY Matsumoto, Y Matsumoto Department of Dermatology, Aichi Medical University, Nagakute, Aichi, Japan Tel: +81 561 62 3311 (ext. 2161); Fax: +81 561 63 9914Search for more papers by this author First published: 17 March 2009 https://doi.org/10.1111/j.1468-3083.2008.02924.xCitations: 6 DOI: 10.1111/j.1468-3083.2008.02924.x Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Citing Literature Volume23, Issue4April 2009Pages 475-477 RelatedInformation

Giant cell lichenoid dermatitis in a patient with baboon syndrome

Giant cell lichenoid dermatitis is a recently described pathological entity, which can be seen as an unusual lichenoid drug eruption, a manifestation of sarcoidosis or within herpes zoster scars. Histopathological findings include focal vacuolar alteration of the basal layer with cytoid bodies, dermal and intraepidermal multinucleated giant cells and a mixed chronic inflammatory infiltrate with a lichenoid pattern consisting of lymphocytes, histiocytes, eosinophils and plasma cells. Here, we report a giant cell lichenoid dermatitis in a 41-year-old male patient who developed, 3 days after intravenous treatment with amoxicillin-clavulanic acid for erysipelas of the left leg, a clinical picture suggesting a baboon syndrome characterized by an erythematous and pruritic eruption on the axillary, inguinal and popliteal areas and the anterior side of elbows. This is the first reported case of giant cell lichenoid dermatitis in a patient with baboon syndrome.

Actinic Granuloma Developed in a Herpes Zoster Scar

Actinic Granuloma Developed in a Herpes Zoster Scar

Dermatological Findings in 3 Generations of a Family with a High Prevalence of Human T Cell Lymphotropic Virus Type 1 Infection in Brazil

Dermatologic manifestations are quite common in patients with adult T cell leukemia and lymphoma and patients with myelopathy and/or tropical spastic paraparesis associated with human T cell lymphotropic virus type 1 (HTLV-1). The aim of this study was to investigate dermatological findings presented by 30 members of a Brazilian family, half of whom are infected with HTLV-1 (as confirmed by enzyme-linked immunosorbent assay and Western blot). The subjects underwent dermatologic examination and laboratory assessment, which included the search for the HTLV-1 genome in peripheral blood mononuclear cells (PBMCs) by qualitative and semiquantitative polymerase chain reaction (PCR) and in skin samples by nested qualitative PCR and immunofluorescence assay. We found that cases of xerotic dermatological alterations, including 3 cases of acquired ichthyosis, were more frequent among the infected patients (7 cases vs. none among the uninfected individuals; P=.0063). Other lesions observed in this group included impetigo, scabies, epidermal nevus, herpes zoster scar, rosacea, and juvenile acne. One HTLV-1-infected individual presented with concurrently acquired ichthyosis, impetigo, scabies, dermatophytosis, and seborrheic dermatitis. The PCR performed on PBMCs and skin samples from 24 patients confirmed the serological results in all cases. Additionally, the HTLV-1 proviral load was higher in patients with >1 skin lesion. Finally, HTLV-1 could be identified in the skin by immunofluorescence assay, which, by use of PCR as the gold standard, showed a sensitivity and specificity of 61.5% and 100%, respectively. Altogether, these clinical and laboratory findings point to an HTLV-1 tropism toward the skin, even in HTLV-1 carriers without adult T cell leukemia/lymphoma or HTLV-1-associated myelopathy and/or tropical spastic paraparesis.

Cutaneous Lupus Erythematosus Limited to the Site of a Laceration

Cutaneous lupus erythematosus is known to occur at sites of trauma or inflammation of the skin, including sites of tattoo, frostbite, herpes zoster scar, burn scar, and implantation by windshield glass. We report a 32-year-old white man who developed cutaneous lupus erythematosus at the site of a laceration. The diagnosis was confirmed by histologic and immunofluorescence examination. The patient responded to intralesional corticosteroid and hydroxychloroquine therapy. Lupus erythematosus may be induced by trauma.

Granuloma annulare on herpes zoster scars in a Hodgkin's disease patient following autologous peripheral stem cell transplantation

Various cutaneous lesions including granulomatous reactions may occur at sites of resolved herpes zoster infection. A 46-year-old man with Hodgkin's disease developed localized granuloma annulare lesions on herpes zoster scars 3 months after allogeneic peripheral stem cell transplantation. This is the first case of granuloma annulare localized on herpes zoster scars that developed following peripheral stem cell transplantation.

Morphea with features of lichen sclerosus et atrophicus at the site of a herpes zoster scar: another case of an isotopic response

Morphea with features of lichen sclerosus et atrophicus at the site of a herpes zoster scar: another case of an isotopic response

Dermatitis granulomatosa sobre lesiones cicatrizales de herpes zóster

Abstract—The development of granulomatous lesions at sites of resolved herpes zoster scars is a rare phenomenon clinically characterized by red-brownish or skin-colored infiltrated papules and nodules that appear several weeks or months after the previous viral infection.In this report, a new case of granulomatous dermatitis at the site of resolved cutaneous herpes zoster lesions in a patient with chronic lymphocytic leukemia is presented. The patient shows a unique clinical picture consisting of large red-brownish plaques and edematous areas, in the absence of infiltrated papules and nodules. Histologically, the lesions are characterized by the presence of tuberculoid granulomas with areas of granulomatous folliculitis.

Lymphomatous Skin Infiltration at the Site of Previous Varicella Zoster Virus Infection in a Patient with T Cell Lymphoma

Cutaneous infiltrations in hemopoietic neoplasias are not uncommon. They are generally localized on the legs, arms, back, anterior chest, scalp and face. In rare cases specific infiltration of neoplastic cells is localized in the site of herpes zoster and herpes simplex scars. In this report a case with T cell lymphoma in leukemic phase with skin infiltration in the previous Varicella Zoster Virus (VZV) site of infection is reported and literature is reviewed.

Herpes zoster in seven disparate dermatomes (zoster multiplex): Report of a case and review of the literature

Noncontiguous multidermatomal herpes zoster is very rare in both immunocompetent and immunocompromised persons. Most of the reported cases have been limited to 2 noncontiguous dermatomes. This unique presentation has been referred to as zoster duplex unilateralis or bilateralis, depending on whether one or both halves of the body are involved. Granulomatous dermatitis at sites of herpes zoster scars, a rare isotopic response, has only been reported in persons with contiguous dermatomes of zoster. We describe an immunocompromised patient who developed herpes zoster in 7 disparate dermatomes. Three months after resolution of the zoster, the patient developed a granulomatous dermatitis in a zosteriform distribution at the sites of previous infection. (J Am Acad Dermatol 1999;40:868-9.)

Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia arising at the site of herpes zoster and herpes simplex scars

Cutaneous lymphoid infiltrates at sites of herpes zoster scars in patients with B-cell chronic lymphocytic leukemia (B-CLL) often are diagnosed as benign lymphoid hyperplasia ("pseudolymphomas"). The histologic and immunophenotypic features of these lesions are not well characterized. Appearance of skin lesions in B-CLL patients is considered a poor prognostic sign. Eight punch biopsies from five patients (three males, two females; mean age, 66.7 years) affected by B-CLL and presenting with lesions at sites of previous herpes simplex (upper lip, one patient) or herpes zoster (trunk, four patients; forehead, one patient) infections were included in the study. Histologic examination was performed on routine sections stained with hematoxylin and eosin and Giemsa. Immunohistologic stainings were performed with a standard three-step immunoperoxidase technique on formalin fixed, paraffin embedded tissue sections. Specific cutaneous infiltrates of B-CLL were diagnosed histopathologically and immunophenotypically in eight biopsies from all five patients. Clinically, patients presented with erythematous papules or plaques confined to the area of previous herpes virus eruptions. Histopathologic features in most cases were characterized by a variably dense perivascular and periadnexal infiltrate of small hyperchromatic lymphocytes throughout the entire dermis, reaching the subcutaneous fat. In one case, a dense, diffuse infiltrate involving the entire dermis was observed. A granulomatous reaction with presence of epithelioid and multinucleated giant cells was a prominent feature in four biopsies from three patients. Light areas containing large lymphoid cells with features of prolymphocytes and paraimmunoblasts (so-called "proliferation centers") could be observed only in the case characterized by a diffuse infiltrate. Immunohistology revealed an aberrant CD20+/CD43+ phenotype of neoplastic B cells, which is not found in normal B lymphocytes (CD20+/CD43-). Reactive T lymphocytes were present in all lesions and had a normal CD20-/CD43+/CD45Ro+ phenotype. At the time of this writing, four patients were alive without signs of skin disease after a mean follow-up of 58.5 months, and one patient died of B-CLL 24 months after the cutaneous eruption. Specific cutaneous infiltrates of B-CLL are not uncommon at sites of herpes virus scars. The diagnosis can be confirmed by histopathologic and immunophenotypic criteria. The prognosis is better than previously reported.

Granuloma annulare perforans in herpes zoster scars

Granuloma annulare perforans limited to a thoracic dermatome that was previously involved by herpes zoster occurred in a 51-year-old woman who also had Lennert's lymphoma. Of the various local granulomatous infiltrates described after herpes zoster, granuloma annulare perforans is unique, although ordinary granuloma annulare has been described in a few patients. A high incidence of specific and nonspecific reaction patterns in herpes zoster scars has been described in patients with malignant lymphoma. In contrast to previous patients, all of whom had chronic lymphatic leukemia, our patient had Lennert's lymphoma.

Chronic Lymphocytic Leukemia and Cutaneous Granulomas at Sites of Herpes Zoster Scars

Chronic Lymphocytic Leukemia and Cutaneous Granulomas at Sites of Herpes Zoster Scars

Granuloma annulare arising in herpes zoster scars: Report of two cases and review of the literature

We present two patients who developed granuloma annulare in the scars from previous herpes zoster. The development of granuloma annulare in herpes zoster scars may represent an atypical delayed hypersensitivity immune reaction to herpes zoster/varicella virus antigen(s) or a tissue antigen altered by the virus.

Cutaneous Sarcoid Granuloma Formation in Herpes Zoster Scars

Sarcoid granulomas have been reported to occur in sites of previous folliculitis,¹surgical scars,²and venipuncture.³To our knowledge, this is the first time it has been reported to occur in a site of previous herpes zoster. <h3>Report of a Case</h3> A 52-year-old woman was seen for evaluation of a shiny papular zosteriform eruption on the right upper thorax. Five months previously the patient had been seen in the medical clinic of the Ohio State University Hospital, Columbus, with the chief complaint of painful and slightly tender blisters with some degree of hyperesthesia on the right upper thorax. Physical examination at that time had disclosed a segmental papulovesicular eruption along the C-5 through T-2 dermatomes. A clinical diagnosis of herpes zoster was made and viral cultures were obtained. Tzanck preparation and/or biopsy material was not obtained. The lesions cleared in approximately three weeks without any therapy. The