Herbal Capsules Research Articles

Phytochemical Study and Clinical Evaluation of Herbal Formula as Obesity Management

Objective: Obesity is a significant global public health issue, affecting 39% of overweight and 13% of obese adults, according to the World Health Organization (WHO). The objective of this study was included preliminary screening of main active compounds with clinical evaluation of herbal formula used in traditional medicine for obesity management. Methods. The methods for this study were included investigation of main active compounds in extracts of line seeds (Linum usitatissimum L.), Celery seeds (Apium graveoleus L.) Husk seeds (Plantago ovata L.) and marshmallow flower (Althea officinalis L.) Also this study contained the clinical evaluation of effects of herbal formula for obesity. The study involved two groups of participants who were given a herbal formula capsule for a duration of 8 weeks. The dosage consisted of one capsule (500mg) taken three times a day after meals. The second group was simultaneously treated with metformin, with a dosage of one tablet (500mg) provided twice daily after meals. Results: The results were referred to flavonoids glycosides which presented in all plants extracts, while other active compounds distributed differently among plants. The results of clinical study were referred to significant reduction in weight, BMI, Total cholesterol, Triglycerides, LDL – C and VLDL with significant increasing of HDL. Conclusion: The herbal mixture may exert beneficial effects on both body mass index and serum lipids profile in humans, which can be linked to its flavonoids and antioxidant components.

Formulation and Evaluation of Herbal Capsules Containing Gum Resin of Boswellia serrata.

Boswellia serrata (Sallaki) is one of the most popular herbs, belonging to the family Burseraceae, whose dietary and therapeutic potential has been practiced since ancient days mainly for the treatment of arthritis and other inflammatory disorders. The therapeutic activity of oleo gum resin is typically due to the presence of active constituents such as 11-keto-β-boswellic acid and 3-o-acetyl-11-keto-β-boswellic acid. The main objective of the present research work was to formulate and evaluate the Boswellia capsule. The plant B. serrata is the best traditional medicine for the treatment of rheumatoid arthritis without causing any side-effects when compared to synthetic drugs (NSAIDs). The herbal capsules were formulated and evaluated. The prepared formulation was subjected to evaluations like physical appearance, pH, dissolution, disintegration and phytochemical screening.

Quality characteristics and HPLC detection of phosphodiesterase inhibitors in some herbal capsules indicated for male sexual disorders in Ghana

BackgroundHerbal medicines used for male sexual disorders are widespread across the globe and have been noted as likely candidates for adulteration. To assure access to safe and quality herbal products, this study aimed at sampling some herbal capsules indicated for male vitality for quality analytical checks.MethodsHerbal capsules sampled from two regions were subjected to physicochemical assessment, using pharmacopeial and regulatory standards. Microbial quality analysis was also performed on the selected products. A validated HPLC method for simultaneous analysis of sildenafil citrate and tadalafil was used to detect and quantify the possible presence of phosphodiesterase inhibitors in the selected products.ResultsOut of a total of 57 herbal capsules, 19 were indicated for male sexual related illnesses of which only 8 fulfilled the inclusion criteria of being used exclusively for male vitality. The majority (62.5%) of the herbal products failed the weight uniformity test but all of them disintegrated within the acceptable limit of 30 min. The moisture and heavy metal contents were within limits of acceptability. Majority (87.5%) of the herbal products failed the test for the aerobic bacteria count; however, none of the isolated bacteria was pathogenic. Sildenafil citrate was detected in the majority (87.5%) of the herbal products in concentrations of 0.98–33.95 mg/g. Two products contained both sildenafil and tadalafil. High batch-to-batch variability was recorded in some physicochemical parameters and pharmaceutical adulterants.ConclusionHigh incidence of quality fails and adulteration of herbal capsules for sexual disorders observed means there is a real risk of unintended dosing with phosphodiesterase inhibitors. This represents a public health issue and necessitates tighter monitoring of production standards by the regulator.

Comparison of the Effects of Govarcin Herbal Capsule and Metoclopramide for Alleviating Gastrointestinal Symptoms in Patients with Functional Dyspepsia: A Randomized Double-blind Clinical Trial.

Functional dyspepsia (FD) is felt as a discomfort or pain on the center line or upper abdomen. In this study, we aimed to compare the effects of Govarcin herbal capsule and Metoclopramide for alleviating gastrointestinal symptoms in patients with FD. Totally, 106 patients enrolled in a double-blind, clinical trial study. The participants had FD and were divided into two groups receiving Govarcin and Metoclopramide by block randomization. The patients were treated for four weeks, taking one Govarcin capsule or Metoclopramide tablet after each meal. The rate of improvement in patients was assessed by mitigation of clinical symptoms, including epigastric pain, fullness, discomfort, nausea, vomiting and heartburn. Also, before and after intervention, we used Nepin questionnaire and ROME III. SPSS statistics 25 software was used for data analyzing. Clinical symptom score changes between Govarcin and Metoclopramide patients' groups showed that there was no significant difference in any of the clinical symptom scores (except for heartburn, p-value=0.012) between the study groups. Nepean score in Govarcin group before and after treatment were 19.3±4.8 and 8.9±2.8, respectively (p-value<0.001). For Metoclopramide group, these values were 19.8±3.5 and 9.4±2.1 respectively (p-value<0.001). No significant difference was found in terms of Nepean score between the Govarcin and Metoclopramide groups (p-value=0.995). Govarcin herbal capsule can be used to remedy symptoms in patients with FD. It seems that Govarcin is as effective as Metoclopramide in fighting symptoms of FD as no significant difference in efficacy has been demonstrated between them.

Clinical evaluation of capsule BP Norm in the management of essential hypertension: A preliminary open-label parallel group study

Abstract Background: Since hypertension is so common and a major risk factor for cardiovascular illnesses and other complications, it is both a significant public health issue and an important topic of research. Hence, a clinical trial was planned. Aims: To evaluate the role of herbal preparation capsule BP Norm containing dry extract of Bhringraja (Eclipta alba (L) Hassk.), Haritaki (Terminalia chebula Retz.), Ashwagandha (Withania somnifera (L.) Dunal), Shankhpushpi (Convolvulus pluricaulis), and Sarpagandha (Rauwolfia serpentina [L.] Benth. Ex Kurzc) in newly diagnosed cases and in combination with allopathic antihypertensive drugs in the uncontrolled cases of essential hypertension. Materials and methods: A total of 103 patients meeting the seventh report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure criteria of essential hypertension (EHT) of age group 20–65 years of either sex participated in the study. Newly diagnosed cases who were not taking any antihypertensives were administered capsule BP Norm (250 mg), two capsules twice daily for 1 month, whereas uncontrolled cases of essential hypertension (systolic blood pressure [SBP] &gt;140 mmHg and &lt;200 mmHg and/or diastolic blood pressure [DBP] &gt;90 mmHg and &lt;120 mmHg) were administered 1 capsule of BP Norm (250 mg) twice daily with water in addition to continuing allopathic antihypertensive drugs for 1 month. The assessment was made through various variables such as SBP, DBP, chief complaints, associated complaints, Hamilton anxiety rating scale (HARS), Hamilton rating scale for depression (HRSD), lipid profile, and serum creatinine. Results: Capsule BP Norm produced highly significant reduction in both the SBP (16.82%, P &lt; 0.001) and DBP (13.71%, P &lt; 0.001) of newly diagnosed patients as well as in the SBP (18.49%, P &lt; 0.001) and DBP (13.95%, P &lt; 0.001) of uncontrolled cases (EHT). Capsule BP Norm provided significant relief in clinical features of EHT, HARS, and HRSD in both groups. Conclusion: Capsule BP Norm has promising antihypertensive effects in newly diagnosed cases as well as synergistic effects when combined with allopathic antihypertensive drugs in uncontrolled cases of essential hypertension.

Case of lead poisoning secondary to intake of herbal medicine for diabetes mellitus in a tertiary care hospital in Kerala.

Although most published cases of lead poisoning come from occupational exposures, some traditional remedies may also contain toxic amounts of lead. Here, we report the case of a 58-year-old female who presented with abdominal pain, generalized tiredness, and decreased food intake, with anemia and elevated levels of lead. The patient was found to be taking herbal capsules for diabetes prior to the presentation. This case highlights the need for increased awareness that some herbal remedies may contain potentially harmful levels of heavy metals, and people who use them are at risk of developing associated toxicities. Individuals who support traditional medicine often incorrectly believe that herbal remedies for diabetes are free from side effects, leading them to favor these treatments over contemporary medications. Herbal medications are freely available online, even without a prescription. The accessibility of herbal medicines without prescriptions, coupled with the false belief in their lack of side effects, misleads educated individuals toward quackery treatments. Misinformation spread via social media exacerbates this issue. Heavy metals are present in toxic levels in the drugs, causing complications. Lead is the most common heavy metal found in such herbal medicines. Lead poisoning leads to anemia and other systemic complications which could have been fatal if not found in time.

Review of Perspectives on Increasing Demand for "Cardamom Tincture Aromatic" in the Global Market

Abstract: Cardamom belongs to the family Zingiberaceae and is indigenous to India and Malesia. The crude drug has potential pharmacological applications such as antioxidant, analgesic, antibacterial antioxidant, and anti-inflammatory activities. Cardamom also contains bioactive constituents, including terpenoids, flavonoids, carbohydrates, essential oils, and carotenoids. The demand for herbal medicines has increased in most emerging nations, and their supply has steadily grown worldwide. Around 80% of people worldwide use herbal medicines to treat their illnesses. There are many dosage forms for herbal products, including tinctures, powders, liniments, lotions, capsules, balms, syrups, and tablets. "Herbal tincture" refers to concentrated herbal extracts with ethanol generally functioning as the solvent. Cardamom can be used as a tincture to extract its beneficial compounds and create a concentrated liquid form for various purposes. These are widely used as folk medicines and are even well-known in many medical systems, including Ayurveda and homeopathy. There are numerous herbal tinctures on the market, including those of tulsi, compound cardamom, and ginger. These preparations are simple to use and store. The current manuscript discusses several tincture preparation techniques, focusing on cardamom tincture and stability conditions, a market overview, and a few patents. : This article briefly overviews the global trading markets for herbal tinctures, particularly cardamom tinctures. Even the paper has explored the general information of cardamom and a market overview of the herbal tinctures.

The pattern of use of herbal plants by the community to increase body immunity

The immune system functions to protect the body from infectious agents. Modulation of the immune system is needed to ensure that it is able to fight various attacks by microorganisms that cause infection. One simple way to increase the body’s immunity is to consume herbal plants. Several studies have proven the activity of several herbal plants as immunostimulant agents. This research was conducted using qualitative methods. The aim of this research was to identify herbal plants for body immunity, and describe patterns of use of herbal plants to increase body immunity. The research finding revealed that herbal plants that can increase the body’s immunity are ginger, turmeric, lemongrass, cinnamon, sungkai leaves, black cumin and various other plants, most of which are still consumed in traditional ways. The largest number of respondents who used herbal concoctions to improve health was 225 respondents. There was a pattern of using herbal plants in the people of North Sumatra to increase the body’s immunity by consuming them in the form of direct decoction, herbal drink products, capsules and powder form, and syrup form.

Formulation and evaluation of herbal capsule based on Indian medicinal plants for cancer therapy

Formulation and evaluation of herbal capsule based on Indian medicinal plants for cancer therapy

Formulation and evaluation of herbal capsule based on Indian medicinal plants for cancer therapy

Formulation and evaluation of herbal capsule based on Indian medicinal plants for cancer therapy

SP-Max-A herbomineral formulation attenuates busulfan-induced oligospermia in mice by preventing loss of reproductive hormones

SP-Max herbal capsule formulation contains Withania somnifera, Asparagus recemosus, Mucuna pruriens, Chlorophytum arundinaceum, Ipomoea digitata, and Dioscorea bulbifera which are reported in the ‘Ayurveda’, an Indian Traditional System of medicine as aphrodisiacs. The present study focused on the effect of herbomineral formulation, SP-Max in the treatment of oligospermia. Oligospermia was induced in male Swiss Albino mice by a single intraperitoneal injection of busulfan at a dose of 45 mg/kg. SP-Max herbomineral formulation was given at various doses of 130, 270, and 390 mg/kg for 45 days. Treatment with SP-Max herbomineral formulation at 130, 270 and 390 mg/kg doses significantly improved the sperm count, sperm motility and viability (p < 0.001). SP-Max treatment at a dose of 390 mg/kg significantly prevented the loss of anti-oxidant enzymes in testicular cells. SP-Max prevented the reduction in the level of testosterone, luteinizing hormone, and follicle-stimulating hormone. Histological findings showed that SP-Max treatment prevented degeneration of spermatid, interstitial cells, and Sertoli cells of the testes and also improved epididymal sperm count. High dose of SP-Max treatment i.e 390 mg/kg found to be more effective. Results showed that SP-Max herbomineral formulation is an effective treatment option for oligospermia by decreasing free radical damage to the testes and improving the levels of reproductive hormones.

EFEK PEMBERIAN KAPSUL EKSTRAK JAMU HIPERGLIKEMI TERHADAP KUALITAS HIDUP

Quality of Life (QoL) in diabetes mellitus (DM) has become highly emphasized in recent years as health care outcome. Hyperglicemic herbs potio, one of scientific herbs, has been proven to be safe and efficacious. The use of extract capsules as an innovative form of herbal medicine continues to be developed. The study aimed to examine the effect of giving hyperglicemic herbal extract capsules on the QoL of hyperglycemic patients at Rumah Riset Jamu (RRJ) Hortus Medicus. The method used was pre and post-test design with quasi-experimental. A total of 60 patients followed the study during September-November 2019. The hyperglycemic herbs formula consisting of 5 grams daun Salam, 5 grams sambiloto, 7 grams kayu manis and 10 grams temulawak which converted to the one extract capsule. For the daily doses are two capsules twice a day. The Metformin 500 mg single dose as a control of the study. Before this study and on day 28th, the patients had been examined the QoL using the short form-36 (SF-36). The data were analyzed using the Wilcoxon and Mann Whitney test. The results showed that there was a significant increase in total score of SF-36 (p=0,000) between before and after taking extract capsules, especially for the general health domain (p=0,002). The total score of SF-36 between extract capsules and Metformin groups was not significantly difference (p=0,323). Hyperglycemic herbal extract capsules improved the QoL of the hyperglycemic patients.

Formulation and Evaluation of Herbal Capsule in Treatment of Migraine

Formulation and Evaluation of Herbal Capsule in Treatment of Migraine

Effect of Curcumex on Serum Lipid Profile and Fasting Blood Glucose, HbA1c, and Insulin Resistance Levels in Type 2 Diabetic Patients: A Randomized, Double-Blind Clinical Trial

Background: Diabetes is one of the causes of mortality worldwide. Turmeric, ginger, and black pepper have antioxidant and anti-inflammatory properties. Objectives: The present study was performed to evaluate the effect of Curcumex supplement (Turmeric herbal capsule (320 mg), ginger (150 mg), and black pepper (4 mg) on fasting blood glucose levels, HbA1c levels, insulin resistance, and serum lipid profile in type 2 diabetic patients. Methods: This study was a double-blind, randomized controlled trial conducted on 60 patients with type 2 diabetes who were randomly divided into the intervention (n = 30) and placebo (n = 30) groups. The intervention group received the Curcumex supplement capsule twice a day, every 12 hours for 90 days, and the placebo group received the same amount and duration of the starch capsule. At the beginning and end of the study, blood sugar indices, including fasting blood sugar levels, plasma insulin levels, HbA1C levels, HOMA-B, HOMA-IR, and lipid profile (high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol (Chol), triglyceride (TG), and very low-density lipoprotein (VLDL)) were assessed. Results: The mean values of age, gender, and body mass index (BMI) were not significantly different between the two groups before the study. There was a statistically significant difference and decrease between mean scores of blood sugar indices, including serum levels of HbA1C (P = 0.003), plasma insulin (P = 0.015), HOMA-IR (P = 0.001), fasting blood glucose (P = 0.06), and BMI (P = 0.016) after the intervention. After the intervention, no significant changes were not observed in other variables, such as HDL, LDL, Chol, TG, and VLDL. Conclusions: The consumption of curcumex supplement capsules in patients with type 2 diabetes reduces serum levels of HbA1C, plasma insulin, HOMA-IR, fasting blood glucose, and BMI.

Effects of a Herbal Sex Enhancer (Vigpower) and Zinc Supplementation on Sex Hormones, Hepatic and Renal Function in Male Albino Rats

Aim: This study evaluated the effects of a herbal sex enhancer (Vigpower) and zinc supplementation on sex hormones, hepatic and renal function in male albino rats.&#x0D; Methodology: A total of 49 male Albino rats weighing between 150 to 180g were used for the study. Vigpower, Viagra and zinc were orally administered to the rats daily for 28 days. Testosterone and estradiol were quantitatively determined using a rat-specific sandwich-enzyme linked immunosorbent assay (ELISA) method. The liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined using the Reitman-Frankel method. Alkaline phosphatase (ALP) was determined using the Colorimetric endpoint method. Sodium (Na+), potassium (K+) and chloride (CL-) were determined using ion selective electrode (ISE) method. Urea was determined using Urease bertholet method. Creatinine was determined using Jaffe-Slot method and qualitative phytochemical analysis was done on Vigpower capsule using classical methods.&#x0D; Results: Phytochemical analysis revealed the presence of flavonoids, protodioscin, saponins and phenols in the herbal capsule Vigpower. Testosterone levels were significantly higher in all the treatment groups compared to the negative control, with group 7 (Vigpower + Viagra + zinc) having the highest value. Estradiol levels were significantly lower, whereas testosterone-estradiol (T/E) ratio was significantly higher in all the treatment groups compared to the negative control, except for group 4 (zinc) which showed no significant difference compared to the negative control. ALT levels in the treatment groups were not significantly different from the negative control, except for groups 6 (Viagra + zinc) and 7 (Vigpower + Viagra + Zinc), which had significantly higher levels. AST and ALP levels in the treatment groups were not significantly different from the negative control, except for group 7 (Vigpower + Viagra + Zinc), which was significantly higher than the negative control and all other treatment groups. There was no significant difference in sodium (Na+), chloride (Cl-) and urea levels in the treatment groups, compared to the negative control. Potassium (K+) and creatinine levels were significantly higher in group 7 (Vigpower + Viagra + zinc), compared to the negative control and all other treatment groups.&#x0D; Conclusion: Singular administration of Vigpower, Viagra and zinc increased testosterone levels of the male rats. Vigpower and Viagra had equipotent effects on the sex hormones and also increased the testosterone-estradiol ratio. Vigpower, Viagra and zinc administered singularly, had no impact on liver enzymes and renal function. However, the combination treatment of Vigpower, Viagra and zinc was hepatotoxic and elevated potassium and creatinine levels. Herbal sex enhancers and their combination with other medications could provoke the desired sexual effect, but may damage other organ systems and pose serious public health challenges.

FORMULATION AND EVALUATION OF HERBAL CAPSULE CONTAINING PANEER DODI AND FENUGREEK FOR THE TREATMENT OF DIABETES

Withania coagulans is commonly known as Paneer Dodi belonging to family Solanaceae is a well -known plant in herbal medicinal systems having great potential against diabetic disease by improving the secretion of insulin. In addition, Trigonella Foenum Graecum plant is also known as a Methi or fenugreek which is used as ayurvedic medicines for antidiabetic, anti hypercholesterolemic, anti-toxic and immunomodulatory activity. It was though worthwhile to explore its application into our body to treat type-2 diabetes, it acts on the insulin receptors for the better consumption of insulin. The objective of present study was to formulate a dosage form of antidiabetic herbal capsule dosage form having higher efficacy, less side effect and dose accuracy. Our study focuses on preparation of herbal capsule that consist of antidiabetic activity by combination of Paneer Dodi with Fenugreek. The equal proportion of Paneer Dodi and Fenugreek powder (Biherbal powder) is dried &amp; triturate for increase the surface area of powder during dissolution. The Biherbal powder prepared have lack of dose accuracy and bitter taste during consumption thus to overcome this both limitations Powder is filled in Capsule shell which can retain the 300mg of powder. To achieve 1gm dose per day the capsule is given thrice a day. The capsule is disintegrated in 3.5 to 4 minutes and the drug is released and dissolve within a period of 1 hour. KEY WORDS: Anti-diabetic, Withania coagulans, Trigonella Foenum Graecum

Beneficial Synergistic Effect of Supplementation with Combined M. oleifera and L. speciosa Leaf Capsules in Patients with Type 2 Diabetes

Diabetes mellitus is a metabolic non-communicable chronic disease in which the body's ability to process glucose is impaired, resulting in higher blood glucose levels. If not controlled, this disease can lead to severe complications. Various plants with medicinal properties can treat chronic diseases, such as diabetes, due to therapeutically important phytochemicals and bioactive compounds. This study investigated the effect of antidiabetic medicinal plant leaves in controlling blood glucose levels among Wakhi diabetic patients in the Hunza district of Pakistan. The "Wakhis" are an ethnic group living in the remote region of Pakistan. The method used in this study was a placebo-controlled study. Leaf powders of Moringa oleifera and Lagerstroemia speciosa were filled in capsules of 1000 mg each. The antidiabetic potential of the medicinal plants was estimated by performing the biochemical blood profiles of diabetic patients before and after the trial. After the intervention, the level of glycated hemoglobin (HbA1c) reduced from 8.3±1.8 to 7.5±1.2% significantly (P = 0.0401). The fasting blood sugar (FBS) in the intervention group reduced significantly from 191±49 mg/dL to 169±41 mg/dL (P = 0.0041) after the trial. According to the findings of this study, the combined herbal capsules effectively controlled the blood sugar of type 2 diabetic patients. Conclusively, the combination of M. oleifera and L. speciosa have the potential to lower blood sugar levels supplementary to existing regimens. Further investigation is warranted to explore the mechanism resulting in the observed reduction in sugar levels in type 2 diabetic patients.

The Effect of Palm Pollen and Black Seed Pollen on Male Sex Hormones and Sperm Quality: A Single-Blind, Placebo-Controlled Clinical Trial Study.

Nowadays, using medicinal properties is a good alternative for infertility treatment to use them is increasing in the world. The aim of this study was to determine the effects of Herbal oral capsules included palm pollen extract (DPP) and Nigella Sativa extract (NS) on sex hormones in adult infertile men. In this a single-blind, placebo-controlled clinical trial study, a total of 62 infertile men between 22 and 42 years of age were randomly selected and tested for sex hormones and prolactin. Thirty people in the case group received two 500 mg/kg capsules on a daily basis containing an herbal composition of palm pollen extract (350 mg) and black seed powder extract (250 mg) and the 20 in the control group received a placebo in the morning and at night for 3 months. The herbal composition capsules were manufactured by the Golbadistan Company. At the end of the three -month period, blood and semen tests were performed before and after the intervention in the case group that was compared with the control group. Hormonal assays were performed by Immunoradiometric Assay (IRMA) method. The data entered SPSS statistical software and the level of significance was set at P≤0.05. The spermiogram test results showed significant changes in the sperm count, progressive motility and rapid progressivity of the case group at the end of a quarterly period after consuming plant composition except for morphology (P=0.001, P=0.001, P=0.02, P=0.23). In addition, in the case group, the concentration of testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH) was significantly increased compared to the control group (P=0.000, P=0.004, P=0.012). It seems that taking one 500 mg/kg capsule of DPP and NS extract can significantly increase sperm parameters and testosterone (registration number: IRCT2015020120895N1).

Retracted: Effect of Observation of Shou Hui Tong Bian Capsule (Polygonum Multiflorum and Aloe-Based Herbal Capsule for Cathartic Effect) in Rapid Rehabilitation of Joint Surgery.

[This retracts the article DOI: 10.1155/2021/2268464.].

Treating Acute EXacerbations of COPD with Chinese HerbAL MedIcine to aid AntiBiotic Use Reduction (EXCALIBUR): study protocol of a randomised double-blind, placebo-controlled feasibility trial

BackgroundAcute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major reason for consultations in primary care, hospital admissions, deterioration in function, and mortality. Despite the majority of exacerbations not being caused by bacteria, as many as 70% of patients who present in UK primary care with AECOPD are prescribed antibiotics as part of standard care. However, finding effective non-antibiotic treatments for COPD exacerbations is a priority to reduce antibiotic use. The Chinese herbal medicine Shufeng Jiedu® (SFJD) has the potential to reduce treatment failure and duration of hospital stay. This study aims to determine the feasibility of conducting a fully powered randomised, double blind, placebo-controlled clinical trial on SFJD for AECOPD in UK primary care.MethodsThis study is a phase III, two-arm individually double blind, randomised, placebo-controlled feasibility trial with nested qualitative study, coordinated by the Southampton Clinical Trial Unit (SCTU). Patients aged ≥ 40 years, with a current AECOPD, presenting with increased sputum purulence/volume, or breathlessness, and for whom the GP is considering use of antibiotics, will be eligible to participate. We aim to recruit seven eligible participants per month and randomise them to receive either the patent Chinese herbal medicine SFJD capsules or placebo for 14 consecutive days and to follow-up for 12 weeks. The primary outcomes include the feasibility of recruitment, study retention, and the percentage of diary completion.DiscussionIf this trial demonstrates the feasibility of recruitment, delivery, and follow-up, we will seek funding for a fully powered placebo-controlled trial of SFJD for the treatment of AECOPD in primary care.Trial registrationThis trial is registered via ISRCTN on 1 July 2021, identifier: ISRCTN26614726.