Henry Reaction Of Aldehydes Research Articles

A urea-containing metal-organic framework as a multifunctional heterogeneous hydrogen bond-donating catalyst

A urea-containing metal-organic framework (MOF) was synthesized from a V-shaped dicarboxylate ligand and Cu(II) ions. As the undesirable self-aggregation of the urea moiety has been prohibited in the framework, this MOF can act as a heterogeneous hydrogen bond-donating (HBD) catalyst, which accelerates the cyanosilylation reaction of aldehydes, the Henry reaction of aldehydes, and the methanolysis reaction of epoxides. It also displays a significantly enhanced catalytic activity when compared with its homogeneous urea counterpart and analogous MOF structures.

ChemInform Abstract: Selective Synthesis of Nitroalcohols in the Presence of Ambersep 900 OH as Heterogeneous Catalyst.

AbstractNitroalcohols are prepared by Henry reaction of aldehydes with nitromethane using Ambersep 900 OH anionic ion‐exchanger resin as catalyst.

Cyclen-catalyzed Henry reaction under neutral conditions

A convenient cyclen-catalyzed Henry reaction of aldehydes with nitroalkanes under mild and neutral conditions is reported. This procedure constitutes the first cyclen-catalyzed synthesis of nitroalcohols and is adapted to the condensation of both aromatic and aliphatic aldehydes with nitromethane in THF at room temperature without addition of stoichiometric amount of the base. A wide range of substrates, β-nitroalcohols, were obtained in moderate to good yields (up to 98%) using this methodology.