Hemispheric Bias Research Articles

From Motion to Emotion: Visual Pathways and Potential Interconnections.

The two visual pathway description of [Ungerleider, L. G., & Mishkin, M. Two cortical visual systems. In D. J. Dingle, M. A. Goodale, & R. J. W. Mansfield (Eds.), Analysis of visual behavior (pp. 549-586). Cambridge, MA: MIT, 1982] changed the course of late 20th century systems and cognitive neuroscience. Here, I try to reexamine our laboratory's work through the lens of the [Pitcher, D., & Ungerleider, L. G. Evidence for a third visual pathway specialized for social perception. Trends in Cognitive Sciences, 25, 100-110, 2021] new third visual pathway. I also briefly review the literature related to brain responses to static and dynamic visual displays, visual stimulation involving multiple individuals, and compare existing models of social information processing for the face and body. In this context, I examine how the posterior STS might generate unique social information relative to other brain regions that also respond to social stimuli. I discuss some of the existing challenges we face with assessing how information flow progresses between structures in the proposed functional pathways and how some stimulus types and experimental designs may have complicated our data interpretation and model generation. I also note a series of outstanding questions for the field. Finally, I examine the idea of a potential expansion of the third visual pathway, to include aspects of previously proposed "lateral" visual pathways. Doing this would yield a more general entity for processing motion/action (i.e., "[inter]action") that deals with interactions between people, as well as people and objects. In this framework, a brief discussion of potential hemispheric biases for function, and different forms of neuropsychological impairments created by focal lesions in the posterior brain is highlighted to help situate various brain regions into an expanded [inter]action pathway.

Auditory-motor entrainment and listening experience shape the perceptual learning of concurrent speech.

Plasticity from auditory experience shapes the brain's encoding and perception of sound. Though prior research demonstrates that neural entrainment (i.e., brain-to-acoustic synchronization) aids speech perception, how long- and short-term plasticity influence entrainment to concurrent speech has not been investigated. Here, we explored neural entrainment mechanisms and the interplay between short- and long-term neuroplasticity for rapid auditory perceptual learning of concurrent speech sounds in young, normal-hearing musicians and nonmusicians. Participants learned to identify double-vowel mixtures during ∼45 min training sessions with concurrent high-density EEG recordings. We examined the degree to which brain responses entrained to the speech-stimulus train (∼9 Hz) to investigate whether entrainment to speech prior to behavioral decision predicted task performance. Source and directed functional connectivity analyses of the EEG probed whether behavior was driven by group differences auditory-motor coupling. Both musicians and nonmusicians showed rapid perceptual learning in accuracy with training. Interestingly, listeners' neural entrainment strength prior to target speech mixtures predicted behavioral identification performance; stronger neural synchronization was observed preceding incorrect compared to correct trial responses. We also found stark hemispheric biases in auditory-motor coupling during speech entrainment, with greater auditory-motor connectivity in the right compared to left hemisphere for musicians (R>L) but not in nonmusicians (R=L). Our findings confirm stronger neuroacoustic synchronization and auditory-motor coupling during speech processing in musicians. Stronger neural entrainment to rapid stimulus trains preceding incorrect behavioral responses supports the notion that alpha-band (∼10 Hz) arousal/suppression in brain activity is an important modulator of trial-by-trial success in perceptual processing.

Fear is more right lateralized than happiness and anger: Evidence for the motivational hypothesis of emotional face perception?

ABSTRACT Facial emotion processing (FEP) tends to be right hemisphere lateralized. This right-hemispheric bias (RHB) for FEP varies within and between individuals. The aim of the present research was to examine evidence pertaining to the prominent theories of FEP hemispheric bias as measured by a half-emotional half-neutral (no emotion) chimeric faces task. FEP hemispheric bias was indexed using laterality quotients (LQs) calculated from a Chimeric Faces Task completed by 427 adults recruited from the general population aged 18–67 years. Participants indicated which of two identical (but mirrored) emotional-neutral chimeric faces were more emotive. While all investigated emotions (fear, anger, and happiness) were right lateralized, fear was significantly more right lateralized than anger and happiness. These results provide evidence for both the right hemisphere hypothesis and the motivational hypothesis of emotion perception.

Location- and Object-Based Representational Mechanisms Account for Bilateral Field Advantage in Multiple-Object Tracking.

Keeping track of multiple visually identical and independently moving objects is a remarkable feature of the human visual system. Theoretical accounts for this ability focus on resource-based models that describe parametric decreases of performance with increasing demands during the task (i.e., more relevant items, closer distances, higher speed). Additionally, the presence of two central tracking resources, one within each hemisphere, has been proposed, allowing for an independent maintenance of moving targets within each visual hemifield. Behavioral evidence in favor of such a model shows that human subjects are able to track almost twice as many targets across both hemifields compared with within one hemifield. A number of recent publications argue for two separate and parallel tracking mechanisms during standard object tracking tasks that allow for the maintenance of the relevant information in a location-based and object-based manner. Unique electrophysiological correlates for each of those processes have been identified. The current study shows that these electrophysiological components are differentially present during tracking within either the left or right hemifield. The present results suggest that targets are mostly maintained as an object-based representation during left hemifield tracking, while location-based resources are preferentially engaged during right hemifield tracking. Interestingly, the manner of representation does not seem to have an impact on behavioral performance within the subjects, while the electrophysiological component indicating object-based tracking does correlate with performance between subjects. We propose that hemifield independence during multiple-object tracking may be an indication of the underlying hemispheric bias for parallel location-based and object-based tracking mechanisms.

Short- and long-term neuroplasticity interact during the perceptual learning of concurrent speech.

Plasticity from auditory experience shapes the brain's encoding and perception of sound. However, whether such long-term plasticity alters the trajectory of short-term plasticity during speech processing has yet to be investigated. Here, we explored the neural mechanisms and interplay between short- and long-term neuroplasticity for rapid auditory perceptual learning of concurrent speech sounds in young, normal-hearing musicians and nonmusicians. Participants learned to identify double-vowel mixtures during ~ 45min training sessions recorded simultaneously with high-density electroencephalography (EEG). We analyzed frequency-following responses (FFRs) and event-related potentials (ERPs) to investigate neural correlates of learning at subcortical and cortical levels, respectively. Although both groups showed rapid perceptual learning, musicians showed faster behavioral decisions than nonmusicians overall. Learning-related changes were not apparent in brainstem FFRs. However, plasticity was highly evident in cortex, where ERPs revealed unique hemispheric asymmetries between groups suggestive of different neural strategies (musicians: right hemisphere bias; nonmusicians: left hemisphere). Source reconstruction and the early (150-200ms) time course of these effects localized learning-induced cortical plasticity to auditory-sensory brain areas. Our findings reinforce the domain-general benefits of musicianship but reveal that successful speech sound learning is driven by a critical interplay between long- and short-term mechanisms of auditory plasticity, which first emerge at a cortical level.

Temporal hierarchy of observed goal-directed actions

During social interactions, we continuously integrate current and previous information over varying timescales to infer other people's action intentions. Motor cognition theories argue for a hierarchical organization of goal-directed actions based on temporal scales. Accordingly, transient motor primitives are represented at lower levels of the hierarchy, a combination of primitives building motor sequences at subordinate levels, and more stable overarching action goals at superordinate levels. A neural topography of hierarchal timescales for information accumulation was previously shown in the visual and auditory domains. However, whether such a temporal hierarchy can also account for observed goal-directed action representations in motor pathways remains to be determined. Thus, the current study examined the neural architecture underlying the processing of observed goal-directed actions using inter-subject correlation (ISC) of fMRI activity. Observers (n = 24) viewed sequential hand movements presented in their intact order or piecewise scrambled at three timescales pertaining to goal-directed action evolution (Primitives: ± 1.5 s, Sub-Goals: ± 4 s, and High-Goals: ± 10 s). The results revealed differential intrinsic temporal capacities for integrating goal-directed action information across brain areas engaged in action observation. Longer timescales (> ± 10 s) were found in the posterior parietal and dorsal premotor compared to the ventral premotor (± 4 s) and anterior parietal (± 1.5 s) cortex. Moreover, our results revealed a hemispheric bias with more extended timescales in the right MT+, primary somatosensory, and early visual cortices compared to their homotopic regions in the left hemisphere. Our findings corroborate a hierarchical neural mapping of observed actions based on temporal scales of goals and provide further support for a ubiquitous time-dependent neural organization of information processing across multiple modalities.

Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of the mouse auditory cortex

Coordinated functioning of the two cortical hemispheres is crucial for perception. The human auditory cortex (ACx) shows functional lateralization with the left hemisphere specialized for processing speech, whereas the right analyzes spectral content. In mice, virgin females demonstrate a left-hemisphere response bias to pup vocalizations that strengthens with motherhood. However, how this lateralized function is established is unclear. We developed a widefield imaging microscope to simultaneously image both hemispheres of mice to bilaterally monitor functional responses. We found that global ACx topography is symmetrical and stereotyped. In both male and virgin female mice, the secondary auditory cortex (A2) in the left hemisphere shows larger responses than right to high-frequency tones and adult vocalizations; however, only virgin female mice show a left-hemisphere bias in A2 in response to adult pain calls. These results indicate hemispheric bias with both sex-independent and -dependent aspects. Analyzing cross-hemispheric functional correlations showed that asymmetries exist in the strength of correlations between DM-AAF and A2-AAF, while other ACx areas showed smaller differences. We found that A2 showed lower cross-hemisphere correlation than other cortical areas, consistent with the lateralized functional activation of A2. Cross-hemispheric activity correlations are lower in deaf, otoferlin knockout (OTOF-/-) mice, indicating that the development of functional cross-hemispheric connections is experience dependent. Together, our results reveal that ACx is topographically symmetric at the macroscopic scale but that higher-order A2 shows sex-dependent and independent lateralized responses due to asymmetric intercortical functional connections. Moreover, our results suggest that sensory experience is required to establish functional cross-hemispheric connectivity.

The Matter With Things: Our Brains, Our Delusions, and the Unmaking of the World

The Matter With Things: Our Brains, Our Delusions, and the Unmaking of the World

Large-scale Spatial Cross-calibration of Hinode/SOT-SP and SDO/HMI

We investigate the cross-calibration of the Hinode/Solar Optical Telescope-Spectro-Polarimeter (SOT-SP) and Solar Dynamics Observatory/Helioseismic and Magnetic Imager (SDO/HMI) instrument metadata, specifically the correspondence of the scaling and pointing information. Accurate calibration of these data sets gives the correspondence needed by interinstrument studies and learning-based magnetogram systems, and is required for physically meaningful photospheric magnetic field vectors. We approach the problem by robustly fitting geometric models on correspondences between images from each instrument’s pipeline. This technique is common in computer vision, but several critical details are required when using scanning-slit spectrograph data like Hinode/SOT-SP. We apply this technique to data spanning a decade of the Hinode mission. Our results suggest corrections to the published Level 2 Hinode/SOT-SP data. First, an analysis on approximately 2700 scans suggests that the reported pixel size in Hinode/SOT-SP Level 2 data is incorrect by around 1%. Second, analysis of over 12,000 scans shows that the pointing information is often incorrect by dozens of arcseconds with a strong bias. Regression of these corrections indicates that thermal effects have caused secular and cyclic drift in Hinode/SOT-SP pointing data over its mission. We offer two solutions. First, direct coalignment with SDO/HMI data via our procedure can improve alignments for many Hinode/SOT-SP scans. Second, since the pointing errors are predictable, simple post-hoc corrections can substantially improve the pointing. We conclude by illustrating the impact of this updated calibration on derived physical data products needed for research and interpretation. Among other things, our results suggest that the pointing errors induce a hemispheric bias in estimates of radial current density.

Hemispheric Patterns of Recruitment of Object Processing Regions in Early Alzheimer's Disease: A Study Along the Entire Ventral Stream.

Investigation of neural response patterns along the entire network of functionally defined object recognition ventral stream regions in Alzheimer's disease (AD) is surprisingly lacking. We aimed to investigate putative functional reorganization along a wide-ranging network of known regions in the ventral visual stream in mild AD. Overall we investigated 6 regions of interest (5 of which were not investigated before), in 19 AD patients and 19 controls, in both hemispheres along the ventral visual stream: Fusiform Face Area, Fusiform Body Area, Extrastriate Body Area, Lateral Occipital Cortex, Parahippocampal Place Area, and Visual Word Form Area, while assessing object recognition performance. We found group differences in dprime measures for all object categories, corroborating generalized deficits in object recognition. Concerning neural responses, we found region dependent group differences respecting a priori expected Hemispheric asymmetries. Patients showed significantly decreased BOLD responses in the right hemisphere-biased Fusiform Body Area, and lower left hemisphere responses in the Visual Word Form Area (with a priori known left hemispheric bias), consistent with deficits in body shape and word/pseudoword processing deficits. This hemispheric dominance related effects were preserved when controlling for performance differences. Whole brain analysis during the recognition task showed enhanced activity in AD group of left dorsolateral prefrontal cortex, left cingulate gyrus, and in the posterior cingulate cortex- a hotspot of amyloid-β accumulation. These findings demonstrate region dependent respecting hemispheric dominance patterns activation changes in independently localized selective regions in mild AD, accompanied by putative compensatory activity of frontal and cingular networks.

Investigation of lateralization of socio-sexual behavior in belugas (Delphinapterus leucas)

The majority of cetacean research suggests a right side/left cerebral hemisphere bias for processing visuospatial information and a left side/right cerebral hemisphere bias for processing social information. Beluga (Delphinapterus leucas) socio-sexual behavior involves motor skills coordination and is also hypothesized to serve a social function. The present study assessed whether 14 belugas in managed care displayed side bias in their lateral socio-sexual presentation behavior. No species-level bias was found, the majority of individuals did not display a side bias, and side use was not dependent on sex of the recipient, although some influence of swim direction was found. Only males had a statistically significant but small left side preference. Furthermore, there was a linear correlation with the left side being used increasingly more over Years 1–6 of life. This study suggests that belugas do not display consistent laterality of socio-sexual presentation behavior, which is in contrast to the laterality of mother-calf positions for belugas and the high levels of laterality that are reported for some behaviors of other cetacean species. Thus, it seems that beluga socio-sexual presentation behavior is flexible and may serve both motor skills practice and social functions, which likely involve both cerebral hemispheres as a cognitively engaging behavior.

Evolution of reading and face circuits during the first three years of reading acquisition

Although words and faces activate neighboring regions in the fusiform gyrus, we lack an understanding of how such category selectivity emerges during development. To investigate the organization of reading and face circuits at the earliest stage of reading acquisition, we measured the fMRI responses to words, faces, houses, and checkerboards in three groups of 60 French children: 6-year-old pre-readers, 6-year-old beginning readers and 9-year-old advanced readers. The results showed that specific responses to written words were absent prior to reading, but emerged in beginning readers, irrespective of age. Likewise, specific responses to faces were barely visible in pre-readers and continued to evolve in the 9-year-olds, yet primarily driven by age rather than by schooling. Crucially, the sectors of ventral visual cortex that become specialized for words and faces harbored their own functional connectivity prior to reading acquisition: the VWFA with left-hemispheric spoken language areas, and the FFA with the contralateral region and the amygdalae. The results support the view that reading acquisition occurs through the recycling of a pre-existing but plastic circuit which, in pre-readers, already connects the VWFA site to other distant language areas. We argue that reading acquisition does not compete with the face system directly, through a pruning of preexisting face responses, but indirectly, by hindering the slow growth of face responses in the left hemisphere, thus increasing a pre-existing right hemispheric bias.

Left Hemisphere Bias of NIH Stroke Scale Is Most Severe for Middle Cerebral Artery Strokes.

NIHSS score is higher for left vs. right hemisphere strokes of equal volumes. However, differences in each vascular territory have not been evaluated yet. We hypothesized that left vs. right differences are driven by the middle cerebral artery (MCA) territory, and there is no difference between hemispheres for other vascular territories. This study is based on data from 802 patients with evidence of acute ischemic stroke in one major arterial territory (MCA, n = 437; PCA, n = 209; ACA, n = 21; vertebrobasilar, n = 46). We examined differences in patients with left or right strokes regarding to lesion volume, NIHSS, and other covariates (age, sex, race). We used linear models to test the effects of these covariates on NIHSS. We looked at the whole sample as well as in the sample stratified by NIHSS (≤5 or >5) and by lesion location (MCA or PCA). Patients with left MCA strokes had significantly higher NIHSS than those with right strokes. Only patients with MCA strokes showed NIHSS score affected by the hemisphere when controlling for stroke volume and patient's age. This difference was driven by the more severe strokes (NIHSS>5). It is important to consider this systematic bias in the NIHSS when using the score for inclusion criteria for treatment or trials. Patients with right MCA stroke may be under-treated and left with disabling deficits that are not captured by the NIHSS.

A Weak Shadow of Early Life Language Processing Persists in the Right Hemisphere of the Mature Brain.

Studies of language organization show a striking change in cerebral dominance for language over development: We begin life with a left hemisphere (LH) bias for language processing, which is weaker than that in adults and which can be overcome if there is a LH injury. Over development this LH bias becomes stronger and can no longer be reversed. Prior work has shown that this change results from a significant reduction in the magnitude of language activation in right hemisphere (RH) regions in adults compared to children. Here we investigate whether the spatial distribution of language activation, albeit weaker in magnitude, still persists in homotopic RH regions of the mature brain. Children aged 4–13 (n = 39) and young adults (n = 14) completed an auditory sentence comprehension fMRI (functional magnetic resonance imaging) task. To equate neural activity across the hemispheres, we applied fixed cutoffs for the number of active voxels that would be included in each hemisphere for each participant. To evaluate homotopicity, we generated left-right flipped versions of each activation map, calculated spatial overlap between the LH and RH activity in frontal and temporal regions, and tested for mean differences in the spatial overlap values between the age groups. We found that, in children as well as in adults, there was indeed a spatially intact shadow of language activity in the right frontal and temporal regions homotopic to the LH language regions. After a LH stroke in adulthood, recovering early-life activation in these regions might assist in enhancing recovery of language abilities.

Gamma Activation and Alpha Suppression within Human Auditory Cortex during a Speech Classification Task.

The dynamics of information flow within the auditory cortical hierarchy associated with speech processing and the emergence of hemispheric specialization remain incompletely understood. To study these questions with high spatiotemporal resolution, intracranial recordings in 29 human neurosurgical patients of both sexes were obtained while subjects performed a semantic classification task. Neural activity was recorded from posteromedial portion of Heschl's gyrus (HGPM) and anterolateral portion of Heschl's gyrus (HGAL), planum temporale (PT), planum polare, insula, and superior temporal gyrus (STG). Responses to monosyllabic words exhibited early gamma power increases and a later suppression of alpha power, envisioned to represent feedforward activity and decreased feedback signaling, respectively. Gamma activation and alpha suppression had distinct magnitude and latency profiles. HGPM and PT had the strongest gamma responses with shortest onset latencies, indicating that they are the earliest auditory cortical processing stages. The origin of attenuated top-down influences in auditory cortex, as indexed by alpha suppression, was in STG and HGAL. Gamma responses and alpha suppression were typically larger to nontarget words than tones. Alpha suppression was uniformly greater to target versus nontarget stimuli. Hemispheric bias for words versus tones and for target versus nontarget words, when present, was left lateralized. Better task performance was associated with increased gamma activity in the left PT and greater alpha suppression in HGPM and HGAL bilaterally. The prominence of alpha suppression during semantic classification and its accessibility for noninvasive electrophysiologic studies suggests that this measure is a promising index of auditory cortical speech processing.SIGNIFICANCE STATEMENT Understanding the dynamics of cortical speech processing requires the use of active tasks. This is the first comprehensive intracranial electroencephalography study to examine cortical activity within the superior temporal plane, lateral superior temporal gyrus, and the insula during a semantic classification task. Distinct gamma activation and alpha suppression profiles clarify the functional organization of feedforward and feedback processing within the auditory cortical hierarchy. Asymmetries in cortical speech processing emerge at early processing stages. Relationships between cortical activity and task performance are interpreted in the context of current models of speech processing. Results lay the groundwork for iEEG studies using connectivity measures of the bidirectional information flow within the auditory processing hierarchy.

On the Hemispheric Bias Seen in Vector Magnetic Field Data

On the Hemispheric Bias Seen in Vector Magnetic Field Data

Magnetoencephalography Studies of the Envelope Following Response During Amplitude-Modulated Sweeps: Diminished Phase Synchrony in Autism Spectrum Disorder.

Prevailing theories of the neural basis of at least a subset of individuals with autism spectrum disorder (ASD) include an imbalance of excitatory and inhibitory neurotransmission. These circuitry imbalances are commonly probed in adults using auditory steady-state responses (ASSR, driven at 40 Hz) to elicit coherent electrophysiological responses (EEG/MEG) from intact circuitry. Challenges to the ASSR methodology occur during development, where the optimal ASSR driving frequency may be unknown. An alternative approach (more agnostic to driving frequency) is the amplitude-modulated (AM) sweep in which the amplitude of a tone (with carrier frequency 500 Hz) is modulated as a sweep from 10 to 100 Hz over the course of ∼15 s. Phase synchrony of evoked responses, measured via intra-trial coherence, is recorded (by EEG or MEG) as a function of frequency. We applied such AM sweep stimuli bilaterally to 40 typically developing and 80 children with ASD, aged 6–18 years. Diagnoses were confirmed by DSM-5 criteria as well as autism diagnostic observation schedule (ADOS) observational assessment. Stimuli were presented binaurally during MEG recording and consisted of 20 AM swept stimuli (500 Hz carrier; sweep 10–100 Hz up and down) with a duration of ∼30 s each. Peak intra-trial coherence values and peak response frequencies of source modeled responses (auditory cortex) were examined. First, the phase synchrony or inter-trial coherence (ITC) of the ASSR is diminished in ASD; second, hemispheric bias in the ASSR, observed in typical development (TD), is maintained in ASD, and third, that the frequency at which the peak response is obtained varies on an individual basis, in part dependent on age, and with altered developmental trajectories in ASD vs. TD. Finally, there appears an association between auditory steady-state phase synchrony (taken as a proxy of neuronal circuitry integrity) and clinical assessment of language ability/impairment. We concluded that (1) the AM sweep stimulus provides a mechanism for probing ASSR in an unbiased fashion, during developmental maturation of peak response frequency, (2) peak frequencies vary, in part due to developmental age, and importantly, (3) ITC at this peak frequency is diminished in ASD, with the degree of ITC disturbance related to clinically assessed language impairment.

Improvement of the Helioseismic and Magnetic Imager (HMI) Vector Magnetic Field Inversion Code

Abstract A spectral line inversion code, Very Fast Inversion of the Stokes Vector (VFISV), has been used since 2010 May to infer the solar atmospheric parameters from the spectropolarimetric observations taken by the Helioseismic and Magnetic Imager (HMI) on board the Solar Dynamics Observatory. The magnetic filling factor, the fraction of the surface with a resolution element occupied by magnetic field, is set to have a constant value of 1 in the current version of VFISV. This report describes an improved inversion strategy for the spectropolarimetric data observed with HMI for magnetic field strengths of intermediate values in areas spatially not fully resolved. The VFISV inversion code has been modified to enable inversion of the Stokes profiles with two different components: one magnetic and one nonmagnetic. In this scheme, both components share the atmospheric components except for the magnetic field vector. In order to determine whether the new strategy is useful, we evaluate the inferred parameters inverted with one magnetic component (the original version of the HMI inversion) and with two components (the improved version) using a Bayesian analysis. In pixels with intermediate magnetic field strengths (e.g., plages), the new version provides statistically significant values of filling fraction and magnetic field vector. Not only does the fitting of the Stokes profile improve, but also the inference of the magnetic parameters and line-of-sight velocity are obtained uniquely. The new strategy is also proven to be effective for mitigating the anomalous hemispheric bias in the east–west magnetic field component in moderate field regions.

The role of neural load effects in predicting individual differences in working memory function

Studies of working memory (WM) function have tended to adopt either a within-subject approach, focusing on effects of load manipulations, or a between-subjects approach, focusing on individual differences. This dichotomy extends to WM neuroimaging studies, with different neural correlates being identified for within- and between-subjects variation in WM. Here, we examined this issue in a systematic fashion, leveraging the large-sample Human Connectome Project dataset, to conduct a well-powered, whole-brain analysis of the N-back WM task. We first demonstrate the advantages of parcellation schemes for dimension reduction, in terms of load-related effect sizes. This parcel-based approach is then utilized to directly compare the relationship between load-related (within-subject) and behavioral individual differences (between-subject) effects through both correlational and predictive analyses. The results suggest a strong linkage of within-subject and between-subject variation, with larger load-effects linked to stronger brain-behavior correlations. In frontoparietal cortex no hemispheric biases were found towards one type of variation, but the Dorsal Attention Network did exhibit greater sensitivity to between over within-subjects variation, whereas in the Somatomotor network, the reverse pattern was observed.Cross-validated predictive modeling capitalizing on this tight relationship between the two effects indicated greater predictive power for load-activated than load-deactivated parcels, while also demonstrating that load-related effect size can serve as an effective guide to feature (i.e., parcel) selection, in maximizing predictive power while maintaining interpretability. Together, the findings demonstrate an important consistency across within- and between-subjects approaches to identifying the neural substrates of WM, which can be effectively harnessed to develop more powerful predictive models.

Multiple Adjoining Word- and Face-Selective Regions in Ventral Temporal Cortex Exhibit Distinct Dynamics.

The map of category-selectivity in human ventral temporal cortex (VTC) provides organizational constraints to models of object recognition. One important principle is lateral-medial response biases to stimuli that are typically viewed in the center or periphery of the visual field. However, little is known about the relative temporal dynamics and location of regions that respond preferentially to stimulus classes that are centrally viewed, such as the face- and word-processing networks. Here, word- and face-selective regions within VTC were mapped using intracranial recordings from 36 patients. Partially overlapping, but also anatomically dissociable patches of face- and word-selectivity, were found in VTC. In addition to canonical word-selective regions along the left posterior occipitotemporal sulcus, selectivity was also located medial and anterior to face-selective regions on the fusiform gyrus at the group level and within individual male and female subjects. These regions were replicated using 7 Tesla fMRI in healthy subjects. Left hemisphere word-selective regions preceded right hemisphere responses by 125 ms, potentially reflecting the left hemisphere bias for language, with no hemispheric difference in face-selective response latency. Word-selective regions along the posterior fusiform responded first, then spread medially and laterally, then anteriorally. Face-selective responses were first seen in posterior fusiform regions bilaterally, then proceeded anteriorally from there. For both words and faces, the relative delay between regions was longer than would be predicted by purely feedforward models of visual processing. The distinct time courses of responses across these regions, and between hemispheres, suggest that a complex and dynamic functional circuit supports face and word perception.SIGNIFICANCE STATEMENT Representations of visual objects in the human brain have been shown to be organized by several principles, including whether those objects tend to be viewed centrally or peripherally in the visual field. However, it remains unclear how regions that process objects that are viewed centrally, such as words and faces, are organized relative to one another. Here, invasive and noninvasive neuroimaging suggests that there is a mosaic of regions in ventral temporal cortex that respond selectively to either words or faces. These regions display differences in the strength and timing of their responses, both within and between brain hemispheres, suggesting that they play different roles in perception. These results illuminate extended, bilateral, and dynamic brain pathways that support face perception and reading.