Helmholtz Association Research Articles

Bibliometric and visualization analysis in the field of epigenetics and glioma (2009–2024)

IntroductionGlioma represents the most prevalent primary malignant tumor in the central nervous system, a deeper understanding of the underlying molecular mechanisms driving glioma is imperative for guiding future treatment strategies. Emerging evidence has implicated a close relationship between glioma development and epigenetic regulation. However, there remains a significant lack of comprehensive summaries in this domain. This study aims to analyze epigenetic publications pertaining to gliomas from 2009 to 2024 using bibliometric methods, consolidate the extant research, and delineate future prospects for investigation in this critical area.MethodsFor the purpose of this study, publications spanning the years 2009 to 2024 were extracted from the esteemed Web of Science Core Collection (WoSCC) database. Utilizing advanced visualization tools such as CiteSpace and VOSviewer, comprehensive data pertaining to various aspects including countries, authors, author co-citations, countries/regions, institutions, journals, cited literature, and keywords were systematically visualized and analyzed.ResultsA thorough analysis was conducted on a comprehensive dataset consisting of 858 publications, which unveiled a discernible trend of steady annual growth in research output within this specific field. The nations of the United States, China, and Germany emerged as the foremost contributors to this research domain. It is noteworthy that von Deimling A and the Helmholtz Association were distinguished as prominent authors and institutions, respectively, in this corpus of literature. A rigorous keyword search and subsequent co-occurrence analysis were executed, ultimately leading to the identification of seven distinct clusters: “epigenetic regulation”, “DNA repair”, “DNA methylation”, “brain tumors”, “diffuse midline glioma (DMG)”, “U-87 MG” and “epigenomics”. Furthermore, an intricate cluster analysis revealed that the primary foci of research within this field were centered around the exploration of glioma pathogenesis and the development of corresponding treatment strategies.ConclusionThis article underscores the prevailing trends and hotspots in glioma epigenetics, offering invaluable insights that can guide future research endeavors. The investigation of epigenetic mechanisms primarily centers on DNA modification, non-coding RNAs (ncRNAs), and histone modification. Furthermore, the pursuit of overcoming temozolomide (TMZ) resistance and the exploration of diverse emerging therapeutic strategies have emerged as pivotal avenues for future research within the field of glioma epigenetics.

Chimeric antigen receptor-natural killer (CAR-NK) cell immunotherapy: A bibliometric analysis from 2004 to 2023

ABSTRACT Chimeric antigen receptor-natural killer (CAR-NK) cells represent a breakthrough in cancer immunotherapy, making this a highly popular research area. However, comprehensive analyses of this field using bibliometric methods are rare. To our knowledge, this study has collected highest number of publications (1,259) on CAR-NK therapy from January 1, 2004, to December 31, 2023, and utilized CiteSpace and VOSviewer to analyze regions, institutions, journals, authors, and keywords to forecast the latest trends in CAR-NK therapy research. The United States and China, contributing over 60% of publications, are the primary drivers in this field. The Helmholtz Association and Harvard University are the most active institutions, with most publications appearing in Frontiers in Immunology. Winfried S. Wels is the most prolific author, while EL Liu is the most frequently co-cited author. “Immunotherapy,” “T-cells,” and “Cancer” are the most extensively covered topics in CAR-NK therapy research. Our study reveals current CAR-NK research trends, identifies potential research hotspots, and visualizes references through bibliometric methods, providing valuable guidance for future research in this field.

Bibliometric analysis of microRNAs and Parkinson's disease from 2014 to 2023.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons. Recent research has emphasized a significant correlation between microRNAs (miRNAs) and PD. To identify key research areas, provide a comprehensive overview of current research in various fields, and propose potential directions for future studies, a bibliometric analysis was conducted on the involvement of miRNAs in Parkinson's disease from 2014 to 2023. Relevant literature records were collected from the Web of Science Core Collection on February 29, 2024. Subsequently, the data underwent analysis using the Bibliometrix R package and VOSviewer (version 1.6.19). The annual scientific publications on miRNAs and Parkinson's disease demonstrated an increasing trend, with an annual growth rate of 12.67%. China, the United States, and India emerged as the top three most productive countries/regions. The University of Barcelona had the highest annual publications, followed by Central South University and the Helmholtz Association. The INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES held the top position in terms of H-index and total citations, reflecting its extensive influence and prolific publication output. Kim, J., Junn, E., Hébert, S.S., and Doxakis, E. were the most frequently co-cited authors in the field. Based on the analysis of keywords, the most frequently occurring terms included "alpha-synuclein," "neurodegenerative disease," "exosome," "neuroinflammation," "oxidative stress," "autophagy," and "amyotrophic lateral sclerosis," which have emerged as prominent research topics. Concurrently, there has been notable interest in topics such as "ceRNA," "lncRNAs," "mitochondrial dysfunction," and "circular RNA." This study focused on identifying emerging trends and critical research topics in the bibliometric analysis of microRNAs related to Parkinson's disease. These findings highlight the diverse research landscape and evolving trend of miRNA-related research in PD. The field of miRNA research in Parkinson's disease is actively exploring the underlying mechanisms of miRNA function, identifying potential diagnostic markers, and developing innovative therapeutic strategies. The results of our study offer significant contributions to researchers' ability to track contemporary developments and guide the trajectory of future research in this domain.

Two decades of progress in glioma methylation research: the rise of temozolomide resistance and immunotherapy insights.

This study aims to systematically analyze the global trends in glioma methylation research using bibliometric methodologies. We focus on identifying the scholarly trajectory and key research interests, and we utilize these insights to predict future research directions within the epigenetic context of glioma. We performed a comprehensive literature search of the Web of Science Core Collection (WoSCC) to identify articles related to glioma methylation published from January 1, 2004, to December 31, 2023. The analysis included full-text publications in the English language and excluded non-research publications. Analysis and visualization were performed using GraphPad Prism, CiteSpace, and VOSviewer software. The search identified 3,744 publications within the WoSCC database, including 3,124 original research articles and 620 review articles. The research output gradually increased from 2004 to 2007, followed by a significant increase after 2008, which peaked in 2022. A minor decline in publication output was noted during 2020-2021, potentially linked to the coronavirus disease 2019 pandemic. The United States and China were the leading contributors, collectively accounting for 57.85% of the total research output. The Helmholtz Association of Germany, the German Cancer Research Center (DKFZ), and the Ruprecht Karls University of Heidelberg were the most productive institutions. The Journal of Neuro-Oncology led in terms of publication volume, while Neuro-Oncology had the highest Impact Factor. The analysis of publishing authors revealed Michael Weller as the most prolific contributor. The co-citation network analysis identified David N. Louis's article as the most frequently cited. The keyword analysis revealed "temozolomide," "expression," "survival," and "DNA methylation" as the most prominent keywords, while "heterogeneity," "overall survival," and "tumor microenvironment" showed the strongest citation bursts. The findings of this study illustrate the increasing scholarly interest in glioma methylation, with a notable increase in research output over the past two decades. This study provides a comprehensive overview of the research landscape, highlighting the importance of temozolomide, DNA methylation, and the tumor microenvironment in glioma research. Despite its limitations, this study offers valuable insights into the current research trends and potential future directions, particularly in the realm of immunotherapy and epigenetic editing techniques.

Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity.

The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach to map T2D induced changes in the miRNAs landscape in human liver samples, and a subsequent robust identification and validation of target genes are still missing. Liver biopsies from age- and gender-matched obese individuals with (n=20) or without (n=20) T2D were used for microRNA microarray analysis. The candidate microRNA and target genes were validated in 85 human liver samples, and subsequently mechanistically characterized in hepatic cells as well as by dietary interventions and hepatic overexpression in mice. Here, we present the human hepatic microRNA transcriptome of type 2 diabetes in liver biopsies and use a novel seed prediction tool to robustly identify microRNA target genes, which were then validated in a unique cohort of 85 human livers. Subsequent mouse studies identified a distinct signature of T2D-associated miRNAs, partly conserved in both species. Of those, human-murine miR-182-5 p was the most associated with whole-body glucose homeostasis and hepatic lipid metabolism. Its target gene LRP6 was consistently lower expressed in livers of obese T2D humans and mice as well as under conditions of miR-182-5 p overexpression. Weight loss in obese mice decreased hepatic miR-182-5 p and restored Lrp6 expression and other miR-182-5 p target genes. Hepatic overexpression of miR-182-5 p in mice rapidly decreased LRP6 protein levels and increased liver triglycerides and fasting insulin under obesogenic conditions after only seven days. By mapping the hepatic miRNA-transcriptome of type 2 diabetic obese subjects, validating conserved miRNAs in diet-induced mice, and establishing a novel miRNA prediction tool, we provide a robust and unique resource that will pave the way for future studies in the field. As proof of concept, we revealed that the repression of LRP6 by miR-182-5 p, which promotes lipogenesis and impairs glucose homeostasis, provides a novel mechanistic link between T2D and non-alcoholic fatty liver disease, and demonstrate in vivo that miR-182-5 p can serve as a future drug target for the treatment of obesity-driven hepatic steatosis. This work was supported by research funding from the Deutsche Forschungsgemeinschaft (KI 1887/2-1, KI 1887/2-2, KI 1887/3-1 and CRC-TR296), the European Research Council (ERC, CoG Yoyo LepReSens no. 101002247; PTP), the Helmholtz Association (Initiative and Networking Fund International Helmholtz Research School for Diabetes; MB) and the German Center for Diabetes Research (DZD Next Grant 82DZD09D1G).

Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids.

Gastrointestinal tumor organoids serve as an effective model for simulating cancer in vitro and have been applied in basic biology and preclinical research. Despite over a decade of development and increasing research achievements in this field, a systematic and comprehensive analysis of the research hotspots and future trends is lacking. To address this problem by employing bibliometric tools to explore the publication years, countries/regions, institutions, journals, authors, keywords, and references in this field. The literature was collected from Web of Science databases. CiteSpace-6.2R4, a widely used bibliometric analysis software package, was used for institutional analysis and reference burst analysis. VOSviewer 1.6.19 was used for journal co-citation analysis, author co-authorship and co-citation analysis. The 'online platform for bibliometric analysis (https://bibliometric.com/app)' was used to assess the total number of publications and the cooperation relationships between countries. Finally, we employed the bibliometric R software package (version R.4.3.1) in R-studio, for a comprehensive scientific analysis of the literature. Our analysis included a total of 1466 publications, revealing a significant yearly increase in articles on the study of gastrointestinal tumor organoids. The United States (n = 393) and Helmholtz Association (n = 93) have emerged as the leading countries and institutions, respectively, in this field, with Hans Clevers and Toshiro Sato being the most contributing authors. The most influential journal in this field is Gastroenterology. The most impactful reference is "Long term expansion of epithelial organs from human colon, adenoma, adenocarcinoma, and Barrett's epithelium". Keywords analysis and citation burst analysis indicate that precision medicine, disease modeling, drug development and screening, and regenerative medicine are the most cutting-edge directions. These focal points were further detailed based on the literature. This bibliometric study offers an objective and quantitative analysis of the research in this field, which can be considered as an important guide for next scientific research.

Fifteen Years of Integrated Terrestrial Environmental Observatories (TERENO) in Germany: Functions, Services, and Lessons Learned

AbstractThe need to develop and provide integrated observation systems to better understand and manage global and regional environmental change is one of the major challenges facing Earth system science today. In 2008, the German Helmholtz Association took up this challenge and launched the German research infrastructure TERrestrial ENvironmental Observatories (TERENO). The aim of TERENO is the establishment and maintenance of a network of observatories as a basis for an interdisciplinary and long‐term research program to investigate the effects of global environmental change on terrestrial ecosystems and their socio‐economic consequences. State‐of‐the‐art methods from the field of environmental monitoring, geophysics, remote sensing, and modeling are used to record and analyze states and fluxes in different environmental disciplines from groundwater through the vadose zone, surface water, and biosphere, up to the lower atmosphere. Over the past 15 years we have collectively gained experience in operating a long‐term observing network, thereby overcoming unexpected operational and institutional challenges, exceeding expectations, and facilitating new research. Today, the TERENO network is a key pillar for environmental modeling and forecasting in Germany, an information hub for practitioners and policy stakeholders in agriculture, forestry, and water management at regional to national levels, a nucleus for international collaboration, academic training and scientific outreach, an important anchor for large‐scale experiments, and a trigger for methodological innovation and technological progress. This article describes TERENO's key services and functions, presents the main lessons learned from this 15‐year effort, and emphasizes the need to continue long‐term integrated environmental monitoring programmes in the future.

Towards a quality indicator for research data publications and research software publications – a vision from the Helmholtz Association

Research data and software are widely accepted as an outcome of scientific work. However, in comparison to text-based publications, there is not yet an established process to assess and evaluate quality of research data and research software publications. This paper presents an attempt to fill this gap. Initiated by the Working Group Open Science of the Helmholtz Association, the Task Group Helmholtz Quality Indicators for Data and Software Publications currently develops a quality indicator for research data and research software publications to be used within the Association. This report summarizes the vision of the group of what all contributes to such an indicator. The proposed approach relies on generic well-established concepts for quality criteria, such as the FAIR Principles and the COBIT Maturity Model. It does – on purpose – not limit itself to technical implementation possibilities to avoid using an existing metric for a new purpose. The intention of this paper is to share the current state for further discussion with all stakeholders, particularly with other groups also working on similar metrics but also with entities that use the metrics.

FAIR-EuMon: a FAIR-enabling resource for biodiversity monitoring schemes.

Within the scope of the Helmholtz Metadata Collaboration (HMC), the ADVANCE project - Advanced metadata standards for biodiversity survey and monitoring data: supporting of research and conservation - aimed at supporting rich metadata generation with interoperable metadata standards and semantic artefacts that facilitate data access, integration and reuse across terrestrial, freshwater and marine realms. HMC's mission is to facilitate the discovery, access, machine-readability, and reuse of research data across and beyond the Helmholtz Association. We revised, adapted and expanded existing metadata schemas, vocabularies and thesauri to build a FAIR metadata schema and a metadata entry form built on it for users to provide their metadata instances focused on biodiversity monitoring data. The schema is FAIR because it is both machine-interpretable and follows domain-relevant community standards. This report provides a general overview of the project results and instructions on how to access, re-use and complete the metadata form.

In-Situ Spectroscopic Investigation of 3-D Gas Diffusion Electrodes for Fuel Cell Reactions in Half-Cell Setups

Significant work has already been done in understanding proton exchange membrane fuel cells (PEMFC) over the past decades. In-situ visualization of the fuel-cell reactions has developed considerably and has also helped in understanding the challenges which still exist in various steps of electrochemical processing. Gas diffusion electrode half-cells have been widely promoted for fundamental catalysis research and when coupled with techniques like X-ray absorption spectroscopy (XAS) can be used for in-situ/operando studies of the reaction mechanisms in fuel cell reactions. This is particularly important to address the challenges in low temperature PEMFCs (eg. degradation of catalyst during durability tests) as well as high temperature PEMFCs (eg. poisoning of the Pt catalyst and low oxygen solubility in phosphoric acid).In this presentation, an effort will be made to illuminate the catalytic characteristics during oxygen reduction reaction using in-situ XAS. The co-adsorption of H3PO3 and CO on platinum catalysts will be investigated using the Δµ XANES technique by following the signatures of different species adsorbed on the catalyst surface, and the Efix technique which follows the variation of signal intensity at a fixed energy near to the white line to follow the changes in Pt oxidation. During CO removal through cyclic voltammetry in the presence of 800 µM H3PO3 (as shown in the figure provided) it is possible to see a clear change in signal intensity around the potential of 250 mVAg/AgCl, which was associated with the oxidation of H3PO3 to H3PO4, since CO oxidation takes place at higher potentials (above 600 mVAg/AgCl). It is also interesting to note that when oxidizing H3PO3 to H3PO4, the platinum surface significantly reduced. With these experiments, it can be concluded that the Efix technique has a great potential to better understand what happens to Pt during the oxidation of H3PO3, as well as to identify more clearly the oxidation potential of this species, which is not easy to do based on the electrochemical data alone. Considering that this species is one of the main species responsible for the poisoning of the Pt catalyst during the operation of fuel cells, it is extremely important to understand the life cycle of this compound so that the operating conditions can be adapted to maximize the performance of the catalyst and develop new catalysts more resistant to poisoning by phosphorous species for HT-PEMFCs.Acknowledgements:Prof. Matthias Arenz from University of Bern, Martin Prokopand Tomàs Bystrom from University of Chemistry and Technology Prague, Michael Haumann, Freie Universität Berlin are gratefully thanked for their collaboration. German Research Foundation DFG Project ID RO 2454/19-1, the Bavarian Gender Equality Grant 2019-2021 (for Women in Academia), Petra III DESY (Hamburg, Germany), a member of the Helmholtz Association HGF, P65 beamline (I-20211432) and KMC-3 beamline BESSY (Berlin,Germany). Figure 1

Colorectal cancer and gut viruses: a visualized analysis based on CiteSpace knowledge graph

BackgroundGut microbiome is a complex community of microbes present in the human gut and plays an important role in the occurrence and progression of colorectal cancer (CRC). However, the relationship between virus and CRC has not been fully understood.ObjectiveTo explore the hot spots and research trends in the field of CRC and virus.MethodsBy using the bibliometric analysis tool CiteSpace and based on the articles of the Web of Science Core Collection (WoSCC) database, the country, institution, highly cited literature, keywords and so on were visually analyzed.ResultsA total of 356 research articles on CRC from 2001 to 2023 were thoroughly analyzed. The USA and China have made the largest contribution in the field of virus and CRC. The Helmholtz Association published the most papers. There were relatively few cooperations among institutions from different countries. The results of keyword cluster analysis proved that the literature on the relationship between human cytomegalovirus (CMV) and CRC was the most widely studied aspect in this field. “Gut microbiota,” “inflammatory bowel disease,” “hepatitis b virus,” and “human papillomavirus infection” are the current research hotspots; “oncolytic virus,” “apoptosis,” and “gut microbiome” are the recent research frontiers and should be paid closer attention.ConclusionBy using CiteSpace bibliometric software, the visual analysis reflected the research trends and hot topics of virus and CRC. In addition, the prevalence and mechanism of specific virus on CRC were also reviewed, which provides valuable references for future CRC research.

Mechanisms of weight loss-induced remission in people with prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS)

Remission of type 2 diabetes can occur as a result of weight loss and is characterised by liver fat and pancreas fat reduction and recovered insulin secretion. In this analysis, we aimed to investigate the mechanisms of weight loss- induced remission in people with prediabetes. In this prespecified post-hoc analysis, weight loss-induced resolution of prediabetes in the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS) was assessed, and the results were validated against participants from the Diabetes Prevention Program (DPP) study. For PLIS, between March 1, 2012, and Aug 31, 2016, participants were recruited from eight clinical study centres (including seven university hospitals) in Germany and randomly assigned to receive either a control intervention, a standard lifestyle intervention (ie, DPP-based intervention), or an intensified lifestyle intervention for 12 months. For DPP, participants were recruited from 23 clinical study centres in the USA between July 31, 1996, and May 18, 1999, and randomly assigned to receive either a standard lifestyle intervention, metformin, or placebo. In both PLIS and DPP, only participants who were randomly assigned to receive lifestyle intervention or placebo and who lost at least 5% of their bodyweight were included in this analysis. Responders were defined as people who returned to normal fasting plasma glucose (FPG; <5·6 mmol/L), normal glucose tolerance (<7·8 mmol/L), and HbA1c less than 39 mmol/mol after 12 months of lifestyle intervention or placebo or control intervention. Non-responders were defined as people who had FPG, 2 h glucose, or HbA1c more than these thresholds. The main outcomes for this analysis were insulin sensitivity, insulin secretion, visceral adipose tissue (VAT), and intrahepatic lipid content (IHL) and were evaluated via linear mixed models. Of 1160 participants recruited to PLIS, 298 (25·7%) had weight loss of 5% or more of their bodyweight at baseline. 128 (43%) of 298 participants were responders and 170 (57%) were non-responders. Responders were younger than non-responders (mean age 55·6 years [SD 9·9] vs 60·4 years [8·6]; p<0·0001). The DPP validation cohort included 683 participants who lost at least 5% of their bodyweight at baseline. Of these, 132 (19%) were responders and 551 (81%) were non-responders. In PLIS, BMI reduction was similar between responders and non-responders (responders mean at baseline 32·4 kg/m2 [SD 5·6] to mean at 12 months 29·0 kg/m2 [4·9] vs non-responders 32·1 kg/m2 [5·9] to 29·2 kg/m2 [5·4]; p=0·86). However, whole-body insulin sensitivity increased more in responders than in non-responders (mean at baseline 291 mL/[min × m2], SD 60 to mean at 12 months 378 mL/[min × m2], 56 vs 278 mL/[min × m2], 62, to 323 mL/[min × m2], 66; p<0·0001), whereas insulin secretion did not differ within groups over time or between groups (responders mean at baseline 175 pmol/mmol [SD 64] to mean at 12 months 163·7 pmol/mmol [60·6] vs non-responders 158·0 pmol/mmol [55·6] to 154·1 pmol/mmol [56·2]; p=0·46). IHL decreased in both groups, without a difference between groups (responders mean at baseline 10·1% [SD 8·7] to mean at 12 months 3·5% [3·9] vs non-responders 10·3% [8·1] to 4·2% [4·2]; p=0·34); however, VAT decreased more in responders than in non-responders (mean at baseline 6·2 L [SD 2·9] to mean at 12 months 4·1 L [2·3] vs 5·7 L [2·3] to 4·5 L [2·2]; p=0·0003). Responders had a 73% lower risk of developing type 2 diabetes than non-responders in the 2 years after the intervention ended. By contrast to remission of type 2 diabetes, resolution of prediabetes was characterised by an improvement in insulin sensitivity and reduced VAT. Because return to normal glucose regulation (NGR) prevents development of type 2 diabetes, we propose the concept of remission of prediabetes in analogy to type 2 diabetes. We suggest that remission of prediabetes should be the primary therapeutic aim in individuals with prediabetes. German Federal Ministry for Education and Research via the German Center for Diabetes Research; the Ministry of Science, Research and the Arts Baden-Württemberg; the Helmholtz Association and Helmholtz Munich; the Cluster of Excellence Controlling Microbes to Fight Infections; and the German Research Foundation.

The HMC Information Portal for Enhanced Metadata Collaboration in the Helmholtz FAIR Data Space

The Helmholtz Metadata Collaboration (HMC) platform was launched in late 2019 to turn FAIR (Findable, Accessible, Interoperable, Reusable) research data into reality within the Helmholtz Association and beyond. The Information Portal was initiated to enable the structured cartography of metadata and FAIR landscape of Helmholtz, providing information for multi-level decision-making and creating a curated knowledge base for research data managers, scientists and other stakeholders.&#x0D; Developed through a top-down approach, 18 categories, and associated metadata schemas were defined and aligned by an HMC taskforce. Data curation followed, with resources collected from different domains based on the aligned metadata schema. The Information Portal is a web application for capturing FAIR data practices across all Helmholtz domains, offering a unified user interface for collecting and exploring results.&#x0D; Built using state-of-the-art technologies, including Python and Docker, the Information Portal leverages GitLab as a database. It offers a public / central read-only version for stakeholders and a personal instance for curation - synchronized to a GitLab repository. Git-based systems offer advantages, such as raw data accessibility, flexible data curation, easy synchronization, and customizable repositories.&#x0D; The single-page web application is user-friendly and developed in multiple iterations for an intuitive and flexible interface. The Information Portal is crucial for creating a sustainable, distributed, semantically enriched Helmholtz data space, promoting seamless data sharing and reuse.

Monitoring the State of Open and FAIR Data in Helmholtz

In this contribution we present an integrated approach to monitoring and assessing the state of open and FAIR data in the Helmholtz Association. The project is part of a multi-method approach by Hub Matter in the Helmholtz Metadata Collaboration (HMC).&#x0D; In a harvesting-approach, data published by Helmholtz researchers is found starting from literature metadata, harvested from the research centers. Data publications linked to that literature are identified using the SCHOLIX API. In a first approach to automated FAIR assessment, we adopted the F-UJI framework, as developed by the FAIRsFAIR consortium.&#x0D; The information collected is presented in an interactive dashboard. It allows to explore in which repositories Helmholtz researchers make their data publicly available, to engage Helmholtz communities, and to identify gaps towards improving the FAIRness of Helmholtz data.&#x0D; The dashboard is publicly available on https://fairdashboard.helmholtz-metadaten.de. The general approach as well as all program code are reusable by all research communities.

Providing AI expertise as an infrastructure in academia

Artificial intelligence (AI) is proliferating and developing faster than any domain scientist can adapt. To support the scientific enterprise in the Helmholtz association, a network of AI specialists has been set up to disseminate AI expertise as an infrastructure among domain scientists. As this effort exposes an evolutionary step in science organization in Germany, this article aspires to describe our setup, goals, and motivations. We comment on past experiences, current developments, and future ideas as we bring our expertise as an infrastructure closer to scientists across our organization. We hope that this offers a brief yet insightful view of our activities as well as inspiration for other science organizations.

Global research on submarine landslides, 2001–2020

Submarine landslides, one of the hotspots in marine geoscience research, are one of the most harmful marine geological disasters. To understand the research status and further research directions of submarine landslides, this paper analyzed the global submarine landslide-related work during the period from 2001 to 2020. To achieve this objective, Science Citation Index Expand and the Social Sciences Citation Index, belonging to the WoS Core Collection, were the two bibliographic databases selected as a reference. In this study, we focused on document types, publishing languages, subject categories, journals’ productivity, countries and author, and co-occurrence keywords network. Geoscience multidisciplinary, Geochemistry Geophysics, Oceanography, Environmental Sciences, and Materials Science Multidisciplinary have been the most commonly used science categories in the past two decades. Marine Geology, Marine and Petroleum Geology, Journal of Volcanology, and Geothermal Research are the three most productive journals on submarine landslides. Marine Geology is the most active journal among all the journals. The United States, the United Kingdom, China, Germany, and France are the five most productive countries. At the institutional level, the Centre National De la Recherche Scientifique (France) is the most active institution, followed by the Chinese Academy of Sciences (China) and Helmholtz Association (Germany). Masson DG and Talling PJ from the United Kingdom contribute to the most high-quality submarine landslide-related publications. Analyzing by CiteSpace, the five largest clusters in the submarine landslide field are “gas hydrate,” “turbidity current,” “thin film,” “debris avalanche,” and “submarine canyon.” Active further research directions of submarine landslides are “south china sea,” “slump,” and “submarine mass failure.”

Cardiometabolic HFpEF: NASH of the Heart.

HomeCirculationVol. 147, No. 6Cardiometabolic HFpEF: NASH of the Heart No AccessArticle CommentaryRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessArticle CommentaryRequest AccessFull TextCardiometabolic HFpEF: NASH of the Heart Federico Capone, MD, Roberto Vettor, MD and Gabriele G. Schiattarella, MD, PhD Federico CaponeFederico Capone Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (F.C., G.G.S.). Division of Internal Medicine, Department of Medicine, University of Padua, Italy (F.C., R.V.). Search for more papers by this author , Roberto VettorRoberto Vettor Division of Internal Medicine, Department of Medicine, University of Padua, Italy (F.C., R.V.). Search for more papers by this author and Gabriele G. SchiattarellaGabriele G. Schiattarella Correspondence to: Gabriele G. Schiattarella, MD, PhD, Max Rubner Center for Cardiovascular Metabolic Renal Research, Charité - Universitätsmedizin Berlin, Berlin, Germany. Email E-mail Address: [email protected] https://orcid.org/0000-0002-7582-7171 Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (F.C., G.G.S.). Max Rubner Center for Cardiovascular Metabolic Renal Research, Charité - Universitätsmedizin Berlin, Germany (G.G.S.). German Center for Cardiovascular Research, Partner Site Berlin, Germany (G.G.S.). Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy (G.G.S.). Search for more papers by this author Originally published6 Feb 2023https://doi.org/10.1161/CIRCULATIONAHA.122.062874Circulation. 2023;147:451–453FootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Sources of Funding and Disclosures, see page 453.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Gabriele G. Schiattarella, MD, PhD, Max Rubner Center for Cardiovascular Metabolic Renal Research, Charité - Universitätsmedizin Berlin, Berlin, Germany. Email gabriele.[email protected]de

GRACE time-variable gravity and its application to geoscience: Quantitative analysis of relevant literature

The Gravity Recovery and Climate Experiment (GRACE) is the most important gravity satellite to date in human history. Since its launch in 2002, GRACE time-varying gravity has had an unprecedented impact on earth science and has generated revolutionary changes. Because of natural phenomena such as climate warming, glacial melting, sea level rise, and earthquakes, earth science research has become an increasingly popular discipline in recent years. This article summarizes the importance of GRACE time-varying gravity, its application to geoscience, and its development. We analyzed the historical development and current status of GRACE time-varying gravity as well as research hotspots by searching the literature in the core collection databases of the China National Knowledge Infrastructure and the Web of Science over the past 20 years. The CiteSpace and VOSviewer software packages were applied with reference to the principle of literature metrology. Our investigation and analysis of characteristic indexes, such as the numbers of publications, co-occurrence of keywords, and co-citation of documents, uncovered the wide application and promotion of gravity satellites, especially GRACE time-varying gravity, in earth science. The results showed that the number of publications addressing GRACE data and time-varying gravity theory is increasing annually and that the USA, China, and Germany are the main producers. The Chinese Academy of Sciences, the National Aeronautics and Space Administration of the United States, and the Helmholtz Association of German Research Centres rank among the top three institutions in the world in terms of producing the most publications on this topic. We found that GRACE time-varying gravity plays unique roles in measuring changes in terrestrial water storage changes, ice and snow melting and sea level changes, and (co)seismic gravity changes, as well as in promoting other disciplines.

HESEB: The Helmholtz state-of-the-art Soft-X-Ray Undulator beamline at SESAME

SESAME and a consortium of five Helmholtz Centers are designing and installing a state-of-the-art soft X-Ray undulator beamline at the SESAME light source in Amman, Jordan. Funding is provided by the Helmholtz Association over a four year project cycle that started in January 2019. This is an interim report covering the first 36 months of the project where the construction and installation has been almost completed and commissioning and characterization of the beamline is about to start. Additionally, seminars, workshops, and a training program are part of the project aimed at establishing a broad user community.

Realizing FAIR Digital Objects for the German Helmholtz Association of Research Centres

Realizing FAIR Digital Objects for the German Helmholtz Association of Research Centres