An observing campaign (SOHO JOP 139), coordinated between ground based and SOHO instruments, has been planned to obtain simultaneous spectroheliograms of the same active region in several spectral lines. The chromospheric lines CaII K, Halpha and Na D as well as HeI 10830, 5876, 584 and HeII 304 AA lines have been observed.These simultaneous observations allow us to build semi-empirical models of the chromosphere and low transition region of an active region, taking into account the estimated total number of photoionizing photons impinging on the target active region and their spectral distribution. We obtained a model that matches very well all the observed line profiles, using a standard value for the He abundance ([He]=0.1) and a modified distribution of microturbulence. For this model we study the influence of the coronal radiation on the computed helium lines. We find that, even in an active region, the incident coronal radiation has a limited effect on the UV He lines, while it results of fundamental importance for the 5876 and 10830 lines. Finally we build two more models assuming values of He abundance [He]= 0.07 and 1.5, only in the region where temperatures are larger than 1.* 10^4 K. This region, between the chromosphere and transition region, has been indicated as a good candidate for processes that might be responsible for strong variations of [He]. The set of our observables can still be well reproduced in both cases changing the atmospheric structure mainly in the low transition region. This implies that,to choose between different values of [He], it is necessary to constrain the transition region with different observables, independent on the He lines.