With the development of urban agglomerations in China, the study of the interactions between cities has become a popular and difficult issue. Exploring the interactions between cities can help decision-makers optimize regional resource allocation and improve regional spatial patterns. Combining the urban flow model and the patch-generating land use simulation (PLUS) model, this study simulates and analyzes the process of urban expansion in the Beijing–Tianjin–Hebei (BTH) region, and investigates the impact of urban hierarchical structure differences on urban expansion. In this study, the role and influence of inter-city economy flow, transportation flow, population flow, and information flow on the development of urban agglomerations are comprehensively considered, and a multilevel urban interaction model is constructed based on a hierarchical generalized linear model (HGLM). Based on the national BTH cooperation and development strategy, a multi-scenario simulation study of urban expansion is carried out using the HGLM-PLUS model. The results indicate the following: (1) compared to the traditional PLUS model, the coupled HGLM-PLUS model, which considers multilevel urban flows, improved the overall accuracy by 0.047, the Kappa coefficient by 0.207, and the figure of merit (FoM) index by 0.051; (2) under different simulation scenarios, the development trend under the cooperation and development policy in the BTH region is more stable, demonstrating a relatively smooth urbanization expansion trend; and (3) under the BTH cooperation and development background, the total area of construction land in the BTH region is expected to be maintained at around 1,164,500 km2 by 2040. The spatial expansion pattern will present a networked expansion with the core driving development, axes and belts connecting, and clusters breaking through.
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