Traditionally, isoscaling has been interpreted and applied within the framework of the grand canonical ensemble, based on the assumption that fragment production occurs following the attainment of a statistical equilibrium state. However, the influence of the symmetry energy can lead to differences in the neutron and density distribution in neutron-rich nuclei. This in turn may impact the isoscaling parameters (usually denoted by α and β). We examine the isoscaling properties for neutron-rich fragments produced in highly asymmetric systems on inverse kinematics, namely Ca and Ni + Be at 140 MeV per nucleon. We evaluate α and β values and sort them as a function of the neutron excess . The significant differences in α extracted from fragments within different ranges of I emphasize the importance of understanding the dependence of isoscaling parameters on fragments generated in various collision regions. Furthermore, the value for a specific fragment in small size and highly isospin asymmetry systems can serve as a probe to detect the variations in neutron density and proton density in different regions of the nucleus and indicate the limitations of theoretical models in investigating these issues.