Abstract This anticipated model investigates the time-dependent, and incompressible 2D magnetized Jeffrey liquid flowing on a sensor surface placed between two infinite parallel plates with the existence of a uniform heat source/sink. The lower plate remains fixed while the upper plate is subject to squeezing. For the heat and mass transmission processes, the consequences of radiative heat flux, chemical reaction, and thermophoretic particle deposition are applied and analyzed. The envisioned model is supported by prescribed heat and mass flux conditions. The uniqueness of the proposed model is the analysis of the unsteady squeezed flow of Jeffrey liquid over a sensor surface, accounting for radiative heat flux, thermophoretic particle deposition, and variable thermal conductivity. The model possesses applications in microfluidic sensors, biomedical devices, thermal management systems, and inkjet printing. The equations comprising the model are subject to similarity transformations. The bvp4c package is utilized to analyze the dynamic flow system. The connotation of arising parameters with the associated profiles is depicted through graphs and tables. It is examined that fluid velocity, temperature, and concentration profiles are dwindling functions of squeezed parameter. It is also witnessed that the concentration of liquid drops with an enhancement of thermophoretic and chemical reaction parameters. The validation of the truthfulness of the envisioned model is an added feature of this study.