Magnetohydrodynamic (MHD) fluid flows attract a lot of attention in the extrusion of polymers, in the theory of nanofluids, as well as in the consideration of biological fluids. The considered problem in the paper is the flow and heat transfer of nano and micropolar fluid in inclined channel. Fluid flow is steady, while nano and micropolar fluids are incompressible, immiscible, and electrically conductive. The upper and lower channel plates are electrically insulated and maintained at constant and different temperatures. External applied magnetic field is perpendicular to the fluid flow and considered problem is in induction-less approximation. The equations of the considered problem are reduced to ordinary differential equations, which are analytically solved in closed form. The influence of characteristics parameters of nano and micropolar fluids on velocity, micro-rotation and temperature fields are graphically shown and discussed. The general conclusions given through the analysis of graphs can be used for better understanding of the flow and heat transfer of nano and micropolar fluid, which have a great practical application. Fluids with nanoparticles innovated the modern era, due to their comprehensive applications in nanotechnology and manufacturing processes, while the theory of micropolar fluids explains the flow of biological fluids and various types of liquid metals and crystals.