Integrating photovoltaic (PV) panels with different tilt angles in building envelopes or roofs is widely employed for environmental sustainability. However, little is known about the influence of different tilt angles on the thermal failure of the photovoltaic façades or roofs in fire conditions. A total of 15 four-edge shielded PV panels (300 × 300 × 4.7 mm3), with five different inclinations of 0°, 15°, 30°, 45° and 60°, were heated to fail using a uniform radiant panel. Measurements were taken to track glass thermal breakage, surface temperatures, incident heat flux and failure characteristics. The glass fracture and pyrolysis of the internal thermoplastic materials were observed under thermal radiation. The average breakage time of glass in PV panels showed an increasing trend with increasing inclination of the PV panels. Moreover, when the PV panels were tilted beyond 30°, the time to failure increased more significantly. The maximum temperature difference and heat flux that the PV panels can withstand were primarily measured within the range of 61–84 °C and 8–15 kW/m2, respectively. Finally, the test results were simulated by a finite element method (FEM) model, calculating the heat transfer and thermal stress of PV panels: the average errors concerning temperature distributions and failure times were smaller than 15 % compared with the experimental results.